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Altered dendritic spine function and integration in a mouse model of fragile X syndrome.

Booker SA, Domanski APF, Dando OR, Jackson AD, Isaac JTR, Hardingham GE, Wyllie DJA, Kind PC.

Nat Commun. 2019 Oct 23;10(1):4813. doi: 10.1038/s41467-019-11891-6.


Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex.

Domanski APF, Booker SA, Wyllie DJA, Isaac JTR, Kind PC.

Nat Commun. 2019 Oct 23;10(1):4814. doi: 10.1038/s41467-019-12736-y.


Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction.

Vasistha NA, Johnstone M, Barton SK, Mayerl SE, Thangaraj Selvaraj B, Thomson PA, Dando O, Grünewald E, Alloza C, Bastin ME, Livesey MR, Economides K, Magnani D, Makedonopolou P, Burr K, Story DJ, Blackwood DHR, Wyllie DJA, McIntosh AM, Millar JK, Ffrench-Constant C, Hardingham GE, Lawrie SM, Chandran S.

Mol Psychiatry. 2019 Nov;24(11):1641-1654. doi: 10.1038/s41380-019-0505-2. Epub 2019 Sep 3.


The human NMDA receptor GluN2AN615K variant influences channel blocker potency.

Marwick KFM, Skehel PA, Hardingham GE, Wyllie DJA.

Pharmacol Res Perspect. 2019 Jun 20;7(4):e00495. doi: 10.1002/prp2.495. eCollection 2019 Aug.


Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome.

Asiminas A, Jackson AD, Louros SR, Till SM, Spano T, Dando O, Bear MF, Chattarji S, Hardingham GE, Osterweil EK, Wyllie DJA, Wood ER, Kind PC.

Sci Transl Med. 2019 May 29;11(494). pii: eaao0498. doi: 10.1126/scitranslmed.aao0498.


In Vitro Generation and Electrophysiological Characterization of OPCs and Oligodendrocytes from Human Pluripotent Stem Cells.

Magnani D, Chandran S, Wyllie DJA, Livesey MR.

Methods Mol Biol. 2019;1936:65-77. doi: 10.1007/978-1-4939-9072-6_4.


Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy.

Marwick KFM, Hansen KB, Skehel PA, Hardingham GE, Wyllie DJA.

J Physiol. 2019 Mar;597(6):1691-1704. doi: 10.1113/JP277292. Epub 2019 Jan 30.


GRIN2A-related disorders: genotype and functional consequence predict phenotype.

Strehlow V, Heyne HO, Vlaskamp DRM, Marwick KFM, Rudolf G, de Bellescize J, Biskup S, Brilstra EH, Brouwer OF, Callenbach PMC, Hentschel J, Hirsch E, Kind PC, Mignot C, Platzer K, Rump P, Skehel PA, Wyllie DJA, Hardingham GE, van Ravenswaaij-Arts CMA, Lesca G, Lemke JR; GRIN2A study group.

Brain. 2019 Jan 1;142(1):80-92. doi: 10.1093/brain/awy304.


Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging.

Johnstone M, Vasistha NA, Barbu MC, Dando O, Burr K, Christopher E, Glen S, Robert C, Fetit R, Macleod KG, Livesey MR, Clair DS, Blackwood DHR, Millar K, Carragher NO, Hardingham GE, Wyllie DJA, Johnstone EC, Whalley HC, McIntosh AM, Lawrie SM, Chandran S.

Mol Psychiatry. 2019 Feb;24(2):294-311. doi: 10.1038/s41380-018-0292-1. Epub 2018 Nov 6.


The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences.

McKay S, Ryan TJ, McQueen J, Indersmitten T, Marwick KFM, Hasel P, Kopanitsa MV, Baxter PS, Martel MA, Kind PC, Wyllie DJA, O'Dell TJ, Grant SGN, Hardingham GE, Komiyama NH.

Cell Rep. 2018 Oct 23;25(4):841-851.e4. doi: 10.1016/j.celrep.2018.09.089.


Modelling the details: integrating structure with function.

Wyllie DJA.

J Physiol. 2018 Sep;596(17):3833-3834. doi: 10.1113/JP276664. Epub 2018 Aug 3. No abstract available.


Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells.

Perkins EM, Clarkson YL, Suminaite D, Lyndon AR, Tanaka K, Rothstein JD, Skehel PA, Wyllie DJA, Jackson M.

Hum Mol Genet. 2018 Aug 1;27(15):2614-2627. doi: 10.1093/hmg/ddy169.


Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

Hasel P, Dando O, Jiwaji Z, Baxter P, Todd AC, Heron S, Márkus NM, McQueen J, Hampton DW, Torvell M, Tiwari SS, McKay S, Eraso-Pichot A, Zorzano A, Masgrau R, Galea E, Chandran S, Wyllie DJA, Simpson TI, Hardingham GE.

Nat Commun. 2018 Feb 6;9:16176. doi: 10.1038/ncomms16176.


C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.

Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB, Perkins EM, Dando O, Lillico SG, Lee YB, Nishimura AL, Poreci U, Thankamony S, Pray M, Vasistha NA, Magnani D, Borooah S, Burr K, Story D, McCampbell A, Shaw CE, Kind PC, Aitman TJ, Whitelaw CBA, Wilmut I, Smith C, Miles GB, Hardingham GE, Wyllie DJA, Chandran S.

Nat Commun. 2018 Jan 24;9(1):347. doi: 10.1038/s41467-017-02729-0.


Postsynaptic GABABRs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons.

Booker SA, Loreth D, Gee AL, Watanabe M, Kind PC, Wyllie DJA, Kulik Á, Vida I.

Cell Rep. 2018 Jan 2;22(1):36-43. doi: 10.1016/j.celrep.2017.12.021.


Parvalbumin interneurons in the dorsal horn: it's not all about GABA.

Booker SA, Wyllie DJA.

J Physiol. 2017 Dec 1;595(23):7019-7020. doi: 10.1113/JP275260. Epub 2017 Nov 9. No abstract available.


Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome.

Thomson SR, Seo SS, Barnes SA, Louros SR, Muscas M, Dando O, Kirby C, Wyllie DJA, Hardingham GE, Kind PC, Osterweil EK.

Neuron. 2017 Aug 2;95(3):550-563.e5. doi: 10.1016/j.neuron.2017.07.013.


Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

McQueen J, Ryan TJ, McKay S, Marwick K, Baxter P, Carpanini SM, Wishart TM, Gillingwater TH, Manson JC, Wyllie DJA, Grant SGN, McColl BW, Komiyama NH, Hardingham GE.

Elife. 2017 Jul 21;6. pii: e17161. doi: 10.7554/eLife.17161.


Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

Hasel P, Dando O, Jiwaji Z, Baxter P, Todd AC, Heron S, Márkus NM, McQueen J, Hampton DW, Torvell M, Tiwari SS, McKay S, Eraso-Pichot A, Zorzano A, Masgrau R, Galea E, Chandran S, Wyllie DJA, Simpson TI, Hardingham GE.

Nat Commun. 2017 May 2;8:15132. doi: 10.1038/ncomms15132. Erratum in: Nat Commun. 2018 Feb 06;9:16176.


Functional assessment of the NMDA receptor variant GluN2A R586K.

Marwick KFM, Parker P, Skehel P, Hardingham G, Wyllie DJA.

Wellcome Open Res. 2017 Mar 17;2:20. doi: 10.12688/wellcomeopenres.10985.2.


Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers.

Zanato C, Pelagalli A, Marwick KF, Piras M, Dall'Angelo S, Spinaci A, Pertwee RG, Wyllie DJ, Hardingham GE, Zanda M.

Org Biomol Chem. 2017 Mar 1;15(9):2086-2096. doi: 10.1039/c6ob02796b.


Reduced local input to fast-spiking interneurons in the somatosensory cortex in the GABAA γ2 R43Q mouse model of absence epilepsy.

Currie SP, Luz LL, Booker SA, Wyllie DJ, Kind PC, Daw MI.

Epilepsia. 2017 Apr;58(4):597-607. doi: 10.1111/epi.13693. Epub 2017 Feb 13.


Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST.

Perkins EM, Suminaite D, Clarkson YL, Lee SK, Lyndon AR, Rothstein JD, Wyllie DJ, Tanaka K, Jackson M.

