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Plasma sRAGE Acts as Genetically Regulated Causal Intermediate in Sepsis-Associated ARDS.

Jones TK, Feng R, Kerchberger VE, Reilly JP, Anderson BJ, Shashaty MGS, Wang F, Dunn TG, Riley TR, Abbott J, Ittner CAG, Christiani DC, Mikacenic C, Wurfel MM, Ware LB, Calfee CS, Matthay MA, Christie JD, Meyer NJ.

Am J Respir Crit Care Med. 2019 Sep 5. doi: 10.1164/rccm.201810-2033OC. [Epub ahead of print]


Interleukin-6 improves infection identification when added to physician judgment during evaluation of potentially septic patients.

Henning DJ, Hall MK, Watsjold BK, Bhatraju PK, Kosamo S, Shapiro NI, Liles WC, Wurfel MM.

Am J Emerg Med. 2019 Jul 25:158361. doi: 10.1016/j.ajem.2019.158361. [Epub ahead of print]


Physician Judgment and Circulating Biomarkers Predict 28-Day Mortality in Emergency Department Patients.

Henning DJ, Bhatraju PK, Johnson NJ, Kosamo S, Shapiro NI, Zelnick LR, Liles WC, Wurfel MM.

Crit Care Med. 2019 Nov;47(11):1513-1521. doi: 10.1097/CCM.0000000000003899.


Reply to: Transcriptomic Analysis of Alveolar Immune Cells in Acute Respiratory Distress Syndrome: To Lump or to Split?

Morrell ED, Bhatraju PK, Mikacenic C, Radella Ii F, Manicone AM, Stapleton RD, Wurfel MW, Gharib SA.

Am J Respir Crit Care Med. 2019 Jul 17. doi: 10.1164/rccm.201907-1309LE. [Epub ahead of print] No abstract available.


Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to Burkholderia pseudomallei.

Dickey AK, Chantratita N, Tandhavanant S, Ducken D, Lovelace-Macon L, Seal S, Robertson J, Myers ND, Schwarz S, Wurfel MM, Kosamo S, West TE.

PLoS Negl Trop Dis. 2019 May 8;13(5):e0007354. doi: 10.1371/journal.pntd.0007354. eCollection 2019 May.


Alveolar Macrophage Transcriptional Programs Are Associated with Outcomes in Acute Respiratory Distress Syndrome.

Morrell ED, Bhatraju PK, Mikacenic CR, Radella F 2nd, Manicone AM, Stapleton RD, Wurfel MM, Gharib SA.

Am J Respir Crit Care Med. 2019 Sep 15;200(6):732-741. doi: 10.1164/rccm.201807-1381OC.


A Prediction Model for Severe AKI in Critically Ill Adults That Incorporates Clinical and Biomarker Data.

Bhatraju PK, Zelnick LR, Katz R, Mikacenic C, Kosamo S, Hahn WO, Dmyterko V, Kestenbaum B, Christiani DC, Liles WC, Himmelfarb J, Wurfel MM.

Clin J Am Soc Nephrol. 2019 Apr 5;14(4):506-514. doi: 10.2215/CJN.04100318. Epub 2019 Mar 27.


Systemic Angiopoietin-1/2 Dysregulation in Pediatric Sepsis and Septic Shock.

Melendez E, Whitney JE, Norton JS, Silverman M, Harju-Baker S, Mikacenic C, Wurfel MM, Liles WC.

Int J Med Sci. 2019 Jan 1;16(2):318-323. doi: 10.7150/ijms.27731. eCollection 2019.


Bronchoalveolar fluid and plasma inflammatory biomarkers in contemporary ARDS patients.

Stapleton RD, Suratt BT, Neff MJ, Wurfel MM, Ware LB, Ruzinski JT, Caldwell E, Hallstrand TS, Parsons PE.

Biomarkers. 2019 Jun;24(4):352-359. doi: 10.1080/1354750X.2019.1581840. Epub 2019 Mar 4.


High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report.

Hersh CP, Adcock IM, Celedón JC, Cho MH, Christiani DC, Himes BE, Kaminski N, Mathias RA, Meyers DA, Quackenbush J, Redline S, Steiling KA, Tabor HK, Tobin MD, Wurfel MM, Yang IV, Koppelman GH.

Ann Am Thorac Soc. 2019 Jan;16(1):1-16. doi: 10.1513/AnnalsATS.201810-716WS.


Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis.

Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ.

Intensive Care Med. 2018 Nov;44(11):1849-1858. doi: 10.1007/s00134-018-5328-0. Epub 2018 Oct 21.


Identification of Acute Kidney Injury Subphenotypes with Differing Molecular Signatures and Responses to Vasopressin Therapy.

Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, Christiani DC, Liles WC, Himmelfarb J, Wurfel MM.

