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Items: 23


Inflammatory Bowel Disease Susceptibility Gene C1ORF106 Regulates Intestinal Epithelial Permeability.

Manzanillo P, Mouchess M, Ota N, Dai B, Ichikawa R, Wuster A, Haley B, Alvarado G, Kwon Y, Caothien R, Roose-Girma M, Warming S, McKenzie BS, Keir ME, Scherl A, Ouyang W, Yi T.

Immunohorizons. 2018 May 30;2(5):164-171. doi: 10.4049/immunohorizons.1800027.


Influence of genetic copy number variants of the human GLUT3 glucose transporter gene SLC2A3 on protein expression, glycolysis and rheumatoid arthritis risk: A genetic replication study.

Simpfendorfer KR, Li W, Shih A, Wen H, Kothari HP, Einsidler EA, Wuster A, Hunkapiller J, Behrens TW, Graham RR, Townsend MJ, Behar DM, Hu R, Greenspan E, Gregersen PK.

Mol Genet Metab Rep. 2019 Apr 6;19:100470. doi: 10.1016/j.ymgmr.2019.100470. eCollection 2019 Jun.


LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation.

Skon-Hegg C, Zhang J, Wu X, Sagolla M, Ota N, Wuster A, Tom J, Doran E, Ramamoorthi N, Caplazi P, Monroe J, Lee WP, Behrens TW.

J Immunol. 2019 Jan 1;202(1):183-193. doi: 10.4049/jimmunol.1800636. Epub 2018 Dec 3.


Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration.

Lim YW, Chen-Harris H, Mayba O, Lianoglou S, Wuster A, Bhangale T, Khan Z, Mariathasan S, Daemen A, Reeder J, Haverty PM, Forrest WF, Brauer M, Mellman I, Albert ML.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11701-E11710. doi: 10.1073/pnas.1804506115. Epub 2018 Nov 21.


Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease.

Rathore N, Ramani SR, Pantua H, Payandeh J, Bhangale T, Wuster A, Kapoor M, Sun Y, Kapadia SB, Gonzalez L, Zarrin AA, Goate A, Hansen DV, Behrens TW, Graham RR.

PLoS Genet. 2018 Nov 2;14(11):e1007427. doi: 10.1371/journal.pgen.1007427. eCollection 2018 Nov.


Enabling genome-wide association testing with multiple diseases and no healthy controls.

Tom J, Chang D, Wuster A, Mukhyala K, Cuenco K, Cowgill A, Vogel J, Reeder J, Yaspan B, Hunkapiller J, Brauer M, Behrens T, Forrest W, Bhangale T.

Gene. 2019 Feb 5;684:118-123. doi: 10.1016/j.gene.2018.10.047. Epub 2018 Oct 23.


Cells alter their tRNA abundance to selectively regulate protein synthesis during stress conditions.

Torrent M, Chalancon G, de Groot NS, Wuster A, Madan Babu M.

Sci Signal. 2018 Sep 4;11(546). pii: eaat6409. doi: 10.1126/scisignal.aat6409.


Previously reported placebo-response-associated variants do not predict patient outcomes in inflammatory disease Phase III trial placebo arms.

Haug-Baltzell A, Bhangale TR, Chang D, Dressen A, Yaspan BL, Ortmann W, Brauer MJ, Hunkapiller J, Reeder J, Mukhyala K, Cuenco KT, Tom JA, Cowgill A, Vogel J, Forrest WF, Behrens TW, Graham RR, Wuster A.

Genes Immun. 2019 Feb;20(2):172-179. doi: 10.1038/s41435-018-0018-z. Epub 2018 Mar 18.


Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes.

Narasimhan VM, Rahbari R, Scally A, Wuster A, Mason D, Xue Y, Wright J, Trembath RC, Maher ER, van Heel DA, Auton A, Hurles ME, Tyler-Smith C, Durbin R.

Nat Commun. 2017 Aug 21;8(1):303. doi: 10.1038/s41467-017-00323-y.


The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.

