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Items: 1 to 50 of 72

1.

Neonatal sepsis: need for consensus definition, collaboration and core outcomes.

Molloy EJ, Wynn JL, Bliss J, Koenig JM, Keij FM, McGovern M, Kuester H, Turner MA, Giannoni E, Mazela J, Degtyaeva M, Strunk T, Simons SHP, Janota J, Plotz FB, van den Hoogen A, de Boode W, Schlapbach LJ, Reiss IKM; on behalf of the Infection, Inflammation, Immunology and Immunisation (I4) section of the ESPR.

Pediatr Res. 2020 Mar 19. doi: 10.1038/s41390-020-0850-5. [Epub ahead of print] No abstract available.

PMID:
32193517
2.

Challenges in developing a consensus definition of neonatal sepsis.

McGovern M, Giannoni E, Kuester H, Turner MA, van den Hoogen A, Bliss JM, Koenig JM, Keij FM, Mazela J, Finnegan R, Degtyareva M, Simons SHP, de Boode WP, Strunk T, Reiss IKM, Wynn JL, Molloy EJ; Infection, Inflammation, Immunology and Immunisation (I4) section of the ESPR.

Pediatr Res. 2020 Mar 3. doi: 10.1038/s41390-020-0785-x. [Epub ahead of print] Review.

PMID:
32126571
3.

Cell-free hemoglobin increases inflammation, lung apoptosis, and microvascular permeability in murine polymicrobial sepsis.

Meegan JE, Shaver CM, Putz ND, Jesse JJ, Landstreet SR, Lee HNR, Sidorova TN, McNeil JB, Wynn JL, Cheung-Flynn J, Komalavilas P, Brophy CM, Ware LB, Bastarache JA.

PLoS One. 2020 Feb 3;15(2):e0228727. doi: 10.1371/journal.pone.0228727. eCollection 2020.

4.

Exploring Clinically-Relevant Experimental Models of Neonatal Shock and Necrotizing Enterocolitis.

Nolan LS, Wynn JL, Good M.

Shock. 2020 Jan 20. doi: 10.1097/SHK.0000000000001507. [Epub ahead of print]

PMID:
31977960
5.

A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants.

Wynn JL, Polin RA.

Pediatr Res. 2019 Aug 8. doi: 10.1038/s41390-019-0517-2. [Epub ahead of print]

PMID:
31394566
6.

Rethinking management of neonates at risk of sepsis.

Lavoie PM, Popescu CR, Molyneux EM, Wynn JL, Chiume M, Keitel K, Lufesi N, Levine GA, Ansermino JM, Kissoon N.

Lancet. 2019 Jul 27;394(10195):279-281. doi: 10.1016/S0140-6736(19)31627-7. No abstract available.

7.

Prolonged early antimicrobials in ELBWs: too much for too little.

Wynn JL.

Pediatr Res. 2019 Jun;85(7):929-930. doi: 10.1038/s41390-019-0360-5. Epub 2019 Mar 5. No abstract available.

8.

Early onset and hospital acquired neonatal sepsis associated with high mortality.

Wynn JL.

J Pediatr. 2019 Jan;204:320-323. doi: 10.1016/j.jpeds.2018.10.075. No abstract available.

PMID:
30579470
9.

Complete Genome Sequence of the Multidrug-Resistant Neonatal Meningitis Escherichia coli Serotype O75:H5:K1 Strain mcjchv-1 (NMEC-O75).

Nielsen DW, Ricker N, Barbieri NL, Wynn JL, Gómez-Duarte OG, Iqbal J, Nolan LK, Allen HK, Logue CM.

Microbiol Resour Announc. 2018 Sep 13;7(10). pii: e01043-18. doi: 10.1128/MRA.01043-18. eCollection 2018 Sep.

10.

Cutting Edge: IL-1α and Not IL-1β Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality.

Benjamin JT, Moore DJ, Bennett C, van der Meer R, Royce A, Loveland R, Wynn JL.

J Immunol. 2018 Nov 15;201(10):2873-2878. doi: 10.4049/jimmunol.1801089. Epub 2018 Oct 10.

11.

Limited achievement of NIH research independence by pediatric K award recipients.

Good M, McElroy SJ, Berger JN, Moore DJ, Wynn JL.

Pediatr Res. 2018 Oct;84(4):479-480. doi: 10.1038/s41390-018-0056-2. Epub 2018 Jun 14. No abstract available.

12.

Impact of toll-like receptor 4 stimulation on human neonatal neutrophil spontaneous migration, transcriptomics, and cytokine production.

Raymond SL, Hawkins RB, Murphy TJ, Rincon JC, Stortz JA, López MC, Ungaro R, Ellett F, Baker HV, Wynn JL, Moldawer LL, Irimia D, Larson SD.

