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Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses.

Sevy AM, Wu NC, Gilchuk IM, Parrish EH, Burger S, Yousif D, Nagel MBM, Schey KL, Wilson IA, Crowe JE Jr, Meiler J.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1597-1602. doi: 10.1073/pnas.1806004116. Epub 2019 Jan 14.


Application of Deep Mutational Scanning in Hepatitis C Virus.

Wu NC, Qi H.

Methods Mol Biol. 2019;1911:183-190. doi: 10.1007/978-1-4939-8976-8_12.


Epidermal epidemic: unravelling the pathogenesis of chytridiomycosis.

Wu NC, Cramp RL, Ohmer MEB, Franklin CE.

J Exp Biol. 2019 Jan 27;222(Pt 2). pii: jeb191817. doi: 10.1242/jeb.191817.


Deception through Mimicry: A Cellular Antiviral Strategy.

Wu NC, Ward AB.

Cell. 2018 Dec 13;175(7):1728-1729. doi: 10.1016/j.cell.2018.11.033.


Immunodominance and antigenic variation of influenza virus hemagglutinin: implications for design of universal vaccine immunogens.

Zost SJ, Wu NC, Hensley SE, Wilson IA.

J Infect Dis. 2018 Dec 9. doi: 10.1093/infdis/jiy696. [Epub ahead of print] No abstract available.


Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease.

Credille CV, Dick BL, Morrison CN, Stokes RW, Adamek RN, Wu NC, Wilson IA, Cohen SM.

J Med Chem. 2018 Nov 21;61(22):10206-10217. doi: 10.1021/acs.jmedchem.8b01363. Epub 2018 Oct 31.


Transcatheter atrioventricular valve-in-valve implantation for Fontan circulation and dextrocardia.

Kuo CC, Shih JY, Wu NC, Cheng BC.

Interact Cardiovasc Thorac Surg. 2019 Mar 1;28(3):496-498. doi: 10.1093/icvts/ivy273.


Recurring and Adaptable Binding Motifs in Broadly Neutralizing Antibodies to Influenza Virus Are Encoded on the D3-9 Segment of the Ig Gene.

Wu NC, Yamayoshi S, Ito M, Uraki R, Kawaoka Y, Wilson IA.

Cell Host Microbe. 2018 Oct 10;24(4):569-578.e4. doi: 10.1016/j.chom.2018.09.010.


Body and tail-assisted pitch control facilitates bipedal locomotion in Australian agamid lizards.

Clemente CJ, Wu NC.

J R Soc Interface. 2018 Sep 26;15(146). pii: 20180276. doi: 10.1098/rsif.2018.0276.


Comparison of central laboratory assessments of ER, PR, HER2, and Ki67 by IHC/FISH and the corresponding mRNAs (ESR1, PGR, ERBB2, and MKi67) by RT-qPCR on an automated, broadly deployed diagnostic platform.

Wu NC, Wong W, Ho KE, Chu VC, Rizo A, Davenport S, Kelly D, Makar R, Jassem J, Duchnowska R, Biernat W, Radecka B, Fujita T, Klein JL, Stonecypher M, Ohta S, Juhl H, Weidler JM, Bates M, Press MF.

Breast Cancer Res Treat. 2018 Nov;172(2):327-338. doi: 10.1007/s10549-018-4889-5. Epub 2018 Aug 17.


Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants.

Lee JM, Huddleston J, Doud MB, Hooper KA, Wu NC, Bedford T, Bloom JD.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8276-E8285. doi: 10.1073/pnas.1806133115. Epub 2018 Aug 13.


Corrigendum to: 'Robotic mitral valve replacements with bioprosthetic valves in 52 patients: experience from a tertiary referral hospital'  [Eur J Cardiothorac Surg 2018;54:853--9].

Kuo CC, Chang HH, Hsing CH, Hii HP, Wu NC, Hsu CM, Chen CI, Cheng BC.

