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Highly flexible, wearable, and disposable cardiac biosensors for remote and ambulatory monitoring.

Lee SP, Ha G, Wright DE, Ma Y, Sen-Gupta E, Haubrich NR, Branche PC, Li W, Huppert GL, Johnson M, Mutlu HB, Li K, Sheth N, Wright JA Jr, Huang Y, Mansour M, Rogers JA, Ghaffari R.

NPJ Digit Med. 2018 Jan 25;1:2. doi: 10.1038/s41746-017-0009-x. eCollection 2018.


Examining Risk: A Systematic Review of Perioperative Cardiac Risk Prediction Indices.

Wright DE, Knuesel SJ, Nagarur A, Philpotts LL, Greenwald JL.

Mayo Clin Proc. 2019 Jun 13. pii: S0025-6196(19)30264-2. doi: 10.1016/j.mayocp.2019.03.008. [Epub ahead of print] Review.


Diabetic neuropathy.

Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, Bril V, Russell JW, Viswanathan V.

Nat Rev Dis Primers. 2019 Jun 13;5(1):41. doi: 10.1038/s41572-019-0092-1. Review.


An approved in vitro approach to preclinical safety and efficacy evaluation of engineered T cell receptor anti-CD3 bispecific (ImmTAC) molecules.

Harper J, Adams KJ, Bossi G, Wright DE, Stacey AR, Bedke N, Martinez-Hague R, Blat D, Humbert L, Buchanan H, Le Provost GS, Donnellan Z, Carreira RJ, Paston SJ, Weigand LU, Canestraro M, Sanderson JP, Botta Gordon-Smith S, Lowe KL, Rygiel KA, Powlesland AS, Vuidepot A, Hassan NJ, Cameron BJ, Jakobsen BK, Dukes J.

PLoS One. 2018 Oct 15;13(10):e0205491. doi: 10.1371/journal.pone.0205491. eCollection 2018.


Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet.

Cooper MA, McCoin C, Pei D, Thyfault JP, Koestler D, Wright DE.

Exp Physiol. 2018 Sep;103(9):1206-1212. doi: 10.1113/EP087083. Epub 2018 Aug 8.


Intrinsic Activity of C57BL/6 Substrains Associates with High-Fat Diet-Induced Mechanical Sensitivity in Mice.

Cooper MA, O'Meara B, Jack MM, Elliot D, Lamb B, Khan ZW, Menta BW, Ryals JM, Winter MK, Wright DE.

J Pain. 2018 Nov;19(11):1285-1295. doi: 10.1016/j.jpain.2018.05.005. Epub 2018 May 25.


A ketogenic diet reduces metabolic syndrome-induced allodynia and promotes peripheral nerve growth in mice.

Cooper MA, Menta BW, Perez-Sanchez C, Jack MM, Khan ZW, Ryals JM, Winter M, Wright DE.

Exp Neurol. 2018 Aug;306:149-157. doi: 10.1016/j.expneurol.2018.05.011. Epub 2018 May 17.


Deletion of the insulin receptor in sensory neurons increases pancreatic insulin levels.

Grote CW, Wilson NM, Katz NK, Guilford BL, Ryals JM, Novikova L, Stehno-Bittel L, Wright DE.

Exp Neurol. 2018 Jul;305:97-107. doi: 10.1016/j.expneurol.2018.04.002. Epub 2018 Apr 9.


Acetylation Regulates Thioredoxin Reductase Oligomerization and Activity.

Wright DE, Altaany Z, Bi Y, Alperstein Z, O'Donoghue P.

Antioxid Redox Signal. 2018 Aug 1;29(4):377-388. doi: 10.1089/ars.2017.7082. Epub 2017 Dec 14.


A kilonova as the electromagnetic counterpart to a gravitational-wave source.

