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Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins.

Xue D, Xu T, Wang H, Wu M, Yuan Y, Wang W, Tan Q, Zhao F, Zhou F, Hu T, Jiang Z, Liu ZJ, Zhao S, Liu D, Wüthrich K, Tao H.

Chemistry. 2019 Jul 31. doi: 10.1002/chem.201903190. [Epub ahead of print]


Financial incentives and physician prescription behavior: Evidence from dispensing regulations.

Burkhard D, Schmid CPR, Wüthrich K.

Health Econ. 2019 Jul 1. doi: 10.1002/hec.3893. [Epub ahead of print]


Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.

Chen S, Lu M, Liu D, Yang L, Yi C, Ma L, Zhang H, Liu Q, Frimurer TM, Wang MW, Schwartz TW, Stevens RC, Wu B, Wüthrich K, Zhao Q.

Nat Commun. 2019 Feb 7;10(1):638. doi: 10.1038/s41467-019-08568-5.


A2A adenosine receptor functional states characterized by 19F-NMR.

Sušac L, Eddy MT, Didenko T, Stevens RC, Wüthrich K.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12733-12738. doi: 10.1073/pnas.1813649115. Epub 2018 Nov 21.


GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures.

Shimada I, Ueda T, Kofuku Y, Eddy MT, Wüthrich K.

Nat Rev Drug Discov. 2019 Jan;18(1):59-82. doi: 10.1038/nrd.2018.180. Epub 2018 Nov 9. Review.


Molecular interactions connecting the function of the serine-arginine-rich protein SRSF1 to protein phosphatase 1.

Aubol BE, Serrano P, Fattet L, Wüthrich K, Adams JA.

J Biol Chem. 2018 Oct 26;293(43):16751-16760. doi: 10.1074/jbc.RA118.004587. Epub 2018 Sep 5.


Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor.

Eddy MT, Gao ZG, Mannes P, Patel N, Jacobson KA, Katritch V, Stevens RC, Wüthrich K.

J Am Chem Soc. 2018 Jul 5;140(26):8228-8235. doi: 10.1021/jacs.8b03805. Epub 2018 Jun 20.


Splicing Site Recognition by Synergy of Three Domains in Splicing Factor RBM10.

Serrano P, Hammond JA, Geralt M, Wüthrich K.

Biochemistry. 2018 Mar 13;57(10):1563-1567. doi: 10.1021/acs.biochem.7b01242. Epub 2018 Feb 16.


Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor.

Eddy MT, Lee MY, Gao ZG, White KL, Didenko T, Horst R, Audet M, Stanczak P, McClary KM, Han GW, Jacobson KA, Stevens RC, Wüthrich K.

Cell. 2018 Jan 11;172(1-2):68-80.e12. doi: 10.1016/j.cell.2017.12.004. Epub 2017 Dec 28.


Prion protein β2-α2 loop conformational landscape.

Caldarulo E, Barducci A, Wüthrich K, Parrinello M.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9617-9622. doi: 10.1073/pnas.1712155114. Epub 2017 Aug 21.


Solvent-accessibility of discrete residue positions in the polypeptide hormone glucagon by 19F-NMR observation of 4-fluorophenylalanine.

Hou Y, Hu W, Li X, Skinner JJ, Liu D, Wüthrich K.

J Biomol NMR. 2017 May;68(1):1-6. doi: 10.1007/s10858-017-0107-8. Epub 2017 May 15.


Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.

Leske H, Hornemann S, Herrmann US, Zhu C, Dametto P, Li B, Laferriere F, Polymenidou M, Pelczar P, Reimann RR, Schwarz P, Rushing EJ, Wüthrich K, Aguzzi A.

PLoS One. 2017 Feb 16;12(2):e0170503. doi: 10.1371/journal.pone.0170503. eCollection 2017.


β2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop.

Eddy MT, Didenko T, Stevens RC, Wüthrich K.

Structure. 2016 Dec 6;24(12):2190-2197. doi: 10.1016/j.str.2016.09.015. Epub 2016 Nov 10.


Dynamic Local Polymorphisms in the Gbx1 Homeodomain Induced by DNA Binding.