Am J Respir Crit Care Med. 2019 Apr 1;199(7):863-872. doi: 10.1164/rccm.201807-1346OC.


Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome.

Madenspacher JH, Stapleton RD, Suratt BT, Dixon AE, Lih FB, Lowe JM, Mould KJ, Janssen WJ, Morrell ED, Wurfel MM, Garantziotis S, Tomer KB, Fessler MB.

J Allergy Clin Immunol. 2019 Jan;143(1):440-442.e8. doi: 10.1016/j.jaci.2018.09.017. Epub 2018 Oct 5. No abstract available.


Cytometry TOF identifies alveolar macrophage subtypes in acute respiratory distress syndrome.

Morrell ED, Wiedeman A, Long SA, Gharib SA, West TE, Skerrett SJ, Wurfel MM, Mikacenic C.

JCI Insight. 2018 May 17;3(10). pii: 99281. doi: 10.1172/jci.insight.99281. eCollection 2018 May 17.


Alveolar levels of immuno-inflammatory mediators in diffuse alveolar hemorrhage after allogeneic transplant.

Vande Vusse LK, Wurfel MM, Madtes DM, Schoch HG, Harju-Baker S, Hill JA, Jerome KR, Boeckh M, Watkins TR.

Bone Marrow Transplant. 2018 Sep;53(9):1206-1209. doi: 10.1038/s41409-018-0168-7. Epub 2018 Apr 18. No abstract available.


Genome-Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor.

Bime C, Pouladi N, Sammani S, Batai K, Casanova N, Zhou T, Kempf CL, Sun X, Camp SM, Wang T, Kittles RA, Lussier YA, Jones TK, Reilly JP, Meyer NJ, Christie JD, Karnes JH, Gonzalez-Garay M, Christiani DC, Yates CR, Wurfel MM, Meduri GU, Garcia JGN.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1421-1432. doi: 10.1164/rccm.201705-0961OC.


Hyaluronic acid is associated with organ dysfunction in acute respiratory distress syndrome.

Esposito AJ, Bhatraju PK, Stapleton RD, Wurfel MM, Mikacenic C.

Crit Care. 2017 Dec 14;21(1):304. doi: 10.1186/s13054-017-1895-7.


Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells.

Gust J, Hay KA, Hanafi LA, Li D, Myerson D, Gonzalez-Cuyar LF, Yeung C, Liles WC, Wurfel M, Lopez JA, Chen J, Chung D, Harju-Baker S, Özpolat T, Fink KR, Riddell SR, Maloney DG, Turtle CJ.

Cancer Discov. 2017 Dec;7(12):1404-1419. doi: 10.1158/2159-8290.CD-17-0698. Epub 2017 Oct 12.


[Plastic surgery and informed consent - need to know].

Bichler C, Würfel M.

Handchir Mikrochir Plast Chir. 2017 Sep;49(4):247-250. doi: 10.1055/s-0043-116217. Epub 2017 Sep 28. German.


Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor-modified T-cell therapy.

Hay KA, Hanafi LA, Li D, Gust J, Liles WC, Wurfel MM, López JA, Chen J, Chung D, Harju-Baker S, Cherian S, Chen X, Riddell SR, Maloney DG, Turtle CJ.

Blood. 2017 Nov 23;130(21):2295-2306. doi: 10.1182/blood-2017-06-793141. Epub 2017 Sep 18.


Genetic Variation in MAP3K1 Associates with Ventilator-Free Days in Acute Respiratory Distress Syndrome.

Morrell ED, O'Mahony DS, Glavan BJ, Harju-Baker S, Nguyen C, Gunderson S, Abrahamson A, Radella F 2nd, Rona G, Black RA, Wurfel MM.

Am J Respir Cell Mol Biol. 2018 Jan;58(1):117-125. doi: 10.1165/rcmb.2017-0030OC.


Circulating levels of soluble Fas (sCD95) are associated with risk for development of a nonresolving acute kidney injury subphenotype.

Bhatraju PK, Robinson-Cohen C, Mikacenic C, Harju-Baker S, Dmyterko V, Slivinski NSJ, Liles WC, Himmelfarb J, Heckbert SR, Wurfel MM.

Crit Care. 2017 Aug 17;21(1):217. doi: 10.1186/s13054-017-1807-x.


Th17 cells are associated with protection from ventilator associated pneumonia.

Orlov M, Dmyterko V, Wurfel MM, Mikacenic C.

PLoS One. 2017 Aug 14;12(8):e0182966. doi: 10.1371/journal.pone.0182966. eCollection 2017.


Peripheral and Alveolar Cell Transcriptional Programs Are Distinct in Acute Respiratory Distress Syndrome.

