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TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages.

Li Y, James SJ, Wyllie DH, Wynne C, Czibula A, Bukhari A, Pye K, Bte Mustafah SM, Fajka-Boja R, Szabo E, Angyal A, Hegedus Z, Kovacs L, Hill AVS, Jefferies CA, Wilson HL, Yongliang Z, Kiss-Toth E.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16479-16488. doi: 10.1073/pnas.1901090116. Epub 2019 Jul 25.


Panton-Valentine leucocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial GWAS.

Young BC, Earle SG, Soeng S, Sar P, Kumar V, Hor S, Sar V, Bousfield R, Sanderson ND, Barker L, Stoesser N, Emary KR, Parry CM, Nickerson EK, Turner P, Bowden R, Crook DW, Wyllie DH, Day NP, Wilson DJ, Moore CE.

Elife. 2019 Feb 22;8. pii: e42486. doi: 10.7554/eLife.42486.


Heterogeneous early immune responses to the S. aureus EapH2 antigen induced by gastrointestinal tract colonisation impact the response to subsequent vaccination.

Flaxman A, Yamaguchi Y, van Diemen PM, Rollier C, Allen E, Elshina E, Wyllie DH.

Vaccine. 2019 Jan 14;37(3):494-501. doi: 10.1016/j.vaccine.2018.11.063. Epub 2018 Nov 28.


Vaccination with the Staphylococcus aureus secreted proteins EapH1 and EapH2 impacts both S. aureus carriage and invasive disease.

Elshina E, Allen ER, Flaxman A, van Diemen PM, Milicic A, Rollier CS, Yamaguchi Y, Wyllie DH.

Vaccine. 2019 Jan 14;37(3):502-509. doi: 10.1016/j.vaccine.2018.11.036. Epub 2018 Nov 28.


A Large, Refractory Nosocomial Outbreak of Klebsiella pneumoniae Carbapenemase-Producing Escherichia coli Demonstrates Carbapenemase Gene Outbreaks Involving Sink Sites Require Novel Approaches to Infection Control.

Decraene V, Phan HTT, George R, Wyllie DH, Akinremi O, Aiken Z, Cleary P, Dodgson A, Pankhurst L, Crook DW, Lenney C, Walker AS, Woodford N, Sebra R, Fath-Ordoubadi F, Mathers AJ, Seale AC, Guiver M, McEwan A, Watts V, Welfare W, Stoesser N, Cawthorne J; TRACE Investigators’ Group.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e01689-18. doi: 10.1128/AAC.01689-18. Print 2018 Dec.


Identifying Mixed Mycobacterium tuberculosis Infection and Laboratory Cross-Contamination during Mycobacterial Sequencing Programs.

Wyllie DH, Robinson E, Peto T, Crook DW, Ajileye A, Rathod P, Allen R, Jarrett L, Smith EG, Walker AS.

J Clin Microbiol. 2018 Oct 25;56(11). pii: e00923-18. doi: 10.1128/JCM.00923-18. Print 2018 Nov.


Trends over time in Escherichia coli bloodstream infections, urinary tract infections, and antibiotic susceptibilities in Oxfordshire, UK, 1998-2016: a study of electronic health records.

Vihta KD, Stoesser N, Llewelyn MJ, Quan TP, Davies T, Fawcett NJ, Dunn L, Jeffery K, Butler CC, Hayward G, Andersson M, Morgan M, Oakley S, Mason A, Hopkins S, Wyllie DH, Crook DW, Wilcox MH, Johnson AP, Peto TEA, Walker AS.

Lancet Infect Dis. 2018 Oct;18(10):1138-1149. doi: 10.1016/S1473-3099(18)30353-0. Epub 2018 Aug 17.


A Quantitative Evaluation of MIRU-VNTR Typing Against Whole-Genome Sequencing for Identifying Mycobacterium tuberculosis Transmission: A Prospective Observational Cohort Study.

Wyllie DH, Davidson JA, Grace Smith E, Rathod P, Crook DW, Peto TEA, Robinson E, Walker T, Campbell C.

EBioMedicine. 2018 Aug;34:122-130. doi: 10.1016/j.ebiom.2018.07.019. Epub 2018 Aug 1.


Control of Artifactual Variation in Reported Intersample Relatedness during Clinical Use of a Mycobacterium tuberculosis Sequencing Pipeline.

Wyllie DH, Sanderson N, Myers R, Peto T, Robinson E, Crook DW, Smith EG, Walker AS.

J Clin Microbiol. 2018 Jul 26;56(8). pii: e00104-18. doi: 10.1128/JCM.00104-18. Print 2018 Aug.


