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Molecular and cellular physiology of organic cation transporter 2.

Wright SH.

Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1669-F1679. doi: 10.1152/ajprenal.00422.2019. Epub 2019 Nov 4.


CCL21 Expression in β-Cells Induces Antigen-Expressing Stromal Cell Networks in the Pancreas and Prevents Autoimmune Diabetes in Mice.

Gonzalez Badillo FE, Zisi Tegou F, Abreu MM, Masina R, Sha D, Najjar M, Wright SH, Bayer AL, Korpos É, Pugliese A, Molano RD, Tomei AA.

Diabetes. 2019 Oct;68(10):1990-2003. doi: 10.2337/db19-0239. Epub 2019 Aug 1.


Kinetic basis of metformin-MPP interactions with organic cation transporter OCT2.

Sandoval PJ, Morales M, Secomb TW, Wright SH.

Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F720-F734. doi: 10.1152/ajprenal.00152.2019. Epub 2019 Jul 17.


Nebulisation of synthetic lamellar lipids mitigates radiation-induced lung injury in a large animal model.

Collie D, Murchison JT, Wright SH, McLean A, Howard L, Del-Pozo J, Smith S, McLachlan G, Lawrence J, Kay E, Schwarz T, Parys M.

Sci Rep. 2018 Sep 6;8(1):13316. doi: 10.1038/s41598-018-31559-3.


Assessment of Substrate-Dependent Ligand Interactions at the Organic Cation Transporter OCT2 Using Six Model Substrates.

Sandoval PJ, Zorn KM, Clark AM, Ekins S, Wright SH.

Mol Pharmacol. 2018 Sep;94(3):1057-1068. doi: 10.1124/mol.117.111443. Epub 2018 Jun 8.


Correlation between Apparent Substrate Affinity and OCT2 Transport Turnover.

Severance AC, Sandoval PJ, Wright SH.

J Pharmacol Exp Ther. 2017 Sep;362(3):405-412. doi: 10.1124/jpet.117.242552. Epub 2017 Jun 14.


Lack of Influence of Substrate on Ligand Interaction with the Human Multidrug and Toxin Extruder, MATE1.

Martínez-Guerrero LJ, Morales M, Ekins S, Wright SH.

Mol Pharmacol. 2016 Sep;90(3):254-64. doi: 10.1124/mol.116.105056. Epub 2016 Jul 14.


The multidrug transporter MATE1 sequesters OCs within an intracellular compartment that has no influence on OC secretion in renal proximal tubules.

Martínez-Guerrero LJ, Evans KK, Dantzler WH, Wright SH.

Am J Physiol Renal Physiol. 2016 Jan 1;310(1):F57-67. doi: 10.1152/ajprenal.00318.2015. Epub 2015 Nov 4.


Making Transporter Models for Drug-Drug Interaction Prediction Mobile.

Ekins S, Clark AM, Wright SH.

Drug Metab Dispos. 2015 Oct;43(10):1642-5. doi: 10.1124/dmd.115.064956. Epub 2015 Jul 21.


Unstirred Water Layers and the Kinetics of Organic Cation Transport.

Shibayama T, Morales M, Zhang X, Martínez-Guerrero LJ, Berteloot A, Secomb TW, Wright SH.

Pharm Res. 2015 Sep;32(9):2937-49. doi: 10.1007/s11095-015-1675-5. Epub 2015 Mar 20.


Xenobiotic transporter expression along the male genital tract.

Klein DM, Wright SH, Cherrington NJ.

Reprod Toxicol. 2014 Aug;47:1-8. doi: 10.1016/j.reprotox.2014.04.009. Epub 2014 May 9.


SLC22, SLC44, and SLC47 transporters--organic anion and cation transporters: molecular and cellular properties.

Pelis RM, Wright SH.

Curr Top Membr. 2014;73:233-61. doi: 10.1016/B978-0-12-800223-0.00006-2. Review.


Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis.

Klein DM, Wright SH, Cherrington NJ.

Drug Metab Dispos. 2014 Jan;42(1):89-93. doi: 10.1124/dmd.113.054577. Epub 2013 Oct 15.


Substrate-dependent inhibition of human MATE1 by cationic ionic liquids.

Martínez-Guerrero LJ, Wright SH.

J Pharmacol Exp Ther. 2013 Sep;346(3):495-503. doi: 10.1124/jpet.113.204206. Epub 2013 Jun 19.


Substrate-dependent ligand inhibition of the human organic cation transporter OCT2.

Belzer M, Morales M, Jagadish B, Mash EA, Wright SH.

J Pharmacol Exp Ther. 2013 Aug;346(2):300-10. doi: 10.1124/jpet.113.203257. Epub 2013 May 24.


