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Items: 6


Protection from Endotoxin Shock by Selective Targeting of Proinflammatory Signaling to the Nucleus Mediated by Importin Alpha 5.

Liu Y, Veach RA, Zienkiewicz J, Boyd KL, Smith TE, Xu ZQ, Wylezinski LS, Hawiger J.

Immunohorizons. 2019 Sep 18;3(9):440-446. doi: 10.4049/immunohorizons.1900064.


Illuminating an Invisible Epidemic: A Systemic Review of the Clinical and Economic Benefits of Early Diagnosis and Treatment in Inflammatory Disease and Related Syndromes.

Wylezinski LS, Gray JD, Polk JB, Harmata AJ, Spurlock CF 3rd.

J Clin Med. 2019 Apr 11;8(4). pii: E493. doi: 10.3390/jcm8040493. Review.


Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles.

Veach RA, Liu Y, Zienkiewicz J, Wylezinski LS, Boyd KL, Wynn JL, Hawiger J.

PLoS One. 2017 Jun 19;12(6):e0179468. doi: 10.1371/journal.pone.0179468. eCollection 2017.


Interleukin 2 Activates Brain Microvascular Endothelial Cells Resulting in Destabilization of Adherens Junctions.

Wylezinski LS, Hawiger J.

J Biol Chem. 2016 Oct 28;291(44):22913-22923. Epub 2016 Sep 6.


The "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation.

DiGiandomenico A, Veach RA, Zienkiewicz J, Moore DJ, Wylezinski LS, Hutchens MA, Hawiger J.

PLoS One. 2014 Oct 20;9(10):e110183. doi: 10.1371/journal.pone.0110183. eCollection 2014.


Intracellular delivery of a cell-penetrating SOCS1 that targets IFN-gamma signaling.

DiGiandomenico A, Wylezinski LS, Hawiger J.

Sci Signal. 2009 Jul 21;2(80):ra37. doi: 10.1126/scisignal.1162191.

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