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Items: 1 to 50 of 65

1.

Microglia morphology and proinflammatory signaling in the nucleus accumbens during nicotine withdrawal.

Adeluyi A, Guerin L, Fisher ML, Galloway A, Cole RD, Chan SSL, Wyatt MD, Davis SW, Freeman LR, Ortinski PI, Turner JR.

Sci Adv. 2019 Oct 9;5(10):eaax7031. doi: 10.1126/sciadv.aax7031. eCollection 2019 Oct.

2.

Clinical significance of a pvrl 4 encoded gene Nectin-4 in metastasis and angiogenesis for tumor relapse.

Sethy C, Goutam K, Nayak D, Pradhan R, Molla S, Chatterjee S, Rout N, Wyatt MD, Narayan S, Kundu CN.

J Cancer Res Clin Oncol. 2019 Oct 15. doi: 10.1007/s00432-019-03055-2. [Epub ahead of print]

PMID:
31617074
3.

The soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-β4.

Siddharth S, Nayak A, Das S, Nayak D, Panda J, Wyatt MD, Kundu CN.

Int J Biochem Cell Biol. 2018 Sep;102:151-160. doi: 10.1016/j.biocel.2018.07.011. Epub 2018 Jul 26.

PMID:
30056265
4.

Potential unintended consequences of getting rigorous with scientific rigor.

Wyatt MD, Pittman DL.

Carcinogenesis. 2018 Jan 12;39(1):26-27. doi: 10.1093/carcin/bgx101. No abstract available.

PMID:
29045573
5.

Thiopurine-induced mitotic catastrophe in Rad51d-deficient mammalian cells.

Wyatt MD, Reilly NM, Patel S, Rajesh P, Schools GP, Smiraldo PG, Pittman DL.

Environ Mol Mutagen. 2018 Jan;59(1):38-48. doi: 10.1002/em.22138. Epub 2017 Sep 25.

6.

Nectin-4 is a breast cancer stem cell marker that induces WNT/β-catenin signaling via Pi3k/Akt axis.

Siddharth S, Goutam K, Das S, Nayak A, Nayak D, Sethy C, Wyatt MD, Kundu CN.

Int J Biochem Cell Biol. 2017 Aug;89:85-94. doi: 10.1016/j.biocel.2017.06.007. Epub 2017 Jun 7.

PMID:
28600142
7.

Human Papillomavirus Type 16 L2 DNA Methylation in Exfoliated Cervical Cells From College-Age Women: Erratum.

Anderson EL, Banister CE, Kassler S, Messersmith A, Pirisi L, Creek KE, Wyatt MD.

J Low Genit Tract Dis. 2017 Apr;21(2):162. doi: 10.1097/LGT.0000000000000295. No abstract available.

PMID:
28548641
8.

Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen.

Oliver D, Ji H, Liu P, Gasparian A, Gardiner E, Lee S, Zenteno A, Perinskaya LO, Chen M, Buckhaults P, Broude E, Wyatt MD, Valafar H, Peña E, Shtutman M.

Sci Rep. 2017 Feb 22;7:43023. doi: 10.1038/srep43023.

9.

Ertapenem-Induced Encephalopathy in a Patient With Normal Renal Function.

Sutton SS, Jumper M, Cook S, Edun B, Wyatt MD.

J Investig Med High Impact Case Rep. 2017 Jan 1;5(1):2324709616689376. doi: 10.1177/2324709616689376. eCollection 2017 Jan-Mar.

10.

Human Papillomavirus Type 16 L2 DNA Methylation in Exfoliated Cervical Cells From College-Age Women.

Anderson EL, Banister CE, Kassler S, Messersmith A, Pirisi L, Creek KE, Wyatt MD.

J Low Genit Tract Dis. 2016 Oct;20(4):332-7. doi: 10.1097/LGT.0000000000000251. Erratum in: J Low Genit Tract Dis. 2017 Apr;21(2):162.

11.

Chk1 inhibitor synergizes quinacrine mediated apoptosis in breast cancer cells by compromising the base excision repair cascade.

Preet R, Siddharth S, Satapathy SR, Das S, Nayak A, Das D, Wyatt MD, Kundu CN.

Biochem Pharmacol. 2016 Apr 1;105:23-33. doi: 10.1016/j.bcp.2016.01.017. Epub 2016 Feb 2.

PMID:
26850987
12.

5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway.

Das D, Preet R, Mohapatra P, Satapathy SR, Siddharth S, Tamir T, Jain V, Bharatam PV, Wyatt MD, Kundu CN.

DNA Repair (Amst). 2014 Dec;24:15-25. doi: 10.1016/j.dnarep.2014.10.006.

13.

Regulatory and clinical considerations for biosimilar oncology drugs.

Bennett CL, Chen B, Hermanson T, Wyatt MD, Schulz RM, Georgantopoulos P, Kessler S, Raisch DW, Qureshi ZP, Lu ZK, Love BL, Noxon V, Bobolts L, Armitage M, Bian J, Ray P, Ablin RJ, Hrushesky WJ, Macdougall IC, Sartor O, Armitage JO.

