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SKA-31, an activator of Ca2+-activated K+ channels, improves cardiovascular function in aging.

Mathew John C, Khaddaj Mallat R, Mishra RC, George G, Singh V, Turnbull JD, Umeshappa CS, Kendrick DJ, Kim T, Fauzi FM, Visser F, Fedak PW, Wulff H, Braun AP.

Pharmacol Res. 2019 Nov 7:104539. doi: 10.1016/j.phrs.2019.104539. [Epub ahead of print]


Assessing the Effects of Cytoprotectants on Selective Neuronal Loss, Sensorimotor Deficit and Microglial Activation after Temporary Middle Cerebral Occlusion.

Emmrich JV, Ejaz S, Williamson DJ, Hong YT, Sitnikov S, Fryer TD, Aigbirhio FI, Wulff H, Baron JC.

Brain Sci. 2019 Oct 22;9(10). pii: E287. doi: 10.3390/brainsci9100287.


The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators.

Shim H, Brown BM, Singh L, Singh V, Fettinger JC, Yarov-Yarovoy V, Wulff H.

Front Pharmacol. 2019 Sep 20;10:972. doi: 10.3389/fphar.2019.00972. eCollection 2019.


Associations between the physical environment and park-based physical activity: A systematic review.

Zhang R, Wulff H, Duan Y, Wagner P.

J Sport Health Sci. 2019 Sep;8(5):412-421. doi: 10.1016/j.jshs.2018.11.002. Epub 2018 Nov 14. Review.


Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels.

Brown BM, Shim H, Christophersen P, Wulff H.

Annu Rev Pharmacol Toxicol. 2019 Jul 23. doi: 10.1146/annurev-pharmtox-010919-023420. [Epub ahead of print]


Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease.

Jin LW, Lucente JD, Nguyen HM, Singh V, Singh L, Chavez M, Bushong T, Wulff H, Maezawa I.

Ann Clin Transl Neurol. 2019 Mar 18;6(4):723-738. doi: 10.1002/acn3.754. eCollection 2019 Apr.


Radiation Increases Functional KCa3.1 Expression and Invasiveness in Glioblastoma.

D'Alessandro G, Monaco L, Catacuzzeno L, Antonangeli F, Santoro A, Esposito V, Franciolini F, Wulff H, Limatola C.

Cancers (Basel). 2019 Feb 26;11(3). pii: E279. doi: 10.3390/cancers11030279.


Recent advances in our understanding of the structure and function of more unusual cation channels.

Brown BM, Nguyen HM, Wulff H.

F1000Res. 2019 Jan 30;8. pii: F1000 Faculty Rev-123. doi: 10.12688/f1000research.17163.1. eCollection 2019. Review.


Antibodies and venom peptides: new modalities for ion channels.

Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V.

Nat Rev Drug Discov. 2019 May;18(5):339-357. doi: 10.1038/s41573-019-0013-8. Review.


The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo.

Di Lucente J, Nguyen HM, Wulff H, Jin LW, Maezawa I.

Glia. 2018 Sep;66(9):1881-1895. doi: 10.1002/glia.23457. Epub 2018 Jul 25.


Ca2+-activated K+ channels modulate microglia affecting motor neuron survival in hSOD1G93A mice.

Cocozza G, di Castro MA, Carbonari L, Grimaldi A, Antonangeli F, Garofalo S, Porzia A, Madonna M, Mainiero F, Santoni A, Grassi F, Wulff H, D'Alessandro G, Limatola C.

Brain Behav Immun. 2018 Oct;73:584-595. doi: 10.1016/j.bbi.2018.07.002. Epub 2018 Jul 3.


Suppression of connexin 43 phosphorylation promotes astrocyte survival and vascular regeneration in proliferative retinopathy.

Slavi N, Toychiev AH, Kosmidis S, Ackert J, Bloomfield SA, Wulff H, Viswanathan S, Lampe PD, Srinivas M.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5934-E5943. doi: 10.1073/pnas.1803907115. Epub 2018 Jun 11.


