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A Rare Mutation in SPLUNC1 Affects Bacterial Adherence and Invasion in Meningococcal Disease.

Mashbat B, Bellos E, Hodeib S, Bidmos F, Thwaites RS, Lu Y, Wright VJ, Herberg JA, Klobassa DS, Zenz W, Hansel TT, Nadel S, Langford PR, Schlapbach LJ, Li MS, Redinbo MR, Di YP, Levin M, Sancho-Shimizu V; European Union Childhood Life-Threatening Infectious Disease Study (EUCLIDS) Consortium.

Clin Infect Dis. 2019 Jul 1. pii: ciz600. doi: 10.1093/cid/ciz600. [Epub ahead of print]


Biosynthetic homeostasis and resilience of the complement system in health and infectious disease.

Willems E, Alkema W, Keizer-Garritsen J, Suppers A, van der Flier M, Philipsen RHLA, van den Heuvel LP, Volokhina E, van der Molen RG, Herberg JA, Levin M, Wright VJ, Ahout IML, Ferwerda G, Emonts M, Boeddha NP, Rivero-Calle I, Torres FM, Wessels HJCT, de Groot R, van Gool AJ, Gloerich J, de Jonge MI.

EBioMedicine. 2019 Jul;45:303-313. doi: 10.1016/j.ebiom.2019.06.008. Epub 2019 Jun 29.


HLA-C variants associated with amino acid substitutions in the peptide binding groove influence susceptibility to Kawasaki disease.

Shimizu C, Kim J, Eleftherohorinou H, Wright VJ, Hoang LT, Tremoulet AH, Franco A, Hibberd ML, Takahashi A, Kubo M, Ito K, Tanaka T, Onouchi Y, Coin LJM, Levin M, Burns JC, Shike H; International Kawasaki Disease Genetic Consortium.

Hum Immunol. 2019 Sep;80(9):731-738. doi: 10.1016/j.humimm.2019.04.020. Epub 2019 May 20.


Identification of regulatory variants associated with genetic susceptibility to meningococcal disease.

Borghini L, Png E, Binder A, Wright VJ, Pinnock E, de Groot R, Hazelzet J, Emonts M, Van der Flier M, Schlapbach LJ, Anderson S, Secka F, Salas A, Fink C, Carrol ED, Pollard AJ, Coin LJ, Kuijpers TW, Martinon-Torres F, Zenz W, Levin M, Hibberd ML, Davila S; EUCLIDS consortium.

Sci Rep. 2019 May 6;9(1):6966. doi: 10.1038/s41598-019-43292-6.


Extensive Ethnic Variation and Linkage Disequilibrium at the FCGR2/3 Locus: Different Genetic Associations Revealed in Kawasaki Disease.

Nagelkerke SQ, Tacke CE, Breunis WB, Tanck MWT, Geissler J, Png E, Hoang LT, van der Heijden J, Naim ANM, Yeung RSM, Levin ML, Wright VJ, Burgner DP, Ponsonby AL, Ellis JA, Cimaz R, Shimizu C, Burns JC, Fijnvandraat K, van der Schoot CE, van den Berg TK, de Boer M, Davila S, Hibberd ML, Kuijpers TW; International Kawasaki Disease Genetics Consortium.

Front Immunol. 2019 Mar 21;10:185. doi: 10.3389/fimmu.2019.00185. eCollection 2019.


Quadratus lumborum block provides improved immediate postoperative analgesia and decreased opioid use compared with a multimodal pain regimen following hip arthroscopy.

McCrum CL, Ben-David B, Shin JJ, Wright VJ.

J Hip Preserv Surg. 2018 Oct 25;5(3):233-239. doi: 10.1093/jhps/hny024. eCollection 2018 Aug.


Diagnosis of Kawasaki Disease Using a Minimal Whole-Blood Gene Expression Signature.