Proudfoot A, Geralt M, Elsliger MA, Wilson IA, Wüthrich K, Serrano P.

Structure. 2016 Aug 2;24(8):1372-1379. doi: 10.1016/j.str.2016.05.013. Epub 2016 Jul 7.


Ring current shifts in (19)F-NMR of membrane proteins.

Liu D, Wüthrich K.

J Biomol NMR. 2016 May;65(1):1-5. doi: 10.1007/s10858-016-0022-4. Epub 2016 May 30.


The formation, function and regulation of amyloids: insights from structural biology.

Landreh M, Sawaya MR, Hipp MS, Eisenberg DS, Wüthrich K, Hartl FU.

J Intern Med. 2016 Aug;280(2):164-76. doi: 10.1111/joim.12500. Epub 2016 May 30. Review.


NMR in structural genomics to increase structural coverage of the protein universe: Delivered by Prof. Kurt Wüthrich on 7 July 2013 at the 38th FEBS Congress in St. Petersburg, Russia.

Serrano P, Dutta SK, Proudfoot A, Mohanty B, Susac L, Martin B, Geralt M, Jaroszewski L, Godzik A, Elsliger M, Wilson IA, Wüthrich K.

FEBS J. 2016 Nov;283(21):3870-3881. doi: 10.1111/febs.13751. Epub 2016 Jun 9.


Directional Phosphorylation and Nuclear Transport of the Splicing Factor SRSF1 Is Regulated by an RNA Recognition Motif.

Serrano P, Aubol BE, Keshwani MM, Forli S, Ma CT, Dutta SK, Geralt M, Wüthrich K, Adams JA.

J Mol Biol. 2016 Jun 5;428(11):2430-2445. doi: 10.1016/j.jmb.2016.04.009. Epub 2016 Apr 15.


The acidic domain is a unique structural feature of the splicing factor SYNCRIP.

Beuck C, Williamson JR, Wüthrich K, Serrano P.

Protein Sci. 2016 Aug;25(8):1545-50. doi: 10.1002/pro.2935. Epub 2016 May 17.


UHM-ULM interactions in the RBM39-U2AF65 splicing-factor complex.

Stepanyuk GA, Serrano P, Peralta E, Farr CL, Axelrod HL, Geralt M, Das D, Chiu HJ, Jaroszewski L, Deacon AM, Lesley SA, Elsliger MA, Godzik A, Wilson IA, Wüthrich K, Salomon DR, Williamson JR.

Acta Crystallogr D Struct Biol. 2016 Apr;72(Pt 4):497-511. doi: 10.1107/S2059798316001248. Epub 2016 Mar 24.


Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome.

Proudfoot A, Axelrod HL, Geralt M, Fletterick RJ, Yumoto F, Deacon AM, Elsliger MA, Wilson IA, Wüthrich K, Serrano P.

J Mol Biol. 2016 Mar 27;428(6):1130-1141. doi: 10.1016/j.jmb.2016.01.023. Epub 2016 Jan 29.


NMR reveals structural rearrangements associated to substrate insertion in nucleotide-adding enzymes.

Mohanty B, Geralt M, Wüthrich K, Serrano P.

Protein Sci. 2016 Apr;25(4):917-25. doi: 10.1002/pro.2872. Epub 2016 Jan 20.


Nuclear Magnetic Resonance Structure of a Novel Globular Domain in RBM10 Containing OCRE, the Octamer Repeat Sequence Motif.

Martin BT, Serrano P, Geralt M, Wüthrich K.

Structure. 2016 Jan 5;24(1):158-164. doi: 10.1016/j.str.2015.10.029. Epub 2015 Dec 17.


Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR.

Lamichhane R, Liu JJ, Pljevaljcic G, White KL, van der Schans E, Katritch V, Stevens RC, Wüthrich K, Millar DP.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14254-9. doi: 10.1073/pnas.1519626112. Epub 2015 Nov 2.


In-Membrane Chemical Modification (IMCM) for Site-Specific Chromophore Labeling of GPCRs.

Sušac L, O'Connor C, Stevens RC, Wüthrich K.

