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Items: 1 to 50 of 105

1.

Tumor-Educated Platelets as a Noninvasive Biomarker Source for Cancer Detection and Progression Monitoring.

Best MG, Wesseling P, Wurdinger T.

Cancer Res. 2018 Jul 1;78(13):3407-3412. doi: 10.1158/0008-5472.CAN-18-0887. Epub 2018 Jun 19. Review.

PMID:
29921699
2.

Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial.

Mackay A, Burford A, Molinari V, Jones DTW, Izquierdo E, Brouwer-Visser J, Giangaspero F, Haberler C, Pietsch T, Jacques TS, Figarella-Branger D, Rodriguez D, Morgan PS, Raman P, Waanders AJ, Resnick AC, Massimino M, Garrè ML, Smith H, Capper D, Pfister SM, Würdinger T, Tam R, Garcia J, Thakur MD, Vassal G, Grill J, Jaspan T, Varlet P, Jones C.

Cancer Cell. 2018 May 14;33(5):829-842.e5. doi: 10.1016/j.ccell.2018.04.004.

3.

Quantification and localization of oncogenic receptor tyrosine kinase variant transcripts using molecular inversion probes.

van den Heuvel CNAM, Das AI, de Bitter T, Simmer F, Wurdinger T, Molina-Vila MA, Leenders WPJ.

Sci Rep. 2018 May 4;8(1):7072. doi: 10.1038/s41598-018-25328-5.

4.

The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth.

Heukers R, Fan TS, de Wit RH, van Senten JR, De Groof TWM, Bebelman MP, Lagerweij T, Vieira J, de Munnik SM, Smits-de Vries L, van Offenbeek J, Rahbar A, van Hoorick D, Söderberg-Naucler C, Würdinger T, Leurs R, Siderius M, Vischer HF, Smit MJ.

Oncogene. 2018 Apr 30. doi: 10.1038/s41388-018-0255-7. [Epub ahead of print]

PMID:
29706656
5.

Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8.

Berenguer J, Lagerweij T, Zhao XW, Dusoswa S, van der Stoop P, Westerman B, de Gooijer MC, Zoetemelk M, Zomer A, Crommentuijn MHW, Wedekind LE, López-López À, Giovanazzi A, Bruch-Oms M, van der Meulen-Muileman IH, Reijmers RM, van Kuppevelt TH, García-Vallejo JJ, van Kooyk Y, Tannous BA, Wesseling P, Koppers-Lalic D, Vandertop WP, Noske DP, van Beusechem VW, van Rheenen J, Pegtel DM, van Tellingen O, Wurdinger T.

J Extracell Vesicles. 2018 Mar 13;7(1):1446660. doi: 10.1080/20013078.2018.1446660. eCollection 2018.

6.

Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients.

Plenker D, Bertrand M, de Langen AJ, Riedel R, Lorenz C, Scheel AH, Müller J, Brägelmann J, Daßler-Plenker J, Kobe C, Persigehl T, Kluge A, Wurdinger T, Schellen P, Hartmann G, Zacherle T, Menon R, Thunnissen E, Büttner R, Griesinger F, Wolf J, Heukamp L, Sos ML, Heuckmann JM.

Clin Cancer Res. 2018 Mar 15;24(6):1337-1343. doi: 10.1158/1078-0432.CCR-17-3001. Epub 2017 Dec 28.

PMID:
29284707
7.

Trimethylation of H3K27 during human cerebellar development in relation to medulloblastoma.

Mir SE, Smits M, Biesmans D, Julsing M, Bugiani M, Aronica E, Kaspers GJL, Cloos J, Würdinger T, Hulleman E.

Oncotarget. 2017 Sep 8;8(45):78978-78988. doi: 10.18632/oncotarget.20741. eCollection 2017 Oct 3.

8.

Recycling drug screen repurposes hydroxyurea as a sensitizer of glioblastomas to temozolomide targeting de novo DNA synthesis, irrespective of molecular subtype.

