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Items: 1 to 50 of 178

1.

Longitudinal profiling of plasma cytokines in melioidosis and their association with mortality: a prospective cohort study.

Kaewarpai T, Ekchariyawat P, Phunpang R, Wright SW, Dulsuk A, Moonmueangsan B, Morakot C, Thiansukhon E, Day NPJ, Lertmemongkolchai G, West TE, Chantratita N.

Clin Microbiol Infect. 2019 Nov 6. pii: S1198-743X(19)30587-7. doi: 10.1016/j.cmi.2019.10.032. [Epub ahead of print]

2.

Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice.

Nanda SK, Petrova T, Marchesi F, Gierlinski M, Razsolkov M, Lee KL, Wright SW, Rao VR, Cohen P, Arthur JSC.

Life Sci Alliance. 2019 Nov 6;2(6). pii: e201900533. doi: 10.26508/lsa.201900533. Print 2019 Dec.

3.

Exonic sequencing identifies TLR1 genetic variation associated with mortality in Thais with melioidosis.

Wright SW, Emond MJ, Lovelace-Macon L, Ducken D, Kashima J, Hantrakun V, Chierakul W, Teparrukkul P, Chantratita N, Limmathurotsakul D, West TE.

Emerg Microbes Infect. 2019;8(1):282-290. doi: 10.1080/22221751.2019.1575172.

4.

Identification of Morpholino-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-ones as Nonsteroidal Mineralocorticoid Antagonists.

Piotrowski DW, Futatsugi K, Casimiro-Garcia A, Wei L, Sammons MF, Herr M, Jiao W, Lavergne SY, Coffey SB, Wright SW, Song K, Loria PM, Banker ME, Petersen DN, Bauman J.

J Med Chem. 2018 Feb 8;61(3):1086-1097. doi: 10.1021/acs.jmedchem.7b01515. Epub 2018 Jan 23.

PMID:
29300474
5.

Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.

Lee KL, Ambler CM, Anderson DR, Boscoe BP, Bree AG, Brodfuehrer JI, Chang JS, Choi C, Chung S, Curran KJ, Day JE, Dehnhardt CM, Dower K, Drozda SE, Frisbie RK, Gavrin LK, Goldberg JA, Han S, Hegen M, Hepworth D, Hope HR, Kamtekar S, Kilty IC, Lee A, Lin LL, Lovering FE, Lowe MD, Mathias JP, Morgan HM, Murphy EA, Papaioannou N, Patny A, Pierce BS, Rao VR, Saiah E, Samardjiev IJ, Samas BM, Shen MWH, Shin JH, Soutter HH, Strohbach JW, Symanowicz PT, Thomason JR, Trzupek JD, Vargas R, Vincent F, Yan J, Zapf CW, Wright SW.

J Med Chem. 2017 Jul 13;60(13):5521-5542. doi: 10.1021/acs.jmedchem.7b00231. Epub 2017 Jun 14.

PMID:
28498658
6.

Acoustic power delivery to pipeline monitoring wireless sensors.

Kiziroglou ME, Boyle DE, Wright SW, Yeatman EM.

Ultrasonics. 2017 May;77:54-60. doi: 10.1016/j.ultras.2017.01.017. Epub 2017 Jan 23.

7.

A Missed Opportunity to Discuss Racial and Gender Bias in Dermatology.

Adamson AS, Wright SW, Pandya AG.

JAMA Dermatol. 2017 Jan 1;153(1):110-111. doi: 10.1001/jamadermatol.2016.3752. No abstract available.

PMID:
28114518
8.

Synthesis of Chiral Azabicycles from Pyroglutaminols.

Choi C, Nuhant P, Mousseau JJ, Yang X, Gerstenberger BS, Williams JM, Wright SW.

Org Lett. 2016 Nov 4;18(21):5748-5751. Epub 2016 Oct 27.

PMID:
27786487
9.

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.