Lancet Oncol. 2014 Dec;15(13):e594-e605. doi: 10.1016/S1470-2045(14)70365-1. Epub 2014 Nov 24. Review.

14.

Iterative conversion of cyclin binding groove peptides into druglike CDK inhibitors with antitumor activity.

Premnath PN, Craig SN, Liu S, Anderson EL, Grigoroudis AI, Kontopidis G, Perkins TL, Wyatt MD, Pittman DL, McInnes C.

J Med Chem. 2015 Jan 8;58(1):433-42. doi: 10.1021/jm5015023. Epub 2014 Dec 17.

15.

Current assessment of polo-like kinases as anti-tumor drug targets.

Craig SN, Wyatt MD, McInnes C.

Expert Opin Drug Discov. 2014 Jul;9(7):773-89. doi: 10.1517/17460441.2014.918100. Epub 2014 May 12. Review.

PMID:
24819909
16.

The contribution of heavy metals in cigarette smoke condensate to malignant transformation of breast epithelial cells and in vivo initiation of neoplasia through induction of a PI3K-AKT-NFκB cascade.

Mohapatra P, Preet R, Das D, Satapathy SR, Siddharth S, Choudhuri T, Wyatt MD, Kundu CN.

Toxicol Appl Pharmacol. 2014 Jan 1;274(1):168-79. doi: 10.1016/j.taap.2013.09.028. Epub 2013 Oct 5.

PMID:
24099783
17.

Advances in understanding the coupling of DNA base modifying enzymes to processes involving base excision repair.

Wyatt MD.

Adv Cancer Res. 2013;119:63-106. doi: 10.1016/B978-0-12-407190-2.00002-2. Review.

PMID:
23870509
18.

Silver-based nanoparticles induce apoptosis in human colon cancer cells mediated through p53.

Satapathy SR, Mohapatra P, Preet R, Das D, Sarkar B, Choudhuri T, Wyatt MD, Kundu CN.

Nanomedicine (Lond). 2013 Aug;8(8):1307-22. doi: 10.2217/nnm.12.176. Epub 2013 Mar 21.

PMID:
23514434
19.

SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress.

Nagaria P, Svilar D, Brown AR, Wang XH, Sobol RW, Wyatt MD.

Mutat Res. 2013 Mar-Apr;743-744:26-32. doi: 10.1016/j.mrfmmm.2012.12.001. Epub 2012 Dec 17.

20.

Quinacrine-mediated autophagy and apoptosis in colon cancer cells is through a p53- and p21-dependent mechanism.

Mohapatra P, Preet R, Das D, Satapathy SR, Choudhuri T, Wyatt MD, Kundu CN.

Oncol Res. 2012;20(2-3):81-91.

PMID:
23193914
21.

Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC.

Preet R, Mohapatra P, Das D, Satapathy SR, Choudhuri T, Wyatt MD, Kundu CN.

Carcinogenesis. 2013 Feb;34(2):277-86. doi: 10.1093/carcin/bgs351. Epub 2012 Nov 5.

PMID:
23129580
22.

Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype.

McInnes C, Estes K, Baxter M, Yang Z, Farag DB, Johnston P, Lazo JS, Wang J, Wyatt MD.

Mol Cancer Ther. 2012 Aug;11(8):1683-92. doi: 10.1158/1535-7163.MCT-12-0006-T. Epub 2012 Jul 30.

23.

Expression and regulation of RAD51 mediate cellular responses to chemotherapeutics.

Yang Z, Waldman AS, Wyatt MD.

Biochem Pharmacol. 2012 Mar 15;83(6):741-6. doi: 10.1016/j.bcp.2011.12.022. Epub 2011 Dec 24.

24.

Whole organism based techniques and approaches in early stage oncology drug discovery-patents and trends.

Hampson RJ, Wyatt MD.

Recent Pat Endocr Metab Immune Drug Discov. 2011 Sep;5(3):183-91. Review.

PMID:
21913888
25.

PLK1 as an oncology target: current status and future potential.

McInnes C, Wyatt MD.

Drug Discov Today. 2011 Jul;16(13-14):619-25. doi: 10.1016/j.drudis.2011.05.002. Epub 2011 May 13. Review.

PMID:
21601650
26.

Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity.

Preet R, Mohapatra P, Mohanty S, Sahu SK, Choudhuri T, Wyatt MD, Kundu CN.

Int J Cancer. 2012 Apr 1;130(7):1660-70. doi: 10.1002/ijc.26158. Epub 2011 Aug 16.

27.

The homologous recombination protein RAD51D mediates the processing of 6-thioguanine lesions downstream of mismatch repair.

Rajesh P, Litvinchuk AV, Pittman DL, Wyatt MD.

Mol Cancer Res. 2011 Feb;9(2):206-14. doi: 10.1158/1541-7786.MCR-10-0451. Epub 2011 Jan 4.

28.

Cation exchange on the surface of gold nanorods with a polymerizable surfactant: polymerization, stability, and toxicity evaluation.

Alkilany AM, Nagaria PK, Wyatt MD, Murphy CJ.

