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Genome-wide assessment of antimicrobial tolerance in Yersinia pseudotuberculosis under ciprofloxacin stress.

Willcocks S, Huse KK, Stabler R, Oyston PCF, Scott A, Atkins HS, Wren BW.

Microb Genom. 2019 Oct 3. doi: 10.1099/mgen.0.000304. [Epub ahead of print] No abstract available.


"The recent emergence of a highly related virulent Clostridium difficile clade with unique characteristics".

Shaw HA, Preston MD, Vendrik KEW, Cairns MD, Browne HP, Stabler RA, Crobach MJT, Corver J, Pituch H, Ingebretsen A, Primohammed M, Faulds-Pain A, Valiente E, Lawley TD, Fairweather NF, Kuijper EJ, Wren BW.

Clin Microbiol Infect. 2019 Sep 13. pii: S1198-743X(19)30489-6. doi: 10.1016/j.cmi.2019.09.004. [Epub ahead of print]


Adaptation of host transmission cycle during Clostridium difficile speciation.

Kumar N, Browne HP, Viciani E, Forster SC, Clare S, Harcourt K, Stares MD, Dougan G, Fairley DJ, Roberts P, Pirmohamed M, Clokie MRJ, Jensen MBF, Hargreaves KR, Ip M, Wieler LH, Seyboldt C, Norén T, Riley TV, Kuijper EJ, Wren BW, Lawley TD.

Nat Genet. 2019 Sep;51(9):1315-1320. doi: 10.1038/s41588-019-0478-8. Epub 2019 Aug 12.


Clostridium perfringens epsilon toxin vaccine candidate lacking toxicity to cells expressing myelin and lymphocyte protein.

Morcrette H, Bokori-Brown M, Ong S, Bennett L, Wren BW, Lewis N, Titball RW.

NPJ Vaccines. 2019 Jul 30;4:32. doi: 10.1038/s41541-019-0128-2. eCollection 2019.


Type III secretion system confers enhanced virulence in clinical non-O1/non-O139 Vibrio cholerae.

Zeb S, Shah MA, Yasir M, Awan HM, Prommeenate P, Klanchui A, Wren BW, Thomson N, Bokhari H.

Microb Pathog. 2019 Oct;135:103645. doi: 10.1016/j.micpath.2019.103645. Epub 2019 Jul 26.


Transmission of Multidrug Resistant Campylobacter jejuni to Children from Different Sources in Pakistan.

Noreen Z, Siddiqui F, Javed S, Wren BW, Bokhari H.

J Glob Antimicrob Resist. 2019 Jul 23. pii: S2213-7165(19)30184-5. doi: 10.1016/j.jgar.2019.07.018. [Epub ahead of print]


Domestication of Campylobacter jejuni NCTC 11168.

Pascoe B, Williams LK, Calland JK, Meric G, Hitchings MD, Dyer M, Ryder J, Shaw S, Lopes BS, Chintoan-Uta C, Allan E, Vidal A, Fearnley C, Everest P, Pachebat JA, Cogan TA, Stevens MP, Humphrey TJ, Wilkinson TS, Cody AJ, Colles FM, Jolley KA, Maiden MCJ, Strachan N, Pearson BM, Linton D, Wren BW, Parkhill J, Kelly DJ, van Vliet AHM, Forbes KJ, Sheppard SK.

Microb Genom. 2019 Jul;5(7). doi: 10.1099/mgen.0.000279. Epub 2019 Jul 16.


Sodium Taurocholate Stimulates Campylobacter jejuni Outer Membrane Vesicle Production via Down-Regulation of the Maintenance of Lipid Asymmetry Pathway.

Davies C, Taylor AJ, Elmi A, Winter J, Liaw J, Grabowska AD, Gundogdu O, Wren BW, Kelly DJ, Dorrell N.

Front Cell Infect Microbiol. 2019 May 29;9:177. doi: 10.3389/fcimb.2019.00177. eCollection 2019.


Recent advances in the production of recombinant glycoconjugate vaccines.

Kay E, Cuccui J, Wren BW.

NPJ Vaccines. 2019 May 1;4:16. doi: 10.1038/s41541-019-0110-z. eCollection 2019. Review.


Quantitative Analyses Reveal Novel Roles for N-Glycosylation in a Major Enteric Bacterial Pathogen.

