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Items: 1 to 50 of 80

1.

The Role of Metabotropic Glutamate Receptor 1 Dependent Signaling in Glioma Viability.

Dalley CB, Wroblewska B, Wolfe BB, Wroblewski JT.

J Pharmacol Exp Ther. 2018 Oct;367(1):59-70. doi: 10.1124/jpet.118.250159. Epub 2018 Jul 27.

PMID:
30054311
2.

Atypical signaling of metabotropic glutamate receptor 1 in human melanoma cells.

Gelb T, Pshenichkin S, Hathaway HA, Grajkowska E, Dalley CB, Wolfe BB, Wroblewski JT.

Biochem Pharmacol. 2015 Nov 1;98(1):182-9. doi: 10.1016/j.bcp.2015.08.091. Epub 2015 Aug 17.

PMID:
26291396
3.

Chloride is an Agonist of Group II and III Metabotropic Glutamate Receptors.

DiRaddo JO, Miller EJ, Bowman-Dalley C, Wroblewska B, Javidnia M, Grajkowska E, Wolfe BB, Liotta DC, Wroblewski JT.

Mol Pharmacol. 2015 Sep;88(3):450-9. doi: 10.1124/mol.114.096420. Epub 2015 Jun 18.

PMID:
26089372
4.

Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism.

Hathaway HA, Pshenichkin S, Grajkowska E, Gelb T, Emery AC, Wolfe BB, Wroblewski JT.

Neuropharmacology. 2015 Jun;93:199-208. doi: 10.1016/j.neuropharm.2015.02.007. Epub 2015 Feb 17.

5.

Triple threat treatment: Exploiting the dependence receptor properties of metabotropic glutamate receptor 1 against melanoma.

Gelb T, Hathaway HA, Wroblewski JT.

Mol Cell Oncol. 2014 Nov 11;1(4):e969163. doi: 10.4161/23723548.2014.969163. eCollection 2014 Oct-Dec.

6.

Metabotropic glutamate receptor 1 acts as a dependence receptor creating a requirement for glutamate to sustain the viability and growth of human melanomas.

Gelb T, Pshenichkin S, Rodriguez OC, Hathaway HA, Grajkowska E, DiRaddo JO, Wroblewska B, Yasuda RP, Albanese C, Wolfe BB, Wroblewski JT.

Oncogene. 2015 May 21;34(21):2711-20. doi: 10.1038/onc.2014.231. Epub 2014 Jul 28.

7.

A real-time method for measuring cAMP production modulated by Gαi/o-coupled metabotropic glutamate receptors.

DiRaddo JO, Miller EJ, Hathaway HA, Grajkowska E, Wroblewska B, Wolfe BB, Liotta DC, Wroblewski JT.

J Pharmacol Exp Ther. 2014 Jun;349(3):373-82. doi: 10.1124/jpet.113.211532. Epub 2014 Mar 21.

PMID:
24659805
8.

Two newly identified exons in human GRM1 express a novel splice variant of metabotropic glutamate 1 receptor.

DiRaddo JO, Pshenichkin S, Gelb T, Wroblewski JT.

Gene. 2013 May 1;519(2):367-73. doi: 10.1016/j.gene.2013.02.009. Epub 2013 Feb 24.

9.

Ligand bias at metabotropic glutamate 1a receptors: molecular determinants that distinguish β-arrestin-mediated from G protein-mediated signaling.

Emery AC, DiRaddo JO, Miller E, Hathaway HA, Pshenichkin S, Takoudjou GR, Grajkowska E, Yasuda RP, Wolfe BB, Wroblewski JT.

Mol Pharmacol. 2012 Aug;82(2):291-301. doi: 10.1124/mol.112.078444. Epub 2012 May 14.

10.

Heat shock enhances CMV-IE promoter-driven metabotropic glutamate receptor expression and toxicity in transfected cells.

Pshenichkin S, Surin A, Surina E, Klauzińska M, Grajkowska E, Luchenko V, Dolińska M, Wroblewska B, Wroblewski JT.

Neuropharmacology. 2011 Jun;60(7-8):1292-300. doi: 10.1016/j.neuropharm.2011.01.010. Epub 2011 Jan 15.

11.

Metabotropic glutamate receptors: from the workbench to the bedside.

Nicoletti F, Bockaert J, Collingridge GL, Conn PJ, Ferraguti F, Schoepp DD, Wroblewski JT, Pin JP.

Neuropharmacology. 2011 Jun;60(7-8):1017-41. doi: 10.1016/j.neuropharm.2010.10.022. Epub 2010 Oct 29. Review.

12.

The protective signaling of metabotropic glutamate receptor 1 Is mediated by sustained, beta-arrestin-1-dependent ERK phosphorylation.

Emery AC, Pshenichkin S, Takoudjou GR, Grajkowska E, Wolfe BB, Wroblewski JT.

J Biol Chem. 2010 Aug 20;285(34):26041-8. doi: 10.1074/jbc.M110.139899. Epub 2010 Jun 21.

