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Items: 1 to 50 of 66

1.

Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists.

Lu H, Yang T, Xu Z, Lin X, Ding Q, Zhang Y, Cai X, Dong K, Gong S, Zhang W, Patel M, Copley RCB, Xiang J, Guan X, Wren P, Ren F.

J Med Chem. 2018 Mar 22;61(6):2518-2532. doi: 10.1021/acs.jmedchem.7b01854. Epub 2018 Feb 28.

PMID:
29406702
2.

Development and Validation of a Quantitative Measure of Adaptive Behaviors in Women With Pelvic Floor Disorders.

Wei JT, Dunn R, Nygaard I, Burgio K, Lukacz ES, Markland A, Wren PA, Brubaker L, Barber MD, Jelovsek JE, Spino C, Meikle S, Janz N; PFDN.

Female Pelvic Med Reconstr Surg. 2017 Jul/Aug;23(4):232-237. doi: 10.1097/SPV.0000000000000431.

3.

Mechanisms of vascular disease in dementia: what does industry want to know?

Wren PB, Hill D, Lockhart A.

Clin Sci (Lond). 2017 May 1;131(9):799-802. doi: 10.1042/CS20160724.

PMID:
28424374
4.

Baseline assessment of campus-wide general health status and mental health: Opportunity for tailored suicide prevention and mental health awareness programming.

Hawley LD, MacDonald MG, Wallace EH, Smith J, Wummel B, Wren PA.

J Am Coll Health. 2016;64(3):174-83. doi: 10.1080/07448481.2015.1085059.

PMID:
26629894
5.

What would brain-computer interface users want: opinions and priorities of potential users with spinal cord injury.

Huggins JE, Moinuddin AA, Chiodo AE, Wren PA.

Arch Phys Med Rehabil. 2015 Mar;96(3 Suppl):S38-45.e1-5. doi: 10.1016/j.apmr.2014.05.028.

PMID:
25721546
6.

2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: discovery of novel and potent CXCR2 antagonists.

Lu H, Yang T, Xu Z, Wren PB, Zhang Y, Cai X, Patel M, Dong K, Zhang Q, Zhang W, Guan X, Xiang J, Elliott JD, Lin X, Ren F.

Bioorg Med Chem Lett. 2014 Dec 1;24(23):5493-6. doi: 10.1016/j.bmcl.2014.10.003. Epub 2014 Oct 12.

PMID:
25455491
7.

GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 inhibitor that demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in preclinical species.

Rutter AR, Poffe A, Cavallini P, Davis TG, Schneck J, Negri M, Vicentini E, Montanari D, Arban R, Gray FA, Davies CH, Wren PB.

J Pharmacol Exp Ther. 2014 Jul;350(1):153-63. doi: 10.1124/jpet.114.214155. Epub 2014 Apr 30.

PMID:
24784567
8.

Patient compliance and suboptimal bowel preparation with split-dose bowel regimen in average-risk screening colonoscopy.

Menees SB, Kim HM, Wren P, Zikmund-Fisher BJ, Elta GH, Foster S, Korsnes S, Graustein B, Schoenfeld P.

Gastrointest Endosc. 2014 May;79(5):811-820.e3. doi: 10.1016/j.gie.2014.01.024. Epub 2014 Mar 13.

9.

p38 MAP kinase activation does not stimulate serotonin transport in rat brain: Implications for sickness behaviour mechanisms.

Andreetta F, Barnes NM, Wren PB, Carboni L.

Life Sci. 2013 Jul 19;93(1):30-7. doi: 10.1016/j.lfs.2013.05.014. Epub 2013 May 30.

PMID:
23727352
10.

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases.

Lu B, Nagappan G, Guan X, Nathan PJ, Wren P.

Nat Rev Neurosci. 2013 Jun;14(6):401-16. doi: 10.1038/nrn3505. Epub 2013 May 15. Review.

PMID:
23674053
11.

Barriers to and mediators of brain-computer interface user acceptance: focus group findings.

Blain-Moraes S, Schaff R, Gruis KL, Huggins JE, Wren PA.

Ergonomics. 2012;55(5):516-25. doi: 10.1080/00140139.2012.661082. Epub 2012 Mar 29.

PMID:
22455595
12.

What would brain-computer interface users want? Opinions and priorities of potential users with amyotrophic lateral sclerosis.

Huggins JE, Wren PA, Gruis KL.