Teng J, Hejazi S, Hiddingh L, Carvalho L, de Gooijer MC, Wakimoto H, Barazas M, Tannous M, Chi AS, Noske DP, Wesseling P, Wurdinger T, Batchelor TT, Tannous BA.

Neuro Oncol. 2018 Apr 9;20(5):642-654. doi: 10.1093/neuonc/nox198.

PMID:
29099956
9.

Platelets harbor prostate cancer biomarkers and the ability to predict therapeutic response to abiraterone in castration resistant patients.

Tjon-Kon-Fat LA, Lundholm M, Schröder M, Wurdinger T, Thellenberg-Karlsson C, Widmark A, Wikström P, Nilsson RJA.

Prostate. 2018 Jan;78(1):48-53. doi: 10.1002/pros.23443. Epub 2017 Nov 2.

PMID:
29094381
10.

Identification of MEK162 as a Radiosensitizer for the Treatment of Glioblastoma.

Narayan RS, Gasol A, Slangen PLG, Cornelissen FMG, Lagerweij T, Veldman HYYE, Dik R, van den Berg J, Slotman BJ, Würdinger T, Haas-Kogan DA, Stalpers LJA, Baumert BG, Westerman BA, Theys J, Sminia P.

Mol Cancer Ther. 2018 Feb;17(2):347-354. doi: 10.1158/1535-7163.MCT-17-0480. Epub 2017 Sep 27.

PMID:
28958992
11.

Platelet RNA in Cancer Diagnostics.

Tjon-Kon-Fat LA, Sol N, Wurdinger T, Nilsson RJA.

Semin Thromb Hemost. 2018 Mar;44(2):135-141. doi: 10.1055/s-0037-1606182. Epub 2017 Sep 13.

PMID:
28905353
12.

Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma.

Ströbel T, Madlener S, Tuna S, Vose S, Lagerweij T, Wurdinger T, Vierlinger K, Wöhrer A, Price BD, Demple B, Saydam O, Saydam N.

Sci Rep. 2017 Aug 29;7(1):9674. doi: 10.1038/s41598-017-10013-w.

13.

Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets.

Best MG, Sol N, In 't Veld SGJG, Vancura A, Muller M, Niemeijer AN, Fejes AV, Tjon Kon Fat LA, Huis In 't Veld AE, Leurs C, Le Large TY, Meijer LL, Kooi IE, Rustenburg F, Schellen P, Verschueren H, Post E, Wedekind LE, Bracht J, Esenkbrink M, Wils L, Favaro F, Schoonhoven JD, Tannous J, Meijers-Heijboer H, Kazemier G, Giovannetti E, Reijneveld JC, Idema S, Killestein J, Heger M, de Jager SC, Urbanus RT, Hoefer IE, Pasterkamp G, Mannhalter C, Gomez-Arroyo J, Bogaard HJ, Noske DP, Vandertop WP, van den Broek D, Ylstra B, Nilsson RJA, Wesseling P, Karachaliou N, Rosell R, Lee-Lewandrowski E, Lewandrowski KB, Tannous BA, de Langen AJ, Smit EF, van den Heuvel MM, Wurdinger T.

Cancer Cell. 2017 Aug 14;32(2):238-252.e9. doi: 10.1016/j.ccell.2017.07.004.

14.

Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment.

Lagerweij T, Dusoswa SA, Negrean A, Hendrikx EML, de Vries HE, Kole J, Garcia-Vallejo JJ, Mansvelder HD, Vandertop WP, Noske DP, Tannous BA, Musters RJP, van Kooyk Y, Wesseling P, Zhao XW, Wurdinger T.

Angiogenesis. 2017 Nov;20(4):533-546. doi: 10.1007/s10456-017-9565-6. Epub 2017 Jul 11.

15.

Identification of a Druggable Pathway Controlling Glioblastoma Invasiveness.

