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Items: 1 to 50 of 231

1.

Gaining Insights into the Function of Post-Translational Protein Modification Using Genome Engineering and Molecular Cell Biology.

Schmidhauser M, Renz PF, Tsikrika P, Freimann R, Wutz A, Wrana JL, Beyer TA.

J Mol Biol. 2019 Jul 12. pii: S0022-2836(19)30444-9. doi: 10.1016/j.jmb.2019.07.015. [Epub ahead of print]

PMID:
31306665
2.

Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility.

Luo Y, Barrios-Rodiles M, Gupta GD, Zhang YY, Ogunjimi AA, Bashkurov M, Tkach JM, Underhill AQ, Zhang L, Bourmoum M, Wrana JL, Pelletier L.

Nat Commun. 2019 May 29;10(1):2356. doi: 10.1038/s41467-019-10241-w.

3.

Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell.

Ayyaz A, Kumar S, Sangiorgi B, Ghoshal B, Gosio J, Ouladan S, Fink M, Barutcu S, Trcka D, Shen J, Chan K, Wrana JL, Gregorieff A.

Nature. 2019 May;569(7754):121-125. doi: 10.1038/s41586-019-1154-y. Epub 2019 Apr 24.

PMID:
31019301
4.

Cell competition during reprogramming gives rise to dominant clones.

Shakiba N, Fahmy A, Jayakumaran G, McGibbon S, David L, Trcka D, Elbaz J, Puri MC, Nagy A, van der Kooy D, Goyal S, Wrana JL, Zandstra PW.

Science. 2019 Apr 26;364(6438). pii: eaan0925. doi: 10.1126/science.aan0925. Epub 2019 Mar 21.

PMID:
30898844
5.

A feed forward loop enforces YAP/TAZ signaling during tumorigenesis.

Gill MK, Christova T, Zhang YY, Gregorieff A, Zhang L, Narimatsu M, Song S, Xiong S, Couzens AL, Tong J, Krieger JR, Moran MF, Zlotta AR, van der Kwast TH, Gingras AC, Sicheri F, Wrana JL, Attisano L.

Nat Commun. 2018 Aug 29;9(1):3510. doi: 10.1038/s41467-018-05939-2.

6.

The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development.

Koefoed K, Skat-Rørdam J, Andersen P, Warzecha CB, Pye M, Andersen TA, Ajbro KD, Bendsen E, Narimatsu M, Vilhardt F, Pedersen LB, Wrana JL, Anderson RH, Møllgård K, Christensen ST, Larsen LA.

Sci Rep. 2018 Jun 22;8(1):9542. doi: 10.1038/s41598-018-27854-8.

7.

Pulmonary pericytes regulate lung morphogenesis.

Kato K, Diéguez-Hurtado R, Park DY, Hong SP, Kato-Azuma S, Adams S, Stehling M, Trappmann B, Wrana JL, Koh GY, Adams RH.

Nat Commun. 2018 Jun 22;9(1):2448. doi: 10.1038/s41467-018-04913-2.

8.

Crucial Role of Postsynaptic Syntaxin 4 in Mediating Basal Neurotransmission and Synaptic Plasticity in Hippocampal CA1 Neurons.

Bin NR, Ma K, Harada H, Tien CW, Bergin F, Sugita K, Luyben TT, Narimatsu M, Jia Z, Wrana JL, Monnier PP, Zhang L, Okamoto K, Sugita S.

Cell Rep. 2018 Jun 5;23(10):2955-2966. doi: 10.1016/j.celrep.2018.05.026.

9.

Exosomes Mediate Mobilization of Autocrine Wnt10b to Promote Axonal Regeneration in the Injured CNS.

Tassew NG, Charish J, Shabanzadeh AP, Luga V, Harada H, Farhani N, D'Onofrio P, Choi B, Ellabban A, Nickerson PEB, Wallace VA, Koeberle PD, Wrana JL, Monnier PP.

Cell Rep. 2017 Jul 5;20(1):99-111. doi: 10.1016/j.celrep.2017.06.009.

10.

Recent advances in understanding contextual TGFβ signaling.

Ayyaz A, Attisano L, Wrana JL.

F1000Res. 2017 May 26;6:749. doi: 10.12688/f1000research.11295.1. eCollection 2017. Review.

11.

Hippo signalling in intestinal regeneration and cancer.

Gregorieff A, Wrana JL.

Curr Opin Cell Biol. 2017 Oct;48:17-25. doi: 10.1016/j.ceb.2017.04.005. Epub 2017 May 18. Review.

PMID:
28527754
12.

LUMIER: A Discovery Tool for Mammalian Protein Interaction Networks.

Barrios-Rodiles M, Ellis JD, Blencowe BJ, Wrana JL.

