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Items: 22

1.

KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice.

Polson ES, Kuchler VB, Abbosh C, Ross EM, Mathew RK, Beard HA, da Silva B, Holding AN, Ballereau S, Chuntharpursat-Bon E, Williams J, Griffiths HBS, Shao H, Patel A, Davies AJ, Droop A, Chumas P, Short SC, Lorger M, Gestwicki JE, Roberts LD, Bon RS, Allison SJ, Zhu S, Markowetz F, Wurdak H.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaar2718. doi: 10.1126/scitranslmed.aar2718.

2.

Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery.

Alli S, Figueiredo CA, Golbourn B, Sabha N, Wu MY, Bondoc A, Luck A, Coluccia D, Maslink C, Smith C, Wurdak H, Hynynen K, O'Reilly M, Rutka JT.

J Control Release. 2018 Jul 10;281:29-41. doi: 10.1016/j.jconrel.2018.05.005. Epub 2018 May 16.

PMID:
29753957
3.

Spontaneous Glioblastoma Spheroid Infiltration of Early-Stage Cerebral Organoids Models Brain Tumor Invasion.

da Silva B, Mathew RK, Polson ES, Williams J, Wurdak H.

SLAS Discov. 2018 Sep;23(8):862-868. doi: 10.1177/2472555218764623. Epub 2018 Mar 15.

4.

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade.

Samson A, Scott KJ, Taggart D, West EJ, Wilson E, Nuovo GJ, Thomson S, Corns R, Mathew RK, Fuller MJ, Kottke TJ, Thompson JM, Ilett EJ, Cockle JV, van Hille P, Sivakumar G, Polson ES, Turnbull SJ, Appleton ES, Migneco G, Rose AS, Coffey MC, Beirne DA, Collinson FJ, Ralph C, Alan Anthoney D, Twelves CJ, Furness AJ, Quezada SA, Wurdak H, Errington-Mais F, Pandha H, Harrington KJ, Selby PJ, Vile RG, Griffin SD, Stead LF, Short SC, Melcher AA.

Sci Transl Med. 2018 Jan 3;10(422). pii: eaam7577. doi: 10.1126/scitranslmed.aam7577.

5.

RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells.

King HO, Brend T, Payne HL, Wright A, Ward TA, Patel K, Egnuni T, Stead LF, Patel A, Wurdak H, Short SC.

Stem Cell Reports. 2017 Jan 10;8(1):125-139. doi: 10.1016/j.stemcr.2016.12.005.

6.

Metastatic site-specific polarization of macrophages in intracranial breast cancer metastases.

Rippaus N, Taggart D, Williams J, Andreou T, Wurdak H, Wronski K, Lorger M.

Oncotarget. 2016 Jul 5;7(27):41473-41487. doi: 10.18632/oncotarget.9445.

7.

Prognostic microRNAs in high-grade glioma reveal a link to oligodendrocyte precursor differentiation.

Hayes J, Thygesen H, Droop A, Hughes TA, Westhead D, Lawler SE, Wurdak H, Short SC.

Oncoscience. 2014 Dec 26;2(3):252-62. eCollection 2015.

8.

Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules.

Guo Y, Partch CL, Key J, Card PB, Pashkov V, Patel A, Bruick RK, Wurdak H, Gardner KH.

ACS Chem Biol. 2013 Mar 15;8(3):626-35. doi: 10.1021/cb300604u. Epub 2012 Dec 26.

9.

Exploring the cancer stem cell phenotype with high-throughput screening applications.

Wurdak H.

Future Med Chem. 2012 Jun;4(10):1229-41. doi: 10.4155/fmc.12.73.

PMID:
22800368
10.

Directed embryonic stem cell differentiation with small molecules.

Zhu S, Wurdak H, Schultz PG.

Future Med Chem. 2010 Jun;2(6):965-73. doi: 10.4155/fmc.10.190.

PMID:
21426114
11.

Chemical control of stem cell fate and developmental potential.

Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG.

Angew Chem Int Ed Engl. 2011 Jan 3;50(1):200-42. doi: 10.1002/anie.201004284. Review.

