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Items: 1 to 50 of 54

1.

A broadly applicable cross-linker for aliphatic polymers containing C-H bonds.

Lepage ML, Simhadri C, Liu C, Takaffoli M, Bi L, Crawford B, Milani AS, Wulff JE.

Science. 2019 Nov 15;366(6467):875-878. doi: 10.1126/science.aay6230.

PMID:
31727835
2.

In Vitro Assessment of Putative PD-1/PD-L1 Inhibitors: Suggestions of an Alternative Mode of Action.

Blevins DJ, Hanley R, Bolduc T, Powell DA, Gignac M, Walker K, Carr MD, Hof F, Wulff JE.

ACS Med Chem Lett. 2019 Jul 2;10(8):1187-1192. doi: 10.1021/acsmedchemlett.9b00221. eCollection 2019 Aug 8.

PMID:
31413804
3.

Rational Adaptation of L3MBTL1 Inhibitors to Create Small-Molecule Cbx7 Antagonists.

Simhadri C, Daze KD, Douglas SF, Milosevich N, Monjas L, Dev A, Brown TM, Hirsch AKH, Wulff JE, Hof F.

ChemMedChem. 2019 Aug 6;14(15):1444-1456. doi: 10.1002/cmdc.201900021. Epub 2019 Jul 22.

PMID:
31254321
4.

Reinvestigation of a robotically revealed reaction.

Sader JK, Wulff JE.

Nature. 2019 Jun;570(7762):E54-E59. doi: 10.1038/s41586-019-1176-5. Epub 2019 Jun 26. No abstract available.

PMID:
31243379
5.

Prying open a Thiele cage: discovery of an unprecedented extended pinacol rearrangement.

Dao N, Sader JK, Oliver AG, Wulff JE.

Chem Commun (Camb). 2019 Jan 31;55(11):1600-1603. doi: 10.1039/c8cc08862d.

PMID:
30656291
6.

Validation of a Metabolite Panel for a More Accurate Estimation of Glomerular Filtration Rate Using Quantitative LC-MS/MS.

Freed TA, Coresh J, Inker LA, Toal DR, Perichon R, Chen J, Goodman KD, Zhang Q, Conner JK, Hauser DM, Vroom KET, Oyaski ML, Wulff JE, Eiríksdóttir G, Gudnason V, Torres VE, Ford LA, Levey AS.

Clin Chem. 2019 Mar;65(3):406-418. doi: 10.1373/clinchem.2018.288092. Epub 2019 Jan 15.

7.

Microfluidic Manufacturing of SN-38-Loaded Polymer Nanoparticles with Shear Processing Control of Drug Delivery Properties.

Cao Y, Silverman L, Lu C, Hof R, Wulff JE, Moffitt MG.

Mol Pharm. 2019 Jan 7;16(1):96-107. doi: 10.1021/acs.molpharmaceut.8b00874. Epub 2018 Dec 6.

PMID:
30477300
8.

Microfluidic Processing Approach to Controlling Drug Delivery Properties of Curcumin-Loaded Block Copolymer Nanoparticles.

Chen R, Wulff JE, Moffitt MG.

Mol Pharm. 2018 Oct 1;15(10):4517-4528. doi: 10.1021/acs.molpharmaceut.8b00529. Epub 2018 Sep 17.

PMID:
30179485
10.

Analyses of SLC13A5-epilepsy patients reveal perturbations of TCA cycle.

Bainbridge MN, Cooney E, Miller M, Kennedy AD, Wulff JE, Donti T, Jhangiani SN, Gibbs RA, Elsea SH, Porter BE, Graham BH.

Mol Genet Metab. 2017 Aug;121(4):314-319. doi: 10.1016/j.ymgme.2017.06.009. Epub 2017 Jun 24.

PMID:
28673551
11.

Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives.

Bettio LEB, Gil-Mohapel J, Patten AR, O'Rourke NF, Hanley RP, Gopalakrishnan K, Wulff JE, Christie BR.

Neurogenesis (Austin). 2017 Jun 1;4(1):e1317692. doi: 10.1080/23262133.2017.1317692. eCollection 2017.

12.

Correction to "Thermally Crosslinked Functionalized Polydicyclopentadiene with a High T g and Tunable Surface Energy".

Cuthbert TJ, Chen J, Burns FP, Moffitt MG, Wulff JE.

ACS Omega. 2017 Jun 9;2(6):2593. doi: 10.1021/acsomega.7b00685. eCollection 2017 Jun 30.

13.

Controlling Structure and Function of Polymeric Drug Delivery Nanoparticles Using Microfluidics.