Basolateral uptake of nucleosides by Sertoli cells is mediated primarily by equilibrative nucleoside transporter 1.

Klein DM, Evans KK, Hardwick RN, Dantzler WH, Wright SH, Cherrington NJ.

J Pharmacol Exp Ther. 2013 Jul;346(1):121-9. doi: 10.1124/jpet.113.203265. Epub 2013 May 2.


Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2.

Harper JN, Wright SH.

Am J Physiol Renal Physiol. 2013 Jan 1;304(1):F56-67. doi: 10.1152/ajprenal.00486.2012. Epub 2012 Oct 3.


Computational modeling to accelerate the identification of substrates and inhibitors for transporters that affect drug disposition.

Ekins S, Polli JE, Swaan PW, Wright SH.

Clin Pharmacol Ther. 2012 Nov;92(5):661-5. doi: 10.1038/clpt.2012.164. Epub 2012 Sep 26. No abstract available.


The goblet cell is the cellular source of the anti-microbial angiogenin 4 in the large intestine post Trichuris muris infection.

Forman RA, deSchoolmeester ML, Hurst RJ, Wright SH, Pemberton AD, Else KJ.

PLoS One. 2012;7(9):e42248. doi: 10.1371/journal.pone.0042248. Epub 2012 Sep 6.


Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein.

Zhang X, He X, Baker J, Tama F, Chang G, Wright SH.

J Biol Chem. 2012 Aug 10;287(33):27971-82. doi: 10.1074/jbc.M112.386979. Epub 2012 Jun 21.


Functional significance of conserved cysteines in the human organic cation transporter 2.

Pelis RM, Dangprapai Y, Cheng Y, Zhang X, Terpstra J, Wright SH.

Am J Physiol Renal Physiol. 2012 Jul 15;303(2):F313-20. doi: 10.1152/ajprenal.00038.2012. Epub 2012 May 9.


Simulations of substrate transport in the multidrug transporter EmrD.

Baker J, Wright SH, Tama F.

Proteins. 2012 Jun;80(6):1620-32. doi: 10.1002/prot.24056. Epub 2012 Mar 20.


Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K.

Astorga B, Ekins S, Morales M, Wright SH.

J Pharmacol Exp Ther. 2012 Jun;341(3):743-55. doi: 10.1124/jpet.112.191577. Epub 2012 Mar 14.


Inflammatory arthritis.

Wright SH.

Adv NPs PAs. 2011 Nov;2(11):29-30, 32. Review. No abstract available.


Renal transport of organic anions and cations.

Pelis RM, Wright SH.

Compr Physiol. 2011 Oct;1(4):1795-835. doi: 10.1002/cphy.c100084. Review.


Characterization of the inhibitory effects of N-butylpyridinium chloride and structurally related ionic liquids on organic cation transporters 1/2 and human toxic extrusion transporters 1/2-k in vitro and in vivo.

Cheng Y, Martinez-Guerrero LJ, Wright SH, Kuester RK, Hooth MJ, Sipes IG.

Drug Metab Dispos. 2011 Sep;39(9):1755-61. doi: 10.1124/dmd.110.035865. Epub 2011 Jun 6.


Interaction of H+ with the extracellular and intracellular aspects of hMATE1.

Dangprapai Y, Wright SH.

Am J Physiol Renal Physiol. 2011 Sep;301(3):F520-8. doi: 10.1152/ajprenal.00075.2011. Epub 2011 May 25.


Differences in the substrate binding regions of renal organic anion transporters 1 (OAT1) and 3 (OAT3).

Astorga B, Wunz TM, Morales M, Wright SH, Pelis RM.

Am J Physiol Renal Physiol. 2011 Aug;301(2):F378-86. doi: 10.1152/ajprenal.00735.2010. Epub 2011 May 4.


Strain-specific copy number variation in the intelectin locus on the 129 mouse chromosome 1.

Lu ZH, di Domenico A, Wright SH, Knight PA, Whitelaw CB, Pemberton AD.

BMC Genomics. 2011 Feb 16;12:110. doi: 10.1186/1471-2164-12-110.


Solution structure of the leader sequence of the patellamide precursor peptide, PatE1-34.

Houssen WE, Wright SH, Kalverda AP, Thompson GS, Kelly SM, Jaspars M.

Chembiochem. 2010 Sep 3;11(13):1867-73. doi: 10.1002/cbic.201000305.


Organic anion transporter 3 (OAT3) and renal transport of the metal chelator 2,3-dimercapto-1-propanesulfonic acid (DMPS).

Rödiger M, Zhang X, Ugele B, Gersdorff N, Wright SH, Burckhardt G, Bahn A.

