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Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor.

Wu JY, Huang TW, Hsieh YT, Wang YF, Yen CC, Lee GL, Yeh CC, Peng YJ, Kuo YY, Wen HT, Lin HC, Hsiao CW, Wu KK, Kung HJ, Hsu YJ, Kuo CC.

Mol Cell. 2020 Jan 16;77(2):213-227.e5. doi: 10.1016/j.molcel.2019.10.023. Epub 2019 Nov 14.


Where you live matters: Regional differences in healthcare resource use for psoriasis in the United States.

Nguyen KB, Read C, Wu KK, Armstrong AW.

J Am Acad Dermatol. 2019 Oct 10. pii: S0190-9622(19)32896-8. doi: 10.1016/j.jaad.2019.10.014. [Epub ahead of print]


Tryptophan metabolite 5-methoxytryptophan ameliorates arterial denudation-induced intimal hyperplasia via opposing effects on vascular endothelial and smooth muscle cells.

Chen CH, Ho YC, Ho HH, Liang LY, Jiang WC, Lee GL, Lee JK, Hsu YJ, Kuo CC, Wu KK, Yet SF.

Aging (Albany NY). 2019 Oct 9;11(19):8604-8622. doi: 10.18632/aging.102350. Epub 2019 Oct 9.


Association between atopic dermatitis and conjunctivitis in adults: a population-based study in the United States.

Wu KK, Borba AJ, Deng PH, Armstrong AW.

J Dermatolog Treat. 2019 Sep 2:1-5. doi: 10.1080/09546634.2019.1659480. [Epub ahead of print]


Does location matter? Geographic variations in healthcare resource use for atopic dermatitis in the United States.

Wu KK, Nguyen KB, Sandhu JK, Armstrong AW.

J Dermatolog Treat. 2019 Sep 2:1-7. doi: 10.1080/09546634.2019.1656796. [Epub ahead of print]


The Hong Kong Survey on the Epidemiology of Trauma Exposure and Posttraumatic Stress Disorder.

Wu KK, Leung PWL, Wong CSM, Yu PMW, Luk BTC, Cheng JPK, Wong RMF, Wong PPS, Lui JCC, Ngan JCF, Leung FLT, Lam LCW.

J Trauma Stress. 2019 Oct;32(5):664-676. doi: 10.1002/jts.22430. Epub 2019 Aug 8.


Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.

Stortz JA, Hollen MK, Nacionales DC, Horiguchi H, Ungaro R, Dirain ML, Wang Z, Wu Q, Wu KK, Kumar A, Foster TC, Stewart BD, Ross JA, Segal M, Bihorac A, Brakenridge S, Moore FA, Wohlgemuth SE, Leeuwenburgh C, Mohr AM, Moldawer LL, Efron PA.

Crit Care Med. 2019 Nov;47(11):e919-e929. doi: 10.1097/CCM.0000000000003926.


[Effects of stabilized N fertilizer combined with straw returning on rice yield and emission of N2O and CH4 in a paddy field].

Wu KK, Zhang LL, Song YC, Li YH, Gong P, Wu ZJ, Yang LJ, Li DP.

Ying Yong Sheng Tai Xue Bao. 2019 Apr;30(4):1287-1294. doi: 10.13287/j.1001-9332.201904.026. Chinese.


Problematic Strength of the Association Between Atopic Dermatitis and Suicidality-Reply.

Wu KK, Bui TL, Armstrong AW.

JAMA Dermatol. 2019 May 1;155(5):638. doi: 10.1001/jamadermatol.2019.0124. No abstract available.


Risk of herpes zoster with IL-17 inhibitor therapy for psoriasis and other inflammatory conditions.

Wu KK, Lee MP, Lee EB, Wu JJ.

J Dermatolog Treat. 2019 Mar 22:1-7. doi: 10.1080/09546634.2019.1597246. [Epub ahead of print]


Psoriasis risk factors and triggers.

Lee EB, Wu KK, Lee MP, Bhutani T, Wu JJ.

Cutis. 2018 Nov;102(5S):18-20. Review.


Association Between Atopic Dermatitis and Suicidality: A Systematic Review and Meta-analysis.

Sandhu JK, Wu KK, Bui TL, Armstrong AW.

JAMA Dermatol. 2019 Feb 1;155(2):178-187. doi: 10.1001/jamadermatol.2018.4566.


[A multicenter clinical study on 1 138 cases of invasive pneumococcal disease in children from 2012 to 2017].