Abouelhadid S, North SJ, Hitchen P, Vohra P, Chintoan-Uta C, Stevens M, Dell A, Cuccui J, Wren BW.

MBio. 2019 Apr 23;10(2). pii: e00297-19. doi: 10.1128/mBio.00297-19.


Ethical issues arising in the provision of medical interventions for gender diverse children and adolescents.

Wren B.

Clin Child Psychol Psychiatry. 2019 Apr;24(2):203-222. doi: 10.1177/1359104518822694.


Reflections on 'Thinking an Ethics of Gender Exploration: Against Delaying Transition for Transgender and Gender Variant Youth'.

Wren B.

Clin Child Psychol Psychiatry. 2019 Apr;24(2):237-240. doi: 10.1177/1359104519838591.


Pathotyping the Zoonotic Pathogen Streptococcus suis: Novel Genetic Markers To Differentiate Invasive Disease-Associated Isolates from Non-Disease-Associated Isolates from England and Wales.

Wileman TM, Weinert LA, Howell KJ, Wang J, Peters SE, Williamson SM, Wells JM, Langford PR, Rycroft AN, Wren BW, Maskell DJ, Tucker AW.

J Clin Microbiol. 2019 Jun 25;57(7). pii: e01712-18. doi: 10.1128/JCM.01712-18. Print 2019 Jul.


Environmental interactions are regulated by temperature in Burkholderia seminalis TC3.4.2R3.

Gonçalves PJRO, Hume CCD, Ferreira AJ, Tsui S, Brocchi M, Wren BW, Araujo WL.

Sci Rep. 2019 Apr 2;9(1):5486. doi: 10.1038/s41598-019-41778-x.


Puberty blocking in gender dysphoria: suitable for all?

Butler G, Wren B, Carmichael P.

Arch Dis Child. 2019 Jun;104(6):509-510. doi: 10.1136/archdischild-2018-315984. Epub 2019 Jan 17. No abstract available.


In vitro and in vivo properties of the bovine antimicrobial peptide, Bactenecin 5.

Price RL, Bugeon L, Mostowy S, Makendi C, Wren BW, Williams HD, Willcocks SJ.

PLoS One. 2019 Jan 9;14(1):e0210508. doi: 10.1371/journal.pone.0210508. eCollection 2019.


An O-Antigen Glycoconjugate Vaccine Produced Using Protein Glycan Coupling Technology Is Protective in an Inhalational Rat Model of Tularemia.

Marshall LE, Nelson M, Davies CH, Whelan AO, Jenner DC, Moule MG, Denman C, Cuccui J, Atkins TP, Wren BW, Prior JL.

J Immunol Res. 2018 Nov 29;2018:8087916. doi: 10.1155/2018/8087916. eCollection 2018.


Cytoplasmic glycoengineering of Apx toxin fragments in the development of Actinobacillus pleuropneumoniae glycoconjugate vaccines.

Passmore IJ, Andrejeva A, Wren BW, Cuccui J.

BMC Vet Res. 2019 Jan 3;15(1):6. doi: 10.1186/s12917-018-1751-2.


The Streptococcos suis sortases SrtB and SrtF are essential for disease in pigs.

Faulds-Pain A, Shaw HA, Terra VS, Kellner S, Brockmeier SL, Wren BW.

Microbiology. 2019 Feb;165(2):163-173. doi: 10.1099/mic.0.000752. Epub 2018 Dec 13.


Review of the literature on self-injurious thoughts and behaviours in gender-diverse children and young people in the United Kingdom.

E Mann G, Taylor A, Wren B, de Graaf N.

Clin Child Psychol Psychiatry. 2019 Apr;24(2):304-321. doi: 10.1177/1359104518812724. Epub 2018 Dec 5. Review.


Reviving Phage Therapy for the Treatment of Cholera.

Bhandare S, Colom J, Baig A, Ritchie JM, Bukhari H, Shah MA, Sarkar BL, Su J, Wren B, Barrow P, Atterbury RJ.

J Infect Dis. 2019 Feb 15;219(5):786-794. doi: 10.1093/infdis/jiy563.


A recombinant conjugated pneumococcal vaccine that protects against murine infections with a similar efficacy to Prevnar-13.