Methods Mol Biol. 2017;1550:137-148. doi: 10.1007/978-1-4939-6747-6_11.

PMID:
28188528
13.

Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors.

Han H, Braunschweig U, Gonatopoulos-Pournatzis T, Weatheritt RJ, Hirsch CL, Ha KCH, Radovani E, Nabeel-Shah S, Sterne-Weiler T, Wang J, O'Hanlon D, Pan Q, Ray D, Zheng H, Vizeacoumar F, Datti A, Magomedova L, Cummins CL, Hughes TR, Greenblatt JF, Wrana JL, Moffat J, Blencowe BJ.

Mol Cell. 2017 Feb 2;65(3):539-553.e7. doi: 10.1016/j.molcel.2017.01.011.

14.

TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation.

Mullen AC, Wrana JL.

Cold Spring Harb Perspect Biol. 2017 Jul 5;9(7). pii: a022186. doi: 10.1101/cshperspect.a022186. Review.

15.

Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells.

Rotin LE, MacLean N, Aman A, Gronda M, Lin FH, Hurren R, Wang X, Wrana JL, Datti A, Al-Awar R, Minden MD, Schimmer AD.

Haematologica. 2016 Nov;101(11):e449-e453. Epub 2016 Sep 1. No abstract available.

16.

Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.

Matsumoto Y, La Rose J, Kent OA, Wagner MJ, Narimatsu M, Levy AD, Omar MH, Tong J, Krieger JR, Riggs E, Storozhuk Y, Pasquale J, Ventura M, Yeganeh B, Post M, Moran MF, Grynpas MD, Wrana JL, Superti-Furga G, Koleske AJ, Pendergast AM, Rottapel R.

J Clin Invest. 2016 Dec 1;126(12):4482-4496. doi: 10.1172/JCI87802. Epub 2016 Oct 31.

17.

KATapulting toward Pluripotency and Cancer.

Hirsch CL, Wrana JL, Dent SYR.

J Mol Biol. 2017 Jun 30;429(13):1958-1977. doi: 10.1016/j.jmb.2016.09.023. Epub 2016 Oct 6. Review.

18.

Regulation of Rho GTPases from the lateral sides of migrating cells.

Zhang L, Wrana JL.

Small GTPases. 2018 Jul 4;9(4):345-348. doi: 10.1080/21541248.2016.1234430. Epub 2016 Nov 1. Review.

19.

The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.

Campbell CI, Samavarchi-Tehrani P, Barrios-Rodiles M, Datti A, Gingras AC, Wrana JL.

J Cell Sci. 2016 Sep 15;129(18):3396-411. doi: 10.1242/jcs.188417. Epub 2016 Aug 12.

20.

A critical role for NF2 and the Hippo pathway in branching morphogenesis.

Reginensi A, Enderle L, Gregorieff A, Johnson RL, Wrana JL, McNeill H.

Nat Commun. 2016 Aug 2;7:12309. doi: 10.1038/ncomms12309.

21.

Multiple roles for the hippo effector yap in gut regeneration and cancer initiation.

Gregorieff A, Wrana JL.

Mol Cell Oncol. 2016 Mar 16;3(3):e1143992. doi: 10.1080/23723556.2016.1143992. eCollection 2016 May.

22.

YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells.

Poitelon Y, Lopez-Anido C, Catignas K, Berti C, Palmisano M, Williamson C, Ameroso D, Abiko K, Hwang Y, Gregorieff A, Wrana JL, Asmani M, Zhao R, Sim FJ, Wrabetz L, Svaren J, Feltri ML.

Nat Neurosci. 2016 Jul;19(7):879-87. doi: 10.1038/nn.4316. Epub 2016 Jun 6.

23.

A lateral signalling pathway coordinates shape volatility during cell migration.

Zhang L, Luga V, Armitage SK, Musiol M, Won A, Yip CM, Plotnikov SV, Wrana JL.

Nat Commun. 2016 May 26;7:11714. doi: 10.1038/ncomms11714.

24.

Seeing is believing: Wnt3 localization in the gut epithelium.

Gregorieff A, Wrana JL.

Cell Res. 2016 May;26(5):515-6. doi: 10.1038/cr.2016.41. Epub 2016 Mar 25.

25.

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma.

Lun X, Wells JC, Grinshtein N, King JC, Hao X, Dang NH, Wang X, Aman A, Uehling D, Datti A, Wrana JL, Easaw JC, Luchman A, Weiss S, Cairncross JG, Kaplan DR, Robbins SM, Senger DL.

Clin Cancer Res. 2016 Aug 1;22(15):3860-75. doi: 10.1158/1078-0432.CCR-15-1798. Epub 2016 Mar 22.

26.

YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis.

