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Items: 1 to 50 of 74

1.

Docking of Meprin α to Heparan Sulphate Protects the Endothelium from Inflammatory Cell Extravasation.

Biasin V, Wygrecka M, Bärnthaler T, Jandl K, Jain PP, Bálint Z, Kovacs G, Leitinger G, Kolb-Lenz D, Kornmueller K, Peters F, Sinn K, Klepetko W, Heinemann A, Olschewski A, Becker-Pauly C, Kwapiszewska G.

Thromb Haemost. 2018 Oct;118(10):1790-1802. doi: 10.1055/s-0038-1670657. Epub 2018 Sep 20.

PMID:
30235485
2.

Transcriptome profiling reveals the complexity of pirfenidone effects in idiopathic pulmonary fibrosis.

Kwapiszewska G, Gungl A, Wilhelm J, Marsh LM, Thekkekara Puthenparampil H, Sinn K, Didiasova M, Klepetko W, Kosanovic D, Schermuly RT, Wujak L, Weiss B, Schaefer L, Schneider M, Kreuter M, Olschewski A, Seeger W, Olschewski H, Wygrecka M.

Eur Respir J. 2018 Nov 22;52(5). pii: 1800564. doi: 10.1183/13993003.00564-2018. Print 2018 Nov.

PMID:
30166321
3.

Factor XII in coagulation, inflammation and beyond.

Didiasova M, Wujak L, Schaefer L, Wygrecka M.

Cell Signal. 2018 Nov;51:257-265. doi: 10.1016/j.cellsig.2018.08.006. Epub 2018 Aug 15.

PMID:
30118759
4.

Osteopontin protects against lung injury caused by extracellular histones.

Kasetty G, Papareddy P, Bhongir RKV, Ali MN, Mori M, Wygrecka M, Erjefält JS, Hultgårdh-Nilsson A, Palmberg L, Herwald H, Egesten A.

Mucosal Immunol. 2018 Aug 16. doi: 10.1038/s41385-018-0079-3. [Epub ahead of print]

PMID:
30115999
5.

Biglycan is a new high-affinity ligand for CD14 in macrophages.

Roedig H, Nastase MV, Frey H, Moreth K, Zeng-Brouwers J, Poluzzi C, Hsieh LT, Brandts C, Fulda S, Wygrecka M, Schaefer L.

Matrix Biol. 2018 May 17. pii: S0945-053X(18)30186-0. doi: 10.1016/j.matbio.2018.05.006. [Epub ahead of print]

PMID:
29777767
6.

Targeting GLI Transcription Factors in Cancer.

Didiasova M, Schaefer L, Wygrecka M.

Molecules. 2018 Apr 24;23(5). pii: E1003. doi: 10.3390/molecules23051003. Review.

7.

Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells.

Zakrzewicz D, Didiasova M, Krüger M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Zakrzewicz A, Schaefer L, Preissner KT, Wygrecka M.

Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1816-1827. doi: 10.1016/j.bbadis.2018.02.021. Epub 2018 Mar 2.

PMID:
29501774
8.

Biomarkers in idiopathic pulmonary fibrosis.

Drakopanagiotakis F, Wujak L, Wygrecka M, Markart P.

Matrix Biol. 2018 Aug;68-69:404-421. doi: 10.1016/j.matbio.2018.01.023. Epub 2018 Jan 31. Review.

PMID:
29408012
9.

Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity.

Frevert CW, Felgenhauer J, Wygrecka M, Nastase MV, Schaefer L.

J Histochem Cytochem. 2018 Apr;66(4):213-227. doi: 10.1369/0022155417740880. Epub 2018 Jan 1.

PMID:
29290139
10.

Small Leucine-Rich Proteoglycans in Renal Inflammation: Two Sides of the Coin.

Nastase MV, Janicova A, Roedig H, Hsieh LT, Wygrecka M, Schaefer L.

J Histochem Cytochem. 2018 Apr;66(4):261-272. doi: 10.1369/0022155417738752. Epub 2018 Jan 1.

PMID:
29290137
11.

