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Anti-IL-13Rα2 therapy promotes recovery in a murine model of inflammatory bowel disease.

Karmele EP, Pasricha TS, Ramalingam TR, Thompson RW, Gieseck RL 3rd, Knilans KJ, Hegen M, Farmer M, Jin F, Kleinman A, Hinds DA; 23andMe Research Team, Almeida Pereira T, de Queiroz Prado R, Bing N, Tchistiakova L, Kasaian MT, Wynn TA, Vannella KM.

Mucosal Immunol. 2019 Jul 15. doi: 10.1038/s41385-019-0189-6. [Epub ahead of print]


Two types of fibroblast drive arthritis.

Wynn TA.

Nature. 2019 Jun;570(7760):169-170. doi: 10.1038/d41586-019-01594-9. No abstract available.


Breast Cancer knowledge, perceptions and practices in a rural Community in Coastal Kenya.

Sayed S, Ngugi AK, Mahoney MR, Kurji J, Talib ZM, Macfarlane SB, Wynn TA, Saleh M, Lakhani A, Nderitu E, Agoi F, Premji Z, Zujewski JA, Moloo Z.

BMC Public Health. 2019 Feb 12;19(1):180. doi: 10.1186/s12889-019-6464-3.


Fibroblast-specific integrin-alpha V differentially regulates type 17 and type 2 driven inflammation and fibrosis.

Sciurba JC, Gieseck RL, Jiwrajka N, White SD, Karmele EP, Redes J, Vannella KM, Henderson NC, Wynn TA, Hart KM.

J Pathol. 2019 May;248(1):16-29. doi: 10.1002/path.5215. Epub 2019 Jan 24.


Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection.

Sutherland TE, Rückerl D, Logan N, Duncan S, Wynn TA, Allen JE.

PLoS Pathog. 2018 Nov 30;14(11):e1007423. doi: 10.1371/journal.ppat.1007423. eCollection 2018 Nov.


An Exploration of Multilevel Physical Activity Correlates Among Low-Income African Americans in Alabama and Mississippi.

OʼNeal LJ, Bateman LB, Smith T, Li Y, Dai C, Wynn TA, Fouad MN.

Fam Community Health. 2018 Oct/Dec;41(4):197-204. doi: 10.1097/FCH.0000000000000203.


Introduction: Impacting the Social Determinants of Health through a Regional Academic-Community Partnership: The Experience of the Mid-South Transdisciplinary Collaborative Center for Health Disparities Research.

Fouad MN, Wynn TA, Scribner R, Schoenberger YM, Antoine-Lavigne D, Eady S, Anderson WA, Bateman LB.

Ethn Dis. 2017 Nov 9;27(Suppl 1):277-286. doi: 10.18865/ed.27.S1.277. eCollection 2017.


Focused Ion Beam Fabrication of LiPON-based Solid-state Lithium-ion Nanobatteries for In Situ Testing.

Lee JZ, Wynn TA, Meng YS, Santhanagopalan D.

J Vis Exp. 2018 Mar 7;(133). doi: 10.3791/56259.


Policy, System and Environmental Correlates of Fruit and Vegetable Consumption in a Low-Income African American Population in the Southeast.

Bateman LB, O'Neal LJ, Smith T, Li Y, Wynn TA, Dai C, Fouad MN.

Ethn Dis. 2017 Nov 9;27(Suppl 1):355-362. doi: 10.18865/ed.27.S1.355. eCollection 2017.


Type 2 immunity in tissue repair and fibrosis.

Gieseck RL 3rd, Wilson MS, Wynn TA.

Nat Rev Immunol. 2018 Jan;18(1):62-76. doi: 10.1038/nri.2017.90. Epub 2017 Aug 30. Review.


Repetitive intradermal bleomycin injections evoke T-helper cell 2 cytokine-driven pulmonary fibrosis.

Singh B, Kasam RK, Sontake V, Wynn TA, Madala SK.

Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L796-L806. doi: 10.1152/ajplung.00184.2017. Epub 2017 Aug 3.


Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids.

Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL 3rd, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander GJ, Sinha S, Hannan NRF, Wynn TA, Karlsen TH, Melum E, Markaki AE, Saeb-Parsy K, Vallier L.

Nat Med. 2017 Aug;23(8):954-963. doi: 10.1038/nm.4360. Epub 2017 Jul 3.


Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β.

Hart KM, Fabre T, Sciurba JC, Gieseck RL 3rd, Borthwick LA, Vannella KM, Acciani TH, de Queiroz Prado R, Thompson RW, White S, Soucy G, Bilodeau M, Ramalingam TR, Arron JR, Shoukry NH, Wynn TA.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3694. doi: 10.1126/scitranslmed.aal3694.