Liu S, Dakin LA, Xing L, Withka JM, Sahasrabudhe PV, Li W, Banker ME, Balbo P, Shanker S, Chrunyk BA, Guo Z, Chen JM, Young JA, Bai G, Starr JT, Wright SW, Bussenius J, Tan S, Gopalsamy A, Lefker BA, Vincent F, Jones LH, Xu H, Hoth LR, Geoghegan KF, Qiu X, Bunnage ME, Thorarensen A.

Sci Rep. 2016 Aug 16;6:30859. doi: 10.1038/srep30859.

10.

Lithium Enolates Derived from Pyroglutaminol: Mechanism and Stereoselectivity of an Azaaldol Addition.

Houghton MJ, Huck CJ, Wright SW, Collum DB.

J Am Chem Soc. 2016 Aug 17;138(32):10276-83. doi: 10.1021/jacs.6b05481. Epub 2016 Aug 8.

11.

Lithium Enolates Derived from Pyroglutaminol: Aggregation, Solvation, and Atropisomerism.

Houghton MJ, Biok NA, Huck CJ, Algera RF, Keresztes I, Wright SW, Collum DB.

J Org Chem. 2016 May 20;81(10):4149-57. doi: 10.1021/acs.joc.6b00459. Epub 2016 Apr 25.

12.

Reversal of Diastereoselection in the Conjugate Addition of Cuprates to Unsaturated Lactams.

Wright SW, Choi C, Chung S, Boscoe BP, Drozda SE, Mousseau JJ, Trzupek JD.

Org Lett. 2015 Nov 6;17(21):5204-7. doi: 10.1021/acs.orglett.5b02533. Epub 2015 Oct 20.

PMID:
26485576
13.

Aminocarbonylation of aryl tosylates to carboxamides.

Chung S, Sach N, Choi C, Yang X, Drozda SE, Singer RA, Wright SW.

Org Lett. 2015 Jun 5;17(11):2848-51. doi: 10.1021/acs.orglett.5b01283. Epub 2015 May 21.

PMID:
25994500
14.

Health literacy and blood glucose among Guyanese emergency department patients without diagnosed diabetes: a cross-sectional study.

McNaughton CD, Korman RR, Kabagambe EK, Wright SW.

Diabetol Metab Syndr. 2015 Apr 8;7:31. doi: 10.1186/s13098-015-0028-1. eCollection 2015.

15.

Prevalence and molecular characteristics of methicillin-resistant Staphylococcus aureus among skin and soft tissue infections in an emergency department in Guyana.

Dozois A, Thomsen I, Jimenez-Truque N, Soper N, Pearson A, Mohamed-Rambaran P, Dettorre KB, Creech CB, Wright SW.

Emerg Med J. 2015 Oct;32(10):800-3. doi: 10.1136/emermed-2013-203373. Epub 2014 Dec 31.

PMID:
25552545
16.

Impact of contextualized pediatric resuscitation training on pediatric healthcare providers in Botswana.

Wright SW, Steenhoff AP, Elci O, Wolfe HA, Ralston M, Kgosiesele T, Makone I, Mazhani L, Nadkarni VM, Meaney PA.

Resuscitation. 2015 Mar;88:57-62. doi: 10.1016/j.resuscitation.2014.12.007. Epub 2014 Dec 19.

PMID:
25534076
17.

Climate change and Southern Ocean ecosystems I: how changes in physical habitats directly affect marine biota.

Constable AJ, Melbourne-Thomas J, Corney SP, Arrigo KR, Barbraud C, Barnes DK, Bindoff NL, Boyd PW, Brandt A, Costa DP, Davidson AT, Ducklow HW, Emmerson L, Fukuchi M, Gutt J, Hindell MA, Hofmann EE, Hosie GW, Iida T, Jacob S, Johnston NM, Kawaguchi S, Kokubun N, Koubbi P, Lea MA, Makhado A, Massom RA, Meiners K, Meredith MP, Murphy EJ, Nicol S, Reid K, Richerson K, Riddle MJ, Rintoul SR, Smith WO Jr, Southwell C, Stark JS, Sumner M, Swadling KM, Takahashi KT, Trathan PN, Welsford DC, Weimerskirch H, Westwood KJ, Wienecke BC, Wolf-Gladrow D, Wright SW, Xavier JC, Ziegler P.

