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Items: 1 to 50 of 162

1.

Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression.

Ibrahim AE, Arends MJ, Silva AL, Wyllie AH, Greger L, Ito Y, Vowler SL, Huang TH, Tavaré S, Murrell A, Brenton JD.

Gut. 2011 Apr;60(4):499-508. doi: 10.1136/gut.2010.223602. Epub 2010 Nov 10.

PMID:
21068132
2.

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.

Poulogiannis G, McIntyre RE, Dimitriadi M, Apps JR, Wilson CH, Ichimura K, Luo F, Cantley LC, Wyllie AH, Adams DJ, Arends MJ.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15145-50. doi: 10.1073/pnas.1009941107. Epub 2010 Aug 9.

3.

"Where, O death, is thy sting?" A brief review of apoptosis biology.

Wyllie AH.

Mol Neurobiol. 2010 Aug;42(1):4-9. doi: 10.1007/s12035-010-8125-5. Epub 2010 Jun 16. Review.

4.

Prognostic relevance of DNA copy number changes in colorectal cancer.

Poulogiannis G, Ichimura K, Hamoudi RA, Luo F, Leung SY, Yuen ST, Harrison DJ, Wyllie AH, Arends MJ.

J Pathol. 2010 Feb;220(3):338-47. doi: 10.1002/path.2640.

PMID:
19911421
5.

New insights into the role of PML in tumour suppression.

Salomoni P, Ferguson BJ, Wyllie AH, Rich T.

Cell Res. 2008 Jun;18(6):622-40. doi: 10.1038/cr.2008.58. Review.

6.

Nuclear phospholipase C gamma: punctate distribution and association with the promyelocytic leukemia protein.

Ferguson BJ, Dovey CL, Lilley K, Wyllie AH, Rich T.

J Proteome Res. 2007 May;6(5):2027-32. Epub 2007 Apr 10.

PMID:
17419608
7.

Evidence for the receipt of DNA damage stimuli by PML nuclear domains.

Varadaraj A, Dovey CL, Laredj L, Ferguson B, Alexander CE, Lubben N, Wyllie AH, Rich T.

J Pathol. 2007 Mar;211(4):471-80.

PMID:
17206596
8.

MMASS: an optimized array-based method for assessing CpG island methylation.

Ibrahim AE, Thorne NP, Baird K, Barbosa-Morais NL, Tavaré S, Collins VP, Wyllie AH, Arends MJ, Brenton JD.

Nucleic Acids Res. 2006;34(20):e136. Epub 2006 Oct 13.

9.

Stress responses of PML nuclear domains are ablated by ataxin-1 and other nucleoprotein inclusions.

Dovey CL, Varadaraj A, Wyllie AH, Rich T.

J Pathol. 2004 Aug;203(4):877-83.

PMID:
15258989
10.

Accuracy of reporting of family history of colorectal cancer.

Mitchell RJ, Brewster D, Campbell H, Porteous ME, Wyllie AH, Bird CC, Dunlop MG.

Gut. 2004 Feb;53(2):291-5.

11.
12.

Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers.

Yuen ST, Chan TL, Ho JW, Chan AS, Chung LP, Lam PW, Tse CW, Wyllie AH, Leung SY.

Oncogene. 2002 Oct 24;21(49):7585-92.

13.

E2F1 selects tumour cells for both life and death.

Wyllie AH.

J Pathol. 2002 Oct;198(2):139-41.

PMID:
12237872
14.

Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background.

Toft NJ, Curtis LJ, Sansom OJ, Leitch AL, Wyllie AH, te Riele H, Arends MJ, Clarke AR.

Oncogene. 2002 Sep 12;21(41):6299-306.

15.

Evidence for an age-related influence of microsatellite instability on colorectal cancer survival.

Farrington SM, McKinley AJ, Carothers AD, Cunningham C, Bubb VJ, Sharp L, Wyllie AH, Dunlop MG.

Int J Cancer. 2002 Apr 20;98(6):844-50.

16.

Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes.

Chan TL, Curtis LC, Leung SY, Farrington SM, Ho JW, Chan AS, Lam PW, Tse CW, Dunlop MG, Wyllie AH, Yuen ST.

Oncogene. 2001 Aug 9;20(35):4871-6.

