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Items: 1 to 50 of 90

1.

Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.

Zhang D, Hop CE, Patilea-Vrana G, Gampa G, Seneviratne HK, Unadkat JD, Kenny JR, Nagapudi K, Di L, Zhou L, Zak M, Wright MR, Bumpus NN, Zang R, Liu X, Lai Y, Khojasteh SC.

Drug Metab Dispos. 2019 Jul 2. pii: dmd.119.086744. doi: 10.1124/dmd.119.086744. [Epub ahead of print]

2.

Relationship Quality among Older Cohabitors: A Comparison to Remarrieds.

Wright MR.

J Gerontol B Psychol Sci Soc Sci. 2019 May 24. pii: gbz069. doi: 10.1093/geronb/gbz069. [Epub ahead of print]

PMID:
31247086
3.

Depressive Symptoms Following Later-life Marital Dissolution and Subsequent Repartnering.

Lin IF, Brown SL, Wright MR, Hammersmith AM.

J Health Soc Behav. 2019 Jun;60(2):153-168. doi: 10.1177/0022146519839683. Epub 2019 Apr 8.

PMID:
30957562
4.

Exposure-Effect Relationships in Established Rat Adjuvant-Induced and Collagen-Induced Arthritis: A Translational Pharmacokinetic-Pharmacodynamic Analysis.

Wong H, Liu L, Ouyang W, Deng Y, Wright MR, Hop CECA.

J Pharmacol Exp Ther. 2019 Jun;369(3):406-418. doi: 10.1124/jpet.118.255562. Epub 2019 Apr 2.

PMID:
30940693
5.

Evaluation of the predictive performance of physiologically based pharmacokinetic models for intramuscular injections of therapeutic proteins.

Chow TW, Wright MR, Hop CECA, Wong H.

Xenobiotica. 2019 Feb 22:1-11. doi: 10.1080/00498254.2019.1571651. [Epub ahead of print]

PMID:
30794022
6.

Repartnering Following Gray Divorce: The Roles of Resources and Constraints for Women and Men.

Brown SL, Lin IF, Hammersmith AM, Wright MR.

Demography. 2019 Apr;56(2):503-523. doi: 10.1007/s13524-018-0752-x.

PMID:
30632111
7.

Evaluating the effectiveness and implementation of evidence-based treatment: A multisite hybrid design.

Ashmore JA, Ditterich KW, Conley CC, Wright MR, Howland PS, Huggins KL, Cooreman J, Andrews PS, Nicholas DR, Roberts L, Hewitt L, Scales JN, Delap JK, Gray CA, Tyler LA, Collins C, Whiting CM, Brothers BM, Ryba MM, Andersen BL.

Am Psychol. 2019 May-Jun;74(4):459-473. doi: 10.1037/amp0000309. Epub 2018 Jul 19.

PMID:
30024215
8.

Compliance on Mandatory Data Reporting in Registered Obstetrics Trials.

Checketts JX, Evans MB, Athale AH, Jawhar OM, Wright MR, Bryant K, Vassar M.

Am J Perinatol. 2018 Oct;35(12):1192-1196. doi: 10.1055/s-0038-1642620. Epub 2018 Apr 25.

PMID:
29695018
9.

Marriage, Cohabitation, and Divorce in Later Life.

Brown SL, Wright MR.

Innov Aging. 2017 Sep 13;1(2):igx015. doi: 10.1093/geroni/igx015. eCollection 2017 Sep.

10.

Psychological Well-Being among Older Adults: The Role of Partnership Status.

Wright MR, Brown SL.

J Marriage Fam. 2017 Jun;79(3):833-849. doi: 10.1111/jomf.12375. Epub 2016 Sep 27.

11.

Antecedents of Gray Divorce: A Life Course Perspective.

Lin IF, Brown SL, Wright MR, Hammersmith AM.

J Gerontol B Psychol Sci Soc Sci. 2018 Aug 14;73(6):1022-1031. doi: 10.1093/geronb/gbw164.

12.

