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Items: 14


MEK inhibitors overcome resistance to BET inhibition across a number of solid and hematologic cancers.

Wyce A, Matteo JJ, Foley SW, Felitsky DJ, Rajapurkar SR, Zhang XP, Musso MC, Korenchuk S, Karpinich NO, Keenan KM, Stern M, Mathew LK, McHugh CF, McCabe MT, Tummino PJ, Kruger RG, Carpenter C, Barbash O.

Oncogenesis. 2018 Apr 20;7(4):35. doi: 10.1038/s41389-018-0043-9.


Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer.

Wyce A, Degenhardt Y, Bai Y, Le B, Korenchuk S, Crouthame MC, McHugh CF, Vessella R, Creasy CL, Tummino PJ, Barbash O.

Oncotarget. 2013 Dec;4(12):2419-29.


BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models.

Wyce A, Ganji G, Smitheman KN, Chung CW, Korenchuk S, Bai Y, Barbash O, Le B, Craggs PD, McCabe MT, Kennedy-Wilson KM, Sanchez LV, Gosmini RL, Parr N, McHugh CF, Dhanak D, Prinjha RK, Auger KR, Tummino PJ.

PLoS One. 2013 Aug 23;8(8):e72967. doi: 10.1371/journal.pone.0072967. eCollection 2013.


Research Resource: The androgen receptor modulates expression of genes with critical roles in muscle development and function.

Wyce A, Bai Y, Nagpal S, Thompson CC.

Mol Endocrinol. 2010 Aug;24(8):1665-74. doi: 10.1210/me.2010-0138. Epub 2010 Jul 7.


The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression.

Zhang XY, Varthi M, Sykes SM, Phillips C, Warzecha C, Zhu W, Wyce A, Thorne AW, Berger SL, McMahon SB.

Mol Cell. 2008 Jan 18;29(1):102-11. doi: 10.1016/j.molcel.2007.12.015.


H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex.

Wyce A, Xiao T, Whelan KA, Kosman C, Walter W, Eick D, Hughes TR, Krogan NJ, Strahl BD, Berger SL.

Mol Cell. 2007 Jul 20;27(2):275-88.


Structure and dimerization of the kinase domain from yeast Snf1, a member of the Snf1/AMPK protein family.

Nayak V, Zhao K, Wyce A, Schwartz MF, Lo WS, Berger SL, Marmorstein R.

Structure. 2006 Mar;14(3):477-85.


Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing.

Emre NC, Ingvarsdottir K, Wyce A, Wood A, Krogan NJ, Henry KW, Li K, Marmorstein R, Greenblatt JF, Shilatifard A, Berger SL.

Mol Cell. 2005 Feb 18;17(4):585-94.


H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex.

Ingvarsdottir K, Krogan NJ, Emre NC, Wyce A, Thompson NJ, Emili A, Hughes TR, Greenblatt JF, Berger SL.

Mol Cell Biol. 2005 Feb;25(3):1162-72.


H2B ubiquitylation and de-ubiquitylation in gene activation.

Wyce A, Henry KW, Berger SL.

Novartis Found Symp. 2004;259:63-73; discussion 73-7, 163-9. Review.


Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.

Henry KW, Wyce A, Lo WS, Duggan LJ, Emre NC, Kao CF, Pillus L, Shilatifard A, Osley MA, Berger SL.

Genes Dev. 2003 Nov 1;17(21):2648-63. Epub 2003 Oct 16.


A novel WD repeat protein component of the methylosome binds Sm proteins.

Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G.

J Biol Chem. 2002 Mar 8;277(10):8243-7. Epub 2001 Dec 26.


The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins.

Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G.

Mol Cell Biol. 2001 Dec;21(24):8289-300.


SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets.

Friesen WJ, Massenet S, Paushkin S, Wyce A, Dreyfuss G.

Mol Cell. 2001 May;7(5):1111-7.

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