Wright VJ, Herberg JA, Kaforou M, Shimizu C, Eleftherohorinou H, Shailes H, Barendregt AM, Menikou S, Gormley S, Berk M, Hoang LT, Tremoulet AH, Kanegaye JT, Coin LJM, Glodé MP, Hibberd M, Kuijpers TW, Hoggart CJ, Burns JC, Levin M; Immunopathology of Respiratory, Inflammatory and Infectious Disease Study (IRIS) Consortium and the Pediatric Emergency Medicine Kawasaki Disease Research Group (PEMKDRG).

JAMA Pediatr. 2018 Oct 1;172(10):e182293. doi: 10.1001/jamapediatrics.2018.2293. Epub 2018 Oct 1.


Genome-wide mapping of the RNA targets of the Pseudomonas aeruginosa riboregulatory protein RsmN.

Romero M, Silistre H, Lovelock L, Wright VJ, Chan KG, Hong KW, Williams P, Cámara M, Heeb S.

Nucleic Acids Res. 2018 Jul 27;46(13):6823-6840. doi: 10.1093/nar/gky324.


Mycobacterium tuberculosis Exploits a Molecular Off Switch of the Immune System for Intracellular Survival.

von Both U, Berk M, Agapow PM, Wright JD, Git A, Hamilton MS, Goldgof G, Siddiqui N, Bellos E, Wright VJ, Coin LJ, Newton SM, Levin M.

Sci Rep. 2018 Jan 12;8(1):661. doi: 10.1038/s41598-017-18528-y.


Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function.

Hemingway C, Berk M, Anderson ST, Wright VJ, Hamilton S, Eleftherohorinou H, Kaforou M, Goldgof GM, Hickman K, Kampmann B, Schoeman J, Eley B, Beatty D, Pienaar S, Nicol MP, Griffiths MJ, Waddell SJ, Newton SM, Coin LJ, Relman DA, Montana G, Levin M.

PLoS One. 2017 Nov 15;12(11):e0185973. doi: 10.1371/journal.pone.0185973. eCollection 2017.


Significant Chondrocyte Viability Is Present in Acetabular Chondral Flaps Associated With Femoroacetabular Impingement.

Wright VJ, McCrum CL, Li H, Tranovich MJ, Huard J.

Am J Sports Med. 2018 Jan;46(1):149-152. doi: 10.1177/0363546517732751. Epub 2017 Oct 12.


Diagnosis of Bacterial Infection Using a 2-Transcript Host RNA Signature in Febrile Infants 60 Days or Younger.

Kaforou M, Herberg JA, Wright VJ, Coin LJM, Levin M.

JAMA. 2017 Apr 18;317(15):1577-1578. doi: 10.1001/jama.2017.1365. No abstract available.


PRINCESS: Privacy-protecting Rare disease International Network Collaboration via Encryption through Software guard extensionS.

Chen F, Wang S, Jiang X, Ding S, Lu Y, Kim J, Sahinalp SC, Shimizu C, Burns JC, Wright VJ, Png E, Hibberd ML, Lloyd DD, Yang H, Telenti A, Bloss CS, Fox D, Lauter K, Ohno-Machado L.

Bioinformatics. 2017 Mar 15;33(6):871-878. doi: 10.1093/bioinformatics/btw758.


Genetic Variation in the SLC8A1 Calcium Signaling Pathway Is Associated With Susceptibility to Kawasaki Disease and Coronary Artery Abnormalities.

Shimizu C, Eleftherohorinou H, Wright VJ, Kim J, Alphonse MP, Perry JC, Cimaz R, Burgner D, Dahdah N, Hoang LT, Khor CC, Salgado A, Tremoulet AH, Davila S, Kuijpers TW, Hibberd ML, Johnson TA, Takahashi A, Tsunoda T, Kubo M, Tanaka T, Onouchi Y, Yeung RS, Coin LJ, Levin M, Burns JC; International Kawasaki Disease Genetics Consortium.