Eur J Cardiothorac Surg. 2018 Nov 1;54(5):967. doi: 10.1093/ejcts/ezy299. No abstract available.


Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library.

Merkouris S, Barde YA, Binley KE, Allen ND, Stepanov AV, Wu NC, Grande G, Lin CW, Li M, Nan X, Chacon-Fernandez P, DiStefano PS, Lindsay RM, Lerner RA, Xie J.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7023-E7032. doi: 10.1073/pnas.1806660115. Epub 2018 Jul 9.


Clinical Correlations of Transcriptional Profile in Patients Infected With Avian Influenza H7N9 Virus.

Guan W, Yang Z, Wu NC, Lee HHY, Li Y, Jiang W, Shen L, Wu DC, Chen R, Zhong N, Wilson IA, Peiris M, Mok CKP.

J Infect Dis. 2018 Sep 8;218(8):1238-1248. doi: 10.1093/infdis/jiy317.


Robotic mitral valve replacements with bioprosthetic valves in 52 patients: experience from a tertiary referral hospital.

Kuo CC, Chang HH, Hsing CH, Hii HP, Wu NC, Hsu CM, Chen CI, Cheng BC.

Eur J Cardiothorac Surg. 2018 Nov 1;54(5):853-859. doi: 10.1093/ejcts/ezy134. Erratum in: Eur J Cardiothorac Surg. 2018 Nov 1;54(5):967.


A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site.

Wu NC, Thompson AJ, Xie J, Lin CW, Nycholat CM, Zhu X, Lerner RA, Paulson JC, Wilson IA.

Nat Commun. 2018 Mar 28;9(1):1264. doi: 10.1038/s41467-018-03663-5.


Body size influences energetic and osmoregulatory costs in frogs infected with Batrachochytrium dendrobatidis.

Wu NC, Cramp RL, Franklin CE.

Sci Rep. 2018 Feb 27;8(1):3739. doi: 10.1038/s41598-018-22002-8.


Structural insights into the design of novel anti-influenza therapies.

Wu NC, Wilson IA.

Nat Struct Mol Biol. 2018 Feb;25(2):115-121. doi: 10.1038/s41594-018-0025-9. Epub 2018 Feb 2. Review.


Purulent constrictive pericarditis caused by Salmonella enteritidis in a patient with adult-onset Still's disease: A case report.

Kuo CC, Yu WL, Lee CH, Wu NC.

Medicine (Baltimore). 2017 Dec;96(50):e8949. doi: 10.1097/MD.0000000000008949.


Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design.

Du Y, Xin L, Shi Y, Zhang TH, Wu NC, Dai L, Gong D, Brar G, Shu S, Luo J, Reiley W, Tseng YW, Bai H, Wu TT, Wang J, Shu Y, Sun R.

Science. 2018 Jan 19;359(6373):290-296. doi: 10.1126/science.aan8806.


A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine.

Wu NC, Zost SJ, Thompson AJ, Oyen D, Nycholat CM, McBride R, Paulson JC, Hensley SE, Wilson IA.

PLoS Pathog. 2017 Oct 23;13(10):e1006682. doi: 10.1371/journal.ppat.1006682. eCollection 2017 Oct.


Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in VH1-69 Antibody Orientation on the HA Stem.

Lang S, Xie J, Zhu X, Wu NC, Lerner RA, Wilson IA.

Cell Rep. 2017 Sep 19;20(12):2935-2943. doi: 10.1016/j.celrep.2017.08.084.


Effects of long-term preservation on amphibian body conditions: implications for historical morphological research.

Shu G, Gong Y, Xie F, Wu NC, Li C.

PeerJ. 2017 Sep 15;5:e3805. doi: 10.7717/peerj.3805. eCollection 2017.


Quantifying perinatal transmission of Hepatitis B viral quasispecies by tag linkage deep sequencing.

Du Y, Chi X, Wang C, Jiang J, Kong F, Yan H, Wang X, Li J, Wu NC, Dai L, Zhang TH, Shu S, Zhou J, Yoshizawa JM, Li X, Bhattacharya D, Wu TT, Niu J, Sun R.