Amyotroph Lateral Scler. 2011 Sep;12(5):318-24. doi: 10.3109/17482968.2011.572978. Epub 2011 May 2.

13.

Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.

Ahn K, Smith SE, Liimatta MB, Beidler D, Sadagopan N, Dudley DT, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stiff C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt BF.

J Pharmacol Exp Ther. 2011 Jul;338(1):114-24. doi: 10.1124/jpet.111.180257. Epub 2011 Apr 19.

14.

Amyotrophic lateral sclerosis patients' self-reported satisfaction with assistive technology.

Gruis KL, Wren PA, Huggins JE.

Muscle Nerve. 2011 May;43(5):643-7. doi: 10.1002/mus.21951. Epub 2011 Apr 1.

15.

Assessing autonomic dysfunction in early diabetic neuropathy: the Survey of Autonomic Symptoms.

Zilliox L, Peltier AC, Wren PA, Anderson A, Smith AG, Singleton JR, Feldman EL, Alexander NB, Russell JW.

Neurology. 2011 Mar 22;76(12):1099-105. doi: 10.1212/WNL.0b013e3182120147.

16.

Preventing stroke.

Wren P.

Diabetes Self Manag. 2011 Jan-Feb;28(1):60, 62, 64-5. No abstract available.

PMID:
21323075
17.

Concussion or mild traumatic brain injury: parents appreciate the nuances of nosology.

Gordon KE, Dooley JM, Fitzpatrick EA, Wren P, Wood EP.

Pediatr Neurol. 2010 Oct;43(4):253-7. doi: 10.1016/j.pediatrneurol.2010.05.012.

PMID:
20837303
18.

Lessons learned from a peri-urban needle exchange.

Knittel AK, Wren PA, Gore L.

Harm Reduct J. 2010 Apr 29;7:8. doi: 10.1186/1477-7517-7-8.

19.

Contrasting the use of 2 vision-specific quality of life questionnaires in subjects with open-angle glaucoma.

Wren PA, Musch DC, Janz NK, Niziol LM, Guire KE, Gillespie BW; CIGTS Study Group.

J Glaucoma. 2009 Jun-Jul;18(5):403-11. doi: 10.1097/IJG.0b013e3181879e63.

20.

The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feeding in rats as a measure of emetogenicity.

Davis TG, Peterson JJ, Kou JP, Capper-Spudich EA, Ball D, Nials AT, Wiseman J, Solanke YE, Lucas FS, Williamson RA, Ferrari L, Wren P, Knowles RG, Barnette MS, Podolin PL.

J Pharmacol Exp Ther. 2009 Sep;330(3):922-31. doi: 10.1124/jpet.109.152454. Epub 2009 Jun 4.

PMID:
19498103
21.

Patient reported symptoms during an ulcerative colitis flare: a Qualitative Focus Group Study.

Waljee AK, Joyce JC, Wren PA, Khan TM, Higgins PD.

Eur J Gastroenterol Hepatol. 2009 May;21(5):558-64. doi: 10.1097/MEG.0b013e328326cacb.

22.

Evaluating clinical change and visual function concerns in drivers and nondrivers with glaucoma.

Janz NK, Musch DC, Gillespie BW, Wren PA, Niziol LM; Collaborative Initial Glaucoma Treatment Study (CIGTS) Investigators.

Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1718-25. doi: 10.1167/iovs.08-2575. Epub 2008 Dec 5.

23.

Risk of sleep apnea in orchestra members.

Brown DL, Zahuranec DB, Majersik JJ, Wren PA, Gruis KL, Zupancic M, Lisabeth LD.

Sleep Med. 2009 Jun;10(6):657-60. doi: 10.1016/j.sleep.2008.05.013. Epub 2008 Nov 17.

PMID:
19014898
24.

Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity.

Joyce JC, Waljee AK, Khan T, Wren PA, Dave M, Zimmermann EM, Wang S, Zhu J, Higgins PD.

Health Qual Life Outcomes. 2008 Sep 20;6:69. doi: 10.1186/1477-7525-6-69.

25.

Serotonin-dopamine interactions: implications for the design of novel therapeutic agents for psychiatric disorders.

Wood MD, Wren PB.

Prog Brain Res. 2008;172:213-30. doi: 10.1016/S0079-6123(08)00911-4. Review.

PMID:
18772035
26.

Enhancing participation of older women in surgical trials.