Sitrin J, Suto E, Wuster A, Eastham-Anderson J, Kim JM, Austin CD, Lee WP, Behrens TW.

J Immunol. 2017 Aug 15;199(4):1238-1249. doi: 10.4049/jimmunol.1700608. Epub 2017 Jul 10.


An Organismal CNV Mutator Phenotype Restricted to Early Human Development.

Liu P, Yuan B, Carvalho CMB, Wuster A, Walter K, Zhang L, Gambin T, Chong Z, Campbell IM, Coban Akdemir Z, Gelowani V, Writzl K, Bacino CA, Lindsay SJ, Withers M, Gonzaga-Jauregui C, Wiszniewska J, Scull J, Stankiewicz P, Jhangiani SN, Muzny DM, Zhang F, Chen K, Gibbs RA, Rautenstrauss B, Cheung SW, Smith J, Breman A, Shaw CA, Patel A, Hurles ME, Lupski JR.

Cell. 2017 Feb 23;168(5):830-842.e7. doi: 10.1016/j.cell.2017.01.037.


geneAttribution: trait agnostic identification of candidate genes associated with noncoding variation.

Wuster A, Chang D, Behrens TW, Bhangale TR.

Bioinformatics. 2017 Feb 15;33(4):599-600. doi: 10.1093/bioinformatics/btw698.


Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.

Rouhani FJ, Nik-Zainal S, Wuster A, Li Y, Conte N, Koike-Yusa H, Kumasaka N, Vallier L, Yusa K, Bradley A.

PLoS Genet. 2016 Apr 7;12(4):e1005932. doi: 10.1371/journal.pgen.1005932. eCollection 2016 Apr.


Thinking differently about lupus.

Wuster A, Behrens TW.

Elife. 2016 Mar 29;5. pii: e15352. doi: 10.7554/eLife.15352.


Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease.

Yang CW, Hojer CD, Zhou M, Wu X, Wuster A, Lee WP, Yaspan BL, Chan AC.

Cell. 2016 Jan 14;164(1-2):141-155. doi: 10.1016/j.cell.2015.11.052. Epub 2016 Jan 7.


Timing, rates and spectra of human germline mutation.

Rahbari R, Wuster A, Lindsay SJ, Hardwick RJ, Alexandrov LB, Turki SA, Dominiczak A, Morris A, Porteous D, Smith B, Stratton MR; UK10K Consortium, Hurles ME.

Nat Genet. 2016 Feb;48(2):126-133. doi: 10.1038/ng.3469. Epub 2015 Dec 14.


DeNovoGear: de novo indel and point mutation discovery and phasing.

Ramu A, Noordam MJ, Schwartz RS, Wuster A, Hurles ME, Cartwright RA, Conrad DF.

Nat Methods. 2013 Oct;10(10):985-7. doi: 10.1038/nmeth.2611. Epub 2013 Aug 25.


Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action.

Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, W├╝ster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ.

Mol Syst Biol. 2010 Dec 21;6:451. doi: 10.1038/msb.2010.107.


Spial: analysis of subtype-specific features in multiple sequence alignments of proteins.

Wuster A, Venkatakrishnan AJ, Schertler GF, Babu MM.

Bioinformatics. 2010 Nov 15;26(22):2906-7. doi: 10.1093/bioinformatics/btq552. Epub 2010 Sep 29.


Transcriptional control of the quorum sensing response in yeast.

Wuster A, Babu MM.

Mol Biosyst. 2010 Jan;6(1):134-41. doi: 10.1039/b913579k. Epub 2009 Sep 1.


Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture.

Jothi R, Balaji S, Wuster A, Grochow JA, Gsponer J, Przytycka TM, Aravind L, Babu MM.

Mol Syst Biol. 2009;5:294. doi: 10.1038/msb.2009.52. Epub 2009 Aug 18.


Chemogenomics and biotechnology.

Wuster A, Madan Babu M.

Trends Biotechnol. 2008 May;26(5):252-8. doi: 10.1016/j.tibtech.2008.01.004. Epub 2008 Mar 17. Review.


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