J Mol Med (Berl). 2018 Jul;96(7):673-684. doi: 10.1007/s00109-018-1646-5. Epub 2018 May 28.

13.

Enteral Feeding as an Adjunct to Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy.

Chang LL, Wynn JL, Pacella MJ, Rossignol CC, Banadera F, Alviedo N, Vargas A, Bennett J, Huene M, Copenhaver N, Sura L, Barnette K, Solomon J, Bliznyuk NA, Neu J, Weiss MD.

Neonatology. 2018;113(4):347-352. doi: 10.1159/000487848. Epub 2018 Mar 6.

PMID:
29510382
14.

Why are preterm newborns at increased risk of infection?

Collins A, Weitkamp JH, Wynn JL.

Arch Dis Child Fetal Neonatal Ed. 2018 Jul;103(4):F391-F394. doi: 10.1136/archdischild-2017-313595. Epub 2018 Jan 30. Review.

15.

Name and Characteristics of National Institutes of Health R01-Funded Pediatric Physician-Scientists: Hope and Challenges for the Vanishing Pediatric Physician-Scientists.

Good M, McElroy SJ, Berger JN, Wynn JL.

JAMA Pediatr. 2018 Mar 1;172(3):297-299. doi: 10.1001/jamapediatrics.2017.4947. No abstract available.

16.

Editorial: The Neonatal Immune System: A Unique Host-Microbial Interface.

Bliss JM, Wynn JL.

Front Pediatr. 2017 Dec 21;5:274. doi: 10.3389/fped.2017.00274. eCollection 2017. No abstract available.

17.

Chorioamnionitis, IL-17A, and fetal origins of neurologic disease.

Lawrence SM, Wynn JL.

Am J Reprod Immunol. 2018 May;79(5):e12803. doi: 10.1111/aji.12803. Epub 2017 Dec 22. Review.

18.

IL-17 in neonatal health and disease.

Lawrence SM, Ruoss JL, Wynn JL.

Am J Reprod Immunol. 2018 May;79(5):e12800. doi: 10.1111/aji.12800. Epub 2017 Dec 15. Review.

19.

Adjuvant pretreatment with alum protects neonatal mice in sepsis through myeloid cell activation.

Rincon JC, Cuenca AL, Raymond SL, Mathias B, Nacionales DC, Ungaro R, Efron PA, Wynn JL, Moldawer LL, Larson SD.

Clin Exp Immunol. 2018 Mar;191(3):268-278. doi: 10.1111/cei.13072. Epub 2017 Nov 16.

20.

Progress in the management of neonatal sepsis: the importance of a consensus definition.

Wynn JL, Polin RA.

Pediatr Res. 2018 Jan;83(1-1):13-15. doi: 10.1038/pr.2017.224. Epub 2017 Oct 11. No abstract available.

PMID:
29019470
21.

Unique transcriptomic response to sepsis is observed among patients of different age groups.

Raymond SL, López MC, Baker HV, Larson SD, Efron PA, Sweeney TE, Khatri P, Moldawer LL, Wynn JL.

PLoS One. 2017 Sep 8;12(9):e0184159. doi: 10.1371/journal.pone.0184159. eCollection 2017.

22.

Neutrophil chemotaxis and transcriptomics in term and preterm neonates.

Raymond SL, Mathias BJ, Murphy TJ, Rincon JC, López MC, Ungaro R, Ellett F, Jorgensen J, Wynn JL, Baker HV, Moldawer LL, Irimia D, Larson SD.

Transl Res. 2017 Dec;190:4-15. doi: 10.1016/j.trsl.2017.08.003. Epub 2017 Sep 1.

23.

Impact of Early-Life Exposures to Infections, Antibiotics, and Vaccines on Perinatal and Long-term Health and Disease.

Raymond SL, Rincon JC, Wynn JL, Moldawer LL, Larson SD.

Front Immunol. 2017 Jun 23;8:729. doi: 10.3389/fimmu.2017.00729. eCollection 2017. Review.

24.

Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles.

Veach RA, Liu Y, Zienkiewicz J, Wylezinski LS, Boyd KL, Wynn JL, Hawiger J.

PLoS One. 2017 Jun 19;12(6):e0179468. doi: 10.1371/journal.pone.0179468. eCollection 2017.

25.

Validation of the Sepsis MetaScore for Diagnosis of Neonatal Sepsis.

Sweeney TE, Wynn JL, Cernada M, Serna E, Wong HR, Baker HV, Vento M, Khatri P.

J Pediatric Infect Dis Soc. 2018 May 15;7(2):129-135. doi: 10.1093/jpids/pix021.

26.

Genome-wide association study of sepsis in extremely premature infants.

