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Items: 1 to 50 of 322

1.

Dedication: Heinz Floss and Christopher Walsh-pioneers in natural product chemical biology.

Müller R, Wright GD.

J Ind Microbiol Biotechnol. 2019 Feb 7. doi: 10.1007/s10295-019-02139-9. [Epub ahead of print] No abstract available.

PMID:
30729342
2.

Drug combinations: a strategy to extend the life of antibiotics in the 21st century.

Tyers M, Wright GD.

Nat Rev Microbiol. 2019 Mar;17(3):141-155. doi: 10.1038/s41579-018-0141-x. Epub 2019 Jan 25. Review.

PMID:
30683887
3.

Three-Dimensional Structured Illumination Microscopy (3D-SIM) to Dissect Signaling Cross-Talks in Motile T-Cells.

Ong ST, Wright GD, Verma NK.

Methods Mol Biol. 2019;1930:41-50. doi: 10.1007/978-1-4939-9036-8_6.

PMID:
30610597
4.

Unlocking the potential of natural products in drug discovery.

Wright GD.

Microb Biotechnol. 2019 Jan;12(1):55-57. doi: 10.1111/1751-7915.13351. Epub 2018 Dec 19.

5.

Heterologous expression-facilitated natural products' discovery in actinomycetes.

Xu M, Wright GD.

J Ind Microbiol Biotechnol. 2018 Nov 16. doi: 10.1007/s10295-018-2097-2. [Epub ahead of print]

PMID:
30446891
6.

Trichlorination of a Teicoplanin-Type Glycopeptide Antibiotic by the Halogenase StaI Evades Resistance.

Yim G, Wang W, Pawlowski AC, Wright GD.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e01540-18. doi: 10.1128/AAC.01540-18. Print 2018 Dec.

PMID:
30275088
7.

A user-interactive algorithm quantifying nuclear pore complex distribution within the nuclear lamina network in single molecular localization microscopic image.

Lim JSY, Wright GD, Burke B, Xie W.

Methods. 2018 Sep 27. pii: S1046-2023(18)30137-3. doi: 10.1016/j.ymeth.2018.09.006. [Epub ahead of print]

PMID:
30268406
8.

Editorial overview: Antimicrobials.

van Wezel GP, Wright GD.

Curr Opin Microbiol. 2018 Oct;45:iii-v. doi: 10.1016/j.mib.2018.08.001. Epub 2018 Aug 31. No abstract available.

PMID:
30177439
9.

Antimicrobial Resistance and Respiratory Infections.

Guitor AK, Wright GD.

Chest. 2018 Nov;154(5):1202-1212. doi: 10.1016/j.chest.2018.06.019. Epub 2018 Jun 28. Review.

PMID:
29959904
10.

Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.

Cox G, Ejim L, Stogios PJ, Koteva K, Bordeleau E, Evdokimova E, Sieron AO, Savchenko A, Serio AW, Krause KM, Wright GD.

ACS Infect Dis. 2018 Jun 8;4(6):980-987. doi: 10.1021/acsinfecdis.8b00001. Epub 2018 Apr 19.

PMID:
29634241
11.

Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis.

Stogios PJ, Cox G, Zubyk HL, Evdokimova E, Wawrzak Z, Wright GD, Savchenko A.

ACS Chem Biol. 2018 May 18;13(5):1322-1332. doi: 10.1021/acschembio.8b00116. Epub 2018 Apr 19.

12.

Centrosome- and Golgi-Localized Protein Kinase N-Associated Protein Serves As a Docking Platform for Protein Kinase A Signaling and Microtubule Nucleation in Migrating T-Cells.

Ong ST, Chalasani MLS, Fazil MHUT, Prasannan P, Kizhakeyil A, Wright GD, Kelleher D, Verma NK.

Front Immunol. 2018 Mar 1;9:397. doi: 10.3389/fimmu.2018.00397. eCollection 2018.

13.

Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs.

Chen M, Qiu T, Wu J, Yang Y, Wright GD, Wu M, Ge R.