Targeting renal fibrosis: Mechanisms and drug delivery systems.

Nastase MV, Zeng-Brouwers J, Wygrecka M, Schaefer L.

Adv Drug Deliv Rev. 2018 Apr;129:295-307. doi: 10.1016/j.addr.2017.12.019. Epub 2017 Dec 27. Review.

PMID:
29288033
12.

LRP1: A chameleon receptor of lung inflammation and repair.

Wujak L, Schnieder J, Schaefer L, Wygrecka M.

Matrix Biol. 2018 Aug;68-69:366-381. doi: 10.1016/j.matbio.2017.12.007. Epub 2017 Dec 17. Review.

PMID:
29262309
13.

Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney.

Nastase MV, Zeng-Brouwers J, Beckmann J, Tredup C, Christen U, Radeke HH, Wygrecka M, Schaefer L.

Matrix Biol. 2018 Aug;68-69:293-317. doi: 10.1016/j.matbio.2017.12.002. Epub 2017 Dec 15.

PMID:
29253517
14.

Low density lipoprotein receptor-related protein 1 couples β1 integrin activation to degradation.

Wujak L, Böttcher RT, Pak O, Frey H, El Agha E, Chen Y, Schmitt S, Bellusci S, Schaefer L, Weissmann N, Fässler R, Wygrecka M.

Cell Mol Life Sci. 2018 May;75(9):1671-1685. doi: 10.1007/s00018-017-2707-6. Epub 2017 Nov 7.

PMID:
29116364
15.

Coagulation factor XII regulates inflammatory responses in human lungs.

Hess R, Wujak L, Hesse C, Sewald K, Jonigk D, Warnecke G, Fieguth HG, de Maat S, Maas C, Bonella F, Preissner KT, Weiss B, Schaefer L, Kuebler WM, Markart P, Wygrecka M.

Thromb Haemost. 2017 Oct 5;117(10):1896-1907. doi: 10.1160/TH16-12-0904. Epub 2017 Aug 17.

PMID:
28816340
16.

FXII promotes proteolytic processing of the LRP1 ectodomain.

Wujak L, Hesse C, Sewald K, Jonigk D, Braubach P, Warnecke G, Fieguth HG, Braun A, Lochnit G, Markart P, Schaefer L, Wygrecka M.

Biochim Biophys Acta Gen Subj. 2017 Aug;1861(8):2088-2098. doi: 10.1016/j.bbagen.2017.05.023. Epub 2017 May 25.

PMID:
28552561
17.

Signaling at the Crossroads: Matrix-Derived Proteoglycan and Reactive Oxygen Species Signaling.

Nastase MV, Janicova A, Wygrecka M, Schaefer L.

Antioxid Redox Signal. 2017 Oct 20;27(12):855-873. doi: 10.1089/ars.2017.7165. Epub 2017 Jul 5. Review.

PMID:
28510506
18.

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants.

Hsieh LT, Nastase MV, Roedig H, Zeng-Brouwers J, Poluzzi C, Schwalm S, Fork C, Tredup C, Brandes RP, Wygrecka M, Huwiler A, Pfeilschifter J, Schaefer L.

Int J Mol Sci. 2017 Mar 9;18(3). pii: E595. doi: 10.3390/ijms18030595.

19.

Amplified canonical transforming growth factor-β signalling via heat shock protein 90 in pulmonary fibrosis.

Sibinska Z, Tian X, Korfei M, Kojonazarov B, Kolb JS, Klepetko W, Kosanovic D, Wygrecka M, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Guenther A, Schermuly RT.

Eur Respir J. 2017 Feb 23;49(2). pii: 1501941. doi: 10.1183/13993003.01941-2015. Print 2017 Feb.

20.

Pirfenidone exerts antifibrotic effects through inhibition of GLI transcription factors.

Didiasova M, Singh R, Wilhelm J, Kwapiszewska G, Wujak L, Zakrzewicz D, Schaefer L, Markart P, Seeger W, Lauth M, Wygrecka M.