Langmuir. 2010 Jun 15;26(12):9328-33. doi: 10.1021/la100253k.

PMID:
20356032
29.

RAD51D protects against MLH1-dependent cytotoxic responses to O(6)-methylguanine.

Rajesh P, Rajesh C, Wyatt MD, Pittman DL.

DNA Repair (Amst). 2010 Apr 4;9(4):458-67. doi: 10.1016/j.dnarep.2010.01.009. Epub 2010 Feb 4.

30.

DNA damage in barn swallows (Hirundo rustica) from the Chernobyl region detected by use of the comet assay.

Bonisoli-Alquati A, Voris A, Mousseau TA, Møller AP, Saino N, Wyatt MD.

Comp Biochem Physiol C Toxicol Pharmacol. 2010 Apr;151(3):271-7. doi: 10.1016/j.cbpc.2009.11.006. Epub 2009 Nov 24.

PMID:
19941973
31.

Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase.

Jones LE Jr, Ying L, Hofseth AB, Jelezcova E, Sobol RW, Ambs S, Harris CC, Espey MG, Hofseth LJ, Wyatt MD.

Carcinogenesis. 2009 Dec;30(12):2123-9. doi: 10.1093/carcin/bgp256.

32.

Cellular uptake and cytotoxicity of gold nanorods: molecular origin of cytotoxicity and surface effects.

Alkilany AM, Nagaria PK, Hexel CR, Shaw TJ, Murphy CJ, Wyatt MD.

Small. 2009 Mar;5(6):701-8. doi: 10.1002/smll.200801546.

PMID:
19226599
33.

One-pot synthesis of silica-coated magnetic plasmonic tracer nanoparticles.

Gole A, Agarwal N, Nagaria P, Wyatt MD, Murphy CJ.

Chem Commun (Camb). 2008 Dec 14;(46):6140-2. doi: 10.1039/b814915a. Epub 2008 Oct 14.

PMID:
19082099
34.

Participation of DNA repair in the response to 5-fluorouracil.

Wyatt MD, Wilson DM 3rd.

Cell Mol Life Sci. 2009 Mar;66(5):788-99. doi: 10.1007/s00018-008-8557-5. Review.

35.

DNA damage and homologous recombination signaling induced by thymidylate deprivation.

Yang Z, Waldman AS, Wyatt MD.

Biochem Pharmacol. 2008 Oct 15;76(8):987-96. doi: 10.1016/j.bcp.2008.08.010. Epub 2008 Aug 19.

36.

Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase.

Waldman BC, Wang Y, Kilaru K, Yang Z, Bhasin A, Wyatt MD, Waldman AS.

DNA Repair (Amst). 2008 Oct 1;7(10):1624-35. doi: 10.1016/j.dnarep.2008.06.006. Epub 2008 Jul 21.

37.

Uracil in DNA: consequences for carcinogenesis and chemotherapy.

Berger SH, Pittman DL, Wyatt MD.

Biochem Pharmacol. 2008 Sep 15;76(6):697-706. doi: 10.1016/j.bcp.2008.05.019. Epub 2008 Jul 1. Review.

38.
39.

Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity.

Connor EE, Mwamuka J, Gole A, Murphy CJ, Wyatt MD.

Small. 2005 Mar;1(3):325-7. No abstract available.

PMID:
17193451
40.

Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks.

Wyatt MD, Pittman DL.

Chem Res Toxicol. 2006 Dec;19(12):1580-94. Review.

41.

Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice.

You S, Ohmori M, Peña MM, Nassri B, Quiton J, Al-Assad ZA, Liu L, Wood PA, Berger SH, Liu Z, Wyatt MD, Price RL, Berger FG, Hrushesky WJ.

Int J Exp Pathol. 2006 Jun;87(3):227-36.

42.

Effect of protein binding on ultrafast DNA dynamics: characterization of a DNA:APE1 complex.

Sen S, Paraggio NA, Gearheart LA, Connor EE, Issa A, Coleman RS, Wilson DM 3rd, Wyatt MD, Berg MA.

Biophys J. 2005 Dec;89(6):4129-38. Epub 2005 Sep 30.

43.
44.
45.

Oxanine DNA glycosylase activity from Mammalian alkyladenine glycosylase.

Hitchcock TM, Dong L, Connor EE, Meira LB, Samson LD, Wyatt MD, Cao W.

J Biol Chem. 2004 Sep 10;279(37):38177-83. Epub 2004 Jul 7.

46.

Involvement of base excision repair in response to therapy targeted at thymidylate synthase.

Li L, Berger SH, Wyatt MD.

Mol Cancer Ther. 2004 Jun;3(6):747-53.

47.
48.

Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG.

Lau AY, Wyatt MD, Glassner BJ, Samson LD, Ellenberger T.

Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13573-8.

49.
50.

3-methyladenine DNA glycosylases: structure, function, and biological importance.

Wyatt MD, Allan JM, Lau AY, Ellenberger TE, Samson LD.

Bioessays. 1999 Aug;21(8):668-76. Review.

PMID:
10440863

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