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Understanding COVID-19: what does viral RNA load really mean?

Joynt GM, Wu WK.

Lancet Infect Dis. 2020 Mar 27. pii: S1473-3099(20)30237-1. doi: 10.1016/S1473-3099(20)30237-1. [Epub ahead of print] No abstract available.


Biological characteristics associated with virulence in Clostridioides difficile ribotype 002 in Hong Kong.

Kong KY, Kwong TNY, Chan H, Wong K, Wong SSY, Chaparala AP, Chan RCY, Zhang L, Sung JJY, Yu J, Hawkey PM, Ip M, Wu WKK, Wong SH.

Emerg Microbes Infect. 2020 Mar 17;9(1):631-638. doi: 10.1080/22221751.2020.1739564. eCollection 2020.


Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study.

Kirichenko TV, Myasoedova VA, Ravani AL, Sobenin IA, Orekhova VA, Romanenko EB, Poggio P, Wu WK, Orekhov AN.

Biology (Basel). 2020 Mar 6;9(3). pii: E48. doi: 10.3390/biology9030048.


Natural Pregnancy and Successful Delivery in A Woman with Endometrial Stromal Sarcoma After Sequential Therapy with Heavy Dosage of Chinese Medicine: A Case Report.

Xie HP, Peng SH, Yi WM, Wang FL, Wu WK.

Chin J Integr Med. 2020 Mar 7. doi: 10.1007/s11655-020-3251-z. [Epub ahead of print] No abstract available.


Signaling Pathways and Key Genes Involved in Regulation of foam Cell Formation in Atherosclerosis.

Poznyak AV, Wu WK, Melnichenko AA, Wetzker R, Sukhorukov V, Markin AM, Khotina VA, Orekhov AN.

Cells. 2020 Mar 1;9(3). pii: E584. doi: 10.3390/cells9030584. Review.


Comparison of DNA stabilizers and storage conditions on preserving fecal microbiota profiles.

Chen CC, Wu WK, Chang CM, Panyod S, Lu TP, Liou JM, Fang YJ, Chuang EY, Wu MS.

J Formos Med Assoc. 2020 Feb 25. pii: S0929-6646(20)30017-6. doi: 10.1016/j.jfma.2020.01.013. [Epub ahead of print]


Allicin Modifies the Composition and Function of the Gut Microbiota in Alcoholic Hepatic Steatosis Mice.

Panyod S, Wu WK, Lu KH, Liu CT, Chu YL, Ho CT, Hsiao WW, Lai YS, Chen WC, Lin YE, Lin SH, Wu MS, Sheen LY.

J Agric Food Chem. 2020 Mar 11;68(10):3088-3098. doi: 10.1021/acs.jafc.9b07555. Epub 2020 Feb 27.


Autophagy in host-microbe interactions.

Wu WKK, Yue J.

Semin Cell Dev Biol. 2020 Feb 8. pii: S1084-9521(20)30024-0. doi: 10.1016/j.semcdb.2020.02.001. [Epub ahead of print] No abstract available.


Cathelicidin preserves intestinal barrier function in polymicrobial sepsis.

Ho J, Chan H, Liang Y, Liu X, Zhang L, Li Q, Zhang Y, Zeng J, Ugwu FN, Ho IHT, Hu W, Yau JCW, Wong SH, Wong WT, Ling L, Cho CH, Gallo RL, Gin T, Tse G, Yu J, Chan MTV, Leung CCH, Wu WKK.

Crit Care. 2020 Feb 10;24(1):47. doi: 10.1186/s13054-020-2754-5.


Role of Phagocytosis in the Pro-Inflammatory Response in LDL-Induced Foam Cell Formation; a Transcriptome Analysis.

Orekhov AN, Nikiforov NG, Sukhorukov VN, Kubekina MV, Sobenin IA, Wu WK, Foxx KK, Pintus S, Stegmaier P, Stelmashenko D, Kel A, Gratchev AN, Melnichenko AA, Wetzker R, Summerhill VI, Manabe I, Oishi Y.