Morrell ED, Radella F 2nd, Manicone AM, Mikacenic C, Stapleton RD, Gharib SA, Wurfel MM.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):528-532. doi: 10.1164/rccm.201703-0614LE. No abstract available.


A Two-Biomarker Model Predicts Mortality in the Critically Ill with Sepsis.

Mikacenic C, Price BL, Harju-Baker S, O'Mahony DS, Robinson-Cohen C, Radella F, Hahn WO, Katz R, Christiani DC, Himmelfarb J, Liles WC, Wurfel MM.

Am J Respir Crit Care Med. 2017 Oct 15;196(8):1004-1011. doi: 10.1164/rccm.201611-2307OC.


Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death.

Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM.

Crit Care. 2016 Nov 17;20(1):372.


Archaic Hominin Admixture Facilitated Adaptation to Out-of-Africa Environments.

Gittelman RM, Schraiber JG, Vernot B, Mikacenic C, Wurfel MM, Akey JM.

Curr Biol. 2016 Dec 19;26(24):3375-3382. doi: 10.1016/j.cub.2016.10.041. Epub 2016 Nov 10.


Melanocortin-1 Receptor Polymorphisms and the Risk of Complicated Sepsis After Trauma: A Candidate Gene Association Study.

Seaton ME, Parent BA, Sood RF, Wurfel MM, Muffley LA, O'Keefe GE, Gibran NS.

Shock. 2017 Jan;47(1):79-85.


Association of markers of endothelial dysregulation Ang1 and Ang2 with acute kidney injury in critically ill patients.

Robinson-Cohen C, Katz R, Price BL, Harju-Baker S, Mikacenic C, Himmelfarb J, Liles WC, Wurfel MM.

Crit Care. 2016 Jul 3;20(1):207. doi: 10.1186/s13054-016-1385-3.


COPD disease severity and innate immune response to pathogen-associated molecular patterns.

Fan VS, Gharib SA, Martin TR, Wurfel MM.

Int J Chron Obstruct Pulmon Dis. 2016 Mar 4;11:467-77. doi: 10.2147/COPD.S94410. eCollection 2016.


Host derived biomarkers of inflammation, apoptosis, and endothelial activation are associated with clinical outcomes in patients with bacteremia and sepsis regardless of microbial etiology.

Hahn WO, Mikacenic C, Price BL, Harju-Baker S, Katz R, Himmelfarb J, Wurfel MM, Liles WC.

Virulence. 2016 May 18;7(4):387-94. doi: 10.1080/21505594.2016.1144003. Epub 2016 Jan 28. No abstract available.


A common TLR1 polymorphism is associated with higher parasitaemia in a Southeast Asian population with Plasmodium falciparum malaria.

Hahn WO, Harju-Baker S, Erdman LK, Krudsood S, Kain KC, Wurfel MM, Liles WC.

Malar J. 2016 Jan 6;15:12. doi: 10.1186/s12936-015-1071-y.


Interleukin-17A Is Associated With Alveolar Inflammation and Poor Outcomes in Acute Respiratory Distress Syndrome.

Mikacenic C, Hansen EE, Radella F, Gharib SA, Stapleton RD, Wurfel MM.

Crit Care Med. 2016 Mar;44(3):496-502. doi: 10.1097/CCM.0000000000001409.


Biomarkers of Endothelial Activation Are Associated with Poor Outcome in Critical Illness.

Mikacenic C, Hahn WO, Price BL, Harju-Baker S, Katz R, Kain KC, Himmelfarb J, Liles WC, Wurfel MM.

PLoS One. 2015 Oct 22;10(10):e0141251. doi: 10.1371/journal.pone.0141251. eCollection 2015.


Associations between single nucleotide polymorphisms in the FAS pathway and acute kidney injury.

Bhatraju P, Hsu C, Mukherjee P, Glavan BJ, Burt A, Mikacenic C, Himmelfarb J, Wurfel M.

Crit Care. 2015 Oct 19;19:368. doi: 10.1186/s13054-015-1084-5.


TNFAIP2 Inhibits Early TNFα-Induced NF-x03BA;B Signaling and Decreases Survival in Septic Shock Patients.

Thair SA, Topchiy E, Boyd JH, Cirstea M, Wang C, Nakada TA, Fjell CD, Wurfel M, Russell JA, Walley KR.

J Innate Immun. 2016;8(1):57-66. doi: 10.1159/000437330. Epub 2015 Sep 9.


Cutting edge: Genetic variation in TLR1 is associated with Pam3CSK4-induced effector T cell resistance to regulatory T cell suppression.

Mikacenic C, Schneider A, Radella F, Buckner JH, Wurfel MM.

J Immunol. 2014 Dec 15;193(12):5786-90. doi: 10.4049/jimmunol.1401185. Epub 2014 Nov 5.


