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Fibroblast-specific Stat1 deletion enhances the myofibroblast phenotype during tissue repair.

Medley SC, Rathnakar BH, Georgescu C, Wren JD, Olson LE.

Wound Repair Regen. 2020 Mar 16. doi: 10.1111/wrr.12807. [Epub ahead of print]


Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood.

Kiss T, Tarantini S, Csipo T, Balasubramanian P, Nyúl-Tóth Á, Yabluchanskiy A, Wren JD, Garman L, Huffman DM, Csiszar A, Ungvari Z.

Geroscience. 2020 Mar 15. doi: 10.1007/s11357-020-00180-6. [Epub ahead of print]


Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects.

Kiss T, Nyúl-Tóth Á, Balasubramanian P, Tarantini S, Ahire C, Yabluchanskiy A, Csipo T, Farkas E, Wren JD, Garman L, Csiszar A, Ungvari Z.

Geroscience. 2020 Feb 13. doi: 10.1007/s11357-020-00165-5. [Epub ahead of print]


KRCC1: A potential therapeutic target in ovarian cancer.

Dwivedi SKD, Shameer K, Dey A, Mustafi SB, Xiong X, Bhattacharya U, Neizer-Ashun F, Rao G, Wang Y, Ivan C, Yang D, Dudley JT, Xu C, Wren JD, Mukherjee P, Bhattacharya R.

FASEB J. 2020 Feb;34(2):2287-2300. doi: 10.1096/fj.201902259R. Epub 2019 Dec 23.


The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43.

Keihani S, Kluever V, Mandad S, Bansal V, Rahman R, Fritsch E, Gomes LC, Gärtner A, Kügler S, Urlaub H, Wren JD, Bonn S, Rizzoli SO, Fornasiero EF.

Sci Adv. 2019 Dec 18;5(12):eaay2670. doi: 10.1126/sciadv.aay2670. eCollection 2019 Dec.


Optimized monoclonal antibody treatment against ELTD1 for GBM in a G55 xenograft mouse model.

Zalles M, Smith N, Ziegler J, Saunders D, Remerowski S, Thomas L, Gulej R, Mamedova N, Lerner M, Fung KM, Chung J, Hwang K, Jin J, Wiley G, Brown C, Battiste J, Wren JD, Towner RA.

J Cell Mol Med. 2020 Jan;24(2):1738-1749. doi: 10.1111/jcmm.14867. Epub 2019 Dec 21.


Examination of CIs in health and medical journals from 1976 to 2019: an observational study.

Barnett AG, Wren JD.

BMJ Open. 2019 Nov 21;9(11):e032506. doi: 10.1136/bmjopen-2019-032506.


Characterization of cxorf21 Provides Molecular Insight Into Female-Bias Immune Response in SLE Pathogenesis.

Harris VM, Koelsch KA, Kurien BT, Harley ITW, Wren JD, Harley JB, Scofield RH.

Front Immunol. 2019 Oct 21;10:2160. doi: 10.3389/fimmu.2019.02160. eCollection 2019.


Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects.

Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Csipo T, Nyúl-Tóth Á, Lipecz A, Szabo C, Farkas E, Wren JD, Csiszar A, Ungvari Z.

Geroscience. 2019 Aug;41(4):419-439. doi: 10.1007/s11357-019-00095-x. Epub 2019 Aug 28.


A TMEFF2-regulated cell cycle derived gene signature is prognostic of recurrence risk in prostate cancer.

Georgescu C, Corbin JM, Thibivilliers S, Webb ZD, Zhao YD, Koster J, Fung KM, Asch AS, Wren JD, Ruiz-Echevarría MJ.

BMC Cancer. 2019 May 6;19(1):423. doi: 10.1186/s12885-019-5592-6.


Targeting ELTD1, an angiogenesis marker for glioblastoma (GBM), also affects VEGFR2: molecular-targeted MRI assessment.

Ziegler J, Zalles M, Smith N, Saunders D, Lerner M, Fung KM, Patel M, Wren JD, Lupu F, Battiste J, Towner RA.

Am J Nucl Med Mol Imaging. 2019 Feb 15;9(1):93-109. eCollection 2019.


Suppression of ILC2 differentiation from committed T cell precursors by E protein transcription factors.

Qian L, Bajana S, Georgescu C, Peng V, Wang HC, Adrianto I, Colonna M, Alberola-Ila J, Wren JD, Sun XH.

J Exp Med. 2019 Apr 1;216(4):884-899. doi: 10.1084/jem.20182100. Epub 2019 Mar 21.


