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Items: 1 to 50 of 162

1.

Increased apoptosis and reduced replication efficiency of the E3 region-modified dl309 adenovirus in cancer cells.

Hibma MH, Real NC, Wiles A, Dobson-Le D, Dix BR, Wynford-Thomas D, Braithwaite AW, Royds JA.

Virus Res. 2009 Oct;145(1):112-20. doi: 10.1016/j.virusres.2009.06.016. Epub 2009 Jul 2.

PMID:
19576936
2.

Cytotoxic action of phorbol esters on human pancreatic cancer cells.

Bond JA, Gescher AJ, Verschoyle RD, Lemoine NR, Errington R, Wiltshire M, Smith PJ, Wynford-Thomas D.

Int J Cancer. 2007 Oct 1;121(7):1445-54.

3.

An immunohistochemical study of p16(INK4a) expression in multistep thyroid tumourigenesis.

Ball E, Bond J, Franc B, Demicco C, Wynford-Thomas D.

Eur J Cancer. 2007 Jan;43(1):194-201. Epub 2006 Oct 13.

PMID:
17046239
4.

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

Gray-Schopfer VC, Cheong SC, Chong H, Chow J, Moss T, Abdel-Malek ZA, Marais R, Wynford-Thomas D, Bennett DC.

Br J Cancer. 2006 Aug 21;95(4):496-505. Epub 2006 Aug 1.

5.

Molecular genetic study comparing follicular variant versus classic papillary thyroid carcinomas: association of N-ras mutation in codon 61 with follicular variant.

Di Cristofaro J, Marcy M, Vasko V, Sebag F, Fakhry N, Wynford-Thomas D, De Micco C.

Hum Pathol. 2006 Jul;37(7):824-30. Epub 2006 May 19.

PMID:
16784981
6.

Analysis of Ras transformation of human thyroid epithelial cells.

Poghosyan Z, Wynford-Thomas D.

Methods Enzymol. 2006;407:648-60.

PMID:
16757359
7.

Comparison of differential gene expression of hot and cold thyroid nodules with primary epithelial cell culture models by investigation of co-regulated gene sets.

Eszlinger M, Krohn K, Beck M, Kipling D, Forbes-Robertson S, Läuter J, Toenjes A, Wynford-Thomas D, Paschke R.

Biochim Biophys Acta. 2006 Mar;1763(3):263-71. Epub 2006 Jan 4.

8.

p53 promotes adenoviral replication and increases late viral gene expression.

Royds JA, Hibma M, Dix BR, Hananeia L, Russell IA, Wiles A, Wynford-Thomas D, Braithwaite AW.

Oncogene. 2006 Mar 9;25(10):1509-20.

PMID:
16247442
9.

Characterisation of novel mutations in Cockayne syndrome type A and xeroderma pigmentosum group C subjects.

Ridley AJ, Colley J, Wynford-Thomas D, Jones CJ.

J Hum Genet. 2005;50(3):151-4. Epub 2005 Mar 3.

PMID:
15744458
10.

Mutant ras-induced proliferation of human thyroid epithelial cells requires three effector pathways.

Bounacer A, McGregor A, Skinner J, Bond J, Poghosyan Z, Wynford-Thomas D.

Oncogene. 2004 Oct 14;23(47):7839-45.

PMID:
15361839
11.

Opposing effects of mutant ras oncoprotein on human fibroblast and epithelial cell proliferation: implications for models of human tumorigenesis.

Skinner J, Bounacer A, Bond JA, Haughton MF, deMicco C, Wynford-Thomas D.

Oncogene. 2004 Aug 5;23(35):5994-9.

PMID:
15208687
12.

DNA damage checkpoint kinase Chk2 triggers replicative senescence.

Gire V, Roux P, Wynford-Thomas D, Brondello JM, Dulic V.

EMBO J. 2004 Jul 7;23(13):2554-63. Epub 2004 Jun 10.

13.

Telomere erosion triggers growth arrest but not cell death in human cancer cells retaining wild-type p53: implications for antitelomerase therapy.

Preto A, Singhrao SK, Haughton MF, Kipling D, Wynford-Thomas D, Jones CJ.