Circ Cardiovasc Genet. 2016 Dec;9(6):559-568. doi: 10.1161/CIRCGENETICS.116.001533. Epub 2016 Nov 21.


A Simple Screening Approach To Prioritize Genes for Functional Analysis Identifies a Role for Interferon Regulatory Factor 7 in the Control of Respiratory Syncytial Virus Disease.

McDonald JU, Kaforou M, Clare S, Hale C, Ivanova M, Huntley D, Dorner M, Wright VJ, Levin M, Martinon-Torres F, Herberg JA, Tregoning JS.

mSystems. 2016 Jun 28;1(3). pii: e00051-16. eCollection 2016 May-Jun.


Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies.

Martinón-Torres F, Png E, Khor CC, Davila S, Wright VJ, Sim KS, Vega A, Fachal L, Inwald D, Nadel S, Carrol ED, Martinón-Torres N, Alonso SM, Carracedo A, Morteruel E, López-Bayón J, Torre AC, Monge CC, de Aguilar PA, Torné EE, Martínez-Padilla MD, Martinón-Sánchez JM, Levin M, Hibberd ML, Salas A; ESIGEM network; ESPID meningococcal consortium – UK; EUCLIDS consortium members - Imperial College London (

Sci Rep. 2016 Nov 2;6:35842. doi: 10.1038/srep35842.


Antimicrobial Proteins and Peptides in Early Life: Ontogeny and Translational Opportunities.

Battersby AJ, Khara J, Wright VJ, Levy O, Kampmann B.

Front Immunol. 2016 Aug 18;7:309. doi: 10.3389/fimmu.2016.00309. eCollection 2016. Review.


Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children.

Herberg JA, Kaforou M, Wright VJ, Shailes H, Eleftherohorinou H, Hoggart CJ, Cebey-López M, Carter MJ, Janes VA, Gormley S, Shimizu C, Tremoulet AH, Barendregt AM, Salas A, Kanegaye J, Pollard AJ, Faust SN, Patel S, Kuijpers T, Martinón-Torres F, Burns JC, Coin LJ, Levin M; IRIS Consortium.

JAMA. 2016 Aug 23-30;316(8):835-45. doi: 10.1001/jama.2016.11236. Erratum in: JAMA. 2017 Feb 7;317(5):538.


Genome-wide Association Studies in Infectious Diseases.

Seaby EG, Wright VJ, Levin M.

Pediatr Infect Dis J. 2016 Jul;35(7):802-4. doi: 10.1097/INF.0000000000001183. Review. No abstract available.


An in vitro model to consider the effect of 2 mM glutamine and KNK437 on endotoxin-stimulated release of heat shock protein 70 and inflammatory mediators.

Marino LV, Pathan N, Meyer RW, Wright VJ, Habibi P.

Nutrition. 2016 Mar;32(3):375-83. doi: 10.1016/j.nut.2015.09.007. Epub 2015 Sep 30.


Chronic exercise preserves brain function in masters athletes when compared to sedentary counterparts.

Zhao E, Tranovich MJ, DeAngelo R, Kontos AP, Wright VJ.

Phys Sportsmed. 2016;44(1):8-13. doi: 10.1080/00913847.2016.1103641. Epub 2015 Oct 29.


Laparoscopic narrow band imaging for detection of occult cancer metastases: a randomized feasibility trial.

Schnelldorfer T, Jenkins RL, Birkett DH, Wright VJ, Price LL, Georgakoudi I.

Surg Endosc. 2016 Apr;30(4):1656-61. doi: 10.1007/s00464-015-4401-9. Epub 2015 Jul 21.


The effect of 2 mMol glutamine supplementation on HSP70 and TNF-α release by LPS stimulated blood from healthy children.

Marino LV, Pathan N, Meyer R, Wright VJ, Habibi P.