Angew Chem Int Ed Engl. 2015 Dec 7;54(50):15246-9. doi: 10.1002/anie.201508506. Epub 2015 Nov 6.


NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor.

O'Connor C, White KL, Doncescu N, Didenko T, Roth BL, Czaplicki G, Stevens RC, Wüthrich K, Milon A.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11852-7. doi: 10.1073/pnas.1510117112. Epub 2015 Sep 8.


Non-Uniform Sampling and J-UNIO Automation for Efficient Protein NMR Structure Determination.

Didenko T, Proudfoot A, Dutta SK, Serrano P, Wüthrich K.

Chemistry. 2015 Aug 24;21(35):12363-9. doi: 10.1002/chem.201502544. Epub 2015 Jul 28.


Cofactor-induced reversible folding of Flavodoxin-4 from Lactobacillus acidophilus.

Dutta SK, Serrano P, Geralt M, Axelrod HL, Xu Q, Lesley SA, Godzik A, Deacon AM, Elsliger MA, Wilson IA, Wüthrich K.

Protein Sci. 2015 Oct;24(10):1600-8. doi: 10.1002/pro.2743. Epub 2015 Jul 30.


Q&A: Science regeneration.

Wüthrich K, Baker M.

Nature. 2015 Apr 30;520(7549):S13. doi: 10.1038/520S13a. No abstract available.


NMR structure determination of the protein NP_344798.1 as the first representative of Pfam PF06042.

Mohanty B, Serrano P, Geralt M, Wüthrich K.

J Biomol NMR. 2015 Jan;61(1):83-7. doi: 10.1007/s10858-014-9878-3. Epub 2014 Nov 28. No abstract available.


J-UNIO protocol used for NMR structure determination of the 206-residue protein NP_346487.1 from Streptococcus pneumoniae TIGR4.

Jaudzems K, Pedrini B, Geralt M, Serrano P, Wüthrich K.

J Biomol NMR. 2015 Jan;61(1):65-72. doi: 10.1007/s10858-014-9886-3. Epub 2014 Nov 27.


APSY-NMR for protein backbone assignment in high-throughput structural biology.

Dutta SK, Serrano P, Proudfoot A, Geralt M, Pedrini B, Herrmann T, Wüthrich K.

J Biomol NMR. 2015 Jan;61(1):47-53. doi: 10.1007/s10858-014-9881-8. Epub 2014 Nov 27.


Walter Jakob Gehring: A master of developmental biology.

Affolter M, Wüthrich K.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12574-5. doi: 10.1073/pnas.1413434111. Epub 2014 Aug 5. No abstract available.


NMR polypeptide backbone conformation of the E. coli outer membrane protein W.

Horst R, Stanczak P, Wüthrich K.

Structure. 2014 Aug 5;22(8):1204-1209. doi: 10.1016/j.str.2014.05.016. Epub 2014 Jul 10.


NMR structures of α-proteobacterial ATPase-regulating ζ-subunits.

Serrano P, Geralt M, Mohanty B, Wüthrich K.

J Mol Biol. 2014 Jul 15;426(14):2547-53. doi: 10.1016/j.jmb.2014.05.004. Epub 2014 May 13.


Solution-NMR characterization of outer-membrane protein A from E. coli in lipid bilayer nanodiscs and detergent micelles.

Sušac L, Horst R, Wüthrich K.

Chembiochem. 2014 May 5;15(7):995-1000. doi: 10.1002/cbic.201300729. Epub 2014 Apr 1.


Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC.

Kurt TD, Bett C, Fernández-Borges N, Joshi-Barr S, Hornemann S, Rülicke T, Castilla J, Wüthrich K, Aguzzi A, Sigurdson CJ.

J Neurosci. 2014 Jan 15;34(3):1022-7. doi: 10.1523/JNEUROSCI.4636-13.2014.


Pheromone discrimination by a pH-tuned polymorphism of the Bombyx mori pheromone-binding protein.

Damberger FF, Michel E, Ishida Y, Leal WS, Wüthrich K.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18680-5. doi: 10.1073/pnas.1317706110. Epub 2013 Oct 24.