Kv1.3 activity perturbs the homeostatic properties of astrocytes in glioma.

Grimaldi A, D'Alessandro G, Di Castro MA, Lauro C, Singh V, Pagani F, Sforna L, Grassi F, Di Angelantonio S, Catacuzzeno L, Wulff H, Limatola C, Catalano M.

Sci Rep. 2018 May 16;8(1):7654. doi: 10.1038/s41598-018-25940-5.


Alpha1 -adrenergic stimulation selectively enhances endothelium-mediated vasodilation in rat cremaster arteries.

Mishra RC, Rahman MM, Davis MJ, Wulff H, Hill MA, Braun AP.

Physiol Rep. 2018 May;6(9):e13703. doi: 10.14814/phy2.13703.


Correction to Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy.

Lee KSS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD.

J Med Chem. 2018 May 10;61(9):4271. doi: 10.1021/acs.jmedchem.8b00582. Epub 2018 Apr 27. No abstract available.


Targeting potassium channels to treat cerebellar ataxia.

Bushart DD, Chopra R, Singh V, Murphy GG, Wulff H, Shakkottai VG.

Ann Clin Transl Neurol. 2018 Jan 22;5(3):297-314. doi: 10.1002/acn3.527. eCollection 2018 Mar.


A multiplatform strategy for the discovery of conventional monoclonal antibodies that inhibit the voltage-gated potassium channel Kv1.3.

Bednenko J, Harriman R, Mariën L, Nguyen HM, Agrawal A, Papoyan A, Bisharyan Y, Cardarelli J, Cassidy-Hanley D, Clark T, Pedersen D, Abdiche Y, Harriman W, van der Woning B, de Haard H, Collarini E, Wulff H, Colussi P.

MAbs. 2018 May/Jun;10(4):636-650. doi: 10.1080/19420862.2018.1445451. Epub 2018 Apr 2.


Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke.

Chen YJ, Nguyen HM, Maezawa I, Jin LW, Wulff H.

Ann Clin Transl Neurol. 2017 Dec 19;5(2):147-161. doi: 10.1002/acn3.513. eCollection 2018 Feb.


[The Use of Social Networks and Physical Activity Patterns of Adolescents in Obesity Therapy - A Sociodemographic Stratified Analysis].

Wulff H, Wagner P.

Rehabilitation (Stuttg). 2018 Oct;57(5):303-313. doi: 10.1055/s-0043-118195. Epub 2018 Jan 12. German.


Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept.

Maezawa I, Nguyen HM, Di Lucente J, Jenkins DP, Singh V, Hilt S, Kim K, Rangaraju S, Levey AI, Wulff H, Jin LW.

Brain. 2018 Feb 1;141(2):596-612. doi: 10.1093/brain/awx346.


Structural insights into the potency of SK channel positive modulators.

Nam YW, Orfali R, Liu T, Yu K, Cui M, Wulff H, Zhang M.

Sci Rep. 2017 Dec 7;7(1):17178. doi: 10.1038/s41598-017-16607-8.


The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells.

Pillozzi S, D'Amico M, Bartoli G, Gasparoli L, Petroni G, Crociani O, Marzo T, Guerriero A, Messori L, Severi M, Udisti R, Wulff H, Chandy KG, Becchetti A, Arcangeli A.

Br J Cancer. 2018 Jan;118(2):200-212. doi: 10.1038/bjc.2017.392. Epub 2017 Nov 21.


GABAA receptor subtype selectivity of the proconvulsant rodenticide TETS.

Pressly B, Nguyen HM, Wulff H.

Arch Toxicol. 2018 Feb;92(2):833-844. doi: 10.1007/s00204-017-2089-4. Epub 2017 Oct 16.


[The drama of aging in film : Dramaturgic notes on a storybook about films about aging].

Wulff HJ.

Z Gerontol Geriatr. 2018 Jan;51(1):128-131. doi: 10.1007/s00391-017-1304-5. German. No abstract available.


Are there superagonists for calcium-activated potassium channels?