Hum Mol Genet. 2016 Oct 15;25(20):4448-4461. doi: 10.1093/hmg/ddw274.


Loss of protohaem IX farnesyltransferase in mature dentate granule cells impairs short-term facilitation at mossy fibre to CA3 pyramidal cell synapses.

Booker SA, Campbell GR, Mysiak KS, Brophy PJ, Kind PC, Mahad DJ, Wyllie DJ.

J Physiol. 2017 Mar 15;595(6):2147-2160. doi: 10.1113/JP273581.


Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons.

Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S, Burr K, Patani R, Rajan R, Sheppard O, Kind PC, Simpson TI, Tybulewicz VL, Wyllie DJ, Fisher EM, Lowell S, Chandran S, Hardingham GE.

Elife. 2016 Oct 1;5. pii: e20337. doi: 10.7554/eLife.20337.


Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition.

Rzechorzek NM, Connick P, Livesey MR, Borooah S, Patani R, Burr K, Story D, Wyllie DJA, Hardingham GE, Chandran S.

EBioMedicine. 2015 Dec 12;3:141-154. doi: 10.1016/j.ebiom.2015.12.010. eCollection 2016 Jan.


Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes.

Livesey MR, Magnani D, Cleary EM, Vasistha NA, James OT, Selvaraj BT, Burr K, Story D, Shaw CE, Kind PC, Hardingham GE, Wyllie DJ, Chandran S.

Stem Cells. 2016 Apr;34(4):1040-53. doi: 10.1002/stem.2273. Epub 2016 Jan 13.


Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells.

Livesey MR, Magnani D, Hardingham GE, Chandran S, Wyllie DJ.

J Physiol. 2016 Nov 15;594(22):6573-6582. doi: 10.1113/JP270660. Epub 2015 Dec 30. Review.


Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice.

Barnes SA, Wijetunge LS, Jackson AD, Katsanevaki D, Osterweil EK, Komiyama NH, Grant SG, Bear MF, Nägerl UV, Kind PC, Wyllie DJ.

J Neurosci. 2015 Nov 11;35(45):15073-81. doi: 10.1523/JNEUROSCI.1087-15.2015.


Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS.

Till SM, Asiminas A, Jackson AD, Katsanevaki D, Barnes SA, Osterweil EK, Bear MF, Chattarji S, Wood ER, Wyllie DJ, Kind PC.

Hum Mol Genet. 2015 Nov 1;24(21):5977-84. doi: 10.1093/hmg/ddv299. Epub 2015 Aug 4.


Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.

Bell KF, Al-Mubarak B, Martel MA, McKay S, Wheelan N, Hasel P, Márkus NM, Baxter P, Deighton RF, Serio A, Bilican B, Chowdhry S, Meakin PJ, Ashford ML, Wyllie DJ, Scannevin RH, Chandran S, Hayes JD, Hardingham GE.

Nat Commun. 2015 May 13;6:7066. doi: 10.1038/ncomms8066.


Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones.

James OT, Livesey MR, Qiu J, Dando O, Bilican B, Haghi G, Rajan R, Burr K, Hardingham GE, Chandran S, Kind PC, Wyllie DJ.

J Physiol. 2014 Oct 1;592(19):4353-63. doi: 10.1113/jphysiol.2014.278994. Epub 2014 Aug 28.


Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons.

Livesey MR, Bilican B, Qiu J, Rzechorzek NM, Haghi G, Burr K, Hardingham GE, Chandran S, Wyllie DJ.

J Neurosci. 2014 Mar 12;34(11):4070-5. doi: 10.1523/JNEUROSCI.5410-13.2014.


Generation of functional neurons from feeder-free, keratinocyte-derived equine induced pluripotent stem cells.

Sharma R, Livesey MR, Wyllie DJ, Proudfoot C, Whitelaw CB, Hay DC, Donadeu FX.

Stem Cells Dev. 2014 Jul 1;23(13):1524-34. doi: 10.1089/scd.2013.0565. Epub 2014 Mar 25.


Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells.

Bilican B, Livesey MR, Haghi G, Qiu J, Burr K, Siller R, Hardingham GE, Wyllie DJ, Chandran S.