Unmet needs in treating laryngo-pharyngeal reflux disease: where do we go from here?

Wright MR, Sharda R, Vaezi MF.

Expert Rev Gastroenterol Hepatol. 2016 Sep;10(9):995-1004. doi: 10.1080/17474124.2016.1179576. Epub 2016 May 13. Review.

PMID:
27137439
13.

Later Life Marital Dissolution and Repartnership Status: A National Portrait.

Brown SL, Lin IF, Hammersmith AM, Wright MR.

J Gerontol B Psychol Sci Soc Sci. 2018 Aug 14;73(6):1032-1042. doi: 10.1093/geronb/gbw051.

14.

Pharmacokinetic considerations of antibody therapeutics.

Wong H, Wright MR.

Biopharm Drug Dispos. 2016 Mar;37(2):49-50. doi: 10.1002/bdd.2002. No abstract available.

PMID:
27028107
15.

Older Adults' Attitudes Toward Cohabitation: Two Decades of Change.

Brown SL, Wright MR.

J Gerontol B Psychol Sci Soc Sci. 2016 Jul;71(4):755-64. doi: 10.1093/geronb/gbv053. Epub 2015 Aug 25.

16.

Y-STR diversity and sex-biased gene flow among Caribbean populations.

Simms TM, Wright MR, Martinez E, Regueiro M, McCartney Q, Herrera RJ.

Gene. 2013 Mar 1;516(1):82-92. doi: 10.1016/j.gene.2012.11.006. Epub 2012 Nov 21.

PMID:
23178184
17.

Y-chromosomal diversity in Haiti and Jamaica: contrasting levels of sex-biased gene flow.

Simms TM, Wright MR, Hernandez M, Perez OA, Ramirez EC, Martinez E, Herrera RJ.

Am J Phys Anthropol. 2012 Aug;148(4):618-31. doi: 10.1002/ajpa.22090. Epub 2012 May 11.

PMID:
22576450
18.

Paternal lineages signal distinct genetic contributions from British Loyalists and continental Africans among different Bahamian islands.

Simms TM, Martinez E, Herrera KJ, Wright MR, Perez OA, Hernandez M, Ramirez EC, McCartney Q, Herrera RJ.

Am J Phys Anthropol. 2011 Dec;146(4):594-608. doi: 10.1002/ajpa.21616. Epub 2011 Oct 12.

PMID:
21989964
19.

Characterization of sandwich-cultured hepatocytes as an in vitro model to assess the hepatobiliary disposition of copper.

Ansede JH, Wright MR, St Claire RL 3rd, Hart RW, Gefroh HA, Brouwer KR.

Drug Metab Dispos. 2009 May;37(5):969-76. doi: 10.1124/dmd.108.024638. Epub 2009 Feb 23.

PMID:
19237514
20.

Lack of evidence for an effect of lopinavir/ritonavir on tenofovir renal clearance.

Ray AS, Wright MR, Rhodes GR.

Clin Pharmacol Ther. 2008 Dec;84(6):660; author reply 661. doi: 10.1038/clpt.2008.140. Epub 2008 Jul 9. No abstract available.

PMID:
18615003
21.

Glucuronidation in the chimpanzee (Pan troglodytes): studies with acetaminophen, oestradiol and morphine.

Wong H, Grace JE Jr, Wright MR, Browning MR, Grossman SJ, Bai SA, Christ DD.

Xenobiotica. 2006 Dec;36(12):1178-90.

PMID:
17162465
22.

Fulfilling prophecy? Sexually transmitted infections and HIV in Indigenous people in Western Australia.

Wright MR, Giele CM, Dance PR, Thompson SC.

Med J Aust. 2005 Aug 1;183(3):124-8.

PMID:
16053413
23.

The chimpanzee (Pan troglodytes) as a pharmacokinetic model for selection of drug candidates: model characterization and application.

Wong H, Grossman SJ, Bai SA, Diamond S, Wright MR, Grace JE Jr, Qian M, He K, Yeleswaram K, Christ DD.