Int J Mol Sci. 2020 Jan 27;21(3). pii: E817. doi: 10.3390/ijms21030817.


Genomics and metagenomics of colorectal cancer.

Ng C, Li H, Wu WKK, Wong SH, Yu J.

J Gastrointest Oncol. 2019 Dec;10(6):1164-1170. doi: 10.21037/jgo.2019.06.04. Review.


wtest: an integrated R package for genetic epistasis testing.

Sun R, Xia X, Chong KC, Zee BC, Wu WKK, Wang MH.

BMC Med Genomics. 2019 Dec 24;12(Suppl 9):180. doi: 10.1186/s12920-019-0638-9.


Emerging roles of non-coding RNAs in scoliosis.

Li Z, Li X, Shen J, Zhang L, Chan MTV, Wu WKK.

Cell Prolif. 2020 Feb;53(2):e12736. doi: 10.1111/cpr.12736. Epub 2019 Dec 12. Review.


Preoperative Vitamin D Concentration and Cardiac, Renal, and Infectious Morbidity after Noncardiac Surgery.

Turan A, Artis AS, Hanline C, Saha P, Maheshwari K, Kurz A, Devereaux PJ, Duceppe E, Patel A, Tiboni M, Ruetzler K, Pearse R, Chan MTV, Wu WKK, Srinathan S, Garg AX, Sapsford R, Sessler DI.

Anesthesiology. 2020 Jan;132(1):121-130. doi: 10.1097/ALN.0000000000003000.


Differentially expressed circular RNAs in air pollution-exposed rat embryos.

Li Z, Ma J, Shen J, Chan MTV, Wu WKK, Wu Z.

Environ Sci Pollut Res Int. 2019 Nov;26(33):34421-34429. doi: 10.1007/s11356-019-06489-w. Epub 2019 Oct 21.


Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration.

Li Z, Chen X, Xu D, Li S, Chan MTV, Wu WKK.

Cell Prolif. 2019 Nov;52(6):e12704. doi: 10.1111/cpr.12704. Epub 2019 Oct 16. Review.


Anaesthesia use in catheter ablation for atrial fibrillation: a systematic review and meta-analysis of observational studies.

Li KHC, Sang T, Chan C, Gong M, Liu Y, Jesuthasan A, Li G, Liu T, Lam MHS, Wu WK, Chan MTV, Liu FZ, Chen C, Ho J, Xia Y, Tse G.

Heart Asia. 2019 Aug 14;11(2):e011155. doi: 10.1136/heartasia-2018-011155. eCollection 2019.


Aberrantly expressed long non-coding RNAs in air pollution-induced congenital defects.

Li Z, Ma J, Li X, Chan MTV, Wu WKK, Wu Z, Shen J.

J Cell Mol Med. 2019 Nov;23(11):7717-7725. doi: 10.1111/jcmm.14645. Epub 2019 Sep 26.


Bufalin, a Traditional Chinese Medicine Compound, Prevents Tumor Formation in Two Murine Models of Colorectal Cancer.

Sun X, Ng TTH, Sham KWY, Zhang L, Chan MTV, Wu WKK, Cheng CHK.

Cancer Prev Res (Phila). 2019 Oct;12(10):653-666. doi: 10.1158/1940-6207.CAPR-19-0134. Epub 2019 Aug 20.


Autophagy in intracellular bacterial infection.

Hu W, Chan H, Lu L, Wong KT, Wong SH, Li MX, Xiao ZG, Cho CH, Gin T, Chan MTV, Wu WKK, Zhang L.

Semin Cell Dev Biol. 2019 Sep 10. pii: S1084-9521(19)30054-0. doi: 10.1016/j.semcdb.2019.07.014. [Epub ahead of print] Review.


ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy.

Tian Y, Yang B, Qiu W, Hao Y, Zhang Z, Yang B, Li N, Cheng S, Lin Z, Rui YC, Cheung OKW, Yang W, Wu WKK, Cheung YS, Lai PBS, Luo J, Sung JJY, Chen R, Wang HY, Cheng ASL, Yang P.

Nat Commun. 2019 Jul 29;10(1):3391. doi: 10.1038/s41467-019-11274-x.


Measurement of gut microbial metabolites in cardiometabolic health and translational research.

Wu WK, Hsu CC, Sheen LY, Wu MS.

Rapid Commun Mass Spectrom. 2019 Jul 25:e8537. doi: 10.1002/rcm.8537. [Epub ahead of print]


Serine and one-carbon metabolism, a bridge that links mTOR signaling and DNA methylation in cancer.

Zeng JD, Wu WKK, Wang HY, Li XX.

Pharmacol Res. 2019 Nov;149:104352. doi: 10.1016/j.phrs.2019.104352. Epub 2019 Jul 16. Review.


Eukaryotic elongation factor-2 kinase expression is an independent prognostic factor in colorectal cancer.

Ng TH, Sham KWY, Xie CM, Ng SSM, To KF, Tong JHM, Liu WYZ, Zhang L, Chan MTV, Wu WKK, Cheng CHK.

BMC Cancer. 2019 Jul 2;19(1):649. doi: 10.1186/s12885-019-5873-0.


Long non-coding RNAs in the spinal cord injury: Novel spotlight.

Li Z, Ho IHT, Li X, Xu D, Wu WKK, Chan MTV, Li S, Liu X.

J Cell Mol Med. 2019 Aug;23(8):4883-4890. doi: 10.1111/jcmm.14422. Epub 2019 May 29. Review.


Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis.

Yuan M, Zhang Z, Tse G, Feng X, Korantzopoulos P, Letsas KP, Yan BP, Wu WKK, Zhang H, Li G, Liu T, Xia Y.

Cardiol Res Pract. 2019 Apr 14;2019:8985273. doi: 10.1155/2019/8985273. eCollection 2019. Review.


Association of Unrecognized Obstructive Sleep Apnea With Postoperative Cardiovascular Events in Patients Undergoing Major Noncardiac Surgery.

Chan MTV, Wang CY, Seet E, Tam S, Lai HY, Chew EFF, Wu WKK, Cheng BCP, Lam CKM, Short TG, Hui DSC, Chung F; Postoperative Vascular Complications in Unrecognized Obstructive Sleep Apnea (POSA) Study Investigators.

JAMA. 2019 May 14;321(18):1788-1798. doi: 10.1001/jama.2019.4783.


Local infiltration with cocktail analgesics during 2 level lumbar spinal fusion surgery: Study protocol of a randomized controlled trial.

Ren Z, Li Z, Li S, Sheng L, Xu D, Chen X, Wu WKK, Chan MTV, Ho J.

Medicine (Baltimore). 2019 May;98(19):e15526. doi: 10.1097/MD.0000000000015526.


Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer.

Xing R, Zhou Y, Yu J, Yu Y, Nie Y, Luo W, Yang C, Xiong T, Wu WKK, Li Z, Bing Y, Lin S, Zhang Y, Hu Y, Li L, Han L, Yang C, Huang S, Huang S, Zhou R, Li J, Wu K, Fan D, Tang G, Dou J, Zhu Z, Ji J, Fang X, Lu Y.

Nat Commun. 2019 May 2;10(1):2037. doi: 10.1038/s41467-019-09644-6.


A Novel Peptide Interfering with proBDNF-Sortilin Interaction Alleviates Chronic Inflammatory Pain.

Ho IHT, Liu X, Zou Y, Liu T, Hu W, Chan H, Tian Y, Zhang Y, Li Q, Kou S, Chan CS, Gin T, Cheng CHK, Wong SH, Yu J, Zhang L, Wu WKK, Chan MTV.