Zhu L, Li WH, Wang XH, Tan K, Fang QF, Zhu QX, Wu KK, Yang QZ, Lin AW, Deng HL, Bi J, Liu J, Zhao SY, Liu Y, Jing SJ, Wang YM, Li LM, Zhao Q, Yao KH, Wang X, Jia L, Wang F, Deng JK, Sun J, Zhu CH, Zhou K, Liang J, Nie XZ, Cao SC, Wang DM, Li SJ, Chen XX, Li J, Wang Y, Ye L, Zhang YH, Dong F, Li Z, Yang YH, Liu G.

Zhonghua Er Ke Za Zhi. 2018 Dec 2;56(12):915-922. doi: 10.3760/cma.j.issn.0578-1310.2018.12.006. Chinese.


The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Aging-Related Metabolic Complications by Induction of Lipodystrophy.

Liu Z, Jin L, Yang JK, Wang B, Wu KKL, Hallenborg P, Xu A, Cheng KKY.

Diabetes. 2018 Nov;67(11):2397-2409. doi: 10.2337/db18-0684. Epub 2018 Aug 21.


CXCR4 Antagonist Reduced the Incidence of Acute Rejection and Controlled Cardiac Allograft Vasculopathy in a Swine Heart Transplant Model Receiving a Mycophenolate-based Immunosuppressive Regimen.

Hsu WT, Lin CH, Jui HY, Tseng YH, Shun CT, Hsu MC, Wu KK, Lee CM.

Transplantation. 2018 Dec;102(12):2002-2011. doi: 10.1097/TP.0000000000002404.


Massive pericardial effusion: A rare and easily missed finding in myocardial perfusion scintigraphy.

Wu KK, Kung BT, Au Yong TK.

World J Nucl Med. 2018 Jul-Sep;17(3):198-200. doi: 10.4103/wjnm.WJNM_39_17.


Suicidality among psoriasis patients: a critical evidence synthesis.

Wu KK, Armstrong AW.

G Ital Dermatol Venereol. 2019 Feb;154(1):56-63. doi: 10.23736/S0392-0488.18.06112-6. Epub 2018 Jul 18. Review.


Posttraumatic Stress after Treatment in an Intensive Care Unit.

Wu KK, Cho VW, Chow FL, Tsang AP, Tse DM.

East Asian Arch Psychiatry. 2018 Jun;28(2):39-44.


Restoration of hydroxyindole O-methyltransferase levels in human cancer cells induces a tryptophan-metabolic switch and attenuates cancer progression.

Chen HL, Yuan CY, Cheng HH, Chang TC, Huang SK, Kuo CC, Wu KK.

J Biol Chem. 2018 Jul 13;293(28):11131-11142. doi: 10.1074/jbc.RA117.000597. Epub 2018 May 24.


The OCT-ORION Study: A Randomized Optical Coherence Tomography Study Comparing Resolute Integrity to Biomatrix Drug-Eluting Stent on the Degree of Early Stent Healing and Late Lumen Loss.

Lee SWL, Tam FCC, Lam SCC, Kong SL, Shea CP, Chan KKW, Wong MKL, Chan MPH, Wong AYT, Yung ASY, Lam YM, Zhang LW, Wu KKY, Mintz GS, Maehara A.

Circ Cardiovasc Interv. 2018 Apr;11(4):e006034. doi: 10.1161/CIRCINTERVENTIONS.117.006034.


Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system.

Wang B, Li A, Li X, Ho PW, Wu D, Wang X, Liu Z, Wu KK, Yau SS, Xu A, Cheng KK.

EMBO Rep. 2018 Apr;19(4). pii: e44977. doi: 10.15252/embr.201744977. Epub 2018 Feb 21.


Epidermal growth factor receptor-targeted immune magnetic liposomes capture circulating colorectal tumor cells efficiently.

Kuai JH, Wang Q, Zhang AJ, Zhang JY, Chen ZF, Wu KK, Hu XZ.

World J Gastroenterol. 2018 Jan 21;24(3):351-359. doi: 10.3748/wjg.v24.i3.351.


Long-term caregiving is associated with impaired cardiovagal baroreflex.

Wu KK, Bos T, Mausbach BT, Milic M, Ziegler MG, von Känel R, Allison MA, Dimsdale JE, Mills PJ, Ancoli-Israel S, Patterson TL, Grant I.

J Psychosom Res. 2017 Dec;103:29-33. doi: 10.1016/j.jpsychores.2017.10.001. Epub 2017 Oct 5.


Cytokine-induced autophagy promotes long-term VCAM-1 but not ICAM-1 expression by degrading late-phase IκBα.