Severe infections emerge from commensal bacteria by adaptive evolution.

Young BC, Wu CH, Gordon NC, Cole K, Price JR, Liu E, Sheppard AE, Perera S, Charlesworth J, Golubchik T, Iqbal Z, Bowden R, Massey RC, Paul J, Crook DW, Peto TE, Walker AS, Llewelyn MJ, Wyllie DH, Wilson DJ.

Elife. 2017 Dec 19;6. pii: e30637. doi: 10.7554/eLife.30637.


Evaluation of Whole-Genome Sequencing for Mycobacterial Species Identification and Drug Susceptibility Testing in a Clinical Setting: a Large-Scale Prospective Assessment of Performance against Line Probe Assays and Phenotyping.

Quan TP, Bawa Z, Foster D, Walker T, Del Ojo Elias C, Rathod P; MMM Informatics Group, Iqbal Z, Bradley P, Mowbray J, Walker AS, Crook DW, Wyllie DH, Peto TEA, Smith EG.

J Clin Microbiol. 2018 Jan 24;56(2). pii: e01480-17. doi: 10.1128/JCM.01480-17. Print 2018 Feb.


BugMat and FindNeighbour: command line and server applications for investigating bacterial relatedness.

Mazariegos-Canellas O, Do T, Peto T, Eyre DW, Underwood A, Crook D, Wyllie DH.

BMC Bioinformatics. 2017 Nov 13;18(1):477. doi: 10.1186/s12859-017-1907-2.


Development of persistent gastrointestinal S. aureus carriage in mice.

Flaxman A, van Diemen PM, Yamaguchi Y, Allen E, Lindemann C, Rollier CS, Milicic A, Wyllie DH.

Sci Rep. 2017 Sep 29;7(1):12415. doi: 10.1038/s41598-017-12576-0.


Mortality risks associated with emergency admissions during weekends and public holidays: an analysis of electronic health records.

Walker AS, Mason A, Quan TP, Fawcett NJ, Watkinson P, Llewelyn M, Stoesser N, Finney J, Davies J, Wyllie DH, Crook DW, Peto TEA.

Lancet. 2017 Jul 1;390(10089):62-72. doi: 10.1016/S0140-6736(17)30782-1. Epub 2017 May 9.


The S. aureus 4-oxalocrotonate tautomerase SAR1376 enhances immune responses when fused to several antigens.

Diemen PMV, Leneghan DB, Brian IJ, Miura K, Long CA, Milicic A, Biswas S, Rollier CS, Wyllie DH.

Sci Rep. 2017 May 11;7(1):1745. doi: 10.1038/s41598-017-01421-z.


Same-Day Diagnostic and Surveillance Data for Tuberculosis via Whole-Genome Sequencing of Direct Respiratory Samples.

Votintseva AA, Bradley P, Pankhurst L, Del Ojo Elias C, Loose M, Nilgiriwala K, Chatterjee A, Smith EG, Sanderson N, Walker TM, Morgan MR, Wyllie DH, Walker AS, Peto TEA, Crook DW, Iqbal Z.

J Clin Microbiol. 2017 May;55(5):1285-1298. doi: 10.1128/JCM.02483-16. Epub 2017 Mar 8.


Effects of control interventions on Clostridium difficile infection in England: an observational study.

Dingle KE, Didelot X, Quan TP, Eyre DW, Stoesser N, Golubchik T, Harding RM, Wilson DJ, Griffiths D, Vaughan A, Finney JM, Wyllie DH, Oakley SJ, Fawley WN, Freeman J, Morris K, Martin J, Howard P, Gorbach S, Goldstein EJC, Citron DM, Hopkins S, Hope R, Johnson AP, Wilcox MH, Peto TEA, Walker AS, Crook DW; Modernising Medical Microbiology Informatics Group.

Lancet Infect Dis. 2017 Apr;17(4):411-421. doi: 10.1016/S1473-3099(16)30514-X. Epub 2017 Jan 25.


Risk factors for dermatitis in submariners during a submerged patrol: an observational cohort study.

Flaxman A, Allen E, Lindemann C, Yamaguchi Y, O'Shea MK, Fallowfield JL, Lindsay M, Gunner F, Knox K, Wyllie DH.

BMJ Open. 2016 Jun 2;6(6):e010975. doi: 10.1136/bmjopen-2015-010975.


MRI Based Localisation and Quantification of Abscesses following Experimental S. aureus Intravenous Challenge: Application to Vaccine Evaluation.