Smartt SJ, Chen TW, Jerkstrand A, Coughlin M, Kankare E, Sim SA, Fraser M, Inserra C, Maguire K, Chambers KC, Huber ME, Krühler T, Leloudas G, Magee M, Shingles LJ, Smith KW, Young DR, Tonry J, Kotak R, Gal-Yam A, Lyman JD, Homan DS, Agliozzo C, Anderson JP, Angus CR, Ashall C, Barbarino C, Bauer FE, Berton M, Botticella MT, Bulla M, Bulger J, Cannizzaro G, Cano Z, Cartier R, Cikota A, Clark P, De Cia A, Della Valle M, Denneau L, Dennefeld M, Dessart L, Dimitriadis G, Elias-Rosa N, Firth RE, Flewelling H, Flörs A, Franckowiak A, Frohmaier C, Galbany L, González-Gaitán S, Greiner J, Gromadzki M, Guelbenzu AN, Gutiérrez CP, Hamanowicz A, Hanlon L, Harmanen J, Heintz KE, Heinze A, Hernandez MS, Hodgkin ST, Hook IM, Izzo L, James PA, Jonker PG, Kerzendorf WE, Klose S, Kostrzewa-Rutkowska Z, Kowalski M, Kromer M, Kuncarayakti H, Lawrence A, Lowe TB, Magnier EA, Manulis I, Martin-Carrillo A, Mattila S, McBrien O, Müller A, Nordin J, O'Neill D, Onori F, Palmerio JT, Pastorello A, Patat F, Pignata G, Podsiadlowski P, Pumo ML, Prentice SJ, Rau A, Razza A, Rest A, Reynolds T, Roy R, Ruiter AJ, Rybicki KA, Salmon L, Schady P, Schultz ASB, Schweyer T, Seitenzahl IR, Smith M, Sollerman J, Stalder B, Stubbs CW, Sullivan M, Szegedi H, Taddia F, Taubenberger S, Terreran G, van Soelen B, Vos J, Wainscoat RJ, Walton NA, Waters C, Weiland H, Willman M, Wiseman P, Wright DE, Wyrzykowski Ł, Yaron O.

Nature. 2017 Nov 2;551(7678):75-79. doi: 10.1038/nature24303. Epub 2017 Oct 16.


Rats bred for low and high running capacity display alterations in peripheral tissues and nerves relevant to neuropathy and pain.

Cooper MA, Jack MM, Ryals JM, Hayley P, Escher T, Koch LG, Britton SL, Raupp SM, Winter MK, McCarson KE, Geiger PC, Thyfault JP, Wright DE.

Brain Behav. 2017 Sep 6;7(10):e00780. doi: 10.1002/brb3.780. eCollection 2017 Oct.


Analysis of Daily Laboratory Orders at a Large Urban Academic Center: A Multifaceted Approach to Changing Test Ordering Patterns.

Rudolf JW, Dighe AS, Coley CM, Kamis IK, Wertheim BM, Wright DE, Lewandrowski KB, Baron JM.

Am J Clin Pathol. 2017 Aug 1;148(2):128-135. doi: 10.1093/ajcp/aqx054.


Dorsal Root Ganglia Mitochondrial Biochemical Changes in Non-diabetic and Streptozotocin-Induced Diabetic Mice Fed with a Standard or High-Fat Diet.

Guilford BL, Ryals JM, Lezi E, Swerdlow RH, Wright DE.

J Neurol Neurosci. 2017;8(2). pii: 180. doi: 10.21767/2171-6625.1000180. Epub 2017 Mar 27.


Increased FNDC5 is associated with insulin resistance in high fat-fed mice.

Guilford BL, Parson JC, Grote CW, Vick SN, Ryals JM, Wright DE.

Physiol Rep. 2017 Jul;5(13). pii: e13319. doi: 10.14814/phy2.13319.


A Role for Insulin in Diabetic Neuropathy.

Grote CW, Wright DE.

Front Neurosci. 2016 Dec 23;10:581. doi: 10.3389/fnins.2016.00581. eCollection 2016. Review.


Modulation of diet-induced mechanical allodynia by metabolic parameters and inflammation.

Cooper MA, Ryals JM, Wu PY, Wright KD, Walter KR, Wright DE.

J Peripher Nerv Syst. 2017 Mar;22(1):39-46. doi: 10.1111/jns.12199.


An Educational and Administrative Intervention to Promote Rational Laboratory Test Ordering on an Academic General Medicine Service.

Wertheim BM, Aguirre AJ, Bhattacharyya RP, Chorba J, Jadhav AP, Kerry VB, Macklin EA, Motyckova G, Raju S, Lewandrowski K, Hunt DP, Wright DE.

Am J Med. 2017 Jan;130(1):47-53. doi: 10.1016/j.amjmed.2016.08.021. Epub 2016 Sep 9.


Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain.

Cooper MA, Kluding PM, Wright DE.

Front Neurosci. 2016 Aug 23;10:372. doi: 10.3389/fnins.2016.00372. eCollection 2016. Review.


Avulsion Fracture of the Tibial Tubercle Associated With Patellar Tendon Avulsion.

Clarke DO, Franklin SA, Wright DE.

Orthopedics. 2016 May 1;39(3):e561-4. doi: 10.3928/01477447-20160414-02. Epub 2016 Apr 18.


Supporting Medical Students' Pursuit of Longitudinal Patient Experiences: Piloting an Innovative Visit Notification Tool at the Massachusetts General Hospital.

Elmore SN, Kopecky KE, Jennings K, de Moya M, Beresin G, Wright DE.