Drug Metab Dispos. 2004 Dec;32(12):1359-69. Epub 2004 Aug 27.

PMID:
15333515
24.

Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1).

Pruitt JR, Pinto DJ, Galemmo RA Jr, Alexander RS, Rossi KA, Wells BL, Drummond S, Bostrom LL, Burdick D, Bruckner R, Chen H, Smallwood A, Wong PC, Wright MR, Bai S, Luettgen JM, Knabb RM, Lam PY, Wexler RR.

J Med Chem. 2003 Dec 4;46(25):5298-315.

PMID:
14640539
25.

Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants.

Lam PY, Clark CG, Li R, Pinto DJ, Orwat MJ, Galemmo RA, Fevig JM, Teleha CA, Alexander RS, Smallwood AM, Rossi KA, Wright MR, Bai SA, He K, Luettgen JM, Wong PC, Knabb RM, Wexler RR.

J Med Chem. 2003 Oct 9;46(21):4405-18.

PMID:
14521405
26.

Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors.

Quan ML, Ellis CD, He MY, Liauw AY, Lam PY, Rossi KA, Knabb RM, Luettgen JM, Wright MR, Wong PC, Wexler RR.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1023-8.

PMID:
12643903
27.

Synthesis, antiviral activity and pharmacokinetics of P1/P1' substituted 3-aminoindazole cyclic urea HIV protease inhibitors.

Kaltenbach RF 3rd, Patel M, Waltermire RE, Harris GD, Stone BR, Klabe RM, Garber S, Bacheler LT, Cordova BC, Logue K, Wright MR, Erickson-Viitanen S, Trainor GL.

Bioorg Med Chem Lett. 2003 Feb 24;13(4):605-8.

PMID:
12639540
28.

Nonbenzamidine tetrazole derivatives as factor Xa inhibitors.

Quan ML, Ellis CD, He MY, Liauw AY, Woerner FJ, Alexander RS, Knabb RM, Lam PY, Luettgen JM, Wong PC, Wright MR, Wexler RR.

Bioorg Med Chem Lett. 2003 Feb 10;13(3):369-73.

PMID:
12565931
29.

Nonpeptide factor Xa inhibitors III: effects of DPC423, an orally-active pyrazole antithrombotic agent, on arterial thrombosis in rabbits.

Wong PC, Crain EJ, Watson CA, Zaspel AM, Wright MR, Lam PY, Pinto DJ, Wexler RR, Knabb RM.

J Pharmacol Exp Ther. 2002 Dec;303(3):993-1000.

PMID:
12438519
30.

Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.

Pinto DJ, Orwat MJ, Wang S, Fevig JM, Quan ML, Amparo E, Cacciola J, Rossi KA, Alexander RS, Smallwood AM, Luettgen JM, Liang L, Aungst BJ, Wright MR, Knabb RM, Wong PC, Wexler RR, Lam PY.

J Med Chem. 2001 Feb 15;44(4):566-78.

PMID:
11170646
31.

Nonpeptide factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis.

Wong PC, Crain EJ, Knabb RM, Meade RP, Quan ML, Watson CA, Wexler RR, Wright MR, Slee AM.

J Pharmacol Exp Ther. 2000 Oct;295(1):212-8.

PMID:
10991981
32.

Isoxazolines and isoxazoles as factor Xa inhibitors.

Pruitt JR, Pinto DJ, Estrella MJ, Bostrom LL, Knabb RM, Wong PC, Wright MR, Wexler RR.

Bioorg Med Chem Lett. 2000 Apr 17;10(8):685-9.

PMID:
10782664
33.

The de novo design and synthesis of cyclic urea inhibitors of factor Xa: optimization of the S4 ligand.

Galemmo RA Jr, Wells BL, Rossi KA, Alexander RS, Dominguez C, Maduskuie TP, Stouten PF, Wright MR, Aungst BJ, Wong PC, Knabb RM, Wexler RR.

Bioorg Med Chem Lett. 2000 Feb 7;10(3):301-4.