Cell Death Differ. 2018 Nov;25(11):1905-1920. doi: 10.1038/s41418-018-0092-9. Epub 2018 Mar 9.

14.

Imaging of native transcription factors and histone phosphorylation at high resolution in live cells.

Conic S, Desplancq D, Ferrand A, Fischer V, Heyer V, Reina San Martin B, Pontabry J, Oulad-Abdelghani M, Babu N K, Wright GD, Molina N, Weiss E, Tora L.

J Cell Biol. 2018 Apr 2;217(4):1537-1552. doi: 10.1083/jcb.201709153. Epub 2018 Feb 12.

15.

Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action.

Koteva K, Cox G, Kelso JK, Surette MD, Zubyk HL, Ejim L, Stogios P, Savchenko A, Sørensen D, Wright GD.

Cell Chem Biol. 2018 Apr 19;25(4):403-412.e5. doi: 10.1016/j.chembiol.2018.01.009. Epub 2018 Feb 1.

PMID:
29398560
16.

The evolution of substrate discrimination in macrolide antibiotic resistance enzymes.

Pawlowski AC, Stogios PJ, Koteva K, Skarina T, Evdokimova E, Savchenko A, Wright GD.

Nat Commun. 2018 Jan 9;9(1):112. doi: 10.1038/s41467-017-02680-0.

17.

The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies.

Pawlowski AC, Westman EL, Koteva K, Waglechner N, Wright GD.

ISME J. 2018 Mar;12(3):885-897. doi: 10.1038/s41396-017-0017-5. Epub 2017 Dec 19.

PMID:
29259290
18.

Lighting-up protein-ligand interactions with fluorescent PET (photoinduced electron transfer) sensor designs.

McLaughlin B, Surender EM, Wright GD, Daly B, de Silva AP.

Chem Commun (Camb). 2018 Feb 1;54(11):1319-1322. doi: 10.1039/c7cc05929a.

PMID:
29210385
19.

The flexibility and dynamics of the tubules in the endoplasmic reticulum.

Georgiades P, Allan VJ, Wright GD, Woodman PG, Udommai P, Chung MA, Waigh TA.

Sci Rep. 2017 Nov 28;7(1):16474. doi: 10.1038/s41598-017-16570-4.

20.

Transformation of the Anticancer Drug Doxorubicin in the Human Gut Microbiome.

Yan A, Culp E, Perry J, Lau JT, MacNeil LT, Surette MG, Wright GD.

ACS Infect Dis. 2018 Jan 12;4(1):68-76. doi: 10.1021/acsinfecdis.7b00166. Epub 2017 Nov 30.

PMID:
29160065
21.

Inhibitors of metallo-β-lactamases.

Rotondo CM, Wright GD.

Curr Opin Microbiol. 2017 Oct;39:96-105. doi: 10.1016/j.mib.2017.10.026. Epub 2017 Nov 16. Review.

PMID:
29154026
22.

Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7.

Bergstrom A, Katko A, Adkins Z, Hill J, Cheng Z, Burnett M, Yang H, Aitha M, Mehaffey MR, Brodbelt JS, Tehrani KHME, Martin NI, Bonomo RA, Page RC, Tierney DL, Fast W, Wright GD, Crowder MW.

ACS Infect Dis. 2018 Feb 9;4(2):135-145. doi: 10.1021/acsinfecdis.7b00106. Epub 2017 Nov 9.

23.

Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites.

Gehrke SS, Kumar G, Yokubynas NA, Côté JP, Wang W, French S, MacNair CR, Wright GD, Brown ED.

ACS Infect Dis. 2017 Dec 8;3(12):955-965. doi: 10.1021/acsinfecdis.7b00149. Epub 2017 Nov 7.

PMID:
29069544
24.

Antibiotic resistance: it's bad, but why isn't it worse?

Waglechner N, Wright GD.

BMC Biol. 2017 Sep 15;15(1):84. doi: 10.1186/s12915-017-0423-1. Review.

25.

Lessons from the Environmental Antibiotic Resistome.

Surette MD, Wright GD.