Acad Med. 2016 Jan;91(1):70-4. doi: 10.1097/ACM.0000000000000830.


(Ubi)quitin' the h2bit: recent insights into the roles of H2B ubiquitylation in DNA replication and transcription.

Wright DE, Kao CF.

Epigenetics. 2015;10(2):122-6. doi: 10.1080/15592294.2014.1003750. Epub 2015 Feb 3. Review.


Central or peripheral delivery of an adenosine A1 receptor agonist improves mechanical allodynia in a mouse model of painful diabetic neuropathy.

Katz NK, Ryals JM, Wright DE.

Neuroscience. 2015 Jan 29;285:312-23. doi: 10.1016/j.neuroscience.2014.10.065. Epub 2014 Nov 8.


Experimental motor neuropathy in diabetes.

Wilson NM, Wright DE.

Handb Clin Neurol. 2014;126:461-7. doi: 10.1016/B978-0-444-53480-4.00030-8. Review.


Safety of aerobic exercise in people with diabetic peripheral neuropathy: single-group clinical trial.

Kluding PM, Pasnoor M, Singh R, D'Silva LJ, Yoo M, Billinger SA, LeMaster JW, Dimachkie MM, Herbelin L, Wright DE.

Phys Ther. 2015 Feb;95(2):223-34. doi: 10.2522/ptj.20140108. Epub 2014 Oct 2.


H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly.

Lin CY, Wu MY, Gay S, Marjavaara L, Lai MS, Hsiao WC, Hung SH, Tseng HY, Wright DE, Wang CY, Hsu GS, Devys D, Chabes A, Kao CF.

PLoS Genet. 2014 Oct 2;10(10):e1004667. doi: 10.1371/journal.pgen.1004667. eCollection 2014 Oct.


Why guidance comes from the research community. Commentary.

Wright DE.

Hastings Cent Rep. 2014 Jul-Aug;44(4 Spec No):S27-8. doi: 10.1002/hast.337. No abstract available.


Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab).

Biessels GJ, Bril V, Calcutt NA, Cameron NE, Cotter MA, Dobrowsky R, Feldman EL, Fernyhough P, Jakobsen J, Malik RA, Mizisin AP, Oates PJ, Obrosova IG, Pop-Busui R, Russell JW, Sima AA, Stevens MJ, Schmidt RE, Tesfaye S, Veves A, Vinik AI, Wright DE, Yagihashi S, Yorek MA, Ziegler D, Zochodne DW.

J Peripher Nerv Syst. 2014 Jun;19(2):77-87. doi: 10.1111/jns5.12072. Review.


A systematic review of biomarkers for disease progression in Alzheimer's disease.

McGhee DJ, Ritchie CW, Thompson PA, Wright DE, Zajicek JP, Counsell CE.

PLoS One. 2014 Feb 18;9(2):e88854. doi: 10.1371/journal.pone.0088854. eCollection 2014. Review. Erratum in: PLoS One. 2014;9(5):e97960.


Case records of the Massachusetts General Hospital. Case 36-2013. A 38-year-old woman with anemia and thrombocytopenia.

Wright DE, Rosovsky RP, Platt MY.

N Engl J Med. 2013 Nov 21;369(21):2032-43. doi: 10.1056/NEJMcpc1215972. No abstract available.


Peripheral nervous system insulin resistance in ob/ob mice.

Grote CW, Groover AL, Ryals JM, Geiger PC, Feldman EL, Wright DE.

Acta Neuropathol Commun. 2013 May 10;1:15. doi: 10.1186/2051-5960-1-15.


The emergence of the Responsible Conduct of Research (RCR) in PHS policy and practice.

Tamot R, Arsenieva D, Wright DE.

Account Res. 2013;20(5-6):349-68. doi: 10.1080/08989621.2013.822258.


Accountability in research: policies and quality assurance. Guest editorial.

Wright DE.

Account Res. 2013;20(5-6):287-90. doi: 10.1080/08989621.2013.822225. No abstract available.


In vivo peripheral nervous system insulin signaling.

Grote CW, Ryals JM, Wright DE.

J Peripher Nerv Syst. 2013 Sep;18(3):209-19. doi: 10.1111/jns5.12033.


Chewing the fat: genetic approaches to model dyslipidemia-induced diabetic neuropathy in mice.

Guilford BL, Wright DE.

Exp Neurol. 2013 Oct;248:504-8. doi: 10.1016/j.expneurol.2013.07.016. Epub 2013 Aug 8.


Exercise-mediated improvements in painful neuropathy associated with prediabetes in mice.

Groover AL, Ryals JM, Guilford BL, Wilson NM, Christianson JA, Wright DE.

