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Muscle xenografts reproduce key molecular features of facioscapulohumeral muscular dystrophy.

Mueller AL, O'Neill A, Jones TI, Llach A, Rojas LA, Sakellariou P, Stadler G, Wright WE, Eyerman D, Jones PL, Bloch RJ.

Exp Neurol. 2019 Oct;320:113011. doi: 10.1016/j.expneurol.2019.113011. Epub 2019 Jul 12.


Catalysis-dependent inactivation of human telomerase and its reactivation by intracellular telomerase-activating factors (iTAFs).

Sayed ME, Cheng A, Yadav GP, Ludlow AT, Shay JW, Wright WE, Jiang QX.

J Biol Chem. 2019 Jul 26;294(30):11579-11596. doi: 10.1074/jbc.RA118.007234. Epub 2019 Jun 11.


Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52.

Min J, Wright WE, Shay JW.

Genes Dev. 2019 Jul 1;33(13-14):814-827. doi: 10.1101/gad.324905.119. Epub 2019 Jun 6.


2D gel electrophoresis reveals dynamics of t-loop formation during the cell cycle and t-loop in maintenance regulated by heterochromatin state.

Zhang Z, Zhang T, Ge Y, Tang M, Ma W, Zhang Q, Gong S, Wright WE, Shay J, Liu H, Zhao Y.

J Biol Chem. 2019 Apr 19;294(16):6645-6656. doi: 10.1074/jbc.RA119.007677. Epub 2019 Feb 28.


Telomeres and telomerase: three decades of progress.

Shay JW, Wright WE.

Nat Rev Genet. 2019 May;20(5):299-309. doi: 10.1038/s41576-019-0099-1. Review.


NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells.

Sayed ME, Yuan L, Robin JD, Tedone E, Batten K, Dahlson N, Wright WE, Shay JW, Ludlow AT.

Oncogene. 2019 Apr;38(16):2937-2952. doi: 10.1038/s41388-018-0639-8. Epub 2018 Dec 19.


Analysis of Keloid Response to 5-Fluorouracil Treatment and Long-Term Prevention of Keloid Recurrence.

LaRanger R, Karimpour-Fard A, Costa C, Mathes D, Wright WE, Chong T.

Plast Reconstr Surg. 2019 Feb;143(2):490-494. doi: 10.1097/PRS.0000000000005257.


Telomere length and telomerase activity in T cells are biomarkers of high-performing centenarians.

Tedone E, Huang E, O'Hara R, Batten K, Ludlow AT, Lai TP, Arosio B, Mari D, Wright WE, Shay JW.

Aging Cell. 2019 Feb;18(1):e12859. doi: 10.1111/acel.12859. Epub 2018 Nov 28.


NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer.

Ludlow AT, Wong MS, Robin JD, Batten K, Yuan L, Lai TP, Dahlson N, Zhang L, Mender I, Tedone E, Sayed ME, Wright WE, Shay JW.

Nat Commun. 2018 Aug 6;9(1):3112. doi: 10.1038/s41467-018-05582-x.


Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance.

Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, Du W, Wu LF, Altschuler SJ, Brekken R, Martinez ED, Minna JD, Wright WE, Shay JW.

Neoplasia. 2018 Aug;20(8):826-837. doi: 10.1016/j.neo.2018.06.002. Epub 2018 Jul 6.


Disentangling seasonal and interannual legacies from inferred patterns of forest water and carbon cycling using tree-ring stable isotopes.

Szejner P, Wright WE, Belmecheri S, Meko D, Leavitt SW, Ehleringer JR, Monson RK.

Glob Chang Biol. 2018 Nov;24(11):5332-5347. doi: 10.1111/gcb.14395. Epub 2018 Aug 1.


Carbon and oxygen isotope fractionations in tree rings reveal interactions between cambial phenology and seasonal climate.

Belmecheri S, Wright WE, Szejner P, Morino KA, Monson RK.

Plant Cell Environ. 2018 Dec;41(12):2758-2772. doi: 10.1111/pce.13401. Epub 2018 Aug 31.


Truncated Adenomatous Polyposis Coli Mutation Induces Asef-Activated Golgi Fragmentation.

Kim SB, Zhang L, Yoon J, Lee J, Min J, Li W, Grishin NV, Moon YA, Wright WE, Shay JW.

Mol Cell Biol. 2018 Aug 15;38(17). pii: e00135-18. doi: 10.1128/MCB.00135-18. Print 2018 Sep 1.


Finding the seasons in tree ring stable isotope ratios.

Monson RK, Szejner P, Belmecheri S, Morino KA, Wright WE.

Am J Bot. 2018 May;105(5):819-821. doi: 10.1002/ajb2.1083. Epub 2018 May 18. No abstract available.


ddTRAP: A Method for Sensitive and Precise Quantification of Telomerase Activity.

Ludlow AT, Shelton D, Wright WE, Shay JW.

Methods Mol Biol. 2018;1768:513-529. doi: 10.1007/978-1-4939-7778-9_29.