Cutting Edge: Eosinophils Undergo Caspase-1-Mediated Pyroptosis in Response to Necrotic Liver Cells.

Palacios-Macapagal D, Connor J, Mustelin T, Ramalingam TR, Wynn TA, Davidson TS.

J Immunol. 2017 Aug 1;199(3):847-853. doi: 10.4049/jimmunol.1601162. Epub 2017 Jun 26.


Inflammation and metabolism in tissue repair and regeneration.

Eming SA, Wynn TA, Martin P.

Science. 2017 Jun 9;356(6342):1026-1030. doi: 10.1126/science.aam7928. Epub 2017 Jun 8. Review.


Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate. Report of an NCI Workshop, September 19, 2016.

Citrin DE, Prasanna PGS, Walker AJ, Freeman ML, Eke I, Barcellos-Hoff MH, Arankalayil MJ, Cohen EP, Wilkins RC, Ahmed MM, Anscher MS, Movsas B, Buchsbaum JC, Mendonca MS, Wynn TA, Coleman CN.

Radiat Res. 2017 Jul;188(1):1-20. doi: 10.1667/RR14784.1. Epub 2017 May 10.


Accurately measuring and modeling Th2 and Th17 endotypes in severe asthma.

Hart KM, Choy DF, Bradding P, Wynn TA, Arron JR.

Ann Transl Med. 2017 Feb;5(4):91. doi: 10.21037/atm.2017.02.07. No abstract available.


IL-13 is a therapeutic target in radiation lung injury.

Chung SI, Horton JA, Ramalingam TR, White AO, Chung EJ, Hudak KE, Scroggins BT, Arron JR, Wynn TA, Citrin DE.

Sci Rep. 2016 Dec 22;6:39714. doi: 10.1038/srep39714.


Mechanisms of Organ Injury and Repair by Macrophages.

Vannella KM, Wynn TA.

Annu Rev Physiol. 2017 Feb 10;79:593-617. doi: 10.1146/annurev-physiol-022516-034356. Epub 2016 Dec 7. Review.


T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions.

Van de Velde LA, Subramanian C, Smith AM, Barron L, Qualls JE, Neale G, Alfonso-Pecchio A, Jackowski S, Rock CO, Wynn TA, Murray PJ.

J Biol Chem. 2017 Jan 6;292(1):15-30. doi: 10.1074/jbc.M116.766238. Epub 2016 Nov 30.


Breaking the Mold: Partnering with the National Institutes of Health Intramural Research Program to Accelerate PhD Training.

Soucy K, Fairhurst RM, Lynn GM, Fomalont K, Wynn TA, Siegel RM.

Trends Immunol. 2016 Dec;37(12):813-815. doi: 10.1016/ Epub 2016 Nov 9.


IL4I1 augments CNS remyelination and axonal protection by modulating T cell driven inflammation.

Psachoulia K, Chamberlain KA, Heo D, Davis SE, Paskus JD, Nanescu SE, Dupree JL, Wynn TA, Huang JK.

Brain. 2016 Dec;139(Pt 12):3121-3136. Epub 2016 Oct 25.


Tailoring Spin Textures in Complex Oxide Micromagnets.

Lee MS, Wynn TA, Folven E, Chopdekar RV, Scholl A, Young AT, Retterer ST, Grepstad JK, Takamura Y.

ACS Nano. 2016 Sep 27;10(9):8545-51. doi: 10.1021/acsnano.6b03770. Epub 2016 Sep 14.


Using Community Feedback to Improve Community Interventions: Results From the Deep South Network for Cancer Control Project.

Wynn TA, Wyatt SB, Hardy CM, Walker SS, Thomas TF, Williams AG, Partridge EE.

Fam Community Health. 2016 Oct-Dec;39(4):234-41. doi: 10.1097/FCH.0000000000000101.


Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation.

Woytschak J, Keller N, Krieg C, Impellizzieri D, Thompson RW, Wynn TA, Zinkernagel AS, Boyman O.

Immunity. 2016 Jul 19;45(1):172-84. doi: 10.1016/j.immuni.2016.06.025.


Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis.

Gieseck RL 3rd, Ramalingam TR, Hart KM, Vannella KM, Cantu DA, Lu WY, Ferreira-González S, Forbes SJ, Vallier L, Wynn TA.

Immunity. 2016 Jul 19;45(1):145-58. doi: 10.1016/j.immuni.2016.06.009. Epub 2016 Jul 12.


Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine-driven inflammation and fibrosis.

Vannella KM, Ramalingam TR, Borthwick LA, Barron L, Hart KM, Thompson RW, Kindrachuk KN, Cheever AW, White S, Budelsky AL, Comeau MR, Smith DE, Wynn TA.

Sci Transl Med. 2016 May 4;8(337):337ra65. doi: 10.1126/scitranslmed.aaf1938.


Enhanced protection from fibrosis and inflammation in the combined absence of IL-13 and IFN-γ.

Ramalingam TR, Gieseck RL, Acciani TH, M Hart K, Cheever AW, Mentink-Kane MM, Vannella KM, Wynn TA.

J Pathol. 2016 Jul;239(3):344-54. doi: 10.1002/path.4733. Epub 2016 Jun 10.


Acidic chitinase primes the protective immune response to gastrointestinal nematodes.

Vannella KM, Ramalingam TR, Hart KM, de Queiroz Prado R, Sciurba J, Barron L, Borthwick LA, Smith AD, Mentink-Kane M, White S, Thompson RW, Cheever AW, Bock K, Moore I, Fitz LJ, Urban JF Jr, Wynn TA.

Nat Immunol. 2016 May;17(5):538-44. doi: 10.1038/ni.3417. Epub 2016 Apr 4.


Macrophages in Tissue Repair, Regeneration, and Fibrosis.

Wynn TA, Vannella KM.

Immunity. 2016 Mar 15;44(3):450-462. doi: 10.1016/j.immuni.2016.02.015. Review.


Interleukin-13 Receptor α1-Dependent Responses in the Intestine Are Critical to Parasite Clearance.

Sun R, Urban JF Jr, Notari L, Vanuytsel T, Madden KB, Bohl JA, Ramalingam TR, Wynn TA, Zhao A, Shea-Donohue T.

Infect Immun. 2016 Mar 24;84(4):1032-1044. doi: 10.1128/IAI.00990-15. Print 2016 Apr.


Biomarker and Therapeutic Potential of CSF1 in Acute Liver Failure.

Tacke F, Wynn TA.

Gastroenterology. 2015 Dec;149(7):1675-8. doi: 10.1053/j.gastro.2015.10.024. Epub 2015 Oct 23. No abstract available.


IL-25 or IL-17E Protects against High-Fat Diet-Induced Hepatic Steatosis in Mice Dependent upon IL-13 Activation of STAT6.

Wang AJ, Yang Z, Grinchuk V, Smith A, Qin B, Lu N, Wang D, Wang H, Ramalingam TR, Wynn TA, Urban JF Jr, Shea-Donohue T, Zhao A.

J Immunol. 2015 Nov 15;195(10):4771-80. doi: 10.4049/jimmunol.1500337. Epub 2015 Sep 30.


TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma.

Choy DF, Hart KM, Borthwick LA, Shikotra A, Nagarkar DR, Siddiqui S, Jia G, Ohri CM, Doran E, Vannella KM, Butler CA, Hargadon B, Sciurba JC, Gieseck RL, Thompson RW, White S, Abbas AR, Jackman J, Wu LC, Egen JG, Heaney LG, Ramalingam TR, Arron JR, Wynn TA, Bradding P.

Sci Transl Med. 2015 Aug 19;7(301):301ra129. doi: 10.1126/scitranslmed.aab3142.


Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis.

Borthwick LA, Barron L, Hart KM, Vannella KM, Thompson RW, Oland S, Cheever A, Sciurba J, Ramalingam TR, Fisher AJ, Wynn TA.

Mucosal Immunol. 2016 Jan;9(1):38-55. doi: 10.1038/mi.2015.34. Epub 2015 Apr 29.


Type 2 cytokines: mechanisms and therapeutic strategies.

Wynn TA.

Nat Rev Immunol. 2015 May;15(5):271-82. doi: 10.1038/nri3831. Epub 2015 Apr 17. Review.


The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.

Evans CM, Raclawska DS, Ttofali F, Liptzin DR, Fletcher AA, Harper DN, McGing MA, McElwee MM, Williams OW, Sanchez E, Roy MG, Kindrachuk KN, Wynn TA, Eltzschig HK, Blackburn MR, Tuvim MJ, Janssen WJ, Schwartz DA, Dickey BF.

Nat Commun. 2015 Feb 17;6:6281. doi: 10.1038/ncomms7281.


Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis.

Vannella KM, Barron L, Borthwick LA, Kindrachuk KN, Narasimhan PB, Hart KM, Thompson RW, White S, Cheever AW, Ramalingam TR, Wynn TA.