13.

Dual neurotoxic and neuroprotective role of metabotropic glutamate receptor 1 in conditions of trophic deprivation - possible role as a dependence receptor.

Pshenichkin S, Dolińska M, Klauzińska M, Luchenko V, Grajkowska E, Wroblewski JT.

Neuropharmacology. 2008 Sep;55(4):500-8. doi: 10.1016/j.neuropharm.2008.06.039. Epub 2008 Jun 27.

14.

Cyclothiazide selectively inhibits mGluR1 receptors interacting with a common allosteric site for non-competitive antagonists.

Surin A, Pshenichkin S, Grajkowska E, Surina E, Wroblewski JT.

Neuropharmacology. 2007 Mar;52(3):744-54. Epub 2006 Nov 7.

15.

Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications.

Iso Y, Grajkowska E, Wroblewski JT, Davis J, Goeders NE, Johnson KM, Sanker S, Roth BL, Tueckmantel W, Kozikowski AP.

J Med Chem. 2006 Feb 9;49(3):1080-100.

PMID:
16451073
16.

Neuroprotective effects of the agonist of metabotropic glutamate receptors ABHxD-I in two animal models of cerebral ischaemia.

Makarewicz D, Gadamski R, Ziembowicz A, Kozikowski AP, Wroblewski JT, Lazarewicz JW.

Resuscitation. 2006 Jan;68(1):119-26. Epub 2005 Dec 1.

PMID:
16325990
17.

Functionalization at position 3 of the phenyl ring of the potent mGluR5 noncompetitive antagonists MPEP.

Alagille D, Baldwin RM, Roth BL, Wroblewski JT, Grajkowska E, Tamagnan GD.

Bioorg Med Chem Lett. 2005 Feb 15;15(4):945-9.

PMID:
15686891
18.

Synthesis and receptor assay of aromatic-ethynyl-aromatic derivatives with potent mGluR5 antagonist activity.

Alagille D, Baldwin RM, Roth BL, Wroblewski JT, Grajkowska E, Tamagnan GD.

Bioorg Med Chem. 2005 Jan 3;13(1):197-209.

PMID:
15582465
19.

NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR.

Olszewski RT, Bukhari N, Zhou J, Kozikowski AP, Wroblewski JT, Shamimi-Noori S, Wroblewska B, Bzdega T, Vicini S, Barton FB, Neale JH.

J Neurochem. 2004 May;89(4):876-85.

20.

Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents.

Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH.

J Med Chem. 2004 Mar 25;47(7):1729-38.

PMID:
15027864
21.

L-homocysteine sulfinic acid and L-homocysteic acid stimulate phosphoinositide hydrolysis in rat cortical neurons.

Shi Q, Hufeisen SJ, Wroblewski JT, Nadeau JH, Roth BL.

Ann N Y Acad Sci. 2003 Nov;1003:461-3. No abstract available.

PMID:
14684489
22.

L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.

Shi Q, Savage JE, Hufeisen SJ, Rauser L, Grajkowska E, Ernsberger P, Wroblewski JT, Nadeau JH, Roth BL.

J Pharmacol Exp Ther. 2003 Apr;305(1):131-42.

PMID:
12649361
23.

Molecular modeling of the interactions of glutamate carboxypeptidase II with its potent NAAG-based inhibitors.

Rong SB, Zhang J, Neale JH, Wroblewski JT, Wang S, Kozikowski AP.

J Med Chem. 2002 Sep 12;45(19):4140-52.

PMID:
12213057
24.

Design of remarkably simple, yet potent urea-based inhibitors of glutamate carboxypeptidase II (NAALADase).

Kozikowski AP, Nan F, Conti P, Zhang J, Ramadan E, Bzdega T, Wroblewska B, Neale JH, Pshenichkin S, Wroblewski JT.

J Med Chem. 2001 Feb 1;44(3):298-301. No abstract available.

PMID:
11462970
25.

Synthesis of N(1)-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors.

Mukhopadhyaya JK, Kozikowski AP, Grajkowska E, Pshenichkin S, Wroblewski JT.

Bioorg Med Chem Lett. 2001 Jul 23;11(14):1919-24.

PMID:
11459661
26.

Dual function glutamate-related ligands: discovery of a novel, potent inhibitor of glutamate carboxypeptidase II possessing mGluR3 agonist activity.

Nan F, Bzdega T, Pshenichkin S, Wroblewski JT, Wroblewska B, Neale JH, Kozikowski AP.

J Med Chem. 2000 Mar 9;43(5):772-4. No abstract available.

PMID:
10715144
27.

1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties.

Kozikowski AP, Araldi GL, Tückmantel W, Pshenichkin S, Surina E, Wroblewski JT.

Bioorg Med Chem Lett. 1999 Jun 21;9(12):1721-6.

PMID:
10397508
28.

Synthesis and biological evaluation of two analogues of (S)-alpha-methyl-3-carboxyphenylalanine.