Allen ER, van Diemen P, Yamaguchi Y, Lindemann C, Soilleux E, Rollier C, Hill F, Schneider J, Wyllie DH.

PLoS One. 2016 May 26;11(5):e0154705. doi: 10.1371/journal.pone.0154705. eCollection 2016.


Natural mutations in a Staphylococcus aureus virulence regulator attenuate cytotoxicity but permit bacteremia and abscess formation.

Das S, Lindemann C, Young BC, Muller J, Österreich B, Ternette N, Winkler AC, Paprotka K, Reinhardt R, Förstner KU, Allen E, Flaxman A, Yamaguchi Y, Rollier CS, van Diemen P, Blättner S, Remmele CW, Selle M, Dittrich M, Müller T, Vogel J, Ohlsen K, Crook DW, Massey R, Wilson DJ, Rudel T, Wyllie DH, Fraunholz MJ.

Proc Natl Acad Sci U S A. 2016 May 31;113(22):E3101-10. doi: 10.1073/pnas.1520255113. Epub 2016 May 16.


Corrigendum: Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis.

Bradley P, Gordon NC, Walker TM, Dunn L, Heys S, Huang B, Earle S, Pankhurst LJ, Anson L, de Cesare M, Piazza P, Votintseva AA, Golubchik T, Wilson DJ, Wyllie DH, Diel R, Niemann S, Feuerriegel S, Kohl TA, Ismail N, Omar SV, Smith EG, Buck D, McVean G, Walker AS, Peto TE, Crook DW, Iqbal Z.

Nat Commun. 2016 Apr 20;7:11465. doi: 10.1038/ncomms11465. No abstract available.


Population variation in anti-S. aureus IgG isotypes influences surface protein A mediated immune subversion.

Whitehouse J, Flaxman A, Rollier C, O'Shea MK, Fallowfield J, Lindsay M, Gunner F, Knox K, Wyllie DH, Yamaguchi Y.

Vaccine. 2016 Apr 4;34(15):1792-9. doi: 10.1016/j.vaccine.2016.02.034. Epub 2016 Feb 26.


Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis.

Bradley P, Gordon NC, Walker TM, Dunn L, Heys S, Huang B, Earle S, Pankhurst LJ, Anson L, de Cesare M, Piazza P, Votintseva AA, Golubchik T, Wilson DJ, Wyllie DH, Diel R, Niemann S, Feuerriegel S, Kohl TA, Ismail N, Omar SV, Smith EG, Buck D, McVean G, Walker AS, Peto TE, Crook DW, Iqbal Z.

Nat Commun. 2015 Dec 21;6:10063. doi: 10.1038/ncomms10063. Erratum in: Nat Commun. 2016;7:11465.


Mycobacterial DNA extraction for whole-genome sequencing from early positive liquid (MGIT) cultures.

Votintseva AA, Pankhurst LJ, Anson LW, Morgan MR, Gascoyne-Binzi D, Walker TM, Quan TP, Wyllie DH, Del Ojo Elias C, Wilcox M, Walker AS, Peto TE, Crook DW.

J Clin Microbiol. 2015 Apr;53(4):1137-43. doi: 10.1128/JCM.03073-14. Epub 2015 Jan 28.


4-1BBL enhances CD8+ T cell responses induced by vectored vaccines in mice but fails to improve immunogenicity in rhesus macaques.

Spencer AJ, Furze J, Honeycutt JD, Calvert A, Saurya S, Colloca S, Wyllie DH, Gilbert SC, Bregu M, Cottingham MG, Hill AV.

PLoS One. 2014 Aug 20;9(8):e105520. doi: 10.1371/journal.pone.0105520. eCollection 2014.


Prevalence of Staphylococcus aureus protein A (spa) mutants in the community and hospitals in Oxfordshire.

Votintseva AA, Fung R, Miller RR, Knox K, Godwin H, Wyllie DH, Bowden R, Crook DW, Walker AS.

BMC Microbiol. 2014 Mar 12;14:63. doi: 10.1186/1471-2180-14-63.


Whole genome sequencing and de novo assembly identifies Sydney-like variant noroviruses and recombinants during the winter 2012/2013 outbreak in England.

Wong TH, Dearlove BL, Hedge J, Giess AP, Piazza P, Trebes A, Paul J, Smit E, Smith EG, Sutton JK, Wilcox MH, Dingle KE, Peto TE, Crook DW, Wilson DJ, Wyllie DH.

Virol J. 2013 Nov 13;10:335. doi: 10.1186/1743-422X-10-335.


Diverse sources of C. difficile infection identified on whole-genome sequencing.