Srinivasan L, Page G, Kirpalani H, Murray JC, Das A, Higgins RD, Carlo WA, Bell EF, Goldberg RN, Schibler K, Sood BG, Stevenson DK, Stoll BJ, Van Meurs KP, Johnson KJ, Levy J, McDonald SA, Zaterka-Baxter KM, Kennedy KA, Sánchez PJ, Duara S, Walsh MC, Shankaran S, Wynn JL, Cotten CM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.

Arch Dis Child Fetal Neonatal Ed. 2017 Sep;102(5):F439-F445. doi: 10.1136/archdischild-2016-311545. Epub 2017 Mar 10.

27.

Immunological Defects in Neonatal Sepsis and Potential Therapeutic Approaches.

Raymond SL, Stortz JA, Mira JC, Larson SD, Wynn JL, Moldawer LL.

Front Pediatr. 2017 Feb 7;5:14. doi: 10.3389/fped.2017.00014. eCollection 2017. Review.

28.

Timing of Multiorgan Dysfunction among Hospitalized Infants with Fatal Fulminant Sepsis.

Wynn JL, Kelly MS, Benjamin DK, Clark RH, Greenberg R, Benjamin DK Jr, Smith PB.

Am J Perinatol. 2017 Jun;34(7):633-639. doi: 10.1055/s-0036-1597130. Epub 2016 Dec 6.

29.

Oral colostrum priming shortens hospitalization without changing the immunomicrobial milieu.

Romano-Keeler J, Azcarate-Peril MA, Weitkamp JH, Slaughter JC, McDonald WH, Meng S, Latuga MS, Wynn JL.

J Perinatol. 2017 Jan;37(1):36-41. doi: 10.1038/jp.2016.161. Epub 2016 Sep 29.

30.

Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model.

Atkinson SJ, Varisco BM, Sandquist M, Daly MN, Klingbeil L, Kuethe JW, Midura EF, Harmon K, Opaka A, Lahni P, Piraino G, Hake P, Zingarelli B, Mortenson JE, Wynn JL, Wong HR.

Mol Med. 2016 Oct;22:455-463. doi: 10.2119/molmed.2016.00058. Epub 2016 Aug 8.

31.

Histological chorioamnionitis shapes the neonatal transcriptomic immune response.

Weitkamp JH, Guthrie SO, Wong HR, Moldawer LL, Baker HV, Wynn JL.

Early Hum Dev. 2016 Jul;98:1-6. doi: 10.1016/j.earlhumdev.2016.06.001. Epub 2016 Jun 16.

32.

Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18.

Wynn JL, Wilson CS, Hawiger J, Scumpia PO, Marshall AF, Liu JH, Zharkikh I, Wong HR, Lahni P, Benjamin JT, Plosa EJ, Weitkamp JH, Sherwood ER, Moldawer LL, Ungaro R, Baker HV, Lopez MC, McElroy SJ, Colliou N, Mohamadzadeh M, Moore DJ.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2627-35. doi: 10.1073/pnas.1515793113. Epub 2016 Apr 25.

33.

Lethal neonatal meningoencephalitis caused by multi-drug resistant, highly virulent Escherichia coli.

Iqbal J, Dufendach KR, Wellons JC, Kuba MG, Nickols HH, Gómez-Duarte OG, Wynn JL.

Infect Dis (Lond). 2016;48(6):461-6. doi: 10.3109/23744235.2016.1144142. Epub 2016 Feb 19.

34.

Defining neonatal sepsis.

Wynn JL.

Curr Opin Pediatr. 2016 Apr;28(2):135-40. doi: 10.1097/MOP.0000000000000315. Review.

35.

Heart rate characteristic index monitoring for bloodstream infection in an NICU: a 3-year experience.

Coggins SA, Weitkamp JH, Grunwald L, Stark AR, Reese J, Walsh W, Wynn JL.

Arch Dis Child Fetal Neonatal Ed. 2016 Jul;101(4):F329-32. doi: 10.1136/archdischild-2015-309210. Epub 2015 Oct 30.

36.

Fanning the Fire: Can Methemoglobin Enhance Neutrophil Activation?

Bastarache JA, Wynn JL, Ware LB.

EBioMedicine. 2015 Feb 2;2(3):184-5. doi: 10.1016/j.ebiom.2015.01.019. eCollection 2015 Mar. No abstract available.

37.

Neonatal CD71+ Erythroid Cells Do Not Modify Murine Sepsis Mortality.

Wynn JL, Scumpia PO, Stocks BT, Romano-Keeler J, Alrifai MW, Liu JH, Kim AS, Alford CE, Matta P, Weitkamp JH, Moore DJ.

J Immunol. 2015 Aug 1;195(3):1064-70. doi: 10.4049/jimmunol.1500771. Epub 2015 Jun 22.