Glob Chang Biol. 2014 Oct;20(10):3004-25. doi: 10.1111/gcb.12623. Epub 2014 Jun 30. Review.

PMID:
24802817
18.

Identification of a novel conformationally constrained glucagon receptor antagonist.

Lee EC, Tu M, Stevens BD, Bian J, Aspnes G, Perreault C, Sammons MF, Wright SW, Litchfield J, Kalgutkar AS, Sharma R, Didiuk MT, Ebner DC, Filipski KJ, Brown J, Atkinson K, Pfefferkorn JA, Guzman-Perez A.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):839-44. doi: 10.1016/j.bmcl.2013.12.090. Epub 2013 Dec 28.

PMID:
24418771
19.

Personal experiences and attitudes towards intimate partner violence in healthcare providers in Guyana.

Mitchell V, Parekh KP, Russ S, Forget NP, Wright SW.

Int Health. 2013 Dec;5(4):273-9. doi: 10.1093/inthealth/iht030. Epub 2013 Nov 13.

PMID:
24225152
20.

Emergency Medicine in Guyana: Lessons from Developing the Country's First Degree-conferring Residency Program.

Forget NP, Rohde JP, Rambaran N, Rambaran M, Wright SW.

West J Emerg Med. 2013 Sep;14(5):477-81. doi: 10.5811/westjem.2013.3.12714.

21.

Patient perspectives on opt-out HIV screening in a Guyanese emergency department.

Christensen A, Russ S, Rambaran N, Wright SW.

Int Health. 2012 Sep;4(3):185-91. doi: 10.1016/j.inhe.2012.03.001.

PMID:
24029398
22.

Response of phytoplankton photophysiology to varying environmental conditions in the Sub-Antarctic and Polar Frontal Zone.

Cheah W, McMinn A, Griffiths FB, Westwood KJ, Wright SW, Clementson LA.

PLoS One. 2013 Aug 19;8(8):e72165. doi: 10.1371/journal.pone.0072165. eCollection 2013.

23.

Performance of a multi-disciplinary emergency department observation protocol for acetaminophen overdose.

Beauchamp GA, Hart KW, Lindsell CJ, Lyons MS, Otten EJ, Smith CL, Ward MJ, Wright SW.

J Med Toxicol. 2013 Sep;9(3):235-41. doi: 10.1007/s13181-013-0310-2.

24.

Who leaves the emergency department without being seen? A public hospital experience in Georgetown, Guyana.

Parekh KP, Russ S, Amsalem DA, Rambaran N, Wright SW.

BMC Emerg Med. 2013 Jun 21;13:10. doi: 10.1186/1471-227X-13-10.

25.

Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children.

Serrano C, Wright SW, Bimczok D, Shaffer CL, Cover TL, Venegas A, Salazar MG, Smythies LE, Harris PR, Smith PD.

Mucosal Immunol. 2013 Sep;6(5):950-959. doi: 10.1038/mi.2012.133. Epub 2013 Jan 9.

26.

From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor.

Futatsugi K, Mascitti V, Guimarães CR, Morishita N, Cai C, DeNinno MP, Gao H, Hamilton MD, Hank R, Harris AR, Kung DW, Lavergne SY, Lefker BA, Lopaze MG, McClure KF, Munchhof MJ, Preville C, Robinson RP, Wright SW, Bonin PD, Cornelius P, Chen Y, Kalgutkar AS.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):194-7. doi: 10.1016/j.bmcl.2012.10.119. Epub 2012 Nov 5.

PMID:
23177788
27.

Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes.

DeNinno MP, Wright SW, Etienne JB, Olson TV, Rocke BN, Corbett JW, Kung DW, DiRico KJ, Andrews KM, Millham ML, Parker JC, Esler W, van Volkenburg M, Boyer DD, Houseknecht KL, Doran SD.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5721-6. doi: 10.1016/j.bmcl.2012.06.079. Epub 2012 Jul 6.

PMID:
22858141
28.

An automated dispensing system for improving medication timing in the emergency department.