Comparison of telomere length measurement methods.

Lai TP, Wright WE, Shay JW.

Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741). pii: 20160451. doi: 10.1098/rstb.2016.0451. Review.


A method for measuring the distribution of the shortest telomeres in cells and tissues.

Lai TP, Zhang N, Noh J, Mender I, Tedone E, Huang E, Wright WE, Danuser G, Shay JW.

Nat Commun. 2017 Nov 7;8(1):1356. doi: 10.1038/s41467-017-01291-z.


Differential KrasV12 protein levels control a switch regulating lung cancer cell morphology and motility.

Schäfer C, Mohan A, Burford W, Driscoll MK, Ludlow AT, Wright WE, Shay JW, Danuser G.

Converg Sci Phys Oncol. 2016 Sep;2(3):035004. doi: 10.1088/2057-1739/2/3/035004. Epub 2016 Sep 20.


Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes.

Min J, Wright WE, Shay JW.

Mol Cell Biol. 2017 Sep 26;37(20). pii: e00226-17. doi: 10.1128/MCB.00226-17. Print 2017 Oct 15.


The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation.

Huang EE, Tedone E, O'Hara R, Cornelius C, Lai TP, Ludlow A, Wright WE, Shay JW.

Sci Rep. 2017 Jul 28;7(1):6785. doi: 10.1038/s41598-017-05174-7.


Reconstituting Mouse Lungs with Conditionally Reprogrammed Human Bronchial Epithelial Cells.

LaRanger R, Peters-Hall JR, Coquelin M, Alabi BR, Chen CT, Wright WE, Shay JW.

Tissue Eng Part A. 2018 Apr;24(7-8):559-568. doi: 10.1089/ten.TEA.2017.0114. Epub 2017 Sep 25.


Telomere Terminal G/C Strand Synthesis: Measuring Telomerase Action and C-Rich Fill-In.

Zhao Y, Shay JW, Wright WE.

Methods Mol Biol. 2017;1587:71-82. doi: 10.1007/978-1-4939-6892-3_7.


Telomere G-Rich Overhang Length Measurement: DSN Method.

Zhao Y, Shay JW, Wright WE.

Methods Mol Biol. 2017;1587:55-62. doi: 10.1007/978-1-4939-6892-3_5.


Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands.

Min J, Wright WE, Shay JW.

Nucleic Acids Res. 2017 Mar 17;45(5):2615-2628. doi: 10.1093/nar/gkw1295.


Regulation of the Human Telomerase Gene TERT by Telomere Position Effect-Over Long Distances (TPE-OLD): Implications for Aging and Cancer.

Kim W, Ludlow AT, Min J, Robin JD, Stadler G, Mender I, Lai TP, Zhang N, Wright WE, Shay JW.

PLoS Biol. 2016 Dec 15;14(12):e2000016. doi: 10.1371/journal.pbio.2000016. eCollection 2016 Dec.


Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer.

Zhang L, Theodoropoulos PC, Eskiocak U, Wang W, Moon YA, Posner B, Williams NS, Wright WE, Kim SB, Nijhawan D, De Brabander JK, Shay JW.

Sci Transl Med. 2016 Oct 19;8(361):361ra140.


Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency.

Holohan B, Kim W, Lai TP, Hoshiyama H, Zhang N, Alazami AM, Wright WE, Meyn MS, Alkuraya FS, Shay JW.

BMC Genomics. 2016 Oct 17;17(Suppl 9):749.


Generation of digoxigenin-incorporated probes to enhance DNA detection sensitivity.

Lai TP, Wright WE, Shay JW.

Biotechniques. 2016 Jun 1;60(6):306-9. doi: 10.2144/000114427. eCollection 2016.


Comparison of DNA Quantification Methods for Next Generation Sequencing.

Robin JD, Ludlow AT, LaRanger R, Wright WE, Shay JW.

Sci Rep. 2016 Apr 6;6:24067. doi: 10.1038/srep24067.


Neuromuscular electrical stimulation promotes development in mice of mature human muscle from immortalized human myoblasts.

Sakellariou P, O'Neill A, Mueller AL, Stadler G, Wright WE, Roche JA, Bloch RJ.

Skelet Muscle. 2016 Feb 27;6:4. doi: 10.1186/s13395-016-0078-6. eCollection 2016.


The Metastatic Potential and Chemoresistance of Human Pancreatic Cancer Stem Cells.

Bhagwandin VJ, Bishop JM, Wright WE, Shay JW.

PLoS One. 2016 Feb 9;11(2):e0148807. doi: 10.1371/journal.pone.0148807. eCollection 2016.


Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses.

Kim SB, Bozeman RG, Kaisani A, Kim W, Zhang L, Richardson JA, Wright WE, Shay JW.

Oncogene. 2016 Jun 30;35(26):3365-75. doi: 10.1038/onc.2015.395. Epub 2015 Oct 19.


SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy.

Robin JD, Ludlow AT, Batten K, Gaillard MC, Stadler G, Magdinier F, Wright WE, Shay JW.