Reglinski M, Ercoli G, Plumptre C, Kay E, Petersen FC, Paton JC, Wren BW, Brown JS.

NPJ Vaccines. 2018 Oct 31;3:53. doi: 10.1038/s41541-018-0090-4. eCollection 2018.


Comprehensive Longitudinal Microbiome Analysis of the Chicken Cecum Reveals a Shift From Competitive to Environmental Drivers and a Window of Opportunity for Campylobacter.

Ijaz UZ, Sivaloganathan L, McKenna A, Richmond A, Kelly C, Linton M, Stratakos AC, Lavery U, Elmi A, Wren BW, Dorrell N, Corcionivoschi N, Gundogdu O.

Front Microbiol. 2018 Oct 15;9:2452. doi: 10.3389/fmicb.2018.02452. eCollection 2018.


The S-layer protein of a Clostridium difficile SLCT-11 strain displays a complex glycan required for normal cell growth and morphology.

Richards E, Bouché L, Panico M, Arbeloa A, Vinogradov E, Morris H, Wren B, Logan SM, Dell A, Fairweather NF.

J Biol Chem. 2018 Nov 23;293(47):18123-18137. doi: 10.1074/jbc.RA118.004530. Epub 2018 Oct 1.


Seeing the child in context: Supporting gender diverse children and their families in multiple ways - An introduction to this special edition.

Langton T, Wren B, Carmichael P.

Clin Child Psychol Psychiatry. 2019 Apr;24(2):199-202. doi: 10.1177/1359104518800143. Epub 2018 Sep 15.


Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria.

Passmore IJ, Letertre MPM, Preston MD, Bianconi I, Harrison MA, Nasher F, Kaur H, Hong HA, Baines SD, Cutting SM, Swann JR, Wren BW, Dawson LF.

PLoS Pathog. 2018 Sep 12;14(9):e1007191. doi: 10.1371/journal.ppat.1007191. eCollection 2018 Sep.


Exploring the oxidative, antimicrobial and genomic properties of Campylobacter jejuni strains isolated from poultry.

Ugarte-Ruiz M, Domínguez L, Corcionivoschi N, Wren BW, Dorrell N, Gundogdu O.

Res Vet Sci. 2018 Aug;119:170-175. doi: 10.1016/j.rvsc.2018.06.016. Epub 2018 Jun 19.


Comparative sequence analysis of the capsular polysaccharide loci of Actinobacillus pleuropneumoniae serovars 1-18, and development of two multiplex PCRs for comprehensive capsule typing.

Bossé JT, Li Y, Fernandez Crespo R, Lacouture S, Gottschalk M, Sárközi R, Fodor L, Casas Amoribieta M, Angen Ø, Nedbalcova K, Holden MTG, Maskell DJ, Tucker AW, Wren BW, Rycroft AN, Langford PR; BRaDP1T consortium.

Vet Microbiol. 2018 Jul;220:83-89. doi: 10.1016/j.vetmic.2018.05.011. Epub 2018 May 20.


High-throughput analysis of Yersinia pseudotuberculosis gene essentiality in optimised in vitro conditions, and implications for the speciation of Yersinia pestis.

Willcocks SJ, Stabler RA, Atkins HS, Oyston PF, Wren BW.

BMC Microbiol. 2018 May 31;18(1):46. doi: 10.1186/s12866-018-1189-5.


Vibrio cholerae accessory colonisation factor AcfC: a chemotactic protein with a role in hyperinfectivity.

Valiente E, Davies C, Mills DC, Getino M, Ritchie JM, Wren BW.

Sci Rep. 2018 May 30;8(1):8390. doi: 10.1038/s41598-018-26570-7.


Production and efficacy of a low-cost recombinant pneumococcal protein polysaccharide conjugate vaccine.

Herbert JA, Kay EJ, Faustini SE, Richter A, Abouelhadid S, Cuccui J, Wren B, Mitchell TJ.

Vaccine. 2018 Jun 18;36(26):3809-3819. doi: 10.1016/j.vaccine.2018.05.036. Epub 2018 May 25.


Inactivation of bpsl1039-1040 ATP-binding cassette transporter reduces intracellular survival in macrophages, biofilm formation and virulence in the murine model of Burkholderia pseudomallei infection.