Proceedings of the 2018 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) conference.

Wren JD, Doerkson RJ, Toby IT, Nanduri B, Homayouni R, Manda P, Thakkar S.

BMC Bioinformatics. 2019 Mar 14;20(Suppl 2):95. doi: 10.1186/s12859-019-2618-7. No abstract available.


MNEMONIC: MetageNomic Experiment Mining to create an OTU Network of Inhabitant Correlations.

Perz AI, Giles CB, Brown CA, Porter H, Roopnarinesingh X, Wren JD.

BMC Bioinformatics. 2019 Mar 14;20(Suppl 2):96. doi: 10.1186/s12859-019-2623-x.


The Need for Greater Rigor in Childhood Nutrition and Obesity Research.

Wood AC, Wren JD, Allison DB.

JAMA Pediatr. 2019 Apr 1;173(4):311-312. doi: 10.1001/jamapediatrics.2019.0015. No abstract available.


Reviewer-coerced citation: case report, update on journal policy and suggestions for future prevention.

Wren JD, Valencia A, Kelso J.

Bioinformatics. 2019 Sep 15;35(18):3217-3218. doi: 10.1093/bioinformatics/btz071. No abstract available.


Insights From Analysis of Human Antigen-Specific Memory B Cell Repertoires.

Shah HB, Smith K, Wren JD, Webb CF, Ballard JD, Bourn RL, James JA, Lang ML.

Front Immunol. 2019 Jan 15;9:3064. doi: 10.3389/fimmu.2018.03064. eCollection 2018. Review.


OKN-007 Increases temozolomide (TMZ) Sensitivity and Suppresses TMZ-Resistant Glioblastoma (GBM) Tumor Growth.

Towner RA, Smith N, Saunders D, Brown CA, Cai X, Ziegler J, Mallory S, Dozmorov MG, Coutinho De Souza P, Wiley G, Kim K, Kang S, Kong DS, Kim YT, Fung KM, Wren JD, Battiste J.

Transl Oncol. 2019 Feb;12(2):320-335. doi: 10.1016/j.tranon.2018.10.002. Epub 2018 Nov 20.


The role of DNA methylation in epigenetics of aging.

Unnikrishnan A, Freeman WM, Jackson J, Wren JD, Porter H, Richardson A.

Pharmacol Ther. 2019 Mar;195:172-185. doi: 10.1016/j.pharmthera.2018.11.001. Epub 2018 Nov 9. Review.


CAGm: a repository of germline microsatellite variations in the 1000 genomes project.

Kinney N, Titus-Glover K, Wren JD, Varghese RT, Michalak P, Liao H, Anandakrishnan R, Pulenthiran A, Kang L, Garner HR.

Nucleic Acids Res. 2019 Jan 8;47(D1):D39-D45. doi: 10.1093/nar/gky969.


ARID3a gene profiles are strongly associated with human interferon alpha production.

Ratliff ML, Garton J, Garman L, Barron MD, Georgescu C, White KA, Chakravarty E, Wren JD, Montgomery CG, James JA, Webb CF.

J Autoimmun. 2019 Jan;96:158-167. doi: 10.1016/j.jaut.2018.09.013. Epub 2018 Oct 5.


Correction to: Tetraspanin-enriched microdomains regulate digitation junctions.

Huang C, Fu C, Wren JD, Wang X, Zhang F, Zhang YH, Connell SA, Chen T, Zhang XA.

Cell Mol Life Sci. 2018 Nov;75(21):4077. doi: 10.1007/s00018-018-2909-6.


Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline.

Valcarcel-Ares MN, Tucsek Z, Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Galvan V, Ballabh P, Richardson A, Freeman WM, Wren JD, Deak F, Ungvari Z, Csiszar A.

J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):290-298. doi: 10.1093/gerona/gly127.


Endothelial dysfunction and angiogenesis impairment in the ageing vasculature.

Ungvari Z, Tarantini S, Kiss T, Wren JD, Giles CB, Griffin CT, Murfee WL, Pacher P, Csiszar A.

Nat Rev Cardiol. 2018 Sep;15(9):555-565. doi: 10.1038/s41569-018-0030-z. Review.


Algorithmically outsourcing the detection of statistical errors and other problems.

Wren JD.

EMBO J. 2018 Jun 15;37(12). pii: e99651. doi: 10.15252/embj.201899651. Epub 2018 May 24. No abstract available.


Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice.