Clin Nutr. 2015 Dec;34(6):1195-201. doi: 10.1016/j.clnu.2014.12.009. Epub 2014 Dec 23.


Host RNA signatures for diagnostics: an example from paediatric tuberculosis in Africa.

Kaforou M, Wright VJ, Levin M.

J Infect. 2014 Nov;69 Suppl 1:S28-31. doi: 10.1016/j.jinf.2014.08.006. Epub 2014 Sep 26. Review.


Diagnosis of childhood tuberculosis and host RNA expression in Africa.

Anderson ST, Kaforou M, Brent AJ, Wright VJ, Banwell CM, Chagaluka G, Crampin AC, Dockrell HM, French N, Hamilton MS, Hibberd ML, Kern F, Langford PR, Ling L, Mlotha R, Ottenhoff THM, Pienaar S, Pillay V, Scott JAG, Twahir H, Wilkinson RJ, Coin LJ, Heyderman RS, Levin M, Eley B.

N Engl J Med. 2014 May 1;370(18):1712-1723. doi: 10.1056/NEJMoa1303657.


A review of femoroacetabular impingement and hip arthroscopy in the athlete.

Tranovich MJ, Salzler MJ, Enseki KR, Wright VJ.

Phys Sportsmed. 2014 Feb;42(1):75-87. doi: 10.3810/psm.2014.02.2050. Review.


The role of mobility as a protective factor of cognitive functioning in aging adults: a review.

Zhao E, Tranovich MJ, Wright VJ.

Sports Health. 2014 Jan;6(1):63-9. doi: 10.1177/1941738113477832.


Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study.

Kaforou M, Wright VJ, Oni T, French N, Anderson ST, Bangani N, Banwell CM, Brent AJ, Crampin AC, Dockrell HM, Eley B, Heyderman RS, Hibberd ML, Kern F, Langford PR, Ling L, Mendelson M, Ottenhoff TH, Zgambo F, Wilkinson RJ, Coin LJ, Levin M.

PLoS Med. 2013 Oct;10(10):e1001538. doi: 10.1371/journal.pmed.1001538. Epub 2013 Oct 22.


Transcriptomic profiling in childhood H1N1/09 influenza reveals reduced expression of protein synthesis genes.

Herberg JA, Kaforou M, Gormley S, Sumner ER, Patel S, Jones KD, Paulus S, Fink C, Martinon-Torres F, Montana G, Wright VJ, Levin M.

J Infect Dis. 2013 Nov 15;208(10):1664-8. doi: 10.1093/infdis/jit348. Epub 2013 Jul 29.


Real-time cardiovascular magnetic resonance subxiphoid pericardial access and pericardiocentesis using off-the-shelf devices in swine.

Halabi M, Faranesh AZ, Schenke WH, Wright VJ, Hansen MS, Saikus CE, Kocaturk O, Lederman RJ, Ratnayaka K.

J Cardiovasc Magn Reson. 2013 Jul 20;15:61. doi: 10.1186/1532-429X-15-61.


Unicompartmental arthritis in the aging athlete: osteotomy and beyond.

Johnstone SF, Tranovich MJ, Vyas D, Wright VJ.

Curr Rev Musculoskelet Med. 2013 Sep;6(3):264-72. doi: 10.1007/s12178-013-9171-1.


Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.

Fatemifar G, Hoggart CJ, Paternoster L, Kemp JP, Prokopenko I, Horikoshi M, Wright VJ, Tobias JH, Richmond S, Zhurov AI, Toma AM, Pouta A, Taanila A, Sipila K, Lähdesmäki R, Pillas D, Geller F, Feenstra B, Melbye M, Nohr EA, Ring SM, St Pourcain B, Timpson NJ, Davey Smith G, Jarvelin MR, Evans DM.

Hum Mol Genet. 2013 Sep 15;22(18):3807-17. doi: 10.1093/hmg/ddt231. Epub 2013 May 23.