Bains A, Cao Y, Kly S, Wulff JE, Moffitt MG.

Mol Pharm. 2017 Aug 7;14(8):2595-2606. doi: 10.1021/acs.molpharmaceut.7b00177. Epub 2017 May 31.

PMID:
28520436
14.

Elucidation of the complex metabolic profile of cerebrospinal fluid using an untargeted biochemical profiling assay.

Kennedy AD, Pappan KL, Donti TR, Evans AM, Wulff JE, Miller LAD, Reid Sutton V, Sun Q, Miller MJ, Elsea SH.

Mol Genet Metab. 2017 Jun;121(2):83-90. doi: 10.1016/j.ymgme.2017.04.005. Epub 2017 Apr 9.

15.
16.

Structure-Activity Relationships of Cbx7 Inhibitors, Including Selectivity Studies against Other Cbx Proteins.

Simhadri C, Gignac MC, Anderson CJ, Milosevich N, Dheri A, Prashar N, Flemmer RT, Dev A, Henderson TG, Douglas SF, Wulff JE, Hof F.

ACS Omega. 2016 Oct 31;1(4):541-551. doi: 10.1021/acsomega.6b00120. Epub 2016 Oct 12.

17.

Thermally Crosslinked Functionalized Polydicyclopentadiene with a High T g and Tunable Surface Energy.

Chen J, Burns FP, Moffitt MG, Wulff JE.

ACS Omega. 2016 Oct 6;1(4):532-540. doi: 10.1021/acsomega.6b00193. eCollection 2016 Oct 31. Erratum in: ACS Omega. 2017 Jun 09;2(6):2593.

18.

Metabolomic Profiling of Human Urine as a Screen for Multiple Inborn Errors of Metabolism.

Kennedy AD, Miller MJ, Beebe K, Wulff JE, Evans AM, Miller LA, Sutton VR, Sun Q, Elsea SH.

Genet Test Mol Biomarkers. 2016 Sep;20(9):485-95. doi: 10.1089/gtmb.2015.0291. Epub 2016 Jul 22.

19.

Erratum to: Untargeted metabolomic analysis for the clinical screening of inborn errors of metabolism.

Miller MJ, Kennedy AD, Eckhart AD, Burrage LC, Wulff JE, Miller LAD, Milburn MV, Ryals JA, Beaudet AL, Sun Q, Sutton VR, Elsea SH.

J Inherit Metab Dis. 2016 Sep;39(5):757. doi: 10.1007/s10545-016-9944-y. No abstract available.

PMID:
27225280
20.

Microfluidic synthesis of dye-loaded polycaprolactone-block-poly(ethylene oxide) nanoparticles: Insights into flow-directed loading and in vitro release for drug delivery.

Bains A, Wulff JE, Moffitt MG.

J Colloid Interface Sci. 2016 Aug 1;475:136-148. doi: 10.1016/j.jcis.2016.04.010. Epub 2016 Apr 20.

PMID:
27163840
21.

Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family.

Milosevich N, Gignac MC, McFarlane J, Simhadri C, Horvath S, Daze KD, Croft CS, Dheri A, Quon TT, Douglas SF, Wulff JE, Paci I, Hof F.

ACS Med Chem Lett. 2015 Dec 7;7(2):139-44. doi: 10.1021/acsmedchemlett.5b00378. eCollection 2016 Feb 11.

22.

Salicylates are interference compounds in TR-FRET assays.

Hanley RP, Horvath S, An J, Hof F, Wulff JE.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):973-977. doi: 10.1016/j.bmcl.2015.12.050. Epub 2015 Dec 17.

PMID:
26733476
23.

Expansion of Thiele's Acid Chemistry in Pursuit of a Suite of Conformationally Constrained Scaffolds.

Chen J, Kilpatrick B, Oliver AG, Wulff JE.

J Org Chem. 2015 Sep 18;80(18):8979-89. doi: 10.1021/acs.joc.5b01332. Epub 2015 Sep 3.

PMID:
26315615
24.

Plasma metabolomic profiles enhance precision medicine for volunteers of normal health.

Guo L, Milburn MV, Ryals JA, Lonergan SC, Mitchell MW, Wulff JE, Alexander DC, Evans AM, Bridgewater B, Miller L, Gonzalez-Garay ML, Caskey CT.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4901-10. doi: 10.1073/pnas.1508425112. Epub 2015 Aug 17.

25.

Untargeted metabolomic analysis for the clinical screening of inborn errors of metabolism.