PMID:
21184400
12.

A small molecule accelerates neuronal differentiation in the adult rat.

Wurdak H, Zhu S, Min KH, Aimone L, Lairson LL, Watson J, Chopiuk G, Demas J, Charette B, Halder R, Weerapana E, Cravatt BF, Cline HT, Peters EC, Zhang J, Walker JR, Wu C, Chang J, Tuntland T, Cho CY, Schultz PG.

Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16542-7. doi: 10.1073/pnas.1010300107. Epub 2010 Sep 7. Erratum in: Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22360. Halder, Rajkumar [added].

13.

An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation.

Wurdak H, Zhu S, Romero A, Lorger M, Watson J, Chiang CY, Zhang J, Natu VS, Lairson LL, Walker JR, Trussell CM, Harsh GR, Vogel H, Felding-Habermann B, Orth AP, Miraglia LJ, Rines DR, Skirboll SL, Schultz PG.

Cell Stem Cell. 2010 Jan 8;6(1):37-47. doi: 10.1016/j.stem.2009.11.002.

14.

A genomic screen identifies TYRO3 as a MITF regulator in melanoma.

Zhu S, Wurdak H, Wang Y, Galkin A, Tao H, Li J, Lyssiotis CA, Yan F, Tu BP, Miraglia L, Walker J, Sun F, Orth A, Schultz PG, Wu X.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17025-30. doi: 10.1073/pnas.0909292106. Epub 2009 Sep 23.

15.

A small molecule primes embryonic stem cells for differentiation.

Zhu S, Wurdak H, Wang J, Lyssiotis CA, Peters EC, Cho CY, Wu X, Schultz PG.

Cell Stem Cell. 2009 May 8;4(5):416-26. doi: 10.1016/j.stem.2009.04.001.

16.

TAF15 and the leukemia-associated fusion protein TAF15-CIZ/NMP4 are cleaved by caspases-3 and -7.

Alves J, Wurdak H, Garay-Malpartida HM, Harris JL, Occhiucci JM, Belizário JE, Li J.

Biochem Biophys Res Commun. 2009 Jul 10;384(4):495-500. doi: 10.1016/j.bbrc.2009.05.009. Epub 2009 May 6.

PMID:
19426707
17.

Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion.

Falk S, Wurdak H, Ittner LM, Ille F, Sumara G, Schmid MT, Draganova K, Lang KS, Paratore C, Leveen P, Suter U, Karlsson S, Born W, Ricci R, Götz M, Sommer L.

Cell Stem Cell. 2008 May 8;2(5):472-83. doi: 10.1016/j.stem.2008.03.006.

18.

Wnt/BMP signal integration regulates the balance between proliferation and differentiation of neuroepithelial cells in the dorsal spinal cord.

Ille F, Atanasoski S, Falk S, Ittner LM, Märki D, Büchmann-Møller S, Wurdak H, Suter U, Taketo MM, Sommer L.

Dev Biol. 2007 Apr 1;304(1):394-408. Epub 2006 Dec 23.

19.

DiGeorge syndrome and pharyngeal apparatus development.

Wurdak H, Ittner LM, Sommer L.

Bioessays. 2006 Nov;28(11):1078-86. Review.

PMID:
17041894
20.

Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells.

Ittner LM, Wurdak H, Schwerdtfeger K, Kunz T, Ille F, Leveen P, Hjalt TA, Suter U, Karlsson S, Hafezi F, Born W, Sommer L.

J Biol. 2005;4(3):11. doi: 10.1186/jbiol29. Epub 2005 Dec 14.

21.

Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling.

Kléber M, Lee HY, Wurdak H, Buchstaller J, Riccomagno MM, Ittner LM, Suter U, Epstein DJ, Sommer L.

J Cell Biol. 2005 Apr 25;169(2):309-20. Epub 2005 Apr 18.

22.

Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome.

Wurdak H, Ittner LM, Lang KS, Leveen P, Suter U, Fischer JA, Karlsson S, Born W, Sommer L.

Genes Dev. 2005 Mar 1;19(5):530-5.

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