Pinweha P, Pumirat P, Cuccui J, Jitprasutwit N, Muangsombut V, Srinon V, Boonyuen U, Thiennimitr P, Vattanaviboon P, Cia F, Willcocks S, Bancroft GJ, Wren BW, Korbsrisate S.

PLoS One. 2018 May 17;13(5):e0196202. doi: 10.1371/journal.pone.0196202. eCollection 2018.


Assessment and support of children and adolescents with gender dysphoria.

Butler G, De Graaf N, Wren B, Carmichael P.

Arch Dis Child. 2018 Jul;103(7):631-636. doi: 10.1136/archdischild-2018-314992. Epub 2018 Apr 12. Review. No abstract available.


Proposal of serovars 17 and 18 of Actinobacillus pleuropneumoniae based on serological and genotypic analysis.

Bossé JT, Li Y, Sárközi R, Fodor L, Lacouture S, Gottschalk M, Casas Amoribieta M, Angen Ø, Nedbalcova K, Holden MTG, Maskell DJ, Tucker AW, Wren BW, Rycroft AN, Langford PR; BRaDP1T consortium.

Vet Microbiol. 2018 Apr;217:1-6. doi: 10.1016/j.vetmic.2018.02.019. Epub 2018 Feb 16.


Structure-activity relationships in a new class of non-substrate-like covalent inhibitors of the bacterial glycosyltransferase LgtC.

Xu Y, Cuccui J, Denman C, Maharjan T, Wren BW, Wagner GK.

Bioorg Med Chem. 2018 Jul 15;26(11):2973-2983. doi: 10.1016/j.bmc.2018.03.006. Epub 2018 Mar 6.


Functional analysis of the Helicobacter pullorum N-linked protein glycosylation system.

Jervis AJ, Wood AG, Cain JA, Butler JA, Frost H, Lord E, Langdon R, Cordwell SJ, Wren BW, Linton D.

Glycobiology. 2018 Apr 1;28(4):233-244. doi: 10.1093/glycob/cwx110.


Zoonotic Transfer of Clostridium difficile Harboring Antimicrobial Resistance between Farm Animals and Humans.

Knetsch CW, Kumar N, Forster SC, Connor TR, Browne HP, Harmanus C, Sanders IM, Harris SR, Turner L, Morris T, Perry M, Miyajima F, Roberts P, Pirmohamed M, Songer JG, Weese JS, Indra A, Corver J, Rupnik M, Wren BW, Riley TV, Kuijper EJ, Lawley TD.

J Clin Microbiol. 2018 Feb 22;56(3). pii: e01384-17. doi: 10.1128/JCM.01384-17. Print 2018 Mar.


The bile salt sodium taurocholate induces Campylobacter jejuni outer membrane vesicle production and increases OMV-associated proteolytic activity.

Elmi A, Dorey A, Watson E, Jagatia H, Inglis NF, Gundogdu O, Bajaj-Elliott M, Wren BW, Smith DGE, Dorrell N.

Cell Microbiol. 2018 Mar;20(3). doi: 10.1111/cmi.12814. Epub 2017 Dec 28.


Use of Proteins Identified through a Functional Genomic Screen To Develop a Protein Subunit Vaccine That Provides Significant Protection against Virulent Streptococcus suis in Pigs.

Brockmeier SL, Loving CL, Nicholson TL, Wang J, Peters SE, Weinert L, Chaudhuri R, Seilly DJ, Langford PR, Rycroft A, Wren BW, Maskell DJ, Tucker AW.

Infect Immun. 2018 Feb 20;86(3). pii: e00559-17. doi: 10.1128/IAI.00559-17. Print 2018 Mar.


Comparative Genomic Analysis and In Vivo Modeling of Streptococcus pneumoniae ST3081 and ST618 Isolates Reveal Key Genetic and Phenotypic Differences Contributing to Clonal Replacement of Serotype 1 in The Gambia.

Bricio-Moreno L, Ebruke C, Chaguza C, Cornick J, Kwambana-Adams B, Yang M, Mackenzie G, Wren BW, Everett D, Antonio M, Kadioglu A.

J Infect Dis. 2017 Dec 5;216(10):1318-1327. doi: 10.1093/infdis/jix472.


Disparate subcellular location of putative sortase substrates in Clostridium difficile.