Platelet count mediates the contribution of a genetic variant in LRRC16A to ARDS risk.

Wei Y, Wang Z, Su L, Chen F, Tejera P, Bajwa EK, Wurfel MM, Lin X, Christiani DC.

Chest. 2015 Mar;147(3):607-617. doi: 10.1378/chest.14-1246.


IL1RN single-nucleotide polymorphisms in septic shock: can genetics clear the fog of the cytokine storm?

Wurfel MM, Mikacenic C.

Am J Respir Crit Care Med. 2014 Sep 15;190(6):599-600. doi: 10.1164/rccm.201408-1506ED. No abstract available.


APOε4 is associated with enhanced in vivo innate immune responses in human subjects.

Gale SC, Gao L, Mikacenic C, Coyle SM, Rafaels N, Murray Dudenkov T, Madenspacher JH, Draper DW, Ge W, Aloor JJ, Azzam KM, Lai L, Blackshear PJ, Calvano SE, Barnes KC, Lowry SF, Corbett S, Wurfel MM, Fessler MB.

J Allergy Clin Immunol. 2014 Jul;134(1):127-34. doi: 10.1016/j.jaci.2014.01.032. Epub 2014 Mar 18.


Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome.

Tejera P, O'Mahony DS, Owen CA, Wei Y, Wang Z, Gupta K, Su L, Villar J, Wurfel M, Christiani DC.

Am J Respir Cell Mol Biol. 2014 Aug;51(2):262-72. doi: 10.1165/rcmb.2013-0238OC.


On-time clinical phenotype prediction based on narrative reports.

Bejan CA, Vanderwende L, Evans HL, Wurfel MM, Yetisgen-Yildiz M.

AMIA Annu Symp Proc. 2013 Nov 16;2013:103-10. eCollection 2013.


A variational Bayes discrete mixture test for rare variant association.

Logsdon BA, Dai JY, Auer PL, Johnsen JM, Ganesh SK, Smith NL, Wilson JG, Tracy RP, Lange LA, Jiao S, Rich SS, Lettre G, Carlson CS, Jackson RD, O'Donnell CJ, Wurfel MM, Nickerson DA, Tang H, Reiner AP, Kooperberg C; NHLBI GO Exome Sequencing Project.

Genet Epidemiol. 2014 Jan;38(1):21-30.


Automated tools for phenotype extraction from medical records.

Yetisgen-Yildiz M, Bejan CA, Vanderwende L, Xia F, Evans HL, Wurfel MM.

AMIA Jt Summits Transl Sci Proc. 2013 Mar 18;2013:283. eCollection 2013.


Survey of innate immune responses to Burkholderia pseudomallei in human blood identifies a central role for lipopolysaccharide.

Chantratita N, Tandhavanant S, Myers ND, Seal S, Arayawichanont A, Kliangsa-Ad A, Hittle LE, Ernst RK, Emond MJ, Wurfel MM, Day NP, Peacock SJ, West TE.

PLoS One. 2013 Nov 26;8(11):e81617. doi: 10.1371/journal.pone.0081617. eCollection 2013.


Genetic variants associated with susceptibility to Helicobacter pylori.

Wurfel MM, Hawn TR.

JAMA. 2013 Sep 4;310(9):976. doi: 10.1001/jama.2013.194762. No abstract available.


Toll-like receptor 1 polymorphisms and associated outcomes in sepsis after traumatic injury: a candidate gene association study.

Thompson CM, Holden TD, Rona G, Laxmanan B, Black RA, OʼKeefe GE, Wurfel MM.

Ann Surg. 2014 Jan;259(1):179-85. doi: 10.1097/SLA.0b013e31828538e8.


IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist.

Meyer NJ, Feng R, Li M, Zhao Y, Sheu CC, Tejera P, Gallop R, Bellamy S, Rushefski M, Lanken PN, Aplenc R, O'Keefe GE, Wurfel MM, Christiani DC, Christie JD.

Am J Respir Crit Care Med. 2013 May 1;187(9):950-9. doi: 10.1164/rccm.201208-1501OC.


Impaired TLR5 functionality is associated with survival in melioidosis.

West TE, Chantratita N, Chierakul W, Limmathurotsakul D, Wuthiekanun V, Myers ND, Emond MJ, Wurfel MM, Hawn TR, Peacock SJ, Skerrett SJ.

J Immunol. 2013 Apr 1;190(7):3373-9. doi: 10.4049/jimmunol.1202974. Epub 2013 Feb 27.


Assessing pneumonia identification from time-ordered narrative reports.

Bejan CA, Vanderwende L, Wurfel MM, Yetisgen-Yildiz M.

AMIA Annu Symp Proc. 2012;2012:1119-28. Epub 2012 Nov 3.

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