Brown BM, Shim H, Wulff H.

Channels (Austin). 2017 Nov 2;11(6):504-506. doi: 10.1080/19336950.2017.1376971. Epub 2017 Oct 5. No abstract available.


Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121).

Brown BM, Shim H, Zhang M, Yarov-Yarovoy V, Wulff H.

Mol Pharmacol. 2017 Oct;92(4):469-480. doi: 10.1124/mol.117.109421. Epub 2017 Jul 31.


KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma.

Brown BM, Pressley B, Wulff H.

Curr Neuropharmacol. 2018;16(5):618-626. doi: 10.2174/1570159X15666170630164226.


A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling.

Mengeling BJ, Wei Y, Dobrawa LN, Streekstra M, Louisse J, Singh V, Singh L, Lein PJ, Wulff H, Murk AJ, Furlow JD.

Aquat Toxicol. 2017 Sep;190:1-10. doi: 10.1016/j.aquatox.2017.06.019. Epub 2017 Jun 21.


Rapid Throughput Analysis of GABAA Receptor Subtype Modulators and Blockers Using DiSBAC1(3) Membrane Potential Red Dye.

Nik AM, Pressly B, Singh V, Antrobus S, Hulsizer S, Rogawski MA, Wulff H, Pessah IN.

Mol Pharmacol. 2017 Jul;92(1):88-99. doi: 10.1124/mol.117.108563. Epub 2017 Apr 20.


Development of Tetramethylenedisulfotetramine (TETS) Hapten Library: Synthesis, Electrophysiological Studies, and Immune Response in Rabbits.

Barnych B, Vasylieva N, Joseph T, Hulsizer S, Nguyen HM, Cajka T, Pessah I, Wulff H, Gee SJ, Hammock BD.

Chemistry. 2017 Jun 22;23(35):8466-8472. doi: 10.1002/chem.201700783. Epub 2017 May 30.


Hydroxy-fipronil is a new urinary biomarker of exposure to fipronil.

Vasylieva N, Barnych B, Wan D, El-Sheikh EA, Nguyen HM, Wulff H, McMahen R, Strynar M, Gee SJ, Hammock BD.

Environ Int. 2017 Jun;103:91-98. doi: 10.1016/j.envint.2017.03.012. Epub 2017 Mar 23.


Potassium channel expression and function in microglia: Plasticity and possible species variations.

Nguyen HM, Blomster LV, Christophersen P, Wulff H.

Channels (Austin). 2017 Jul 4;11(4):305-315. doi: 10.1080/19336950.2017.1300738. Epub 2017 Mar 1. Review.


International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels.

Kaczmarek LK, Aldrich RW, Chandy KG, Grissmer S, Wei AD, Wulff H.

Pharmacol Rev. 2017 Jan;69(1):1-11. doi: 10.1124/pr.116.012864. Epub 2016 Nov 15. Review.


Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension.

Ulu A, Inceoglu B, Yang J, Singh V, Vito S, Wulff H, Hammock BD.

J Clin Toxicol. 2016 Jun;6(3). pii: 1000300. doi: 10.4172/2161-0495.1000300. Epub 2016 May 30.


Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore.

Nguyen HM, Singh V, Pressly B, Jenkins DP, Wulff H, Yarov-Yarovoy V.

Mol Pharmacol. 2017 Apr;91(4):392-402. doi: 10.1124/mol.116.108068. Epub 2017 Jan 26.


From the Cover: BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms.

Chen H, Streifel KM, Singh V, Yang D, Mangini L, Wulff H, Lein PJ.

Toxicol Sci. 2017 Apr 1;156(2):375-386. doi: 10.1093/toxsci/kfw259.


A Metal-Free Method for Producing MRI Contrast at Amyloid-β.

Hilt S, Tang T, Walton JH, Budamagunta M, Maezawa I, Kálai T, Hideg K, Singh V, Wulff H, Gong Q, Jin LW, Louie A, Voss JC.

J Alzheimers Dis. 2017;55(4):1667-1681. doi: 10.3233/JAD-160279.


Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia.

Nguyen HM, Grössinger EM, Horiuchi M, Davis KW, Jin LW, Maezawa I, Wulff H.

Glia. 2017 Jan;65(1):106-121. doi: 10.1002/glia.23078. Epub 2016 Oct 3.


Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents.

Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ.

Ann N Y Acad Sci. 2016 Aug;1378(1):124-136. doi: 10.1111/nyas.13137. Epub 2016 Jul 28. Review.


Endothelial Small- and Intermediate-Conductance K Channels and Endothelium-Dependent Hyperpolarization as Drug Targets in Cardiovascular Disease.

Köhler R, Oliván-Viguera A, Wulff H.

Adv Pharmacol. 2016;77:65-104. doi: 10.1016/bs.apha.2016.04.002. Epub 2016 May 4. Review.


Treatment with the KCa3.1 inhibitor TRAM-34 during diabetic ketoacidosis reduces inflammatory changes in the brain.

Glaser N, Little C, Lo W, Cohen M, Tancredi D, Wulff H, O'Donnell M.

Pediatr Diabetes. 2017 Aug;18(5):356-366. doi: 10.1111/pedi.12396. Epub 2016 May 13.


KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment.

D'Alessandro G, Grimaldi A, Chece G, Porzia A, Esposito V, Santoro A, Salvati M, Mainiero F, Ragozzino D, Di Angelantonio S, Wulff H, Catalano M, Limatola C.

Oncotarget. 2016 May 24;7(21):30781-96. doi: 10.18632/oncotarget.8761.


KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages.

Grimaldi A, D'Alessandro G, Golia MT, Grössinger EM, Di Angelantonio S, Ragozzino D, Santoro A, Esposito V, Wulff H, Catalano M, Limatola C.

Cell Death Dis. 2016 Apr 7;7:e2174. doi: 10.1038/cddis.2016.73.


KCa3.1(-/-) Mice Do Not Develop CIA: Regulatory Role for KCa3.1 in Autoimmune Arthritis.

Raychaudhuri SK, Wulff H, Raychaudhuri SP.

J Cell Physiol. 2016 Nov;231(11):2313-4. doi: 10.1002/jcp.25356. Epub 2016 Mar 16. No abstract available.


Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity.

Singh L, Pressly B, Mengeling BJ, Fettinger JC, Furlow JD, Lein PJ, Wulff H, Singh V.

J Org Chem. 2016 Mar 4;81(5):1870-6. doi: 10.1021/acs.joc.5b02665. Epub 2016 Feb 18.


Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed.

Oliván-Viguera A, Valero MS, Pinilla E, Amor S, García-Villalón ÁL, Coleman N, Laría C, Calvín-Tienza V, García-Otín ÁL, Fernández-Fernández JM, Murillo MD, Gálvez JA, Díaz-de-Villegas MD, Badorrey R, Simonsen U, Rivera L, Wulff H, Köhler R.

Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92. doi: 10.1111/bcpt.12560. Epub 2016 Feb 29.


Diisopropylfluorophosphate Impairs the Transport of Membrane-Bound Organelles in Rat Cortical Axons.

Gao J, Naughton SX, Wulff H, Singh V, Beck WD, Magrane J, Thomas B, Kaidery NA, Hernandez CM, Terry AV Jr.

J Pharmacol Exp Ther. 2016 Mar;356(3):645-55. doi: 10.1124/jpet.115.230839. Epub 2015 Dec 30.


[Media use and physical activity patterns of adolescent participants in obesity therapy: Analysis of the impact of selected sociodemographic factors].

Wulff H, Wagner P.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2016 Feb;59(2):284-91. doi: 10.1007/s00103-015-2289-0. German.


The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke.

Chen YJ, Nguyen HM, Maezawa I, Grössinger EM, Garing AL, Köhler R, Jin LW, Wulff H.

J Cereb Blood Flow Metab. 2016 Dec;36(12):2146-2161. Epub 2015 Nov 2.

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