Eyre DW, Cule ML, Wilson DJ, Griffiths D, Vaughan A, O'Connor L, Ip CLC, Golubchik T, Batty EM, Finney JM, Wyllie DH, Didelot X, Piazza P, Bowden R, Dingle KE, Harding RM, Crook DW, Wilcox MH, Peto TEA, Walker AS.

N Engl J Med. 2013 Sep 26;369(13):1195-205. doi: 10.1056/NEJMoa1216064.


A modified RNA-Seq approach for whole genome sequencing of RNA viruses from faecal and blood samples.

Batty EM, Wong TH, Trebes A, Argoud K, Attar M, Buck D, Ip CL, Golubchik T, Cule M, Bowden R, Manganis C, Klenerman P, Barnes E, Walker AS, Wyllie DH, Wilson DJ, Dingle KE, Peto TE, Crook DW, Piazza P.

PLoS One. 2013 Jun 10;8(6):e66129. doi: 10.1371/journal.pone.0066129. Print 2013.


Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.

Stoesser N, Batty EM, Eyre DW, Morgan M, Wyllie DH, Del Ojo Elias C, Johnson JR, Walker AS, Peto TE, Crook DW.

J Antimicrob Chemother. 2013 Oct;68(10):2234-44. doi: 10.1093/jac/dkt180. Epub 2013 May 30.


Irradiated wild-type and Spa mutant Staphylococcus aureus induce anti-S. aureus immune responses in mice which do not protect against subsequent intravenous challenge.

van Diemen PM, Yamaguchi Y, Paterson GK, Rollier CS, Hill AV, Wyllie DH.

Pathog Dis. 2013 Jun;68(1):20-6. doi: 10.1111/2049-632X.12042.


Relationship between bacterial strain type, host biomarkers, and mortality in Clostridium difficile infection.

Walker AS, Eyre DW, Wyllie DH, Dingle KE, Griffiths D, Shine B, Oakley S, O'Connor L, Finney J, Vaughan A, Crook DW, Wilcox MH, Peto TE; Infections in Oxfordshire Research Database.

Clin Infect Dis. 2013 Jun;56(11):1589-600. doi: 10.1093/cid/cit127. Epub 2013 Mar 5.


Identification of 34 novel proinflammatory proteins in a genome-wide macrophage functional screen.

Wyllie DH, Søgaard KC, Holland K, Yaobo X, Bregu M, Hill AV, Kiss-Toth E.

PLoS One. 2012;7(7):e42388. doi: 10.1371/journal.pone.0042388. Epub 2012 Jul 31.


Surveillance of infection severity: a registry study of laboratory diagnosed Clostridium difficile.

Schlackow I, Walker AS, Dingle K, Griffiths D, Oakley S, Finney J, Vaughan A, Gill MJ, Crook DW, Peto TE, Wyllie DH.

PLoS Med. 2012;9(7):e1001279. doi: 10.1371/journal.pmed.1001279. Epub 2012 Jul 31.


Fusion of the Mycobacterium tuberculosis antigen 85A to an oligomerization domain enhances its immunogenicity in both mice and non-human primates.

Spencer AJ, Hill F, Honeycutt JD, Cottingham MG, Bregu M, Rollier CS, Furze J, Draper SJ, Søgaard KC, Gilbert SC, Wyllie DH, Hill AV.

PLoS One. 2012;7(3):e33555. doi: 10.1371/journal.pone.0033555. Epub 2012 Mar 28.


Increasing incidence of Escherichia coli bacteraemia is driven by an increase in antibiotic-resistant isolates: electronic database study in Oxfordshire 1999-2011.

Schlackow I, Stoesser N, Walker AS, Crook DW, Peto TE, Wyllie DH; Infections in Oxfordshire Research Database Team.

J Antimicrob Chemother. 2012 Jun;67(6):1514-24. doi: 10.1093/jac/dks082. Epub 2012 Mar 21.


Mixed vector immunization with recombinant adenovirus and MVA can improve vaccine efficacy while decreasing antivector immunity.

Reyes-Sandoval A, Rollier CS, Milicic A, Bauza K, Cottingham MG, Tang CK, Dicks MD, Wang D, Longley RJ, Wyllie DH, Hill AV.

Mol Ther. 2012 Aug;20(8):1633-47. doi: 10.1038/mt.2012.25. Epub 2012 Feb 21.


Characterisation of Clostridium difficile hospital ward-based transmission using extensive epidemiological data and molecular typing.

Walker AS, Eyre DW, Wyllie DH, Dingle KE, Harding RM, O'Connor L, Griffiths D, Vaughan A, Finney J, Wilcox MH, Crook DW, Peto TE.