Sci Rep. 2017 Aug 31;7(1):10168. doi: 10.1038/s41598-017-10591-9.


Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin.

Wu NC, Xie J, Zheng T, Nycholat CM, Grande G, Paulson JC, Lerner RA, Wilson IA.

Cell Host Microbe. 2017 Aug 9;22(2):247-248. doi: 10.1016/j.chom.2017.07.001. No abstract available.


Intravenous superoxide dismutase as a protective agent to prevent impairment of lung function induced by high tidal volume ventilation.

Wu NC, Liao FT, Cheng HM, Sung SH, Yang YC, Wang JJ.

BMC Pulm Med. 2017 Jul 26;17(1):105. doi: 10.1186/s12890-017-0448-9.


Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin.

Wright ZVF, Wu NC, Kadam RU, Wilson IA, Wolan DW.

Bioorg Med Chem Lett. 2017 Aug 15;27(16):3744-3748. doi: 10.1016/j.bmcl.2017.06.074. Epub 2017 Jun 28.


A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus.

Wu NC, Wilson IA.

J Mol Biol. 2017 Aug 18;429(17):2694-2709. doi: 10.1016/j.jmb.2017.06.015. Epub 2017 Jun 23. Review.


Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin.

Wu NC, Xie J, Zheng T, Nycholat CM, Grande G, Paulson JC, Lerner RA, Wilson IA.

Cell Host Microbe. 2017 Jun 14;21(6):742-753.e8. doi: 10.1016/j.chom.2017.05.011. Erratum in: Cell Host Microbe. 2017 Aug 9;22(2):247-248.


Living with a leaky skin: upregulation of ion transport proteins during sloughing.

Wu NC, Cramp RL, Franklin CE.

J Exp Biol. 2017 Jun 1;220(Pt 11):2026-2035. doi: 10.1242/jeb.151738.


In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity.

Wu NC, Grande G, Turner HL, Ward AB, Xie J, Lerner RA, Wilson IA.

Nat Commun. 2017 May 15;8:15371. doi: 10.1038/ncomms15371.


Correction: Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality.

Wu NC, Olson CA, Du Y, Le S, Tran K, Remenyi R, Gong D, Al-Mawsawi LQ, Qi H, Wu TT, Sun R.

PLoS Genet. 2017 Apr 25;13(4):e1006709. doi: 10.1371/journal.pgen.1006709. eCollection 2017 Apr.


A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure.

Lee JH, Andrabi R, Su CY, Yasmeen A, Julien JP, Kong L, Wu NC, McBride R, Sok D, Pauthner M, Cottrell CA, Nieusma T, Blattner C, Paulson JC, Klasse PJ, Wilson IA, Burton DR, Ward AB.

Immunity. 2017 Apr 18;46(4):690-702. doi: 10.1016/j.immuni.2017.03.017.


Immunochemical engineering of cell surfaces to generate virus resistance.

Xie J, Sok D, Wu NC, Zheng T, Zhang W, Burton DR, Lerner RA.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4655-4660. doi: 10.1073/pnas.1702764114. Epub 2017 Apr 10.


Systematic identification of anti-interferon function on hepatitis C virus genome reveals p7 as an immune evasion protein.

Qi H, Chu V, Wu NC, Chen Z, Truong S, Brar G, Su SY, Du Y, Arumugaswami V, Olson CA, Chen SH, Lin CY, Wu TT, Sun R.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2018-2023. doi: 10.1073/pnas.1614623114. Epub 2017 Feb 3.


Long Single-Molecule Reads Can Resolve the Complexity of the Influenza Virus Composed of Rare, Closely Related Mutant Variants.

Artyomenko A, Wu NC, Mangul S, Eskin E, Sun R, Zelikovsky A.

J Comput Biol. 2017 Jun;24(6):558-570. doi: 10.1089/cmb.2016.0146. Epub 2016 Nov 30.