Peltier J, Shaw HA, Wren BW, Fairweather NF.

Sci Rep. 2017 Aug 23;7(1):9204. doi: 10.1038/s41598-017-08322-1.


Patterns of antimicrobial resistance in Streptococcus suis isolates from pigs with or without streptococcal disease in England between 2009 and 2014.

Hernandez-Garcia J, Wang J, Restif O, Holmes MA, Mather AE, Weinert LA, Wileman TM, Thomson JR, Langford PR, Wren BW, Rycroft A, Maskell DJ, Tucker AW; BRADP1T Consortium.

Vet Microbiol. 2017 Aug;207:117-124. doi: 10.1016/j.vetmic.2017.06.002. Epub 2017 Jun 13.


Galleria mellonella is low cost and suitable surrogate host for studying virulence of human pathogenic Vibrio cholerae.

Bokhari H, Ali A, Noreen Z, Thomson N, Wren BW.

Gene. 2017 Sep 10;628:1-7. doi: 10.1016/j.gene.2017.07.019. Epub 2017 Jul 8.


"Pathotyping" Multiplex PCR Assay for Haemophilus parasuis: a Tool for Prediction of Virulence.

Howell KJ, Weinert LA, Peters SE, Wang J, Hernandez-Garcia J, Chaudhuri RR, Luan SL, Angen Ø, Aragon V, Williamson SM, Langford PR, Rycroft AN, Wren BW, Maskell DJ, Tucker AW.

J Clin Microbiol. 2017 Sep;55(9):2617-2628. doi: 10.1128/JCM.02464-16. Epub 2017 Jun 14.


Correction for Cairns et al., "Comparative Genome Analysis and Global Phylogeny of the Toxin Variant Clostridium difficile PCR Ribotype 017 Reveals the Evolution of Two Independent Sublineages".

Cairns MD, Preston MD, Hall CL, Gerding DN, Hawkey PM, Kato H, Kim H, Kuijper EJ, Lawley TD, Pituch H, Reid S, Kullin B, Riley TV, Solomon K, Tsai PJ, Weese JS, Stabler RA, Wren BW.

J Clin Microbiol. 2017 Jun;55(6):1971. doi: 10.1128/JCM.00487-17. No abstract available.


The In Vitro and In Vivo Effect of Carvacrol in Preventing Campylobacter Infection, Colonization and in Improving Productivity of Chicken Broilers.

Kelly C, Gundogdu O, Pircalabioru G, Cean A, Scates P, Linton M, Pinkerton L, Magowan E, Stef L, Simiz E, Pet I, Stewart S, Stabler R, Wren B, Dorrell N, Corcionivoschi N.

Foodborne Pathog Dis. 2017 Jun;14(6):341-349. doi: 10.1089/fpd.2016.2265. Epub 2017 Feb 27.


Whole Genome Sequencing for Surveillance of Antimicrobial Resistance in Actinobacillus pleuropneumoniae.

Bossé JT, Li Y, Rogers J, Fernandez Crespo R, Li Y, Chaudhuri RR, Holden MT, Maskell DJ, Tucker AW, Wren BW, Rycroft AN, Langford PR.

Front Microbiol. 2017 Mar 6;8:311. doi: 10.3389/fmicb.2017.00311. eCollection 2017.


The importance of the glycosylation of antimicrobial peptides: natural and synthetic approaches.

Bednarska NG, Wren BW, Willcocks SJ.

Drug Discov Today. 2017 Jun;22(6):919-926. doi: 10.1016/j.drudis.2017.02.001. Epub 2017 Feb 16. Review.


Draft Genome Sequence of Campylobacter jejuni 11168H.

Macdonald SE, Gundogdu O, Dorrell N, Wren BW, Blake D, Stabler R.

Genome Announc. 2017 Feb 2;5(5). pii: e01556-16. doi: 10.1128/genomeA.01556-16.


The Campylobacter jejuni Oxidative Stress Regulator RrpB Is Associated with a Genomic Hypervariable Region and Altered Oxidative Stress Resistance.

Gundogdu O, da Silva DT, Mohammad B, Elmi A, Wren BW, van Vliet AH, Dorrell N.

Front Microbiol. 2016 Dec 26;7:2117. doi: 10.3389/fmicb.2016.02117. eCollection 2016.

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