17.

T cell death and transforming growth factor beta1.

Golstein P, Wyllie AH.

J Exp Med. 2001 Aug 20;194(4):F19-22. No abstract available.

18.

p53-dependent apoptosis induced by proteasome inhibition in mammary epithelial cells.

MacLaren AP, Chapman RS, Wyllie AH, Watson CJ.

Cell Death Differ. 2001 Mar;8(3):210-8.

19.

Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.

Abdel-Rahman WM, Katsura K, Rens W, Gorman PA, Sheer D, Bicknell D, Bodmer WF, Arends MJ, Wyllie AH, Edwards PA.

Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2538-43. Epub 2001 Feb 20.

20.

A polymorphic tetranucleotide repeat in the CYP19 gene and male breast cancer.

Young IE, Kurian KM, MacKenzie MA, Kunkler IH, Cohen BB, Hooper ML, Wyllie AH, Steel CM.

Br J Cancer. 2000 Apr;82(7):1247-8.

21.

More than one way to go.

Wyllie AH, Golstein P.

Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):11-3. No abstract available.

22.

Specific patterns of chromosomal abnormalities are associated with RER status in sporadic colorectal cancer.

Curtis LJ, Georgiades IB, White S, Bird CC, Harrison DJ, Wyllie AH.

J Pathol. 2000 Dec;192(4):440-5.

PMID:
11113860
23.

Defying death after DNA damage.

Rich T, Allen RL, Wyllie AH.

Nature. 2000 Oct 12;407(6805):777-83. Review.

PMID:
11048728
24.

Retroviral vectors.

Kurian KM, Watson CJ, Wyllie AH.

Mol Pathol. 2000 Aug;53(4):173-6. Review.

25.

Familial adenomatous polyposis coli in South Africa--molecular basis and diagnosis.

Grobbelaar JJ, Fortuin R, Scholtz CL, Zikind A, Langenhoven E, Wyllie AH, Bubb VJ, Kotze MJ.

S Afr Med J. 2000 Jul;90(7):715-9.

PMID:
10985135
26.

Chromosomal instability and p53 inactivation are required for genesis of glioblastoma but not for colorectal cancer in patients with germline mismatch repair gene mutation.

Leung SY, Yuen ST, Chan TL, Chan AS, Ho JW, Kwan K, Fan YW, Hung KN, Chung LP, Wyllie AH.

Oncogene. 2000 Aug 17;19(35):4079-83.

27.

The CAG repeat within the androgen receptor gene in male breast cancer patients.

Young IE, Kurian KM, Mackenzie MA, Kunkler IH, Cohen BB, Hooper ML, Wyllie AH, Steel CM.

J Med Genet. 2000 Feb;37(2):139-40. No abstract available.

28.

Heterogeneity studies identify a subset of sporadic colorectal cancers without evidence for chromosomal or microsatellite instability.

Georgiades IB, Curtis LJ, Morris RM, Bird CC, Wyllie AH.

Oncogene. 1999 Dec 23;18(56):7933-40.

29.

Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice.

Kongkanuntn R, Bubb VJ, Sansom OJ, Wyllie AH, Harrison DJ, Clarke AR.

Oncogene. 1999 Dec 2;18(51):7219-25.

30.

A polymorphism in the CYP17 gene is associated with male breast cancer.

Young IE, Kurian KM, Annink C, Kunkler IH, Anderson VA, Cohen BB, Hooper ML, Wyllie AH, Steel CM.

Br J Cancer. 1999 Sep;81(1):141-3.

31.

Apoptosis and carcinogenesis.

Wyllie AH, Bellamy CO, Bubb VJ, Clarke AR, Corbet S, Curtis L, Harrison DJ, Hooper ML, Toft N, Webb S, Bird CC.

Br J Cancer. 1999 Jul;80 Suppl 1:34-7. Review.

PMID:
10466759
32.

Frequent microsatellite instability and mismatch repair gene mutations in young Chinese patients with colorectal cancer.

Chan TL, Yuen ST, Chung LP, Ho JW, Kwan KY, Chan AS, Ho JC, Leung SY, Wyllie AH.

J Natl Cancer Inst. 1999 Jul 21;91(14):1221-6.