Ward MJ, Boyd JS, Harger NJ, Deledda JM, Smith CL, Walker SM, Hice JD, Hart KW, Lindsell CJ, Wright SW.

World J Emerg Med. 2012 Jun 12;3(2):102-107.

29.

Prevalence of intimate partner violence in patients presenting with traumatic injuries to a Guyanese emergency department.

Parekh KP, Russ S, Amsalem DA, Rambaran N, Langston S, Wright SW.

Int J Emerg Med. 2012 May 29;5(1):23. doi: 10.1186/1865-1380-5-23.

30.

A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity.

Filipski KJ, Bian J, Ebner DC, Lee EC, Li JC, Sammons MF, Wright SW, Stevens BD, Didiuk MT, Tu M, Perreault C, Brown J, Atkinson K, Tan B, Salatto CT, Litchfield J, Pfefferkorn JA, Guzman-Perez A.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):415-20. doi: 10.1016/j.bmcl.2011.10.113. Epub 2011 Nov 6.

PMID:
22119466
31.

PHOTOSYNTHETIC PIGMENT AND GENETIC DIFFERENCES BETWEEN TWO SOUTHERN OCEAN MORPHOTYPES OF EMILIANIA HUXLEYI (HAPTOPHYTA)1.

Cook SS, Whittock L, Wright SW, Hallegraeff GM.

J Phycol. 2011 Jun;47(3):615-626. doi: 10.1111/j.1529-8817.2011.00992.x. Epub 2011 May 9.

PMID:
27021991
32.

1,5-Substituted nipecotic amides: selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability.

DeNinno MP, Wright SW, Visser MS, Etienne JB, Moore DE, Olson TV, Rocke BN, Andrews MP, Zarbo C, Millham ML, Boscoe BP, Boyer DD, Doran SD, Houseknecht KL.

Bioorg Med Chem Lett. 2011 May 15;21(10):3095-8. doi: 10.1016/j.bmcl.2011.03.022. Epub 2011 Mar 11.

PMID:
21459572
33.

PHOTOPROTECTION OF SEA-ICE MICROALGAL COMMUNITIES FROM THE EAST ANTARCTIC PACK ICE(1).

Petrou K, Hill R, Doblin MA, McMinn A, Johnson R, Wright SW, Ralph PJ.

J Phycol. 2011 Feb;47(1):77-86. doi: 10.1111/j.1529-8817.2010.00944.x. Epub 2011 Jan 13.

PMID:
27021712
34.

The degree of bandemia in septic ED patients does not predict inpatient mortality.

Ward MJ, Fertel BS, Bonomo JB, Smith CL, Hart KW, Lindsell CJ, Wright SW.

Am J Emerg Med. 2012 Jan;30(1):181-3. doi: 10.1016/j.ajem.2010.08.018. Epub 2010 Oct 20.

PMID:
20970296
35.

Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats.

Litchfield J, Sharma R, Atkinson K, Filipski KJ, Wright SW, Pfefferkorn JA, Tan B, Kosa RE, Stevens B, Tu M, Kalgutkar AS.

Bioorg Med Chem Lett. 2010 Nov 1;20(21):6262-7. doi: 10.1016/j.bmcl.2010.08.095. Epub 2010 Aug 21.

PMID:
20829042
36.

Needle and guidewire visualization in ultrasound-guided internal jugular vein cannulation.

Moak JH, Lyons MS, Wright SW, Lindsell CJ.

Am J Emerg Med. 2011 May;29(4):432-6. doi: 10.1016/j.ajem.2010.01.004. Epub 2010 Apr 13.

PMID:
20825840
37.

Subclavian vein thrombosis following clavicular fracture.

Wright SW.

Emerg Med J. 2009 Nov;26(11):840. doi: 10.1136/emj.2008.070318.

PMID:
19850821
38.

A piece of my mind. Oh, to live in an age when men had breasts....

Wright SW.

JAMA. 2009 Oct 14;302(14):1511-2. doi: 10.1001/jama.2009.1402. No abstract available.

PMID:
19826013
39.

A photosynthetic alveolate closely related to apicomplexan parasites.