A new scoring system derived from base excess and platelet count at presentation predicts mortality in paediatric meningococcal sepsis.

Couto-Alves A, Wright VJ, Perumal K, Binder A, Carrol ED, Emonts M, de Groot R, Hazelzet J, Kuijpers T, Nadel S, Zenz W, Ramnarayan P, Levin M, Coin L, Inwald DP.

Crit Care. 2013 Apr 11;17(2):R68. doi: 10.1186/cc12609.


Transthoracic delivery of large devices into the left ventricle through the right ventricle and interventricular septum: preclinical feasibility.

Halabi M, Ratnayaka K, Faranesh AZ, Hansen MS, Barbash IM, Eckhaus MA, Wilson JR, Chen MY, Slack MC, Kocaturk O, Schenke WH, Wright VJ, Lederman RJ.

J Cardiovasc Magn Reson. 2013 Jan 18;15:10. doi: 10.1186/1532-429X-15-10.


Masterful care of the aging triathlete.

Wright VJ.

Sports Med Arthrosc Rev. 2012 Dec;20(4):231-6. doi: 10.1097/JSA.0b013e31826c75a3. Review.


Real-time MRI-guided right heart catheterization in adults using passive catheters.

Ratnayaka K, Faranesh AZ, Hansen MS, Stine AM, Halabi M, Barbash IM, Schenke WH, Wright VJ, Grant LP, Kellman P, Kocaturk O, Lederman RJ.

Eur Heart J. 2013 Feb;34(5):380-9. doi: 10.1093/eurheartj/ehs189. Epub 2012 Aug 1.


Biologic approaches to enhance rotator cuff healing after injury.

Isaac C, Gharaibeh B, Witt M, Wright VJ, Huard J.

J Shoulder Elbow Surg. 2012 Feb;21(2):181-90. doi: 10.1016/j.jse.2011.10.004. Review.


Phenotypic and genome-wide analysis of an antibiotic-resistant small colony variant (SCV) of Pseudomonas aeruginosa.

Wei Q, Tarighi S, Dötsch A, Häussler S, Müsken M, Wright VJ, Cámara M, Williams P, Haenen S, Boerjan B, Bogaerts A, Vierstraete E, Verleyen P, Schoofs L, Willaert R, De Groote VN, Michiels J, Vercammen K, Crabbé A, Cornelis P.

PLoS One. 2011;6(12):e29276. doi: 10.1371/journal.pone.0029276. Epub 2011 Dec 15.


Closed-chest transthoracic magnetic resonance imaging-guided ventricular septal defect closure in swine.

Ratnayaka K, Saikus CE, Faranesh AZ, Bell JA, Barbash IM, Kocaturk O, Reyes CA, Sonmez M, Schenke WH, Wright VJ, Hansen MS, Slack MC, Lederman RJ.

JACC Cardiovasc Interv. 2011 Dec;4(12):1326-34. doi: 10.1016/j.jcin.2011.09.012.


Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.

Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright VJ, Yeung RS, Tan DE, Sim KS, Wang JJ, Wong TY, Pang J, Mitchell P, Cimaz R, Dahdah N, Cheung YF, Huang GY, Yang W, Park IS, Lee JK, Wu JY, Levin M, Burns JC, Burgner D, Kuijpers TW, Hibberd ML; Hong Kong–Shanghai Kawasaki Disease Genetics Consortium; Korean Kawasaki Disease Genetics Consortium; Taiwan Kawasaki Disease Genetics Consortium; International Kawasaki Disease Genetics Consortium; US Kawasaki Disease Genetics Consortium; Blue Mountains Eye Study.

Nat Genet. 2011 Nov 13;43(12):1241-6. doi: 10.1038/ng.981.


Single-center experience in systemic stress and short-term morbidity of single-incision cholecystectomy.

Froghi F, Sodergren MH, Wright VJ, Coomber R, Courtney AP, Darzi A, Paraskeva P.