Pencheva N, de Gooijer MC, Vis DJ, Wessels LFA, Würdinger T, van Tellingen O, Bernards R.

Cell Rep. 2017 Jul 5;20(1):48-60. doi: 10.1016/j.celrep.2017.06.036.

16.

Platelet RNA signatures for the detection of cancer.

Sol N, Wurdinger T.

Cancer Metastasis Rev. 2017 Jun;36(2):263-272. doi: 10.1007/s10555-017-9674-0. Review.

17.

Platelet RNA as a circulating biomarker trove for cancer diagnostics.

Best MG, Vancura A, Wurdinger T.

J Thromb Haemost. 2017 Jul;15(7):1295-1306. doi: 10.1111/jth.13720. Review.

PMID:
28671345
18.

The G2 checkpoint-a node-based molecular switch.

de Gooijer MC, van den Top A, Bockaj I, Beijnen JH, Würdinger T, van Tellingen O.

FEBS Open Bio. 2017 Mar 4;7(4):439-455. doi: 10.1002/2211-5463.12206. eCollection 2017 Apr.

19.

Development of bioluminescent chick chorioallantoic membrane (CAM) models for primary pancreatic cancer cells: a platform for drug testing.

Rovithi M, Avan A, Funel N, Leon LG, Gomez VE, Wurdinger T, Griffioen AW, Verheul HM, Giovannetti E.

Sci Rep. 2017 Mar 17;7:44686. doi: 10.1038/srep44686.

20.

Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression.

Baglio SR, Lagerweij T, Pérez-Lanzón M, Ho XD, Léveillé N, Melo SA, Cleton-Jansen AM, Jordanova ES, Roncuzzi L, Greco M, van Eijndhoven MAJ, Grisendi G, Dominici M, Bonafede R, Lougheed SM, de Gruijl TD, Zini N, Cervo S, Steffan A, Canzonieri V, Martson A, Maasalu K, Köks S, Wurdinger T, Baldini N, Pegtel DM.

Clin Cancer Res. 2017 Jul 15;23(14):3721-3733. doi: 10.1158/1078-0432.CCR-16-2726. Epub 2017 Jan 4. Erratum in: Clin Cancer Res. 2018 Feb 1;24(3):724.

PMID:
28053020
21.

A new humanized in vivo model of KIT D816V+ advanced systemic mastocytosis monitored using a secreted luciferase.

Bibi S, Zhang Y, Hugonin C, Mangean MD, He L, Wedeh G, Launay JM, Van Rijn S, Würdinger T, Louache F, Arock M.

Oncotarget. 2016 Dec 13;7(50):82985-83000. doi: 10.18632/oncotarget.12824.

22.

PI3K-mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models.

Lin F, de Gooijer MC, Hanekamp D, Chandrasekaran G, Buil LC, Thota N, Sparidans RW, Beijnen JH, Würdinger T, van Tellingen O.

Clin Cancer Res. 2017 Mar 1;23(5):1286-1298. doi: 10.1158/1078-0432.CCR-16-1276. Epub 2016 Aug 23.

23.

Systemically administered AAV9-sTRAIL combats invasive glioblastoma in a patient-derived orthotopic xenograft model.

Crommentuijn MH, Kantar R, Noske DP, Vandertop WP, Badr CE, Würdinger T, Maguire CA, Tannous BA.

Mol Ther Oncolytics. 2016 Jun 22;3:16017. doi: 10.1038/mto.2016.17. eCollection 2016.

24.

Non‑invasive prostate cancer detection by measuring miRNA variants (isomiRs) in urine extracellular vesicles.

Koppers-Lalic D, Hackenberg M, de Menezes R, Misovic B, Wachalska M, Geldof A, Zini N, de Reijke T, Wurdinger T, Vis A, van Moorselaar J, Pegtel M, Bijnsdorp I.