FASEB J. 2017 May;31(5):1916-1928. doi: 10.1096/fj.201600892RR. Epub 2017 Feb 1.

PMID:
28148565
21.

Meprin β contributes to collagen deposition in lung fibrosis.

Biasin V, Wygrecka M, Marsh LM, Becker-Pauly C, Brcic L, Ghanim B, Klepetko W, Olschewski A, Kwapiszewska G.

Sci Rep. 2017 Jan 6;7:39969. doi: 10.1038/srep39969.

22.

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart P.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199. doi: 10.1164/rccm.201604-0712OC.

PMID:
28005404
23.

Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells.

Zakrzewicz D, Bergmann S, Didiasova M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Lochnit G, Schaefer L, Hammerschmidt S, Preissner KT, Wygrecka M.

Sci Rep. 2016 Nov 28;6:37758. doi: 10.1038/srep37758.

24.

The low density lipoprotein receptor-related protein (LRP) 1 and its function in lung diseases.

Wujak L, Markart P, Wygrecka M.

Histol Histopathol. 2016 Jul;31(7):733-45. doi: 10.14670/HH-11-746. Epub 2016 Mar 1. Review.

PMID:
26926950
25.

FXYD1 negatively regulates Na(+)/K(+)-ATPase activity in lung alveolar epithelial cells.

Wujak ŁA, Blume A, Baloğlu E, Wygrecka M, Wygowski J, Herold S, Mayer K, Vadász I, Besuch P, Mairbäurl H, Seeger W, Morty RE.

Respir Physiol Neurobiol. 2016 Jan;220:54-61. doi: 10.1016/j.resp.2015.09.008. Epub 2015 Sep 26.

PMID:
26410457
26.

Elevated protein arginine methyltransferase 1 expression regulates fibroblast motility in pulmonary fibrosis.

Zakrzewicz D, Zakrzewicz A, Didiasova M, Korencak M, Kosanovic D, Schermuly RT, Markart P, Wygrecka M.

Biochim Biophys Acta. 2015 Dec;1852(12):2678-88. doi: 10.1016/j.bbadis.2015.09.008. Epub 2015 Sep 21.

27.

Maggot excretion products from the blowfly Lucilia sericata contain contact phase/intrinsic pathway-like proteases with procoagulant functions.

Kahl M, Gökçen A, Fischer S, Bäumer M, Wiesner J, Lochnit G, Wygrecka M, Vilcinskas A, Preissner KT.

Thromb Haemost. 2015 Aug;114(2):277-88. doi: 10.1160/TH14-06-0499. Epub 2015 May 7.

PMID:
25948398
28.

STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.

Didiasova M, Zakrzewicz D, Magdolen V, Nagaraj C, Bálint Z, Rohde M, Preissner KT, Wygrecka M.

J Biol Chem. 2015 May 8;290(19):11983-99. doi: 10.1074/jbc.M114.598425. Epub 2015 Mar 24.

29.

Heparan sulfate proteoglycans mediate factor XIIa binding to the cell surface.

Wujak L, Didiasova M, Zakrzewicz D, Frey H, Schaefer L, Wygrecka M.

J Biol Chem. 2015 Mar 13;290(11):7027-39. doi: 10.1074/jbc.M114.606343. Epub 2015 Jan 14.

30.

From plasminogen to plasmin: role of plasminogen receptors in human cancer.

Didiasova M, Wujak L, Wygrecka M, Zakrzewicz D.

Int J Mol Sci. 2014 Nov 17;15(11):21229-52. doi: 10.3390/ijms151121229. Review.

31.

Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1α depletion or imatinib treatment.

Veith C, Zakrzewicz D, Dahal BK, Bálint Z, Murmann K, Wygrecka M, Seeger W, Schermuly RT, Weissmann N, Kwapiszewska G.

Thromb Haemost. 2014 Dec;112(6):1288-303. doi: 10.1160/TH13-12-1031. Epub 2014 Sep 18.

PMID:
25231004
32.

Histological characterization of mast cell chymase in patients with pulmonary hypertension and chronic obstructive pulmonary disease.