Annotating Protein Functional Residues by Coupling High-Throughput Fitness Profile and Homologous-Structure Analysis.

Du Y, Wu NC, Jiang L, Zhang T, Gong D, Shu S, Wu TT, Sun R.

MBio. 2016 Nov 1;7(6). pii: e01801-16. doi: 10.1128/mBio.01801-16.


Adaptation in protein fitness landscapes is facilitated by indirect paths.

Wu NC, Dai L, Olson CA, Lloyd-Smith JO, Sun R.

Elife. 2016 Jul 8;5. pii: e16965. doi: 10.7554/eLife.16965.


A benchmark study on error-correction by read-pairing and tag-clustering in amplicon-based deep sequencing.

Zhang TH, Wu NC, Sun R.

BMC Genomics. 2016 Feb 12;17:108. doi: 10.1186/s12864-016-2388-9.


Coupling high-throughput genetics with phylogenetic information reveals an epistatic interaction on the influenza A virus M segment.

Wu NC, Du Y, Le S, Young AP, Zhang TH, Wang Y, Zhou J, Yoshizawa JM, Dong L, Li X, Wu TT, Sun R.

BMC Genomics. 2016 Jan 12;17:46. doi: 10.1186/s12864-015-2358-7.


Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling.

York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ.

Cell. 2015 Dec 17;163(7):1716-29. doi: 10.1016/j.cell.2015.11.045. Epub 2015 Dec 10.


High-throughput identification of protein mutant stability computed from a double mutant fitness landscape.

Wu NC, Olson CA, Sun R.

Protein Sci. 2016 Feb;25(2):530-9. doi: 10.1002/pro.2840. Epub 2015 Dec 8.


High-resolution genetic profile of viral genomes: why it matters.

Qi H, Wu NC, Du Y, Wu TT, Sun R.

Curr Opin Virol. 2015 Oct;14:62-70. doi: 10.1016/j.coviro.2015.08.005. Epub 2015 Sep 10. Review.


Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality.

Wu NC, Olson CA, Du Y, Le S, Tran K, Remenyi R, Gong D, Al-Mawsawi LQ, Qi H, Wu TT, Sun R.

PLoS Genet. 2015 Jul 1;11(7):e1005310. doi: 10.1371/journal.pgen.1005310. eCollection 2015 Jul. Erratum in: PLoS Genet. 2017 Apr 25;13(4):e1006709.


Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and fluorouracil-based treatment in Taiwan colorectal cancer.

Wu NC, Su SM, Lin TJ, Chin J, Hou CF, Yang JY, Liu WS, Chang LC.

Anticancer Drugs. 2015 Sep;26(8):888-93. doi: 10.1097/CAD.0000000000000261.


Morphology and burrowing energetics of semi-fossorial skinks (Liopholis spp.).

Wu NC, Alton LA, Clemente CJ, Kearney MR, White CR.

J Exp Biol. 2015 Aug;218(Pt 15):2416-26. doi: 10.1242/jeb.113803. Epub 2015 Jun 8.


High-throughput profiling of point mutations across the HIV-1 genome.

Al-Mawsawi LQ, Wu NC, Olson CA, Shi VC, Qi H, Zheng X, Wu TT, Sun R.

Retrovirology. 2014 Dec 19;11:124. doi: 10.1186/s12977-014-0124-6.


A comprehensive biophysical description of pairwise epistasis throughout an entire protein domain.

Olson CA, Wu NC, Sun R.

Curr Biol. 2014 Nov 17;24(22):2643-51. doi: 10.1016/j.cub.2014.09.072. Epub 2014 Oct 16.


A comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins.

Remenyi R, Qi H, Su SY, Chen Z, Wu NC, Arumugaswami V, Truong S, Chu V, Stokelman T, Lo HH, Olson CA, Wu TT, Chen SH, Lin CY, Sun R.

MBio. 2014 Sep 30;5(5):e01469-14. doi: 10.1128/mBio.01469-14.

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