Moore RB, Oborník M, Janouskovec J, Chrudimský T, Vancová M, Green DH, Wright SW, Davies NW, Bolch CJ, Heimann K, Slapeta J, Hoegh-Guldberg O, Logsdon JM, Carter DA.

Nature. 2008 Feb 21;451(7181):959-63. doi: 10.1038/nature06635. Erratum in: Nature. 2008 Apr 17;452(7189):900.

PMID:
18288187
40.

Helicobacter pylori gastritis in children is associated with a regulatory T-cell response.

Harris PR, Wright SW, Serrano C, Riera F, Duarte I, Torres J, Peña A, Rollán A, Viviani P, Guiraldes E, Schmitz JM, Lorenz RG, Novak L, Smythies LE, Smith PD.

Gastroenterology. 2008 Feb;134(2):491-9. doi: 10.1053/j.gastro.2007.11.006. Epub 2007 Nov 4.

PMID:
18242215
41.

(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.

Wright SW, Ammirati MJ, Andrews KM, Brodeur AM, Danley DE, Doran SD, Lillquist JS, Liu S, McClure LD, McPherson RK, Olson TV, Orena SJ, Parker JC, Rocke BN, Soeller WC, Soglia CB, Treadway JL, Vanvolkenburg MA, Zhao Z, Cox ED.

Bioorg Med Chem Lett. 2007 Oct 15;17(20):5638-42. Epub 2007 Aug 22.

PMID:
17822893
42.

Evidence-based emergency medicine. Creating a system to facilitate translation of evidence into standardized clinical practice: a preliminary report.

Wright SW, Trott A, Lindsell CJ, Smith C, Gibler WB.

Ann Emerg Med. 2008 Jan;51(1):80-6, 86.e1-8. Epub 2007 Aug 23.

PMID:
17719134
43.

Outbreak of pertussis on a college campus.

Craig AS, Wright SW, Edwards KM, Greene JW, Haynes M, Dake AD, Schaffner W.

Am J Med. 2007 Apr;120(4):364-8.

PMID:
17398232
44.

High fidelity medical simulation in the difficult environment of a helicopter: feasibility, self-efficacy and cost.

Wright SW, Lindsell CJ, Hinckley WR, Williams A, Holland C, Lewis CH, Heimburger G.

BMC Med Educ. 2006 Oct 5;6:49.

45.

cis-2,5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization.

Wright SW, Ammirati MJ, Andrews KM, Brodeur AM, Danley DE, Doran SD, Lillquist JS, McClure LD, McPherson RK, Orena SJ, Parker JC, Polivkova J, Qiu X, Soeller WC, Soglia CB, Treadway JL, VanVolkenburg MA, Wang H, Wilder DC, Olson TV.

J Med Chem. 2006 Jun 1;49(11):3068-76.

PMID:
16722626
46.

A convenient preparation of heteroaryl sulfonamides and sulfonyl fluorides from heteroaryl thiols.

Wright SW, Hallstrom KN.

J Org Chem. 2006 Feb 3;71(3):1080-4.

PMID:
16438524
47.

Should physicians have facial piercings?

Newman AW, Wright SW, Wrenn KD, Bernard A.

J Gen Intern Med. 2005 Mar;20(3):213-8.

48.

5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.

Wright SW, Rath VL, Genereux PE, Hageman DL, Levy CB, McClure LD, McCoid SC, McPherson RK, Schelhorn TM, Wilder DE, Zavadoski WJ, Gibbs EM, Treadway JL.

Bioorg Med Chem Lett. 2005 Jan 17;15(2):459-65.

PMID:
15603973
49.

Chronic pain in the ED.

Bernard AM, Wright SW.

Am J Emerg Med. 2004 Oct;22(6):444-7.

PMID:
15520937
50.

Cause-and-effect analysis of risk management files to assess patient care in the emergency department.

White AA, Wright SW, Blanco R, Lemonds B, Sisco J, Bledsoe S, Irwin C, Isenhour J, Pichert JW.

Acad Emerg Med. 2004 Oct;11(10):1035-41.

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