Chu LY, Hsueh YC, Cheng HL, Wu KK.

Sci Rep. 2017 Sep 29;7(1):12472. doi: 10.1038/s41598-017-12641-8.


5-methoxytryptophan protects MSCs from stress induced premature senescence by upregulating FoxO3a and mTOR.

Chang TC, Hsu MF, Shih CY, Wu KK.

Sci Rep. 2017 Sep 11;7(1):11133. doi: 10.1038/s41598-017-11077-4.


Reply to letter: "5-Methoxytryptophan: A promising early marker for predicting post-myocardial infarction heart failure".

Lin YH, Kuo CC, Wu KK.

Int J Cardiol. 2017 May 1;234:100. doi: 10.1016/j.ijcard.2016.12.154. Epub 2016 Dec 26. No abstract available.


APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes.

Jiang X, Zhou Y, Wu KK, Chen Z, Xu A, Cheng KK.

Diabetologia. 2017 Mar;60(3):464-474. doi: 10.1007/s00125-016-4185-z. Epub 2016 Dec 23.


Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials.

Wang LT, Ting CH, Yen ML, Liu KJ, Sytwu HK, Wu KK, Yen BL.

J Biomed Sci. 2016 Nov 4;23(1):76. Review.


5-methoxytryptophan is a potential marker for post-myocardial infarction heart failure - a preliminary approach to clinical utility.

Lin YH, Kuo CC, Lee CM, Chou CH, Chen YH, Yeh JF, Huang CC, Hung CS, Liu LD, Ho YL, Wu KK.

Int J Cardiol. 2016 Nov 1;222:895-900. doi: 10.1016/j.ijcard.2016.07.293. Epub 2016 Aug 2.


Evaluation of Early Healing Profile and Neointimal Transformation Over 24 Months Using Longitudinal Sequential Optical Coherence Tomography Assessments and 3-Year Clinical Results of the New Dual-Therapy Endothelial Progenitor Cell Capturing Sirolimus-Eluting Combo Stent: The EGO-Combo Study.

Lee SW, Lam SC, Tam FC, Chan KK, Shea CP, Kong SL, Wong AY, Yung A, Zhang LW, Tse HF, Wu KK, Chan R, Haude M, Mehran R, Mintz GS, Maehara A.

Circ Cardiovasc Interv. 2016 Jul;9(7). pii: e003469. doi: 10.1161/CIRCINTERVENTIONS.115.003469.


Human pluripotent stem cell (PSC)-derived mesenchymal stem cells (MSCs) show potent neurogenic capacity which is enhanced with cytoskeletal rearrangement.

Peng KY, Lee YW, Hsu PJ, Wang HH, Wang Y, Liou JY, Hsu SH, Wu KK, Yen BL.

Oncotarget. 2016 Jul 12;7(28):43949-43959. doi: 10.18632/oncotarget.9947.


Endothelium-Derived 5-Methoxytryptophan Is a Circulating Anti-Inflammatory Molecule That Blocks Systemic Inflammation.

Wang YF, Hsu YJ, Wu HF, Lee GL, Yang YS, Wu JY, Yet SF, Wu KK, Kuo CC.

Circ Res. 2016 Jul 8;119(2):222-36. doi: 10.1161/CIRCRESAHA.116.308559. Epub 2016 May 5. Erratum in: Circ Res. 2016 Sep 2;119(6):e108.


A Novel Protective Function of 5-Methoxytryptophan in Vascular Injury.

Ho YC, Wu ML, Su CH, Chen CH, Ho HH, Lee GL, Lin WS, Lin WY, Hsu YJ, Kuo CC, Wu KK, Yet SF.

Sci Rep. 2016 May 5;6:25374. doi: 10.1038/srep25374.


Inhibition of cancer cell epithelial mesenchymal transition by normal fibroblasts via production of 5-methoxytryptophan.

Cheng HH, Chu LY, Chiang LY, Chen HL, Kuo CC, Wu KK.

Oncotarget. 2016 May 24;7(21):31243-56. doi: 10.18632/oncotarget.9111.


Posttraumatic Growth After Motor Vehicle Crashes.

Wu KK, Leung PW, Cho VW, Law LS.

J Clin Psychol Med Settings. 2016 Jun;23(2):181-91. doi: 10.1007/s10880-016-9456-9.


Presenting hydrothorax predicts failure of needle aspiration in primary spontaneous pneumothorax.

Wu KK, Lui CT, Ho CL, Tsui KL, Fung HT.