Ma D, Ma Z, Kozikowski AP, Pshenichkin S, Wroblewski JT.

Bioorg Med Chem Lett. 1998 Sep 22;8(18):2447-50.

PMID:
9873559
29.

alpha-substituted quisqualic acid analogs: new metabotropic glutamate receptor group II selective antagonists.

Kozikowski AP, Steensma D, Varasi M, Pshenichkin S, Surina E, Wroblewski JT.

Bioorg Med Chem Lett. 1998 Mar 3;8(5):447-52.

PMID:
9871596
30.

Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells.

Bruno V, Wroblewska B, Wroblewski JT, Fiore L, Nicoletti F.

Neuroscience. 1998 Aug;85(3):751-7.

PMID:
9639269
31.

Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.

Kozikowski AP, Steensma D, Araldi GL, Tückmantel W, Wang S, Pshenichkin S, Surina E, Wroblewski JT.

J Med Chem. 1998 May 7;41(10):1641-50.

PMID:
9572889
32.

Apoptosis induced by hyperthermia and verapamil in vitro in a human colon cancer cell line.

Shchepotin IB, Soldatenkov V, Wroblewski JT, Surin A, Shabahang M, Buras RR, Nauta RJ, Pulyaeva H, Evans SR.

Int J Hyperthermia. 1997 Sep-Oct;13(5):547-57.

PMID:
9354939
33.

N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells.

Wroblewska B, Wroblewski JT, Pshenichkin S, Surin A, Sullivan SE, Neale JH.

J Neurochem. 1997 Jul;69(1):174-81.

34.

Concanavalin A enhances quisqualate-induced calcium influx in cerebellar granule cells in culture.

Danysz W, Raulli R, Wroblewski JT.

Acta Neurobiol Exp (Wars). 1996;56(3):649-56.

35.
36.
37.

Acute and long-term inhibition of agonist-stimulated phosphoinositide hydrolysis by pulse treatment of cerebellar granule cells with TPA.

Paulsen RE, Raulli R, Grayson DR, Wroblewski JT.

Mol Chem Neuropathol. 1994 May;22(1):67-79.

PMID:
7916769
38.

Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate.

Kiedrowski L, Wroblewski JT, Costa E.

Mol Pharmacol. 1994 May;45(5):1050-4.

PMID:
7910657
39.
40.

Glutamate impairs neuronal calcium extrusion while reducing sodium gradient.

Kiedrowski L, Brooker G, Costa E, Wroblewski JT.

Neuron. 1994 Feb;12(2):295-300.

PMID:
7906528
41.

Gangliosides in the protection against glutamate excitotoxicity.

Costa E, Armstrong DM, Guidotti A, Kharlamov A, Kiedrowski L, Manev H, Polo A, Wroblewski JT.

Prog Brain Res. 1994;101:357-73. Review. No abstract available.

PMID:
8029464
42.

Synthesis and metabotropic receptor activity of the novel rigidified glutamate analogues (+)- and (-)-trans-azetidine-2,4-dicarboxylic acid and their N-methyl derivatives.

Kozikowski AP, Tückmantel W, Liao Y, Manev H, Ikonomovic S, Wroblewski JT.

J Med Chem. 1993 Sep 3;36(18):2706-8. No abstract available.

PMID:
8410984
43.
44.

The envelope glycoprotein of HIV-1 alters NMDA receptor function.

Sweetnam PM, Saab OH, Wroblewski JT, Price CH, Karbon EW, Ferkany JW.

Eur J Neurosci. 1993 Mar 1;5(3):276-83.

PMID:
7726990
45.

Ganglioside GM1 and its semisynthetic lysogangliosides reduce glutamate neurotoxicity by a novel mechanism.

Costa E, Armstrong D, Guidotti A, Kharlamov A, Kiedrowski L, Wroblewski JT.

Adv Exp Med Biol. 1993;341:129-41. Review. No abstract available.

PMID:
7906915
46.
47.

In vitro interaction between cerebellar astrocytes and granule cells: a putative role for nitric oxide.

Kiedrowski L, Costa E, Wroblewski JT.

Neurosci Lett. 1992 Jan 20;135(1):59-61.

PMID:
1371859
48.

NMDA receptor-mediated arachidonic acid release in neurons: role in signal transduction and pathological aspects.

Lazarewicz JW, Salinska E, Wroblewski JT.

Adv Exp Med Biol. 1992;318:73-89.

PMID:
1386178
49.

Glutamate receptor agonists stimulate nitric oxide synthase in primary cultures of cerebellar granule cells.

Kiedrowski L, Costa E, Wroblewski JT.

J Neurochem. 1992 Jan;58(1):335-41.

PMID:
1370078
50.

Inhibition of glutamate-induced cell death by sodium nitroprusside is not mediated by nitric oxide.

Kiedrowski L, Manev H, Costa E, Wroblewski JT.

Neuropharmacology. 1991 Nov;30(11):1241-3.

PMID:
1685560

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