PLoS Pathog. 2014 Sep 11;10(9):e1004372. doi: 10.1371/journal.ppat.1004372. eCollection 2014 Sep.


African American organ donor registration: a mixed methods design using the theory of planned behavior.

DuBay DA, Ivankova N, Herby I, Wynn TA, Kohler C, Berry B, Foushee H, Carson AP, Redden DT, Holt C, Siminoff L, Fouad M, Martin MY.

Prog Transplant. 2014 Sep;24(3):273-83. doi: 10.7182/pit2014936.


Macrophage activation and polarization: nomenclature and experimental guidelines.

Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, Natoli G, Saeij JP, Schultze JL, Shirey KA, Sica A, Suttles J, Udalova I, van Ginderachter JA, Vogel SN, Wynn TA.

Immunity. 2014 Jul 17;41(1):14-20. doi: 10.1016/j.immuni.2014.06.008.


TNF-α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction.

Badalyan V, Thompson R, Addo K, Borthwick LA, Fisher AJ, Ort T, Myers TG, Wynn TA, Ramalingam TR.

J Allergy Clin Immunol. 2014 Oct;134(4):975-8.e5. doi: 10.1016/j.jaci.2014.05.019. Epub 2014 Jun 20. No abstract available.


IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses.

Lajoie S, Lewkowich I, Herman NS, Sproles A, Pesce JT, Wynn TA, Grusby MJ, Hamid Q, Wills-Karp M.

Clin Exp Allergy. 2014 Jul;44(7):976-85. doi: 10.1111/cea.12341.


Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture.

Gieseck RL 3rd, Hannan NR, Bort R, Hanley NA, Drake RA, Cameron GW, Wynn TA, Vallier L.

PLoS One. 2014 Jan 22;9(1):e86372. doi: 10.1371/journal.pone.0086372. eCollection 2014.


Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity.

Spencer SP, Wilhelm C, Yang Q, Hall JA, Bouladoux N, Boyd A, Nutman TB, Urban JF Jr, Wang J, Ramalingam TR, Bhandoola A, Wynn TA, Belkaid Y.

Science. 2014 Jan 24;343(6169):432-7. doi: 10.1126/science.1247606.


Conventional NK cells can produce IL-22 and promote host defense in Klebsiella pneumoniae pneumonia.

Xu X, Weiss ID, Zhang HH, Singh SP, Wynn TA, Wilson MS, Farber JM.

J Immunol. 2014 Feb 15;192(4):1778-86. doi: 10.4049/jimmunol.1300039. Epub 2014 Jan 17.


Genetic deletion of IL-25 (IL-17E) confers resistance to dextran sulfate sodium-induced colitis in mice.

Wang AJ, Smith A, Li Y, Urban JF Jr, Ramalingam TR, Wynn TA, Lu N, Shea-Donohue T, Yang Z, Zhao A.

Cell Biosci. 2014 Nov 26;4:72. doi: 10.1186/2045-3701-4-72. eCollection 2014.


The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells.

Meylan F, Hawley ET, Barron L, Barlow JL, Penumetcha P, Pelletier M, Sciumè G, Richard AC, Hayes ET, Gomez-Rodriguez J, Chen X, Paul WE, Wynn TA, McKenzie AN, Siegel RM.

Mucosal Immunol. 2014 Jul;7(4):958-68. doi: 10.1038/mi.2013.114. Epub 2013 Dec 25.


A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity.

De Muylder G, Daulouède S, Lecordier L, Uzureau P, Morias Y, Van Den Abbeele J, Caljon G, Hérin M, Holzmuller P, Semballa S, Courtois P, Vanhamme L, Stijlemans B, De Baetselier P, Barrett MP, Barlow JL, McKenzie AN, Barron L, Wynn TA, Beschin A, Vincendeau P, Pays E.

PLoS Pathog. 2013 Oct;9(10):e1003731. doi: 10.1371/journal.ppat.1003731. Epub 2013 Oct 31.


IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts.

Suwara MI, Green NJ, Borthwick LA, Mann J, Mayer-Barber KD, Barron L, Corris PA, Farrow SN, Wynn TA, Fisher AJ, Mann DA.

Mucosal Immunol. 2014 May;7(3):684-93. doi: 10.1038/mi.2013.87. Epub 2013 Oct 30.


Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.

Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE Jr, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP.

Am J Respir Crit Care Med. 2014 Jan 15;189(2):214-22. doi: 10.1164/rccm.201306-1141WS.

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