Annu Rev Microbiol. 2017 Sep 8;71:309-329. doi: 10.1146/annurev-micro-090816-093420. Epub 2017 Jun 28. Review.

PMID:
28657887
26.

Opportunities for natural products in 21st century antibiotic discovery.

Wright GD.

Nat Prod Rep. 2017 Jul 1;34(7):694-701. doi: 10.1039/c7np00019g. Epub 2017 Jun 1. Review.

PMID:
28569300
27.

Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.

Lu H, Galeano MCR, Ott E, Kaeslin G, Kausalya PJ, Kramer C, Ortiz-Brüchle N, Hilger N, Metzis V, Hiersche M, Tay SY, Tunningley R, Vij S, Courtney AD, Whittle B, Wühl E, Vester U, Hartleben B, Neuber S, Frank V, Little MH, Epting D, Papathanasiou P, Perkins AC, Wright GD, Hunziker W, Gee HY, Otto EA, Zerres K, Hildebrandt F, Roy S, Wicking C, Bergmann C.

Nat Genet. 2017 Jul;49(7):1025-1034. doi: 10.1038/ng.3871. Epub 2017 May 22.

28.

Pharmacodynamics of dose-escalated 'front-loading' polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli.

Smith NM, Bulman ZP, Sieron AO, Bulitta JB, Holden PN, Nation RL, Li J, Wright GD, Tsuji BT.

J Antimicrob Chemother. 2017 Aug 1;72(8):2297-2303. doi: 10.1093/jac/dkx121.

29.

Compartmentation of Mitochondrial and Oxidative Metabolism in Growing Hair Follicles: A Ring of Fire.

Lemasters JJ, Ramshesh VK, Lovelace GL, Lim J, Wright GD, Harland D, Dawson TL Jr.

J Invest Dermatol. 2017 Jul;137(7):1434-1444. doi: 10.1016/j.jid.2017.02.983. Epub 2017 Mar 23.

30.

Pushing the boundaries of high content imaging.

Wright GD, Ward AM, Bard F, Calvert ME.

Cytometry A. 2017 Feb;91(2):113-114. doi: 10.1002/cyto.a.23063. No abstract available.

31.

A Common Platform for Antibiotic Dereplication and Adjuvant Discovery.

Cox G, Sieron A, King AM, De Pascale G, Pawlowski AC, Koteva K, Wright GD.

Cell Chem Biol. 2017 Jan 19;24(1):98-109. doi: 10.1016/j.chembiol.2016.11.011. Epub 2016 Dec 22.

32.

Decentralization can help reduce deforestation when user groups engage with local government.

Wright GD, Andersson KP, Gibson CC, Evans TP.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):14958-14963. doi: 10.1073/pnas.1610650114. Epub 2016 Dec 12.

33.

A diverse intrinsic antibiotic resistome from a cave bacterium.

Pawlowski AC, Wang W, Koteva K, Barton HA, McArthur AG, Wright GD.

Nat Commun. 2016 Dec 8;7:13803. doi: 10.1038/ncomms13803.

34.

Bacterial proteases, untapped antimicrobial drug targets.

Culp E, Wright GD.

J Antibiot (Tokyo). 2017 Apr;70(4):366-377. doi: 10.1038/ja.2016.138. Epub 2016 Nov 30. Review.

PMID:
27899793
35.

GapmeR cellular internalization by macropinocytosis induces sequence-specific gene silencing in human primary T-cells.

Fazil MH, Ong ST, Chalasani ML, Low JH, Kizhakeyil A, Mamidi A, Lim CF, Wright GD, Lakshminarayanan R, Kelleher D, Verma NK.

Sci Rep. 2016 Nov 24;6:37721. doi: 10.1038/srep37721.

36.

Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism.

Wildenhain J, Spitzer M, Dolma S, Jarvik N, White R, Roy M, Griffiths E, Bellows DS, Wright GD, Tyers M.

Sci Data. 2016 Nov 22;3:160095. doi: 10.1038/sdata.2016.95.

37.

Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates.

Brieke C, Yim G, Peschke M, Wright GD, Cryle MJ.