38.

Postnatal Age Is a Critical Determinant of the Neonatal Host Response to Sepsis.

Wynn JL, Guthrie SO, Wong HR, Lahni P, Ungaro R, Lopez MC, Baker HV, Moldawer LL.

Mol Med. 2015 Jun 2;21:496-504. doi: 10.2119/molmed.2015.00064.

39.

Infectious causes of necrotizing enterocolitis.

Coggins SA, Wynn JL, Weitkamp JH.

Clin Perinatol. 2015 Mar;42(1):133-54, ix. doi: 10.1016/j.clp.2014.10.012. Epub 2014 Nov 27. Review.

40.

Reappraisal of guidelines for management of neonates with suspected early-onset sepsis.

Benitz WE, Wynn JL, Polin RA.

J Pediatr. 2015 Apr;166(4):1070-4. doi: 10.1016/j.jpeds.2014.12.023. Epub 2015 Jan 29. Review. No abstract available.

41.

TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis.

Cuenca AG, Joiner DN, Gentile LF, Cuenca AL, Wynn JL, Kelly-Scumpia KM, Scumpia PO, Behrns KE, Efron PA, Nacionales D, Lui C, Wallet SM, Reeves WH, Mathews CE, Moldawer LL.

J Immunol. 2015 Feb 1;194(3):1169-77. doi: 10.4049/jimmunol.1302676. Epub 2014 Dec 29.

42.

Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA.

Vucovich MM, Cotton RB, Shelton EL, Goettel JA, Ehinger NJ, Poole SD, Brown N, Wynn JL, Paria BC, Slaughter JC, Clark RH, Rojas MA, Reese J.

Am J Physiol Heart Circ Physiol. 2014 Sep 1;307(5):H732-40. doi: 10.1152/ajpheart.00838.2013. Epub 2014 Jul 3.

43.

Time for a neonatal-specific consensus definition for sepsis.

Wynn JL, Wong HR, Shanley TP, Bizzarro MJ, Saiman L, Polin RA.

Pediatr Crit Care Med. 2014 Jul;15(6):523-8. doi: 10.1097/PCC.0000000000000157. Review.

44.

Great expectorations: the potential of salivary 'omic' approaches in neonatal intensive care.

Romano-Keeler J, Wynn JL, Maron JL.

J Perinatol. 2014 Mar;34(3):169-73. doi: 10.1038/jp.2013.170. Epub 2014 Jan 9. Review.

45.

A prime time for trained immunity: innate immune memory in newborns and infants.

Levy O, Wynn JL.

Neonatology. 2014;105(2):136-41. doi: 10.1159/000356035. Epub 2013 Dec 18. Review.

46.

Use of a computerized C-reactive protein (CRP) based sepsis evaluation in very low birth weight (VLBW) infants: a five-year experience.

Coggins SA, Wynn JL, Hill ML, Slaughter JC, Ozdas-Weitkamp A, Jalloh O, Waitman LR, Carnevale RJ, Weitkamp JH.

PLoS One. 2013 Nov 11;8(11):e78602. doi: 10.1371/journal.pone.0078602. eCollection 2013.

47.

TLRs, SNPs and VLBWs: oh my!

Wynn JL.

J Perinatol. 2013 Oct;33(10):745-7. doi: 10.1038/jp.2013.94. No abstract available.

48.

Determining population and developmental pharmacokinetics of metronidazole using plasma and dried blood spot samples from premature infants.

Cohen-Wolkowiez M, Sampson M, Bloom BT, Arrieta A, Wynn JL, Martz K, Harper B, Kearns GL, Capparelli EV, Siegel D, Benjamin DK Jr, Smith PB; Best Pharmaceuticals for Children Act–Pediatric Trials Network.

Pediatr Infect Dis J. 2013 Sep;32(9):956-61. doi: 10.1097/INF.0b013e3182947cf8.

49.

Effects of low-dose dopamine on urine output in normotensive very low birth weight neonates.

Crouchley JL, Smith PB, Cotten CM, Hornik CD, Goldberg RN, Foreman JW, Wynn JL.

J Perinatol. 2013 Aug;33(8):619-21. doi: 10.1038/jp.2013.20. Epub 2013 Feb 28.

50.

Blood stream infection is associated with altered heptavalent pneumococcal conjugate vaccine immune responses in very low birth weight infants.

Wynn JL, Li L, Cotten CM, Phelps DL, Shankaran S, Goldberg RN, Carlo WA, Van Meurs K, Das A, Vohr BR, Higgins RD, Stoll BJ, D'Angio CT.

J Perinatol. 2013 Aug;33(8):613-8. doi: 10.1038/jp.2013.5. Epub 2013 Jan 31.

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