Oncotarget. 2016 Apr 19;7(16):22566-78. doi: 10.18632/oncotarget.8124.

25.

A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer.

Lagerweij T, Hiddingh L, Biesmans D, Crommentuijn MH, Cloos J, Li XN, Kogiso M, Tannous BA, Vandertop WP, Noske DP, Kaspers GJ, Würdinger T, Hulleman E.

Oncotarget. 2016 Jun 14;7(24):35776-35788. doi: 10.18632/oncotarget.7980.

26.

miR-129-3p controls centrosome number in metastatic prostate cancer cells by repressing CP110.

Bijnsdorp IV, Hodzic J, Lagerweij T, Westerman B, Krijgsman O, Broeke J, Verweij F, Nilsson RJ, Rozendaal L, van Beusechem VW, van Moorselaar JA, Wurdinger T, Geldof AA.

Oncotarget. 2016 Mar 29;7(13):16676-87. doi: 10.18632/oncotarget.7572.

27.

Re: a Word of Caution on New and Revolutionary Diagnostic Tests.

Best MG, Sol N, Tannous BA, Wesseling P, Wurdinger T.

Cancer Cell. 2016 Feb 8;29(2):143-4. doi: 10.1016/j.ccell.2016.01.004. No abstract available.

28.

Sensing of latent EBV infection through exosomal transfer of 5'pppRNA.

Baglio SR, van Eijndhoven MA, Koppers-Lalic D, Berenguer J, Lougheed SM, Gibbs S, Léveillé N, Rinkel RN, Hopmans ES, Swaminathan S, Verkuijlen SA, Scheffer GL, van Kuppeveld FJ, de Gruijl TD, Bultink IE, Jordanova ES, Hackenberg M, Piersma SR, Knol JC, Voskuyl AE, Wurdinger T, Jiménez CR, Middeldorp JM, Pegtel DM.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E587-96. doi: 10.1073/pnas.1518130113. Epub 2016 Jan 14.

29.

Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma.

Crommentuijn MH, Maguire CA, Niers JM, Vandertop WP, Badr CE, Würdinger T, Tannous BA.

Mol Oncol. 2016 Apr;10(4):625-34. doi: 10.1016/j.molonc.2015.11.011. Epub 2015 Dec 11.

30.

Rearranged EML4-ALK fusion transcripts sequester in circulating blood platelets and enable blood-based crizotinib response monitoring in non-small-cell lung cancer.

Nilsson RJ, Karachaliou N, Berenguer J, Gimenez-Capitan A, Schellen P, Teixido C, Tannous J, Kuiper JL, Drees E, Grabowska M, van Keulen M, Heideman DA, Thunnissen E, Dingemans AM, Viteri S, Tannous BA, Drozdowskyj A, Rosell R, Smit EF, Wurdinger T.

Oncotarget. 2016 Jan 5;7(1):1066-75. doi: 10.18632/oncotarget.6279.

31.

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics.

Best MG, Sol N, Kooi I, Tannous J, Westerman BA, Rustenburg F, Schellen P, Verschueren H, Post E, Koster J, Ylstra B, Ameziane N, Dorsman J, Smit EF, Verheul HM, Noske DP, Reijneveld JC, Nilsson RJA, Tannous BA, Wesseling P, Wurdinger T.

Cancer Cell. 2015 Nov 9;28(5):666-676. doi: 10.1016/j.ccell.2015.09.018. Epub 2015 Oct 29.

32.

Bioluminescence-mediated longitudinal monitoring of adipose-derived stem cells in a large mammal ex vivo organ culture.

Peeters M, van Rijn S, Vergroesen PP, Paul CP, Noske DP, Vandertop WP, Wurdinger T, Helder MN.

Sci Rep. 2015 Sep 9;5:13960. doi: 10.1038/srep13960.

33.

In Vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior.