Can J Physiol Pharmacol. 2010 Feb;88(2):141-6. doi: 10.1139/Y09-123.


Membrane transporters in drug development.

International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L.

Nat Rev Drug Discov. 2010 Mar;9(3):215-36. doi: 10.1038/nrd3028. Review.


Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell.

D'Elia R, DeSchoolmeester ML, Zeef LA, Wright SH, Pemberton AD, Else KJ.

BMC Genomics. 2009 Oct 24;10:492. doi: 10.1186/1471-2164-10-492.


MATE1 has an external COOH terminus, consistent with a 13-helix topology.

Zhang X, Wright SH.

Am J Physiol Renal Physiol. 2009 Aug;297(2):F263-71. doi: 10.1152/ajprenal.00123.2009. Epub 2009 Jun 10.


Localization of multidrug resistance-associated protein 2 in the nonpigmented ciliary epithelium of the eye.

Pelis RM, Shahidullah M, Ghosh S, Coca-Prados M, Wright SH, Delamere NA.

J Pharmacol Exp Ther. 2009 May;329(2):479-85. doi: 10.1124/jpet.108.149625. Epub 2009 Feb 6.


Characterization of the disposition and toxicokinetics of N-butylpyridinium chloride in male F-344 rats and female B6C3F1 mice and its transport by organic cation transporter 2.

Cheng Y, Wright SH, Hooth MJ, Sipes IG.

Drug Metab Dispos. 2009 Apr;37(4):909-16. doi: 10.1124/dmd.108.022681. Epub 2009 Jan 26.


The effect of fertilization on the below-ground diversity and community composition of ectomycorrhizal fungi associated with western hemlock (Tsuga heterophylla).

Wright SHA, Berch SM, Berbee ML.

Mycorrhiza. 2009 Apr;19(4):267-276. doi: 10.1007/s00572-008-0218-x. Epub 2009 Jan 13.


Marine metabolites and metal ion chelation: intact recovery and identification of an iron(II) complex in the extract of the ascidian Eudistoma gilboviride.

Wright SH, Raab A, Tabudravu JN, Feldmann J, Long PF, Battershill CN, Dunlap WC, Milne BF, Jaspars M.

Angew Chem Int Ed Engl. 2008;47(42):8090-2. doi: 10.1002/anie.200802060. No abstract available.


Influence of estrogen and xenoestrogens on basolateral uptake of tetraethylammonium by opossum kidney cells in culture.

Pelis RM, Hartman RC, Wright SH, Wunz TM, Groves CE.

J Pharmacol Exp Ther. 2007 Nov;323(2):555-61. Epub 2007 Aug 7.


Molecular identification and functional characterization of rabbit MATE1 and MATE2-K.

Zhang X, Cherrington NJ, Wright SH.

Am J Physiol Renal Physiol. 2007 Jul;293(1):F360-70. Epub 2007 Apr 18.


Pentavalent arsenic can bind to biomolecules.

Raab A, Wright SH, Jaspars M, Meharg AA, Feldmann J.

Angew Chem Int Ed Engl. 2007;46(15):2594-7. No abstract available.


Inorganic mercury interacts with cysteine residues (C451 and C474) of hOCT2 to reduce its transport activity.

Pelis RM, Dangprapai Y, Wunz TM, Wright SH.

Am J Physiol Renal Physiol. 2007 May;292(5):F1583-91. Epub 2007 Feb 6.


Cysteine accessibility in the hydrophilic cleft of human organic cation transporter 2.

Pelis RM, Zhang X, Dangprapai Y, Wright SH.

J Biol Chem. 2006 Nov 17;281(46):35272-80. Epub 2006 Sep 21.


New methods for medicinal chemistry--universal gene cloning and expression systems for production of marine bioactive metabolites.

Dunlap WC, Jaspars M, Hranueli D, Battershill CN, Perić-Concha N, Zucko J, Wright SH, Long PF.

Curr Med Chem. 2006;13(6):697-710. Review.


Functional influence of N-glycosylation in OCT2-mediated tetraethylammonium transport.

Pelis RM, Suhre WM, Wright SH.

Am J Physiol Renal Physiol. 2006 May;290(5):F1118-26. Epub 2005 Dec 20.


The proteome of mouse mucosal mast cell homologues: the role of transforming growth factor beta1.

Pemberton AD, Brown JK, Wright SH, Knight PA, Miller HR.

Proteomics. 2006 Jan;6(2):623-31.


A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2).

Zhang X, Shirahatti NV, Mahadevan D, Wright SH.

J Biol Chem. 2005 Oct 14;280(41):34813-22. Epub 2005 Aug 8.

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