PMID:
10698459
34.

Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2.

Quan ML, Ellis CD, Liauw AY, Alexander RS, Knabb RM, Lam G, Wright MR, Wong PC, Wexler RR.

J Med Chem. 1999 Jul 29;42(15):2760-73.

PMID:
10425087
35.

Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors

Rodgers JD, Lam PY, Johnson BL, Wang H, Ko SS, Seitz SP, Trainor GL, Anderson PS, Klabe RM, Bacheler LT, Cordova B, Garber S, Reid C, Wright MR, Chang CH, Erickson-Viitanen S.

Chem Biol. 1998 Nov;5(11):R312. No abstract available.

36.

Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors.

Rodgers JD, Lam PY, Johnson BL, Wang H, Li R, Ru Y, Ko SS, Seitz SP, Trainor GL, Anderson PS, Klabe RM, Bacheler LT, Cordova B, Garber S, Reid C, Wright MR, Chang CH, Erickson-Viitanen S.

Chem Biol. 1998 Oct;5(10):597-608. Erratum in: Chem Biol 1998 Nov;5(11):R312.

37.

Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure-activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues.

De Lucca GV, Kim UT, Liang J, Cordova B, Klabe RM, Garber S, Bacheler LT, Lam GN, Wright MR, Logue KA, Erickson-Viitanen S, Ko SS, Trainor GL.

J Med Chem. 1998 Jun 18;41(13):2411-23.

PMID:
9632373
38.
39.

Toxicokinetics of indomethacin-induced intestinal permeability in the rat.

Wright MR, Davies NM, Jamali F.

Pharmacol Res. 1997 Jun;35(6):499-504.

PMID:
9356198
40.

Effect of the enantiomers of flurbiprofen, ibuprofen, and ketoprofen on intestinal permeability.

Davies NM, Wright MR, Russell AS, Jamali F.

J Pharm Sci. 1996 Nov;85(11):1170-3.

PMID:
8923320
41.

Possible role of the intestinal P-450 enzyme system in a cyclosporine-clarithromycin interaction.

Sketris IS, Wright MR, West ML.

Pharmacotherapy. 1996 Mar-Apr;16(2):301-5.

PMID:
8820476
42.

Rationalising ophthalmic admissions.

Wright MR, Bowler GM, Bartholomew RS, Snowden B.

Eye (Lond). 1995;9 ( Pt 6 Su):65-6.

PMID:
8729024
43.

Antiinflammatory drug-induced small intestinal permeability: the rat is a suitable model.

Davies NM, Wright MR, Jamali F.

Pharm Res. 1994 Nov;11(11):1652-6.

PMID:
7870685
44.

Dose-dependency of flurbiprofen enantiomer pharmacokinetics in the rat.

Jamali F, Berry BW, Wright MR.

J Pharm Sci. 1994 Aug;83(8):1077-80.

PMID:
7983589
45.

Increased cyclosporine bioavailability from a microemulsion formulation in a liver transplant recipient.

Sketris IS, McAlister V, Wright MR.

Ann Pharmacother. 1994 Jul-Aug;28(7-8):962-3. No abstract available.

PMID:
7949523
46.

Pulse oximetry in newborn babies.

Wright MR, Puntis JW.

Lancet. 1994 Jun 11;343(8911):1500. No abstract available.

PMID:
7911196
47.
48.

Transplacental and nonplacental clearances, metabolism and pharmacodynamics of labetalol in the fetal lamb after direct intravenous administration.

Yeleswaram K, Rurak DW, Kwan E, Hall C, Doroudian A, Wright MR, Abbott FS, Axelson JE.

J Pharmacol Exp Ther. 1993 Oct;267(1):425-31.

PMID:
8229771
50.

Methods for the analysis of enantiomers of racemic drugs application to pharmacological and pharmacokinetic studies.

Wright MR, Jamali F.

J Pharmacol Toxicol Methods. 1993 Feb;29(1):1-9. Review.

PMID:
8481555

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