Zomer A, Maynard C, Verweij FJ, Kamermans A, Schäfer R, Beerling E, Schiffelers RM, de Wit E, Berenguer J, Ellenbroek SIJ, Wurdinger T, Pegtel DM, van Rheenen J.

Cell. 2015 May 21;161(5):1046-1057. doi: 10.1016/j.cell.2015.04.042.

34.

Identification of a novel MET mutation in high-grade glioma resulting in an auto-active intracellular protein.

Navis AC, van Lith SA, van Duijnhoven SM, de Pooter M, Yetkin-Arik B, Wesseling P, Hendriks WJ, Venselaar H, Timmer M, van Cleef P, van Bergen En Henegouwen P, Best MG, Wurdinger TD, Tops BB, Leenders WP.

Acta Neuropathol. 2015 Jul;130(1):131-44. doi: 10.1007/s00401-015-1420-5. Epub 2015 Apr 11.

35.

Overcoming the blood-brain tumor barrier for effective glioblastoma treatment.

van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE.

Drug Resist Updat. 2015 Mar;19:1-12. doi: 10.1016/j.drup.2015.02.002. Epub 2015 Mar 6. Review.

PMID:
25791797
36.

Liquid biopsies in patients with diffuse glioma.

Best MG, Sol N, Zijl S, Reijneveld JC, Wesseling P, Wurdinger T.

Acta Neuropathol. 2015 Jun;129(6):849-65. doi: 10.1007/s00401-015-1399-y. Epub 2015 Feb 27.

37.

Analysis of AKT and ERK1/2 protein kinases in extracellular vesicles isolated from blood of patients with cancer.

van der Mijn JC, Sol N, Mellema W, Jimenez CR, Piersma SR, Dekker H, Schutte LM, Smit EF, Broxterman HJ, Skog J, Tannous BA, Wurdinger T, Verheul HM.

J Extracell Vesicles. 2014 Dec 8;3:25657. doi: 10.3402/jev.v3.25657. eCollection 2014.

38.

Mechanisms of intimate and long-distance cross-talk between glioma and myeloid cells: how to break a vicious cycle.

Wurdinger T, Deumelandt K, van der Vliet HJ, Wesseling P, de Gruijl TD.

Biochim Biophys Acta. 2014 Dec;1846(2):560-75. doi: 10.1016/j.bbcan.2014.10.003. Epub 2014 Oct 20. Review.

PMID:
25453365
39.

Rationale and study design of the IRENE-trial (NVALT-16): a phase II trial to evaluate iressa rechallenge in advanced NSCLC patients with an activating EGFR mutation who responded to an EGFR-TKI used as first-line or previous treatment.

Kuiper JL, Heideman DA, Würdinger T, Grünberg K, Groen HJ, Smit EF.

Clin Lung Cancer. 2015 Jan;16(1):60-6. doi: 10.1016/j.cllc.2014.07.008. Epub 2014 Aug 15.

PMID:
25242669
40.

Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes.

Koppers-Lalic D, Hackenberg M, Bijnsdorp IV, van Eijndhoven MAJ, Sadek P, Sie D, Zini N, Middeldorp JM, Ylstra B, de Menezes RX, Würdinger T, Meijer GA, Pegtel DM.

Cell Rep. 2014 Sep 25;8(6):1649-1658. doi: 10.1016/j.celrep.2014.08.027. Epub 2014 Sep 18.

41.

A dual program for translation regulation in cellular proliferation and differentiation.

Gingold H, Tehler D, Christoffersen NR, Nielsen MM, Asmar F, Kooistra SM, Christophersen NS, Christensen LL, Borre M, Sørensen KD, Andersen LD, Andersen CL, Hulleman E, Wurdinger T, Ralfkiær E, Helin K, Grønbæk K, Ørntoft T, Waszak SM, Dahan O, Pedersen JS, Lund AH, Pilpel Y.

Cell. 2014 Sep 11;158(6):1281-1292. doi: 10.1016/j.cell.2014.08.011.