PLoS Med. 2012 Feb;9(2):e1001172. doi: 10.1371/journal.pmed.1001172. Epub 2012 Feb 7.


The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody.

Douglas AD, Williams AR, Illingworth JJ, Kamuyu G, Biswas S, Goodman AL, Wyllie DH, Crosnier C, Miura K, Wright GJ, Long CA, Osier FH, Marsh K, Turner AV, Hill AV, Draper SJ.

Nat Commun. 2011 Dec 20;2:601. doi: 10.1038/ncomms1615. Erratum in: Nat Commun. 2013;4. doi:10.1038/ncomms3355.


Clostridium difficile mixed infection and reinfection.

Eyre DW, Walker AS, Griffiths D, Wilcox MH, Wyllie DH, Dingle KE, Crook DW, Peto TE.

J Clin Microbiol. 2012 Jan;50(1):142-4. doi: 10.1128/JCM.05177-11. Epub 2011 Nov 9.


Identification of antigens specific to non-tuberculous mycobacteria: the Mce family of proteins as a target of T cell immune responses.

Checkley AM, Wyllie DH, Scriba TJ, Golubchik T, Hill AV, Hanekom WA, McShane H.

PLoS One. 2011;6(10):e26434. doi: 10.1371/journal.pone.0026434. Epub 2011 Oct 25.


Decline of meticillin-resistant Staphylococcus aureus in Oxfordshire hospitals is strain-specific and preceded infection-control intensification.

Wyllie DH, Walker AS, Miller R, Moore C, Williamson SR, Schlackow I, Finney JM, O'Connor L, Peto TE, Crook DW.

BMJ Open. 2011 Aug 27;1(1):e000160. doi: 10.1136/bmjopen-2011-000160.


CD8+ T effector memory cells protect against liver-stage malaria.

Reyes-Sandoval A, Wyllie DH, Bauza K, Milicic A, Forbes EK, Rollier CS, Hill AV.

J Immunol. 2011 Aug 1;187(3):1347-57. doi: 10.4049/jimmunol.1100302. Epub 2011 Jun 29.


An efficient record linkage scheme using graphical analysis for identifier error detection.

Finney JM, Walker AS, Peto TE, Wyllie DH.

BMC Med Inform Decis Mak. 2011 Feb 1;11:7. doi: 10.1186/1472-6947-11-7.


Long-term thermostabilization of live poxviral and adenoviral vaccine vectors at supraphysiological temperatures in carbohydrate glass.

Alcock R, Cottingham MG, Rollier CS, Furze J, De Costa SD, Hanlon M, Spencer AJ, Honeycutt JD, Wyllie DH, Gilbert SC, Bregu M, Hill AV.

Sci Transl Med. 2010 Feb 17;2(19):19ra12. doi: 10.1126/scitranslmed.3000490.


Comment on "CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node".

Wong SH, Vannberg FO, Spencer AJ, van der Weyden L, Hill AV, Wyllie DH.

J Immunol. 2010 Apr 15;184(8):4052-3. doi: 10.4049/jimmunol.1090017. No abstract available.


Expression of tak1 and tram induces synergistic pro-inflammatory signalling and adjuvants DNA vaccines.

Larsen KC, Spencer AJ, Goodman AL, Gilchrist A, Furze J, Rollier CS, Kiss-Toth E, Gilbert SC, Bregu M, Soilleux EJ, Hill AV, Wyllie DH.

Vaccine. 2009 Sep 18;27(41):5589-98. doi: 10.1016/j.vaccine.2009.07.025. Epub 2009 Jul 29.


Hospital exposure in a UK population, and its association with bacteraemia.

Wyllie DH, Walker AS, Peto TE, Crook DW.

J Hosp Infect. 2007 Dec;67(4):301-7. Epub 2007 Nov 19.


Mortality after Staphylococcus aureus bacteraemia in two hospitals in Oxfordshire, 1997-2003: cohort study.

Wyllie DH, Crook DW, Peto TE.

BMJ. 2006 Aug 5;333(7562):281. Epub 2006 Jun 23. Erratum in: BMJ. 2006 Sep 2;333(7566):468.


Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context.

Chen H, Wilkins LM, Aziz N, Cannings C, Wyllie DH, Bingle C, Rogus J, Beck JD, Offenbacher S, Cork MJ, Rafie-Kolpin M, Hsieh CM, Kornman KS, Duff GW.

Hum Mol Genet. 2006 Feb 15;15(4):519-29. Epub 2006 Jan 6.


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