Theranostics. 2019 Feb 28;9(6):1651-1665. doi: 10.7150/thno.29703. eCollection 2019.


The phytochemical polydatin ameliorates non-alcoholic steatohepatitis by restoring lysosomal function and autophagic flux.

Chen X, Chan H, Zhang L, Liu X, Ho IHT, Zhang X, Ho J, Hu W, Tian Y, Kou S, Chan CS, Yu J, Wong SH, Gin T, Chan MTV, Sun X, Wu WKK.

J Cell Mol Med. 2019 Jun;23(6):4290-4300. doi: 10.1111/jcmm.14320. Epub 2019 Apr 11.


Autophagy inhibition enhances PD-L1 expression in gastric cancer.

Wang X, Wu WKK, Gao J, Li Z, Dong B, Lin X, Li Y, Li Y, Gong J, Qi C, Peng Z, Yu J, Shen L.

J Exp Clin Cancer Res. 2019 Mar 29;38(1):140. doi: 10.1186/s13046-019-1148-5.


Evaluation and Optimization of Sample Handling Methods for Quantification of Short-Chain Fatty Acids in Human Fecal Samples by GC-MS.

Hsu YL, Chen CC, Lin YT, Wu WK, Chang LC, Lai CH, Wu MS, Kuo CH.

J Proteome Res. 2019 May 3;18(5):1948-1957. doi: 10.1021/acs.jproteome.8b00536. Epub 2019 Apr 1.


Examination of the Hand and Wrist.

Day CS, Wu WK, Smith CC.

N Engl J Med. 2019 Mar 21;380(12):e15. doi: 10.1056/NEJMvcm1407111. No abstract available.


MicroRNA signature of air pollution exposure-induced congenital defects.

Li Z, Ma J, Bi J, Guo H, Chan MTV, Wu WKK, Wu Z, Shen J.

J Cell Physiol. 2019 Aug;234(10):17896-17904. doi: 10.1002/jcp.28422. Epub 2019 Mar 18.


Cancer genomics: From benchtop to bedside.

Wong SH, Wu WKK.

Semin Cancer Biol. 2019 Apr;55:iii-iv. doi: 10.1016/j.semcancer.2019.03.001. Epub 2019 Mar 6. No abstract available.


Response to the letter: Identification of trimethylamine N-oxide (TMAO)-producer phenotype is interesting, but is it helpful?

Wu WK, Sheen LY, Wu MS.

Gut. 2020 Mar;69(3):610-611. doi: 10.1136/gutjnl-2018-318187. Epub 2019 Feb 22. No abstract available.


Real-time tracking of fluorescent magnetic spore-based microrobots for remote detection of C. diff toxins.

Zhang Y, Zhang L, Yang L, Vong CI, Chan KF, Wu WKK, Kwong TNY, Lo NWS, Ip M, Wong SH, Sung JJY, Chiu PWY, Zhang L.

Sci Adv. 2019 Jan 11;5(1):eaau9650. doi: 10.1126/sciadv.aau9650. eCollection 2019 Jan.


Melatonin protected against the detrimental effects of microRNA-363 in a rat model of vitamin A-associated congenital spinal deformities: Involvement of Notch signaling.

Li Z, Li X, Bi J, Chan MTV, Wu WKK, Shen J.

J Pineal Res. 2019 Apr;66(3):e12558. doi: 10.1111/jpi.12558. Epub 2019 Feb 14.


The Role of Connexins in Gastrointestinal Diseases.

Wong J, Chopra J, Chiang LLW, Liu T, Ho J, Wu WKK, Tse G, Wong SH.

J Mol Biol. 2019 Feb 15;431(4):643-652. doi: 10.1016/j.jmb.2019.01.007. Epub 2019 Jan 11. Review.


Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells.