Surg Innov. 2012 Jun;19(2):117-22. doi: 10.1177/1553350611420453. Epub 2011 Sep 13.


Disruption of vascular homeostasis in patients with Kawasaki disease: involvement of vascular endothelial growth factor and angiopoietins.

Breunis WB, Davila S, Shimizu C, Oharaseki T, Takahashi K, van Houdt M, Khor CC, Wright VJ, Levin M, Burns JC, Burgner D, Hibberd ML, Kuijpers TW; International Kawasaki Disease Genetics Consortium.

Arthritis Rheum. 2012 Jan;64(1):306-15. doi: 10.1002/art.33316.


Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways.

Eleftherohorinou H, Hoggart CJ, Wright VJ, Levin M, Coin LJ.

Hum Mol Genet. 2011 Sep 1;20(17):3494-506. doi: 10.1093/hmg/ddr248. Epub 2011 Jun 8.


Genome-wide linkage and association mapping identify susceptibility alleles in ABCC4 for Kawasaki disease.

Khor CC, Davila S, Shimizu C, Sheng S, Matsubara T, Suzuki Y, Newburger JW, Baker A, Burgner D, Breunis W, Kuijpers T, Wright VJ, Levin M, Hibberd ML, Burns JC; US and International Kawasaki Disease Genetics Consortia.

J Med Genet. 2011 Jul;48(7):467-72. doi: 10.1136/jmg.2010.086611. Epub 2011 May 13.


Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase.

Pathan N, Franklin JL, Eleftherohorinou H, Wright VJ, Hemingway CA, Waddell SJ, Griffiths M, Dennis JL, Relman DA, Harding SE, Levin M.

Crit Care Med. 2011 Jul;39(7):1692-711. doi: 10.1097/CCM.0b013e3182186d27.


Evaluating systemic stress response in single port vs. multi-port laparoscopic cholecystectomy.

McGregor CG, Sodergren MH, Aslanyan A, Wright VJ, Purkayastha S, Darzi A, Paraskeva P.

J Gastrointest Surg. 2011 Apr;15(4):614-22. doi: 10.1007/s11605-011-1432-y. Epub 2011 Feb 10.


Vascular effects dominate solid tumor response to treatment with combretastatin A-4-phosphate.

Lunt SJ, Akerman S, Hill SA, Fisher M, Wright VJ, Reyes-Aldasoro CC, Tozer GM, Kanthou C.

Int J Cancer. 2011 Oct 15;129(8):1979-89. doi: 10.1002/ijc.25848. Epub 2011 Apr 13.


Transforming growth factor-beta signaling pathway in patients with Kawasaki disease.

Shimizu C, Jain S, Davila S, Hibberd ML, Lin KO, Molkara D, Frazer JR, Sun S, Baker AL, Newburger JW, Rowley AH, Shulman ST, Burgner D, Breunis WB, Kuijpers TW, Wright VJ, Levin M, Eleftherohorinou H, Coin L, Popper SJ, Relman DA, Fury W, Lin C, Mellis S, Tremoulet AH, Burns JC.

Circ Cardiovasc Genet. 2011 Feb;4(1):16-25. doi: 10.1161/CIRCGENETICS.110.940858. Epub 2010 Dec 2. Erratum in: Circ Cardiovasc Genet. 2011 Apr;4(2):e9. Davila, Sonia [removed].


Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease.

Davila S, Wright VJ, Khor CC, Sim KS, Binder A, Breunis WB, Inwald D, Nadel S, Betts H, Carrol ED, de Groot R, Hermans PW, Hazelzet J, Emonts M, Lim CC, Kuijpers TW, Martinon-Torres F, Salas A, Zenz W, Levin M, Hibberd ML; International Meningococcal Genetics Consortium.

Nat Genet. 2010 Sep;42(9):772-6. doi: 10.1038/ng.640. Epub 2010 Aug 8.


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