Goode PS, Fitzgerald MP, Richter HE, Whitehead WE, Nygaard I, Wren PA, Zyczynski HM, Cundiff G, Menefee S, Senka JM, Gao X, Weber AM; Pelvic Floor Disorders Network.

J Am Coll Surg. 2008 Sep;207(3):303-11. doi: 10.1016/j.jamcollsurg.2008.03.012. Epub 2008 May 19.

27.

Optimism in women undergoing abdominal sacrocolpopexy for pelvic organ prolapse.

Wren PA, Janz NK, FitzGerald MP, Barber MD, Burgio KL, Cundiff GW, Nygaard IE, Zyczynski HM, Gao X; Pelvic Floor Disorders Network.

J Am Coll Surg. 2008 Aug;207(2):240-5. doi: 10.1016/j.jamcollsurg.2008.02.019. Epub 2008 May 12.

28.

Evaluation of a polyacrylamide soil additive to reduce agricultural-associated contamination.

Krauth DM, Bouldin JL, Green VS, Wren PS, Baker WH.

Bull Environ Contam Toxicol. 2008 Aug;81(2):116-23. doi: 10.1007/s00128-008-9448-z. Epub 2008 May 8.

PMID:
18463774
29.

Bowel symptoms in women 1 year after sacrocolpopexy.

Bradley CS, Nygaard IE, Brown MB, Gutman RE, Kenton KS, Whitehead WE, Goode PS, Wren PA, Ghetti C, Weber AM; Pelvic Floor Disorders Network.

Am J Obstet Gynecol. 2007 Dec;197(6):642.e1-8.

PMID:
18060963
30.

Sexual function before and after sacrocolpopexy for pelvic organ prolapse.

Handa VL, Zyczynski HM, Brubaker L, Nygaard I, Janz NK, Richter HE, Wren PA, Brown MB, Weber AM; Pelvic Floor Disorders Network.

Am J Obstet Gynecol. 2007 Dec;197(6):629.e1-6.

31.

Lower urinary tract symptoms, quality of life and pelvic organ prolapse: irritative bladder and obstructive voiding symptoms in women planning to undergo abdominal sacrocolpopexy for advanced pelvic organ prolapse.

Richter HE, Nygaard I, Burgio KL, Handa VL, Fitzgerald MP, Wren P, Zyczynski H, Fine P, Brown MB, Weber AM; Pelvic Floor Disorders Network.

J Urol. 2007 Sep;178(3 Pt 1):965-9; discussion 969. Epub 2007 Jul 16.

PMID:
17632167
32.

Spanish language translation of pelvic floor disorders instruments.

Young AE, Fine PM, McCrery R, Wren PA, Richter HE, Brubaker L, Brown MB, Weber AM; Pelvic Floor Disorders Network.

Int Urogynecol J Pelvic Floor Dysfunct. 2007 Oct;18(10):1171-8. Epub 2007 Jun 19.

PMID:
17576498
33.

Depression and mood indicators in newly diagnosed glaucoma patients.

Jampel HD, Frick KD, Janz NK, Wren PA, Musch DC, Rimal R, Lichter PR; CIGTS Study Group.

Am J Ophthalmol. 2007 Aug;144(2):238-244. Epub 2007 Jun 11.

PMID:
17560843
34.

Fear of blindness in the Collaborative Initial Glaucoma Treatment Study: patterns and correlates over time.

Janz NK, Wren PA, Guire KE, Musch DC, Gillespie BW, Lichter PR; Collaborative Initial Glaucoma Treatment Study.

Ophthalmology. 2007 Dec;114(12):2213-20. Epub 2007 May 9.

PMID:
17490746
35.

Prolapse severity, symptoms and impact on quality of life among women planning sacrocolpopexy.

Fitzgerald MP, Janz NK, Wren PA, Wei JT, Weber AM, Ghetti C, Cundiff GW; Pelvic Floor Disorders Network.

Int J Gynaecol Obstet. 2007 Jul;98(1):24-8. Epub 2007 May 3.

36.

The quantitative validation of non-endoscopic disease activity indices in ulcerative colitis.

Higgins PD, Leung J, Schwartz M, Mapili J, Wren PA, Zimmermann EM.

Aliment Pharmacol Ther. 2007 Feb 1;25(3):333-42.

37.

Cataract extraction in the collaborative initial glaucoma treatment study: incidence, risk factors, and the effect of cataract progression and extraction on clinical and quality-of-life outcomes.