Pain. 2013 Dec;154(12):2658-67. doi: 10.1016/j.pain.2013.07.052. Epub 2013 Aug 6.


Streptozotocin-induced diabetes partially attenuates the effects of a high-fat diet on liver and brain fatty acid composition in mice.

Levant B, Ozias MK, Guilford BL, Wright DE.

Lipids. 2013 Sep;48(9):939-48. doi: 10.1007/s11745-013-3817-z. Epub 2013 Jul 28.


A systematic review of biomarkers for disease progression in Parkinson's disease.

McGhee DJ, Royle PL, Thompson PA, Wright DE, Zajicek JP, Counsell CE.

BMC Neurol. 2013 Apr 12;13:35. doi: 10.1186/1471-2377-13-35. Review.


Preparing whistleblowers for reporting research misconduct.

Bonito AJ, Titus SL, Greene AM, Amoozegar J, Eicheldinger C, Wright DE.

Account Res. 2012;19(5):308-28.


Core competency review: aortic stenosis and noncardiac surgery.

Wright DE, Hunt DP.

J Hosp Med. 2012 Oct;7(8):655-60. doi: 10.1002/jhm.1952. Epub 2012 Jun 25. Review.


The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy.

Kluding PM, Pasnoor M, Singh R, Jernigan S, Farmer K, Rucker J, Sharma NK, Wright DE.

J Diabetes Complications. 2012 Sep-Oct;26(5):424-9. doi: 10.1016/j.jdiacomp.2012.05.007. Epub 2012 Jun 18.


Histone ubiquitylation and chromatin dynamics.

Wright DE, Wang CY, Kao CF.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1051-78. Review.


Protection from diabetes-induced peripheral sensory neuropathy--a role for elevated glyoxalase I?

Jack MM, Ryals JM, Wright DE.

Exp Neurol. 2012 Mar;234(1):62-9. doi: 10.1016/j.expneurol.2011.12.015. Epub 2011 Dec 19.


Phenotypic changes in diabetic neuropathy induced by a high-fat diet in diabetic C57BL/6 mice.

Guilford BL, Ryals JM, Wright DE.

Exp Diabetes Res. 2011;2011:848307. doi: 10.1155/2011/848307. Epub 2011 Nov 14.


The use of multiple sclerosis condition-specific measures to inform health policy decision-making: mapping from the MSWS-12 to the EQ-5D.

Hawton A, Green C, Telford CJ, Wright DE, Zajicek JP.

Mult Scler. 2012 Jun;18(6):853-61. doi: 10.1177/1352458511429319. Epub 2011 Nov 22.


Vitamin D deficiency promotes skeletal muscle hypersensitivity and sensory hyperinnervation.

Tague SE, Clarke GL, Winter MK, McCarson KE, Wright DE, Smith PG.

J Neurosci. 2011 Sep 28;31(39):13728-38. doi: 10.1523/JNEUROSCI.3637-11.2011.


Flickin' the ubiquitin switch: the role of H2B ubiquitylation in development.

Wright DE, Wang CY, Kao CF.

Epigenetics. 2011 Oct 1;6(10):1165-75. doi: 10.4161/epi.6.10.17745. Epub 2011 Oct 1. Review.


Exercise increases insulin content and basal secretion in pancreatic islets in type 1 diabetic mice.

Huang HH, Farmer K, Windscheffel J, Yost K, Power M, Wright DE, Stehno-Bittel L.

Exp Diabetes Res. 2011;2011:481427. doi: 10.1155/2011/481427. Epub 2011 Sep 11.


Statistical analysis, trial design and duration in Alzheimer's disease clinical trials: a review.

Thompson PA, Wright DE, Counsell CE, Zajicek J.

Int Psychogeriatr. 2012 May;24(5):689-97. doi: 10.1017/S1041610211001116. Epub 2011 Sep 13. Review.


The C-terminus of histone H2B is involved in chromatin compaction specifically at telomeres, independently of its monoubiquitylation at lysine 123.

Wang CY, Hua CY, Hsu HE, Hsu CL, Tseng HY, Wright DE, Hsu PH, Jen CH, Lin CY, Wu MY, Tsai MD, Kao CF.

PLoS One. 2011;6(7):e22209. doi: 10.1371/journal.pone.0022209. Epub 2011 Jul 29.


Insulin receptor substrate 2 expression and involvement in neuronal insulin resistance in diabetic neuropathy.

Grote CW, Morris JK, Ryals JM, Geiger PC, Wright DE.

Exp Diabetes Res. 2011;2011:212571. doi: 10.1155/2011/212571. Epub 2011 Jun 15.

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