Deepa SS, Pharaoh G, Kinter M, Diaz V, Fok WC, Riddle K, Pulliam D, Hill S, Fischer KE, Soto V, Georgescu C, Wren JD, Viscomi C, Richardson A, Van Remmen H.

Aging Cell. 2018 Aug;17(4):e12769. doi: 10.1111/acel.12769. Epub 2018 Apr 25.


Tetraspanin-enriched microdomains regulate digitation junctions.

Huang C, Fu C, Wren JD, Wang X, Zhang F, Zhang YH, Connel SA, Chen T, Zhang XA.

Cell Mol Life Sci. 2018 Sep;75(18):3423-3439. doi: 10.1007/s00018-018-2803-2. Epub 2018 Mar 27. Erratum in: Cell Mol Life Sci. 2018 Nov;75(21):4077.


Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability.

Min KW, Zealy RW, Davila S, Fomin M, Cummings JC, Makowsky D, Mcdowell CH, Thigpen H, Hafner M, Kwon SH, Georgescu C, Wren JD, Yoon JH.

Aging Cell. 2018 Jun;17(3):e12753. doi: 10.1111/acel.12753. Epub 2018 Mar 23.


Carbohydrate Mouth Rinsing Does Not Prevent the Decline in Maximal Strength After Fatiguing Exercise.

Black CD, Schubert DJ, Szczyglowski MK, Wren JD.

J Strength Cond Res. 2018 Sep;32(9):2466-2473. doi: 10.1519/JSC.0000000000002444.


Algorithmic identification of discrepancies between published ratios and their reported confidence intervals and P-values.

Georgescu C, Wren JD.

Bioinformatics. 2018 May 15;34(10):1758-1766. doi: 10.1093/bioinformatics/btx811.


Proceedings of the 2017 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference.

Wren JD, Dozmorov MG, Toby I, Nanduri B, Homayouni R, Manda P, Thakkar S.

BMC Bioinformatics. 2017 Dec 28;18(Suppl 14):498. doi: 10.1186/s12859-017-1887-2. No abstract available.


ALE: automated label extraction from GEO metadata.

Giles CB, Brown CA, Ripperger M, Dennis Z, Roopnarinesingh X, Porter H, Perz A, Wren JD.

BMC Bioinformatics. 2017 Dec 28;18(Suppl 14):509. doi: 10.1186/s12859-017-1888-1.


APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development.

Piccini A, Castroflorio E, Valente P, Guarnieri FC, Aprile D, Michetti C, Bramini M, Giansante G, Pinto B, Savardi A, Cesca F, Bachi A, Cattaneo A, Wren JD, Fassio A, Valtorta F, Benfenati F, Giovedì S.

Cell Rep. 2017 Dec 19;21(12):3596-3611. doi: 10.1016/j.celrep.2017.11.073.


Predictive bioinformatics identifies novel regulators of proliferation in a cancer stem cell model.

Fields E, Wren JD, Georgescu C, Daum JR, Gorbsky GJ.

Stem Cell Res. 2018 Jan;26:1-7. doi: 10.1016/j.scr.2017.11.009. Epub 2017 Nov 21.


Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency.

Hopiavuori BR, Deák F, Wilkerson JL, Brush RS, Rocha-Hopiavuori NA, Hopiavuori AR, Ozan KG, Sullivan MT, Wren JD, Georgescu C, Szweda L, Awasthi V, Towner R, Sherry DM, Anderson RE, Agbaga MP.

Mol Neurobiol. 2018 Feb;55(2):1795-1813. doi: 10.1007/s12035-017-0824-8. Epub 2017 Nov 22.


CD4+CD28+KIR+CD11ahi T cells correlate with disease activity and are characterized by a pro-inflammatory epigenetic and transcriptional profile in lupus patients.

Gensterblum E, Renauer P, Coit P, Strickland FM, Kilian NC, Miller S, Ognenovski M, Wren JD, Tsou PS, Lewis EE, Maksimowicz-McKinnon K, McCune WJ, Richardson BC, Sawalha AH.

J Autoimmun. 2018 Jan;86:19-28. doi: 10.1016/j.jaut.2017.09.011. Epub 2017 Oct 20.


Sexually divergent DNA methylation patterns with hippocampal aging.

Masser DR, Hadad N, Porter HL, Mangold CA, Unnikrishnan A, Ford MM, Giles CB, Georgescu C, Dozmorov MG, Wren JD, Richardson A, Stanford DR, Freeman WM.