Hu W, Zhang L, Li MX, Shen J, Liu XD, Xiao ZG, Wu DL, Ho IHT, Wu JCY, Cheung CKY, Zhang YC, Lau AHY, Ashktorab H, Smoot DT, Fang EF, Chan MTV, Gin T, Gong W, Wu WKK, Cho CH.

Autophagy. 2019 Apr;15(4):707-725. doi: 10.1080/15548627.2018.1557835. Epub 2019 Jan 6.


WITHDRAWN: Acute Cellular Rejection and Infection Rates in Alemtuzumab vs Traditional Induction Therapy Agents for Lung and Heart Transplantation: A Systematic Review and Meta-analysis.

Li KHC, Ho JCS, Recaldin B, Gong M, Ho J, Li G, Liu T, Wu WKK, Wong MCS, Xia Y, Dong M, Tse G; International Health Informatics Study (IHIS) Network.

Transplant Proc. 2018 Dec;50(10):3739-3747. doi: 10.1016/j.transproceed.2018.08.018. Epub 2018 Sep 7.


Acute Cellular Rejection and Infection Rates in Alemtuzumab vs Traditional Induction Therapy Agents for Lung and Heart Transplantation: A Systematic Review and Meta-analysis.

Li KHC, Ho JCS, Recaldin B, Gong M, Ho J, Li G, Liu T, Wu WKK, Wong MCS, Xia Y, Dong M, Tse G; International Health Informatics Study Network.

Transplant Proc. 2018 Dec;50(10):3723-3731. doi: 10.1016/j.transproceed.2018.08.044. Epub 2018 Sep 7.


Quantification of Beat-To-Beat Variability of Action Potential Durations in Langendorff-Perfused Mouse Hearts.

Tse G, Du Y, Hao G, Li KHC, Chan FYW, Liu T, Li G, Bazoukis G, Letsas KP, Wu WKK, Cheng SH, Wong WT.

Front Physiol. 2018 Nov 27;9:1578. doi: 10.3389/fphys.2018.01578. eCollection 2018.


Genome sequence characterization of canine parvoviruses prevalent in the Sichuan province of China.

Zhuang QY, Qiu Y, Pan ZH, Wang SC, Wang B, Wu WK, Yu JM, Yi Y, Sun FL, Wang KC.

Transbound Emerg Dis. 2019 Mar;66(2):897-907. doi: 10.1111/tbed.13100. Epub 2019 Jan 10.


Effect of cultural background and healthcare environment on postoperative opioid requirement.

Konstantatos AH, Zhong T, Paul E, Tsang S, Tian S, Liu M, Liang Y, Tian Y, Qiao S, Wu WKK, Chan MTV.

Can J Anaesth. 2019 Mar;66(3):309-317. doi: 10.1007/s12630-018-01267-7. Epub 2018 Dec 10.


Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer.

Coker OO, Nakatsu G, Dai RZ, Wu WKK, Wong SH, Ng SC, Chan FKL, Sung JJY, Yu J.

Gut. 2019 Apr;68(4):654-662. doi: 10.1136/gutjnl-2018-317178. Epub 2018 Nov 24.



Kwong TNY, Wu WKK, Wong SH.

Gastroenterology. 2019 Jan;156(1):292. doi: 10.1053/j.gastro.2018.11.047. Epub 2018 Nov 22. No abstract available.


Cancer antigen-125 and outcomes in acute heart failure: a systematic review and meta-analysis.

Li KHC, Gong M, Li G, Baranchuk A, Liu T, Wong MCS, Jesuthasan A, Lai RWC, Lai JCL, Lee APW, Bayés-Genis A, de la Espriella R, Sanchis J, Wu WKK, Tse G, Nuñez J; International Health Informatics Study (IHIS) Network.

Heart Asia. 2018 Oct 26;10(2):e011044. doi: 10.1136/heartasia-2018-011044. eCollection 2018.

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