Am J Emerg Med. 2016 Jun;34(6):1075-9. doi: 10.1016/j.ajem.2016.03.023. Epub 2016 Mar 11.


Endothelium-Derived 5-Methoxytryptophan Protects Endothelial Barrier Function by Blocking p38 MAPK Activation.

Chu LY, Wang YF, Cheng HH, Kuo CC, Wu KK.

PLoS One. 2016 Mar 22;11(3):e0152166. doi: 10.1371/journal.pone.0152166. eCollection 2016.


Rho-associated kinase inhibitors promote the cardiac differentiation of embryonic and induced pluripotent stem cells.

Cheng YT, Yeih DF, Liang SM, Chien CY, Yu YL, Ko BS, Jan YJ, Kuo CC, Sung LY, Shyue SK, Chen MF, Yet SF, Wu KK, Liou JY.

Int J Cardiol. 2015 Dec 15;201:441-8. doi: 10.1016/j.ijcard.2015.08.118. Epub 2015 Aug 15.


Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects.

Song J, Chen F, Campos M, Bolgiano D, Houck K, Chambless LE, Wu KK, Folsom AR, Couper D, Boerwinkle E, Dong JF.

PLoS One. 2015 Aug 5;10(8):e0132626. doi: 10.1371/journal.pone.0132626. eCollection 2015.


High glucose induces bone marrow-derived mesenchymal stem cell senescence by upregulating autophagy.

Chang TC, Hsu MF, Wu KK.

PLoS One. 2015 May 11;10(5):e0126537. doi: 10.1371/journal.pone.0126537. eCollection 2015.


Prostacyclin protects vascular integrity via PPAR/14-3-3 pathway.

Chu LY, Liou JY, Wu KK.

Prostaglandins Other Lipid Mediat. 2015 Apr-Jun;118-119:19-27. doi: 10.1016/j.prostaglandins.2015.04.006. Epub 2015 Apr 21. Review.


PTSD and loss: preliminary findings from a territory-wide epidemiology study in Hong Kong.

Wu KK.

Eur J Psychotraumatol. 2014 Dec 9;5:26517. doi: 10.3402/ejpt.v5.26517. eCollection 2014.


The N-terminal portion of autoinhibitory element modulates human endothelial nitric-oxide synthase activity through coordinated controls of phosphorylation at Thr495 and Ser1177.

Wu PR, Chen BR, Hsieh CC, Lin WC, Wu KK, Hwu Y, Chen PF.

Biosci Rep. 2014 Aug 6;34(4). pii: e00129. doi: 10.1042/BSR20140079.


CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction.

Hsu WT, Jui HY, Huang YH, Su MY, Wu YW, Tseng WY, Hsu MC, Chiang BL, Wu KK, Lee CM.

Cell Transplant. 2015;24(7):1313-28. doi: 10.3727/096368914X681739. Epub 2014 May 12.


5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis.

Wu KK, Cheng HH, Chang TC.

J Biomed Sci. 2014 Mar 3;21:17. doi: 10.1186/1423-0127-21-17. Review.


Quiescent and proliferative fibroblasts exhibit differential p300 HAT activation through control of 5-methoxytryptophan production.

Cheng HH, Wang KH, Chu LY, Chang TC, Kuo CC, Wu KK.

PLoS One. 2014 Feb 11;9(2):e88507. doi: 10.1371/journal.pone.0088507. eCollection 2014.


Possible race and gender divergence in association of genetic variations with plasma von Willebrand factor: a study of ARIC and 1000 genome cohorts.

Zhou Z, Yu F, Buchanan A, Fu Y, Campos M, Wu KK, Chambless LE, Folsom AR, Boerwinkle E, Dong JF.

PLoS One. 2014 Jan 17;9(1):e84810. doi: 10.1371/journal.pone.0084810. eCollection 2014.


Prostaglandin E₂ promotes post-infarction cardiomyocyte replenishment by endogenous stem cells.

Hsueh YC, Wu JM, Yu CK, Wu KK, Hsieh PC.

EMBO Mol Med. 2014 Apr;6(4):496-503. doi: 10.1002/emmm.201303687. Epub 2014 Jan 21.


Prostacyclin and PPARα agonists control vascular smooth muscle cell apoptosis and phenotypic switch through distinct 14-3-3 isoforms.

Chen YC, Chu LY, Yang SF, Chen HL, Yet SF, Wu KK.

PLoS One. 2013 Jul 3;8(7):e69702. doi: 10.1371/journal.pone.0069702. Print 2013.

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