Miller MJ, Kennedy AD, Eckhart AD, Burrage LC, Wulff JE, Miller LA, Milburn MV, Ryals JA, Beaudet AL, Sun Q, Sutton VR, Elsea SH.

J Inherit Metab Dis. 2015 Nov;38(6):1029-39. doi: 10.1007/s10545-015-9843-7. Epub 2015 Apr 15. Erratum in: J Inherit Metab Dis. 2016 Sep;39(5):757.

26.

Diastereoselective tandem reactions of substituted 3-sulfolenes with bis-vinyl ketones leading to highly functionalized bicyclic and tricyclic frameworks.

Brant MG, Friedmann JN, Bohlken CG, Oliver AG, Wulff JE.

Org Biomol Chem. 2015 Apr 21;13(15):4581-8. doi: 10.1039/c5ob00387c.

PMID:
25778983
27.

Bladder cancer biomarker discovery using global metabolomic profiling of urine.

Wittmann BM, Stirdivant SM, Mitchell MW, Wulff JE, McDunn JE, Li Z, Dennis-Barrie A, Neri BP, Milburn MV, Lotan Y, Wolfert RL.

PLoS One. 2014 Dec 26;9(12):e115870. doi: 10.1371/journal.pone.0115870. eCollection 2014.

28.

Plasma metabolomic biomarker panel to distinguish patients with amyotrophic lateral sclerosis from disease mimics.

Lawton KA, Brown MV, Alexander D, Li Z, Wulff JE, Lawson R, Jaffa M, Milburn MV, Ryals JA, Bowser R, Cudkowicz ME, Berry JD; Northeast ALS Consortium.

Amyotroph Lateral Scler Frontotemporal Degener. 2014 Sep;15(5-6):362-70. doi: 10.3109/21678421.2014.908311. Epub 2014 Jul 1.

PMID:
24984169
29.

Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7).

Simhadri C, Daze KD, Douglas SF, Quon TT, Dev A, Gignac MC, Peng F, Heller M, Boulanger MJ, Wulff JE, Hof F.

J Med Chem. 2014 Apr 10;57(7):2874-83. doi: 10.1021/jm401487x. Epub 2014 Mar 26.

PMID:
24625057
30.
31.

Assessment of genetically modified soybean in relation to natural variation in the soybean seed metabolome.

Clarke JD, Alexander DC, Ward DP, Ryals JA, Mitchell MW, Wulff JE, Guo L.

Sci Rep. 2013 Oct 30;3:3082. doi: 10.1038/srep03082. Erratum in: Sci Rep. 2014;4:3871.

32.

Synthetic trimethyllysine receptors that bind histone 3, trimethyllysine 27 (H3K27me3) and disrupt its interaction with the epigenetic reader protein CBX7.

Tabet S, Douglas SF, Daze KD, Garnett GA, Allen KJ, Abrioux EM, Quon TT, Wulff JE, Hof F.

Bioorg Med Chem. 2013 Nov 15;21(22):7004-10. doi: 10.1016/j.bmc.2013.09.024. Epub 2013 Sep 19.

PMID:
24100156
33.

Dipolar addition to cyclic vinyl sulfones leading to dual conformation tricycles.

Wong SS, Brant MG, Barr C, Oliver AG, Wulff JE.

Beilstein J Org Chem. 2013 Jul 15;9:1419-25. doi: 10.3762/bjoc.9.159. eCollection 2013.

34.

Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats.

Yamazaki M, Miyake M, Sato H, Masutomi N, Tsutsui N, Adam KP, Alexander DC, Lawton KA, Milburn MV, Ryals JA, Wulff JE, Guo L.

Toxicol Appl Pharmacol. 2013 Apr 1;268(1):79-89. doi: 10.1016/j.taap.2013.01.018. Epub 2013 Jan 27.

PMID:
23360887
35.

A rigid bicyclic platform for the generation of conformationally locked neuraminidase inhibitors.

Brant MG, Wulff JE.

Org Lett. 2012 Dec 7;14(23):5876-9. doi: 10.1021/ol3027939. Epub 2012 Nov 26.

36.

Cascading radical cyclization of bis-vinyl ethers: mechanistic investigation reveals a 5-exo/3-exo/retro-3-exo/5-exo pathway.

O'Rourke NF, Davies KA, Wulff JE.

J Org Chem. 2012 Oct 5;77(19):8634-47. doi: 10.1021/jo301565u. Epub 2012 Sep 21.

PMID:
22950812
37.

Investigating terephthalate biodegradation: structural characterization of a putative decarboxylating cis-dihydrodiol dehydrogenase.

Bains J, Wulff JE, Boulanger MJ.