Kosanovic D, Dahal BK, Peters DM, Seimetz M, Wygrecka M, Hoffmann K, Antel J, Reiss I, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Schermuly RT.

Pulm Circ. 2014 Mar;4(1):128-36. doi: 10.1086/675642.

33.

The interaction of enolase-1 with caveolae-associated proteins regulates its subcellular localization.

Zakrzewicz D, Didiasova M, Zakrzewicz A, Hocke AC, Uhle F, Markart P, Preissner KT, Wygrecka M.

Biochem J. 2014 Jun 1;460(2):295-307. doi: 10.1042/BJ20130945.

PMID:
24628430
34.

TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.

Peters DM, Vadász I, Wujak L, Wygrecka M, Olschewski A, Becker C, Herold S, Papp R, Mayer K, Rummel S, Brandes RP, Günther A, Waldegger S, Eickelberg O, Seeger W, Morty RE.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E374-83. doi: 10.1073/pnas.1306798111. Epub 2013 Dec 9.

35.

Meprin β, a novel mediator of vascular remodelling underlying pulmonary hypertension.

Biasin V, Marsh LM, Egemnazarov B, Wilhelm J, Ghanim B, Klepetko W, Wygrecka M, Olschewski H, Eferl R, Olschewski A, Kwapiszewska G.

J Pathol. 2014 May;233(1):7-17. doi: 10.1002/path.4303. Epub 2014 Jan 31.

PMID:
24258247
36.

Protease-activated receptors (PAR)-1 and -3 drive epithelial-mesenchymal transition of alveolar epithelial cells - potential role in lung fibrosis.

Wygrecka M, Didiasova M, Berscheid S, Piskulak K, Taborski B, Zakrzewicz D, Kwapiszewska G, Preissner KT, Markart P.

Thromb Haemost. 2013 Aug;110(2):295-307. doi: 10.1160/TH12-11-0854. Epub 2013 Jun 6.

PMID:
23739922
37.

Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: role of transmembrane SCF and the PAR-2/PKC-α/Raf-1/p44/42 signaling pathway.

Wygrecka M, Dahal BK, Kosanovic D, Petersen F, Taborski B, von Gerlach S, Didiasova M, Zakrzewicz D, Preissner KT, Schermuly RT, Markart P.

Am J Pathol. 2013 Jun;182(6):2094-108. doi: 10.1016/j.ajpath.2013.02.013. Epub 2013 Apr 4.

PMID:
23562441
38.

Mast cell chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis?

Kosanovic D, Dahal BK, Wygrecka M, Reiss I, Günther A, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Banat GA.

Histol Histopathol. 2013 Jun;28(6):691-9. doi: 10.14670/HH-28.691. Epub 2013 Feb 25. Review.

PMID:
23436625
39.

Protein Arginine Methyltransferases (PRMTs): promising targets for the treatment of pulmonary disorders.

Zakrzewicz D, Zakrzewicz A, Preissner KT, Markart P, Wygrecka M.

Int J Mol Sci. 2012 Sep 27;13(10):12383-400. doi: 10.3390/ijms131012383. Review.

40.

BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension.

Kwapiszewska G, Chwalek K, Marsh LM, Wygrecka M, Wilhelm J, Best J, Egemnazarov B, Weisel FC, Osswald SL, Schermuly RT, Olschewski A, Seeger W, Weissmann N, Eickelberg O, Fink L.

Am J Pathol. 2012 Dec;181(6):2018-29. doi: 10.1016/j.ajpath.2012.08.028. Epub 2012 Oct 8.

PMID:
23058367
41.

Paxillin regulates pulmonary arterial smooth muscle cell function in pulmonary hypertension.

Veith C, Marsh LM, Wygrecka M, Rutschmann K, Seeger W, Weissmann N, Kwapiszewska G.

Am J Pathol. 2012 Nov;181(5):1621-33. doi: 10.1016/j.ajpath.2012.07.026. Epub 2012 Sep 6.

PMID:
22959909
42.