Aging Cell. 2017 Dec;16(6):1342-1352. doi: 10.1111/acel.12681. Epub 2017 Sep 25.


Activated signature of antiphospholipid syndrome neutrophils reveals potential therapeutic target.

Knight JS, Meng H, Coit P, Yalavarthi S, Sule G, Gandhi AA, Grenn RC, Mazza LF, Ali RA, Renauer P, Wren JD, Bockenstedt PL, Wang H, Eitzman DT, Sawalha AH.

JCI Insight. 2017 Sep 21;2(18). pii: 93897. doi: 10.1172/jci.insight.93897. eCollection 2017 Sep 21.


GTSE1 regulates spindle microtubule dynamics to control Aurora B kinase and Kif4A chromokinesin on chromosome arms.

Tipton AR, Wren JD, Daum JR, Siefert JC, Gorbsky GJ.

J Cell Biol. 2017 Oct 2;216(10):3117-3132. doi: 10.1083/jcb.201610012. Epub 2017 Aug 18.


Erratum to: The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain.

Buckley DA, Jennings EM, Burke NN, Roche M, McInerney V, Wren JD, Finn DP, McHugh PC.

Mol Neurobiol. 2018 Mar;55(3):2431. doi: 10.1007/s12035-017-0655-7. No abstract available.


Pancreatic Polypeptide Cell Proliferation in the Pancreas and Duodenum Coexisting in a Patient With Pancreatic Adenocarcinoma Treated With a GLP-1 Analog.

Talmon GA, Wren JD, Nguyen CL, Pour PM.

Pancreas. 2017 Jul;46(6):820-824. doi: 10.1097/MPA.0000000000000844.


DNA replication timing during development anticipates transcriptional programs and parallels enhancer activation.

Siefert JC, Georgescu C, Wren JD, Koren A, Sansam CL.

Genome Res. 2017 Aug;27(8):1406-1416. doi: 10.1101/gr.218602.116. Epub 2017 May 16.


Role of DNA methylation in the dietary restriction mediated cellular memory.

Unnikrishnan A, Jackson J, Matyi SA, Hadad N, Wronowski B, Georgescu C, Garrett KP, Wren JD, Freeman WM, Richardson A.

Geroscience. 2017 Jun;39(3):331-345. doi: 10.1007/s11357-017-9976-8. Epub 2017 May 5.


The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain.

Buckley DA, Jennings EM, Burke NN, Roche M, McInerney V, Wren JD, Finn DP, McHugh PC.

Mol Neurobiol. 2018 Mar;55(3):2420-2430. doi: 10.1007/s12035-017-0492-8. Epub 2017 Mar 30. Erratum in: Mol Neurobiol. 2017 Jul 1;:.


Use it or lose it: citations predict the continued online availability of published bioinformatics resources.

Wren JD, Georgescu C, Giles CB, Hennessey J.

Nucleic Acids Res. 2017 Apr 20;45(7):3627-3633. doi: 10.1093/nar/gkx182. Review.


Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.

Tarantini S, Valcarcel-Ares NM, Yabluchanskiy A, Springo Z, Fulop GA, Ashpole N, Gautam T, Giles CB, Wren JD, Sonntag WE, Csiszar A, Ungvari Z.

Aging Cell. 2017 Jun;16(3):469-479. doi: 10.1111/acel.12583. Epub 2017 Mar 14.


Loss of Nrf2 exacerbates the visual deficits and optic neuritis elicited by experimental autoimmune encephalomyelitis.

Larabee CM, Desai S, Agasing A, Georgescu C, Wren JD, Axtell RC, Plafker SM.

Mol Vis. 2016 Dec 30;22:1503-1513. eCollection 2016.


Systemic lupus erythematosus biomarkers: the challenging quest.

Arriens C, Wren JD, Munroe ME, Mohan C.

Rheumatology (Oxford). 2017 Apr 1;56(suppl_1):i32-i45. doi: 10.1093/rheumatology/kew407. Review.


Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice.

Salmon AB, Kim G, Liu C, Wren JD, Georgescu C, Richardson A, Levine RL.

Redox Biol. 2016 Dec;10:251-256. doi: 10.1016/j.redox.2016.10.012. Epub 2016 Oct 25.


Proceedings of the 2016 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference.

Wren JD, Toby I, Hong H, Nanduri B, Kaundal R, Dozmorov MG, Thakkar S.

BMC Bioinformatics. 2016 Oct 6;17(Suppl 13):356. No abstract available.

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