PLoS One. 2014 Jan 17;9(1):e85932. doi: 10.1371/journal.pone.0085932. eCollection 2014.


Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals.

Qiu J, Tan YW, Hagenston AM, Martel MA, Kneisel N, Skehel PA, Wyllie DJ, Bading H, Hardingham GE.

Nat Commun. 2013;4:2034. doi: 10.1038/ncomms3034.


Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".

Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S.

Sci Transl Med. 2013 Jun 5;5(188):188le2. doi: 10.1126/scitranslmed.3005065.


Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure.

McKay S, Bengtson CP, Bading H, Wyllie DJ, Hardingham GE.

Neuropharmacology. 2013 Nov;74:119-25. doi: 10.1016/j.neuropharm.2013.01.024. Epub 2013 Feb 10.


Influence of GluN2 subunit identity on NMDA receptor function.

Wyllie DJ, Livesey MR, Hardingham GE.

Neuropharmacology. 2013 Nov;74:4-17. doi: 10.1016/j.neuropharm.2013.01.016. Epub 2013 Jan 31. Review.


Fragile X syndrome: from targets to treatments.

Wijetunge LS, Chattarji S, Wyllie DJ, Kind PC.

Neuropharmacology. 2013 May;68:83-96. doi: 10.1016/j.neuropharm.2012.11.028. Epub 2012 Dec 17. Review.


3-Fluoro-N-methyl-D-aspartic acid (3F-NMDA) stereoisomers as conformational probes for exploring agonist binding at NMDA receptors.

Chia PW, Livesey MR, Slawin AM, van Mourik T, Wyllie DJ, O'Hagan D.

Chemistry. 2012 Jul 9;18(28):8813-9. doi: 10.1002/chem.201200071. Epub 2012 Jun 12.


SynGAP isoforms exert opposing effects on synaptic strength.

McMahon AC, Barnett MW, O'Leary TS, Stoney PN, Collins MO, Papadia S, Choudhary JS, Komiyama NH, Grant SG, Hardingham GE, Wyllie DJ, Kind PC.

Nat Commun. 2012 Jun 12;3:900. doi: 10.1038/ncomms1900.


Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis.

Patani R, Lewis PA, Trabzuni D, Puddifoot CA, Wyllie DJ, Walker R, Smith C, Hardingham GE, Weale M, Hardy J, Chandran S, Ryten M.

J Neurochem. 2012 Aug;122(4):738-51. doi: 10.1111/j.1471-4159.2012.07825.x. Epub 2012 Jul 10.


PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity.

Puddifoot C, Martel MA, Soriano FX, Camacho A, Vidal-Puig A, Wyllie DJ, Hardingham GE.

J Neurosci. 2012 May 16;32(20):6995-7000. doi: 10.1523/JNEUROSCI.6407-11.2012.


TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.

Edman S, McKay S, Macdonald LJ, Samadi M, Livesey MR, Hardingham GE, Wyllie DJ.

Neuropharmacology. 2012 Sep;63(3):441-9. doi: 10.1016/j.neuropharm.2012.04.027. Epub 2012 May 1.


The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults.

Martel MA, Ryan TJ, Bell KF, Fowler JH, McMahon A, Al-Mubarak B, Komiyama NH, Horsburgh K, Kind PC, Grant SG, Wyllie DJ, Hardingham GE.

Neuron. 2012 May 10;74(3):543-56. doi: 10.1016/j.neuron.2012.03.021.


Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability.

Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5803-8. doi: 10.1073/pnas.1202922109. Epub 2012 Mar 26.


NMDA receptor permeation: a light in the tunnel.

Wyllie DJ, Traynelis SF.

Nat Neurosci. 2012 Feb 24;15(3):343-4. doi: 10.1038/nn.3058.


Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.

McKay S, Griffiths NH, Butters PA, Thubron EB, Hardingham GE, Wyllie DJ.

Br J Pharmacol. 2012 Jun;166(3):924-37. doi: 10.1111/j.1476-5381.2011.01748.x.


Neuronal homeostasis: time for a change?

O'Leary T, Wyllie DJ.

J Physiol. 2011 Oct 15;589(Pt 20):4811-26. doi: 10.1113/jphysiol.2011.210179. Epub 2011 Aug 8. Review.

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