TGF-β1 induces tissue factor expression in human lung fibroblasts in a PI3K/JNK/Akt-dependent and AP-1-dependent manner.

Wygrecka M, Zakrzewicz D, Taborski B, Didiasova M, Kwapiszewska G, Preissner KT, Markart P.

Am J Respir Cell Mol Biol. 2012 Nov;47(5):614-27. doi: 10.1165/rcmb.2012-0097OC. Epub 2012 Jul 5.

PMID:
22771387
43.

Src tyrosine kinase is crucial for potassium channel function in human pulmonary arteries.

Nagaraj C, Tang B, Bálint Z, Wygrecka M, Hrzenjak A, Kwapiszewska G, Stacher E, Lindenmann J, Weir EK, Olschewski H, Olschewski A.

Eur Respir J. 2013 Jan;41(1):85-95. doi: 10.1183/09031936.00211811. Epub 2012 Apr 20.

44.

PAR-2 inhibition reverses experimental pulmonary hypertension.

Kwapiszewska G, Markart P, Dahal BK, Kojonazarov B, Marsh LM, Schermuly RT, Taube C, Meinhardt A, Ghofrani HA, Steinhoff M, Seeger W, Preissner KT, Olschewski A, Weissmann N, Wygrecka M.

Circ Res. 2012 Apr 27;110(9):1179-91. doi: 10.1161/CIRCRESAHA.111.257568. Epub 2012 Mar 29.

PMID:
22461388
45.

Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury.

Grommes J, Alard JE, Drechsler M, Wantha S, Mörgelin M, Kuebler WM, Jacobs M, von Hundelshausen P, Markart P, Wygrecka M, Preissner KT, Hackeng TM, Koenen RR, Weber C, Soehnlein O.

Am J Respir Crit Care Med. 2012 Mar 15;185(6):628-36. doi: 10.1164/rccm.201108-1533OC. Epub 2012 Jan 12.

46.

Update in diffuse parenchymal lung disease 2010.

Markart P, Wygrecka M, Guenther A.

Am J Respir Crit Care Med. 2011 May 15;183(10):1316-21. doi: 10.1164/rccm.201102-0298UP. Review. No abstract available.

PMID:
21596834
47.

Shedding of low-density lipoprotein receptor–related protein-1 in acute respiratory distress syndrome.

Wygrecka M, Wilhelm J, Jablonska E, Zakrzewicz D, Preissner KT, Seeger W, Guenther A, Markart P.

Am J Respir Crit Care Med. 2011 Aug 15;184(4):438-48. doi: 10.1164/rccm.201009-1422OC.

PMID:
21471105
48.

Role of protease-activated receptor-2 in idiopathic pulmonary fibrosis.

Wygrecka M, Kwapiszewska G, Jablonska E, von Gerlach S, Henneke I, Zakrzewicz D, Guenther A, Preissner KT, Markart P.

Am J Respir Crit Care Med. 2011 Jun 15;183(12):1703-14. doi: 10.1164/rccm.201009-1479OC. Epub 2011 Mar 11.

PMID:
21471103
49.

Testosterone replacement effectively inhibits the development of experimental autoimmune orchitis in rats: evidence for a direct role of testosterone on regulatory T cell expansion.

Fijak M, Schneider E, Klug J, Bhushan S, Hackstein H, Schuler G, Wygrecka M, Gromoll J, Meinhardt A.

J Immunol. 2011 May 1;186(9):5162-72. doi: 10.4049/jimmunol.1001958. Epub 2011 Mar 25.

50.

Neurotrophic tyrosine kinase receptor B/neurotrophin 4 signaling axis is perturbed in clinical and experimental pulmonary fibrosis.

Avcuoglu S, Wygrecka M, Marsh LM, Günther A, Seeger W, Weissmann N, Fink L, Morty RE, Kwapiszewska G.

Am J Respir Cell Mol Biol. 2011 Oct;45(4):768-80. doi: 10.1165/rcmb.2010-0195OC. Epub 2011 Feb 17.

PMID:
21330466

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