PMID:
10413423
33.

Microsomal epoxide hydrolase gene polymorphism and susceptibility to colon cancer.

Harrison DJ, Hubbard AL, MacMillan J, Wyllie AH, Smith CA.

Br J Cancer. 1999 Jan;79(1):168-71.

34.

DNA chip technology.

Kurian KM, Watson CJ, Wyllie AH.

J Pathol. 1999 Feb;187(3):267-71.

PMID:
10398077
35.

Identification of a region of frequent loss of heterozygosity at 11q24 in colorectal cancer.

Connolly KC, Gabra H, Millwater CJ, Taylor KJ, Rabiasz GJ, Watson JE, Smyth JF, Wyllie AH, Jodrell DI.

Cancer Res. 1999 Jun 15;59(12):2806-9.

36.

Role of BAX mutations in mismatch repair-deficient colorectal carcinogenesis.

Abdel-Rahman WM, Georgiades IB, Curtis LJ, Arends MJ, Wyllie AH.

Oncogene. 1999 Mar 25;18(12):2139-42.

37.

P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells.

Corbet SW, Clarke AR, Gledhill S, Wyllie AH.

Oncogene. 1999 Feb 25;18(8):1537-44.

38.

Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine.

Toft NJ, Winton DJ, Kelly J, Howard LA, Dekker M, te Riele H, Arends MJ, Wyllie AH, Margison GP, Clarke AR.

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3911-5.

39.

Caspase-mediated cleavage of APC results in an amino-terminal fragment with an intact armadillo repeat domain.

Webb SJ, Nicholson D, Bubb VJ, Wyllie AH.

FASEB J. 1999 Feb;13(2):339-46.

PMID:
9973322
40.

p53-independent DNA repair and cell cycle arrest in embryonic stem cells.

Prost S, Bellamy CO, Clarke AR, Wyllie AH, Harrison DJ.

FEBS Lett. 1998 Apr 3;425(3):499-504.

41.

Detection of mutations associated with colorectal cancer in DNA from whole-gut lavage fluid.

Potter MA, Morris RG, Ferguson A, Wyllie AH.

J Natl Cancer Inst. 1998 Apr 15;90(8):623-6. No abstract available.

PMID:
9554446
42.

N-acetyl transferase 1: two polymorphisms in coding sequence identified in colorectal cancer patients.

Hubbard AL, Moyes C, Wyllie AH, Smith CA, Harrison DJ.

Br J Cancer. 1998 Mar;77(6):913-6.

43.

No female embryonic lethality in mice nullizygous for Msh2 and p53.

Toft NJ, Arends MJ, Wyllie AH, Clarke AR.

Nat Genet. 1998 Jan;18(1):17. No abstract available.

PMID:
9425892
44.

UV but not gamma-irradiation induces specific transcriptional activity of p53 in primary hepatocytes.

Bellamy CO, Prost S, Wyllie AH, Harrison DJ.

J Pathol. 1997 Oct;183(2):177-81.

PMID:
9390030
45.

N-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions.

Hubbard AL, Harrison DJ, Moyes C, Wyllie AH, Cunningham C, Mannion E, Smith CA.

Gut. 1997 Aug;41(2):229-34.

46.

Apoptosis and carcinogenesis.

Wyllie AH.

Eur J Cell Biol. 1997 Jul;73(3):189-97. Review.

PMID:
9243179
47.
48.

APC expression in normal human tissues.

Midgley CA, White S, Howitt R, Save V, Dunlop MG, Hall PA, Lane DP, Wyllie AH, Bubb VJ.

J Pathol. 1997 Apr;181(4):426-33.

PMID:
9196441
49.

The pattern of K-ras mutation in pulmonary adenocarcinoma defines a new pathway of tumour development in the human lung.

Cooper CA, Carby FA, Bubb VJ, Lamb D, Kerr KM, Wyllie AH.

J Pathol. 1997 Apr;181(4):401-4.

PMID:
9196437
50.

Ki-ras mutations in stool and whole-gut lavage fluid.

Potter MA, Morris RM, Ferguson A, Wyllie AH.

Gastroenterology. 1997 Apr;112(4):1427-8. No abstract available.

PMID:
9098037

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