Genome Res. 2015 Dec;25(12):1781-90. doi: 10.1101/gr.190660.115. Epub 2015 Sep 10.


Perifosine as a potential novel anti-telomerase therapy.

Holohan B, Hagiopian MM, Lai TP, Huang E, Friedman DR, Wright WE, Shay JW.

Oncotarget. 2015 Sep 8;6(26):21816-26.


Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening.

Holohan B, De Meyer T, Batten K, Mangino M, Hunt SC, Bekaert S, De Buyzere ML, Rietzschel ER, Spector TD, Wright WE, Shay JW.

Aging Cell. 2015 Aug;14(4):669-77. doi: 10.1111/acel.12347. Epub 2015 May 7.


Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis.

Zhang L, Kim S, Jia G, Buhmeida A, Dallol A, Wright WE, Fornace AJ, Al-Qahtani M, Shay JW.

BMC Genomics. 2015;16 Suppl 1:S8. doi: 10.1186/1471-2164-16-S1-S8. Epub 2015 Jan 15.


Isolation and immortalization of patient-derived cell lines from muscle biopsy for disease modeling.

Robin JD, Wright WE, Zou Y, Cossette SC, Lawlor MW, Gussoni E.

J Vis Exp. 2015 Jan 18;(95):52307. doi: 10.3791/52307.


Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs.

Pandita RK, Chow TT, Udayakumar D, Bain AL, Cubeddu L, Hunt CR, Shi W, Horikoshi N, Zhao Y, Wright WE, Khanna KK, Shay JW, Pandita TK.

Cancer Res. 2015 Mar 1;75(5):858-69. doi: 10.1158/0008-5472.CAN-14-2289. Epub 2015 Jan 14.


CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation.

El-Ashmawy M, Delgado O, Cardentey A, Wright WE, Shay JW.

PLoS One. 2014 Dec 23;9(12):e115600. doi: 10.1371/journal.pone.0115600. eCollection 2014.


Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine.

Mender I, Gryaznov S, Dikmen ZG, Wright WE, Shay JW.

Cancer Discov. 2015 Jan;5(1):82-95. doi: 10.1158/2159-8290.CD-14-0609. Epub 2014 Dec 16.


The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch.

Lue NF, Chan J, Wright WE, Hurwitz J.

Nat Commun. 2014 Dec 12;5:5762. doi: 10.1038/ncomms6762.


Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances.

Robin JD, Ludlow AT, Batten K, Magdinier F, Stadler G, Wagner KR, Shay JW, Wright WE.

Genes Dev. 2014 Nov 15;28(22):2464-76. doi: 10.1101/gad.251041.114.


Alternative splicing regulation of telomerase: a new paradigm?

Wong MS, Wright WE, Shay JW.

Trends Genet. 2014 Oct;30(10):430-8. doi: 10.1016/j.tig.2014.07.006. Epub 2014 Aug 26.


Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolution.

Ludlow AT, Robin JD, Sayed M, Litterst CM, Shelton DN, Shay JW, Wright WE.

Nucleic Acids Res. 2014 Jul;42(13):e104. doi: 10.1093/nar/gku439. Epub 2014 May 26.


Branching morphogenesis of immortalized human bronchial epithelial cells in three-dimensional culture.

Kaisani A, Delgado O, Fasciani G, Kim SB, Wright WE, Minna JD, Shay JW.

Differentiation. 2014 Mar-Apr;87(3-4):119-26. doi: 10.1016/j.diff.2014.02.003. Epub 2014 May 13.


Cell biology of disease: Telomeropathies: an emerging spectrum disorder.

Holohan B, Wright WE, Shay JW.

J Cell Biol. 2014 May 12;205(3):289-99. doi: 10.1083/jcb.201401012. Review.


KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer.

Singel SM, Cornelius C, Zaganjor E, Batten K, Sarode VR, Buckley DL, Peng Y, John GB, Li HC, Sadeghi N, Wright WE, Lum L, Corson TW, Shay JW.

Neoplasia. 2014 Mar;16(3):247-56, 256.e2. doi: 10.1016/j.neo.2014.03.008.


Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways.

Singel SM, Batten K, Cornelius C, Jia G, Fasciani G, Barron SL, Wright WE, Shay JW.

Breast Cancer Res. 2014 Mar 19;16(2):R28. doi: 10.1186/bcr3629.


Regulation of human telomerase splicing by RNA:RNA pairing.

Wong MS, Shay JW, Wright WE.

Nat Commun. 2014 Feb 28;5:3306. doi: 10.1038/ncomms4306.


Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer.

Delgado O, Batten KG, Richardson JA, Xie XJ, Gazdar AF, Kaisani AA, Girard L, Behrens C, Suraokar M, Fasciani G, Wright WE, Story MD, Wistuba II, Minna JD, Shay JW.

Clin Cancer Res. 2014 Mar 15;20(6):1610-22. doi: 10.1158/1078-0432.CCR-13-2589. Epub 2014 Jan 31.

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