Musch DC, Gillespie BW, Niziol LM, Janz NK, Wren PA, Rockwood EJ, Lichter PR; Collaborative Initial Glaucoma Treatment Study Group.

Arch Ophthalmol. 2006 Dec;124(12):1694-700.

PMID:
17159028
38.

Impact of an educational video on patient decision making in early breast cancer treatment.

Wilkins EG, Lowery JC, Copeland LA, Goldfarb SL, Wren PA, Janz NK.

Med Decis Making. 2006 Nov-Dec;26(6):589-98.

PMID:
17099197
39.

Bowel symptoms in women planning surgery for pelvic organ prolapse.

Bradley CS, Brown MB, Cundiff GW, Goode PS, Kenton KS, Nygaard IE, Whitehead WE, Wren PA, Weber AM; Pelvic Floor Disorders Network.

Am J Obstet Gynecol. 2006 Dec;195(6):1814-9. Epub 2006 Sep 25.

PMID:
16996465
40.

SB-649915, a novel, potent 5-HT1A and 5-HT1B autoreceptor antagonist and 5-HT re-uptake inhibitor in native tissue.

Scott C, Soffin EM, Hill M, Atkinson PJ, Langmead CJ, Wren PB, Faedo S, Gordon LJ, Price GW, Bromidge S, Johnson CN, Hagan JJ, Watson J.

Eur J Pharmacol. 2006 Apr 24;536(1-2):54-61. Epub 2006 Feb 28.

PMID:
16571351
41.

Social and emotional impact of strabismus surgery on quality of life in children.

Archer SM, Musch DC, Wren PA, Guire KE, Del Monte MA.

J AAPOS. 2005 Apr;9(2):148-51.

PMID:
15838442
42.

Reliability of health-related quality-of-life measures 1 year after surgical procedures for pelvic floor disorders.

Wren PA, Janz NK, Brubaker L, Fitzgerald MP, Weber AM, LaPorte FB, Wei JT; Pelvic Floor Disorders Network.

Am J Obstet Gynecol. 2005 Mar;192(3):780-8.

PMID:
15746672
43.

Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists.

Palin R, Barn DR, Clark JK, Cottney JE, Cowley PM, Crockatt M, Evans L, Feilden H, Goodwin RR, Griekspoor F, Grove SJ, Houghton AK, Jones PS, Morphy RJ, Smith AR, Sundaram H, Vrolijk D, Weston MA, Wishart G, Wren P.

Bioorg Med Chem Lett. 2005 Feb 1;15(3):589-93.

PMID:
15664818
44.

Taking CHARGE: A self-management program for women following breast cancer treatment.

Cimprich B, Janz NK, Northouse L, Wren PA, Given B, Given CW.

Psychooncology. 2005 Sep;14(9):704-17.

45.

Patient-physician concordance: preferences, perceptions, and factors influencing the breast cancer surgical decision.

Janz NK, Wren PA, Copeland LA, Lowery JC, Goldfarb SL, Wilkins EG.

J Clin Oncol. 2004 Aug 1;22(15):3091-8.

PMID:
15284259
46.

A staffing-effectiveness methodology for analyzing human resource and clinical/service screening indicator data.

Sullivan J, Brust P, Wren PJ, Rich V.

Jt Comm J Qual Saf. 2004 Jun;30(6):322-30.

PMID:
15208981
47.

Profiles in patient safety: medication errors in the emergency department.

Croskerry P, Shapiro M, Campbell S, LeBlanc C, Sinclair D, Wren P, Marcoux M.

Acad Emerg Med. 2004 Mar;11(3):289-99.

48.

Colorectal cancer screening attitudes and behavior: a population-based study.

Janz NK, Wren PA, Schottenfeld D, Guire KE.

Prev Med. 2003 Dec;37(6 Pt 1):627-34.

PMID:
14636796
49.

Three potentially fatal adverse effects of psychotropic medications.

Wren P, Frizzell LA, Keltner NL, Wright AV.

Perspect Psychiatr Care. 2003 Apr-Jun;39(2):75-81. Review. No abstract available.

PMID:
12894601
50.

The collaborative initial glaucoma treatment study: baseline visual field and test-retest variability.

Gillespie BW, Musch DC, Guire KE, Mills RP, Lichter PR, Janz NK, Wren PA; CIGTS (Collaborative Initial Glaucoma Treatment Study) Study Group.

Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2613-20.

PMID:
12766064

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