42.

Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis.

Hiddingh L, Raktoe RS, Jeuken J, Hulleman E, Noske DP, Kaspers GJ, Vandertop WP, Wesseling P, Wurdinger T.

Sci Rep. 2014 Jun 11;4:5260. doi: 10.1038/srep05260.

43.

Human pontine glioma cells can induce murine tumors.

Caretti V, Sewing AC, Lagerweij T, Schellen P, Bugiani M, Jansen MH, van Vuurden DG, Navis AC, Horsman I, Vandertop WP, Noske DP, Wesseling P, Kaspers GJ, Nazarian J, Vogel H, Hulleman E, Monje M, Wurdinger T.

Acta Neuropathol. 2014;127(6):897-909. doi: 10.1007/s00401-014-1272-4. Epub 2014 Apr 29.

44.

ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy.

Lin F, de Gooijer MC, Roig EM, Buil LC, Christner SM, Beumer JH, Würdinger T, Beijnen JH, van Tellingen O.

Clin Cancer Res. 2014 May 15;20(10):2703-13. doi: 10.1158/1078-0432.CCR-14-0084. Epub 2014 Mar 19.

45.

Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation: clinical and genetic characterization and target for therapy.

van Berge L, Hamilton EM, Linnankivi T, Uziel G, Steenweg ME, Isohanni P, Wolf NI, Krägeloh-Mann I, Brautaset NJ, Andrews PI, de Jong BA, al Ghamdi M, van Wieringen WN, Tannous BA, Hulleman E, Würdinger T, van Berkel CG, Polder E, Abbink TE, Struys EA, Scheper GC, van der Knaap MS; LBSL Research Group.

Brain. 2014 Apr;137(Pt 4):1019-29. doi: 10.1093/brain/awu026. Epub 2014 Feb 24.

PMID:
24566671
46.

EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastoma.

Hiddingh L, Tannous BA, Teng J, Tops B, Jeuken J, Hulleman E, Boots-Sprenger SH, Vandertop WP, Noske DP, Kaspers GJ, Wesseling P, Wurdinger T.

Oncotarget. 2014 Jan 30;5(2):363-74.

47.

Pre-B-cell leukemia homeobox interacting protein 1 is overexpressed in astrocytoma and promotes tumor cell growth and migration.

van Vuurden DG, Aronica E, Hulleman E, Wedekind LE, Biesmans D, Malekzadeh A, Bugiani M, Geerts D, Noske DP, Vandertop WP, Kaspers GJ, Cloos J, Würdinger T, van der Stoop PP.

Neuro Oncol. 2014 Jul;16(7):946-59.

48.

Role of CYB5A in pancreatic cancer prognosis and autophagy modulation.

Giovannetti E, Wang Q, Avan A, Funel N, Lagerweij T, Lee JH, Caretti V, van der Velde A, Boggi U, Wang Y, Vasile E, Peters GJ, Wurdinger T, Giaccone G.

J Natl Cancer Inst. 2014 Jan;106(1):djt346. doi: 10.1093/jnci/djt346. Epub 2013 Dec 3.

49.

Multiplex functional bioluminescent reporters using Gaussia luciferase fused to epitope tags in an immunobinding assay.

van Rijn S, Würdinger T, Nilsson J.

Methods Mol Biol. 2014;1098:231-47. doi: 10.1007/978-1-62703-718-1_18.

PMID:
24166381
50.

Multiplex blood reporters for simultaneous monitoring of cellular processes.

Bovenberg MS, Degeling MH, Hejazi S, Amante RJ, van Keulen M, Jeuken JW, Akbaripanahi S, Vleggeert-Lankamp CL, Tannous M, Wesseling P, Wurdinger T, Tannous BA.

Anal Chem. 2013 Nov 5;85(21):10205-10. doi: 10.1021/ac401798v. Epub 2013 Oct 16.

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