Chem Commun (Camb). 2016 Nov 17;52(94):13679-13682.

PMID:
27812569
38.

CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database.

Jia B, Raphenya AR, Alcock B, Waglechner N, Guo P, Tsang KK, Lago BA, Dave BM, Pereira S, Sharma AN, Doshi S, Courtot M, Lo R, Williams LE, Frye JG, Elsayegh T, Sardar D, Westman EL, Pawlowski AC, Johnson TA, Brinkman FS, Wright GD, McArthur AG.

Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26.

39.

Antibiotic Adjuvants: Rescuing Antibiotics from Resistance: (Trends in Microbiology 24, 862-871; October 17, 2016).

Wright GD.

Trends Microbiol. 2016 Nov;24(11):928. doi: 10.1016/j.tim.2016.07.008. Epub 2016 Aug 10. No abstract available.

PMID:
27522372
40.

Antibiotic Adjuvants: Rescuing Antibiotics from Resistance.

Wright GD.

Trends Microbiol. 2016 Nov;24(11):862-871. doi: 10.1016/j.tim.2016.06.009. Epub 2016 Jul 15. Review. Erratum in: Trends Microbiol. 2016 Nov;24(11):928.

PMID:
27430191
41.

Antifungal Drugs: The Current Armamentarium and Development of New Agents.

Robbins N, Wright GD, Cowen LE.

Microbiol Spectr. 2016 Oct;4(5). doi: 10.1128/microbiolspec.FUNK-0002-2016. Review.

PMID:
27763259
42.

How To Make a Glycopeptide: A Synthetic Biology Approach To Expand Antibiotic Chemical Diversity.

Yim G, Wang W, Thaker MN, Tan S, Wright GD.

ACS Infect Dis. 2016 Sep 9;2(9):642-650. Epub 2016 Aug 5.

PMID:
27759388
43.

Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function.

Robbins N, Spitzer M, Wang W, Waglechner N, Patel DJ, O'Brien JS, Ejim L, Ejim O, Tyers M, Wright GD.

Cell Chem Biol. 2016 Nov 17;23(11):1383-1394. doi: 10.1016/j.chembiol.2016.08.015. Epub 2016 Oct 13.

44.

Empowering Older Antibiotics.

Wright GD.

Cell. 2016 Oct 6;167(2):301. doi: 10.1016/j.cell.2016.09.032.

45.

Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure-Activity Relationships.

Albu SA, Koteva K, King AM, Al-Karmi S, Wright GD, Capretta A.

Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13259-13262. doi: 10.1002/anie.201606657.

PMID:
27633338
46.

Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae.

Falconer SB, Reid-Yu SA, King AM, Gehrke SS, Wang W, Britten JF, Coombes BK, Wright GD, Brown ED.

ACS Infect Dis. 2015 Nov 13;1(11):533-43. doi: 10.1021/acsinfecdis.5b00033. Epub 2015 May 26.

PMID:
27623408
47.

New developments and novel applications in high throughput and high content imaging.

Calvert ME, Ward AM, Wright GD, Bard F.

Cytometry A. 2016 Aug;89(8):705-7. doi: 10.1002/cyto.a.22921. No abstract available.

48.

Combinatorial strategies for combating invasive fungal infections.

Spitzer M, Robbins N, Wright GD.

Virulence. 2017 Feb 17;8(2):169-185. doi: 10.1080/21505594.2016.1196300. Epub 2016 Jun 7. Review.

49.

Superresolution Microscopy of the Nuclear Envelope and Associated Proteins.

Xie W, Horn HF, Wright GD.

Methods Mol Biol. 2016;1411:83-97. doi: 10.1007/978-1-4939-3530-7_4.

PMID:
27147035
50.

Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning.

Wildenhain J, Spitzer M, Dolma S, Jarvik N, White R, Roy M, Griffiths E, Bellows DS, Wright GD, Tyers M.

Cell Syst. 2015 Dec 23;1(6):383-95. doi: 10.1016/j.cels.2015.12.003. Epub 2015 Dec 23.

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