J Mol Biol. 2012 Oct 26;423(3):284-93. doi: 10.1016/j.jmb.2012.07.022. Epub 2012 Aug 11.

PMID:
22889862
38.

Xanthates as synthetic equivalents of oxyacyl radicals: access to lactones under tin-free conditions.

Davy JA, Mason JW, Moreau B, Wulff JE.

J Org Chem. 2012 Jul 20;77(14):6332-9. doi: 10.1021/jo300939f. Epub 2012 Jul 5.

PMID:
22708663
39.

Biochemical alterations associated with ALS.

Lawton KA, Cudkowicz ME, Brown MV, Alexander D, Caffrey R, Wulff JE, Bowser R, Lawson R, Jaffa M, Milburn MV, Ryals JA, Berry JD.

Amyotroph Lateral Scler. 2012 Jan;13(1):110-8. doi: 10.3109/17482968.2011.619197. Epub 2011 Nov 25.

PMID:
22117131
40.

The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase.

Bromba CM, Mason JW, Brant MG, Chan T, Lunke MD, Petric M, Boulanger MJ, Wulff JE.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7137-41. doi: 10.1016/j.bmcl.2011.09.076. Epub 2011 Sep 24.

PMID:
22001088
41.

Toxicogenomics and metabolomics of pentamethylchromanol (PMCol)-induced hepatotoxicity.

Parman T, Bunin DI, Ng HH, McDunn JE, Wulff JE, Wang A, Swezey R, Rasay L, Fairchild DG, Kapetanovic IM, Green CE.

Toxicol Sci. 2011 Dec;124(2):487-501. doi: 10.1093/toxsci/kfr238. Epub 2011 Sep 13.

42.

Marrying iterative synthesis to cascading radical cyclization: 6-endo/5-exo radical cascade across bis-vinyl ethers.

Davies KA, Wulff JE.

Org Lett. 2011 Oct 21;13(20):5552-5. doi: 10.1021/ol202286q. Epub 2011 Sep 15.

PMID:
21919477
43.

Effects of triclocarban, triclosan, and methyl triclosan on thyroid hormone action and stress in frog and mammalian culture systems.

Hinther A, Bromba CM, Wulff JE, Helbing CC.

Environ Sci Technol. 2011 Jun 15;45(12):5395-402. doi: 10.1021/es1041942. Epub 2011 May 16.

PMID:
21574574
44.

Tandem vinylogous 1,2-addition/anionic oxy-Cope reaction leading from butadiene sulfone to an orthogonally functionalized bicycle.

Brant MG, Bromba CM, Wulff JE.

J Org Chem. 2010 Sep 17;75(18):6312-5. doi: 10.1021/jo101389c.

PMID:
20795719
45.

Assessment of the effects of dentifrice on periodontal disease biomarkers in gingival crevicular fluid.

Barnes VM, Teles R, Trivedi HM, Devizio W, Xu T, Lee DP, Mitchell MW, Wulff JE, Milburn MV, Guo L.

J Periodontol. 2010 Sep;81(9):1273-9. doi: 10.1902/jop.2010.100070.

PMID:
20450373
46.

Operationally simple copper-promoted coupling of terminal alkynes with benzyl halides.

Davies KA, Abel RC, Wulff JE.

J Org Chem. 2009 May 15;74(10):3997-4000. doi: 10.1021/jo900444x.

PMID:
19422268
47.

The natural product avrainvillamide binds to the oncoprotein nucleophosmin.

Wulff JE, Siegrist R, Myers AG.

J Am Chem Soc. 2007 Nov 21;129(46):14444-51. Epub 2007 Oct 25.

48.

Evidence for the rapid conversion of stephacidin B into the electrophilic monomer avrainvillamide in cell culture.

Wulff JE, Herzon SB, Siegrist R, Myers AG.

J Am Chem Soc. 2007 Apr 25;129(16):4898-9. Epub 2007 Mar 31. No abstract available.

49.

Aza-Morita-Baylis-Hillman reactions and cyclizations of conjugated dienes activated by sulfone, ester, and keto groups.

Sorbetti JM, Clary KN, Rankic DA, Wulff JE, Parvez M, Back TG.

J Org Chem. 2007 Apr 27;72(9):3326-31. Epub 2007 Mar 24.

PMID:
17381156
50.

Morita-Baylis-Hillman reaction and cyclization of 1-(p-toluenesulfonyl)-1,3-butadiene with aldimines.

Back TG, Rankic DA, Sorbetti JM, Wulff JE.

Org Lett. 2005 Jun 9;7(12):2377-9.

PMID:
15932202

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