β₂-adrenergic receptor activation by agonists studied with ¹⁹F NMR spectroscopy.

Horst R, Liu JJ, Stevens RC, Wüthrich K.

Angew Chem Int Ed Engl. 2013 Oct 4;52(41):10762-5. doi: 10.1002/anie.201305286. Epub 2013 Aug 16. No abstract available.


Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs.

Didenko T, Liu JJ, Horst R, Stevens RC, Wüthrich K.

Curr Opin Struct Biol. 2013 Oct;23(5):740-747. doi: 10.1016/ Epub 2013 Aug 7. Review.


NMR-profiles of protein solutions.

Pedrini B, Serrano P, Mohanty B, Geralt M, Wüthrich K.

Biopolymers. 2013 Nov;99(11):825-31. doi: 10.1002/bip.22348.


Structural plasticity of the cellular prion protein and implications in health and disease.

Christen B, Damberger FF, Pérez DR, Hornemann S, Wüthrich K.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8549-54. doi: 10.1073/pnas.1306178110. Epub 2013 May 6.


Amino acid-selective segmental isotope labeling of multidomain proteins for structural biology.

Michel E, Skrisovska L, Wüthrich K, Allain FH.

Chembiochem. 2013 Mar 4;14(4):457-66. doi: 10.1002/cbic.201200732. Epub 2013 Jan 30.


Thermodynamic stability of psychrophilic and mesophilic pheromones of the protozoan ciliate euplotes.

Geralt M, Alimenti C, Vallesi A, Luporini P, Wüthrich K.

Biology (Basel). 2013 Jan 14;2(1):142-50. doi: 10.3390/biology2010142.


The GPCR Network: a large-scale collaboration to determine human GPCR structure and function.

Stevens RC, Cherezov V, Katritch V, Abagyan R, Kuhn P, Rosen H, Wüthrich K.

Nat Rev Drug Discov. 2013 Jan;12(1):25-34. doi: 10.1038/nrd3859. Epub 2012 Dec 14. Review.


Coding genes and molecular structures of the diffusible signalling proteins (pheromones) of the polar ciliate, Euplotes nobilii.

Vallesi A, Alimenti C, Pedrini B, Di Giuseppe G, Dini F, Wüthrich K, Luporini P.

Mar Genomics. 2012 Dec;8:9-13. doi: 10.1016/j.margen.2012.03.004. Epub 2012 May 1.


β2-Adrenergic receptor solutions for structural biology analyzed with microscale NMR diffusion measurements.

Horst R, Stanczak P, Stevens RC, Wüthrich K.

Angew Chem Int Ed Engl. 2013 Jan 2;52(1):331-5. doi: 10.1002/anie.201205474. Epub 2012 Oct 24.


In support of the BMRB.

Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, Cross TA, Dames S, Kessler H, Lange O, Madl T, Reif B, Sattler M, Eliezer D, Fersht A, Forman-Kay J, Kay LE, Fraser J, Gross J, Kortemme T, Sali A, Fujiwara T, Gardner K, Luo X, Rizo-Rey J, Rosen M, Gil RR, Ho C, Rule G, Gronenborn AM, Ishima R, Klein-Seetharaman J, Tang P, van der Wel P, Xu Y, Grzesiek S, Hiller S, Seelig J, Laue ED, Mott H, Nietlispach D, Barsukov I, Lian LY, Middleton D, Blumenschein T, Moore G, Campbell I, Schnell J, Vakonakis IJ, Watts A, Conte MR, Mason J, Pfuhl M, Sanderson MR, Craven J, Williamson M, Dominguez C, Roberts G, Günther U, Overduin M, Werner J, Williamson P, Blindauer C, Crump M, Driscoll P, Frenkiel T, Golovanov A, Matthews S, Parkinson J, Uhrin D, Williams M, Neuhaus D, Oschkinat H, Ramos A, Shaw DE, Steinbeck C, Vendruscolo M, Vuister GW, Walters KJ, Weinstein H, Wüthrich K, Yokoyama S.

Nat Struct Mol Biol. 2012 Sep;19(9):854-60. doi: 10.1038/nsmb.2371. No abstract available.


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