Oncogene. 2004 May 20;23(23):4136-45.

PMID:
15064743
14.
15.
16.

Biological activity of activating thyroid-stimulating hormone receptor mutants depends on the cellular context.

Fuhrer D, Lewis MD, Alkhafaji F, Starkey K, Paschke R, Wynford-Thomas D, Eggo M, Ludgate M.

Endocrinology. 2003 Sep;144(9):4018-30.

PMID:
12933676
17.

p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.

Sviderskaya EV, Gray-Schopfer VC, Hill SP, Smit NP, Evans-Whipp TJ, Bond J, Hill L, Bataille V, Peters G, Kipling D, Wynford-Thomas D, Bennett DC.

J Natl Cancer Inst. 2003 May 21;95(10):723-32.

PMID:
12759390
18.

Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21(WAF1) expression.

Wyllie F, Haughton M, Bartek J, Rowson J, Wynford-Thomas D.

Exp Cell Res. 2003 May 1;285(2):236-42.

PMID:
12706118
19.

Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms.

Davis T, Singhrao SK, Wyllie FS, Haughton MF, Smith PJ, Wiltshire M, Wynford-Thomas D, Jones CJ, Faragher RG, Kipling D.

J Cell Sci. 2003 Apr 1;116(Pt 7):1349-57.

20.

Extensive allelic variation and ultrashort telomeres in senescent human cells.

Baird DM, Rowson J, Wynford-Thomas D, Kipling D.

Nat Genet. 2003 Feb;33(2):203-7. Epub 2003 Jan 21.

PMID:
12539050
21.
22.

Telomerase activity and telomere length in thyroid neoplasia: biological and clinical implications.

Matthews P, Jones CJ, Skinner J, Haughton M, de Micco C, Wynford-Thomas D.

J Pathol. 2001 Jun;194(2):183-93.

PMID:
11400147
23.

Simian virus 40 detection in human mesothelioma: reliability and significance of the available molecular evidence.

Jasani B, Jones CJ, Radu C, Wynford-Thomas D, Navabi H, Mason M, Adams M, Gibbs A.

Front Biosci. 2001 Apr 1;6:E12-22. Review.

PMID:
11282566
24.

Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death.

Weng LP, Gimm O, Kum JB, Smith WM, Zhou XP, Wynford-Thomas D, Leone G, Eng C.

Hum Mol Genet. 2001 Feb 1;10(3):251-8.

PMID:
11159944
25.

Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells.

Jones CJ, Kipling D, Morris M, Hepburn P, Skinner J, Bounacer A, Wyllie FS, Ivan M, Bartek J, Wynford-Thomas D, Bond JA.

Mol Cell Biol. 2000 Aug;20(15):5690-9.

26.

Replicative senescence: mechanisms and implications for human cancer.

Wynford-Thomas D.

Pathol Biol (Paris). 2000 Apr;48(3):301-7. Review.

PMID:
10858962
27.
28.

Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage.

Webley K, Bond JA, Jones CJ, Blaydes JP, Craig A, Hupp T, Wynford-Thomas D.

Mol Cell Biol. 2000 Apr;20(8):2803-8.

29.
30.

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts.

Wyllie FS, Jones CJ, Skinner JW, Haughton MF, Wallis C, Wynford-Thomas D, Faragher RG, Kipling D.

Nat Genet. 2000 Jan;24(1):16-7. No abstract available.

PMID:
10615119
32.

Contrasting effects of activating mutations of GalphaS and the thyrotropin receptor on proliferation and differentiation of thyroid follicular cells.

Ludgate M, Gire V, Crisp M, Ajjan R, Weetman A, Ivan M, Wynford-Thomas D.

Oncogene. 1999 Aug 26;18(34):4798-807.

33.

p53-Dependent growth arrest and altered p53-immunoreactivity following metabolic labelling with 32P ortho-phosphate in human fibroblasts.

Bond JA, Webley K, Wyllie FS, Jones CJ, Craig A, Hupp T, Wynford-Thomas D.

Oncogene. 1999 Jun 24;18(25):3788-92.

34.

Cellular senescence and cancer.

Wynford-Thomas D.

J Pathol. 1999 Jan;187(1):100-11. Review.

PMID:
10341711
35.

[Molecular basis of tumors arising in thyroid follicular cells].

Wynford-Thomas D.

Ann Chir. 1999;53(3):237-43. Review. French.

PMID:
10339867
36.

Telomere-dependent senescence.

Kipling D, Wynford-Thomas D, Jones CJ, Akbar A, Aspinall R, Bacchetti S, Blasco MA, Broccoli D, DePinho RA, Edwards DR, Effros RB, Harley CB, Lansdorp PM, Linskens MH, Prowse KR, Newbold RF, Olovnikov AM, Parkinson EK, Pawelec G, Pontén J, Shall S, Zijlmans M, Faragher RG.

Nat Biotechnol. 1999 Apr;17(4):313-4. No abstract available.

PMID:
10207859
37.

Human thyroid cancer cells as a source of iso-genic, iso-phenotypic cell lines with or without functional p53.

Wyllie FS, Haughton MF, Rowson JM, Wynford-Thomas D.

Br J Cancer. 1999 Mar;79(7-8):1111-20.

38.

Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis.

Bond JA, Haughton MF, Rowson JM, Smith PJ, Gire V, Wynford-Thomas D, Wyllie FS.

Mol Cell Biol. 1999 Apr;19(4):3103-14.

39.

Segregational fidelity of chromosomes in human thyroid tumour cells.

Parry EM, Ulucan H, Wyllie FS, Wynford-Thomas D, Parry JM.

Chromosoma. 1998 Dec;107(6-7):491-7.

PMID:
9914382
40.

Papillary thyroid carcinoma oncogene (RET/PTC) alters the nuclear envelope and chromatin structure.

Fischer AH, Bond JA, Taysavang P, Battles OE, Wynford-Thomas D.

Am J Pathol. 1998 Nov;153(5):1443-50.

41.

SV40 DNA sequences in mesotheliomas.

Gibbs AR, Jasani B, Pepper C, Navabi H, Wynford-Thomas D.

Dev Biol Stand. 1998;94:41-5. Review.

PMID:
9776224
42.

[Origin and progression of thyroid epithelial tumors: molecular and cellular mechanisms].

Gire V, Wynford-Thomas D.

Arch Anat Cytol Pathol. 1998;46(1-2):11-8. Review. French.

PMID:
9754356
43.

Induction of cell death by stimulation of protein kinase C in human epithelial cells expressing a mutant ras oncogene: a potential therapeutic target.

Hall-Jackson CA, Jones T, Eccles NG, Dawson TP, Bond JA, Gescher A, Wynford-Thomas D.

Br J Cancer. 1998 Sep;78(5):641-51.

44.

Sporadic ret-rearranged papillary carcinoma of the thyroid: a subset of slow growing, less aggressive thyroid neoplasms?

Soares P, Fonseca E, Wynford-Thomas D, Sobrinho-Simões M.

J Pathol. 1998 May;185(1):71-8.

PMID:
9713362
45.
46.

Dissociation of telomere dynamics from telomerase activity in human thyroid cancer cells.

Jones CJ, Soley A, Skinner JW, Gupta J, Haughton MF, Wyllie FS, Schlumberger M, Bacchetti S, Wynford-Thomas D.

Exp Cell Res. 1998 May 1;240(2):333-9.

PMID:
9597006
48.

The influence of cell context on the selection pressure for p53 mutation in human cancer.

Wynford-Thomas D, Blaydes J.

Carcinogenesis. 1998 Jan;19(1):29-36. Review.

PMID:
9472689
49.

Telomerase. Cancer and the knockout mouse.

Wynford-Thomas D, Kipling D.

Nature. 1997 Oct 9;389(6651):551-2. No abstract available.

PMID:
9335490
50.

An amphotropic retroviral vector expressing a mutant gsp oncogene: effects on human thyroid cells in vitro.

Ivan M, Ludgate M, Gire V, Bond JA, Wynford-Thomas D.

J Clin Endocrinol Metab. 1997 Aug;82(8):2702-9.

PMID:
9253357

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