Szeto SG, Narimatsu M, Lu M, He X, Sidiqi AM, Tolosa MF, Chan L, De Freitas K, Bialik JF, Majumder S, Boo S, Hinz B, Dan Q, Advani A, John R, Wrana JL, Kapus A, Yuen DA.

J Am Soc Nephrol. 2016 Oct;27(10):3117-3128. doi: 10.1681/ASN.2015050499. Epub 2016 Mar 9.

27.

Analysis of Hippo and TGFβ signaling in polarizing epithelial cells and mouse embryos.

Narimatsu M, Labibi B, Wrana JL, Attisano L.

Differentiation. 2016 Apr-Jun;91(4-5):109-18. doi: 10.1016/j.diff.2016.01.003. Epub 2016 Jan 21.

PMID:
26803209
28.

YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells.

Dey A, Robitaille M, Remke M, Maier C, Malhotra A, Gregorieff A, Wrana JL, Taylor MD, Angers S, Kenney AM.

Oncogene. 2016 Aug 11;35(32):4256-68. doi: 10.1038/onc.2015.491. Epub 2016 Jan 4.

29.

The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling.

Giampietro C, Disanza A, Bravi L, Barrios-Rodiles M, Corada M, Frittoli E, Savorani C, Lampugnani MG, Boggetti B, Niessen C, Wrana JL, Scita G, Dejana E.

J Cell Biol. 2015 Dec 21;211(6):1177-92. doi: 10.1083/jcb.201501089. Epub 2015 Dec 14.

30.

TCF1 links GIPR signaling to the control of beta cell function and survival.

Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X, Liu Y, Lamont BJ, Morii T, Streutker CJ, Tamarina N, Philipson LH, Wrana JL, MacDonald PE, Drucker DJ.

Nat Med. 2016 Jan;22(1):84-90. doi: 10.1038/nm.3997. Epub 2015 Dec 7.

PMID:
26642437
31.

Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer.

Gregorieff A, Liu Y, Inanlou MR, Khomchuk Y, Wrana JL.

Nature. 2015 Oct 29;526(7575):715-8. doi: 10.1038/nature15382. Epub 2015 Oct 21.

PMID:
26503053
32.

PTEN regulates cilia through Dishevelled.

Shnitsar I, Bashkurov M, Masson GR, Ogunjimi AA, Mosessian S, Cabeza EA, Hirsch CL, Trcka D, Gish G, Jiao J, Wu H, Winklbauer R, Williams RL, Pelletier L, Wrana JL, Barrios-Rodiles M.

Nat Commun. 2015 Sep 24;6:8388. doi: 10.1038/ncomms9388.

33.

Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network.

Cassar PA, Carpenedo RL, Samavarchi-Tehrani P, Olsen JB, Park CJ, Chang WY, Chen Z, Choey C, Delaney S, Guo H, Guo H, Tanner RM, Perkins TJ, Tenenbaum SA, Emili A, Wrana JL, Gibbings D, Stanford WL.

EMBO Rep. 2015 Oct;16(10):1334-57. doi: 10.15252/embr.201540974. Epub 2015 Aug 11.

34.

Corrigendum: Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming.

Hirsch CL, Akdemir ZC, Wang L, Jayakumaran G, Trcka D, Weiss A, Hernandez JJ, Pan Q, Han H, Xu X, Xia Z, Salinger AP, Wilson M, Vizeacoumar F, Datti A, Li W, Cooney AJ, Barton MC, Blencowe BJ, Wrana JL, Dent SY.

Genes Dev. 2015 Jun 15;29(12):1341. doi: 10.1101/gad.266601.115. No abstract available.

35.

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death.

Lee EA, Angka L, Rota SG, Hanlon T, Mitchell A, Hurren R, Wang XM, Gronda M, Boyaci E, Bojko B, Minden M, Sriskanthadevan S, Datti A, Wrana JL, Edginton A, Pawliszyn J, Joseph JW, Quadrilatero J, Schimmer AD, Spagnuolo PA.

Cancer Res. 2015 Jun 15;75(12):2478-88. doi: 10.1158/0008-5472.CAN-14-2676.

36.

Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling.

Shathasivam P, Kollara A, Ringuette MJ, Virtanen C, Wrana JL, Brown TJ.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3000-9. doi: 10.1073/pnas.1504671112. Epub 2015 May 26.

37.

Cancer Cells Hijack PRC2 to Modify Multiple Cytokine Pathways.

Abou El Hassan M, Huang K, Eswara MB, Zhao M, Song L, Yu T, Liu Y, Liu JC, McCurdy S, Ma A, Wither J, Jin J, Zacksenhaus E, Wrana JL, Bremner R.

PLoS One. 2015 Jun 1;10(6):e0126466. doi: 10.1371/journal.pone.0126466. eCollection 2015.

38.

Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming.

Hirsch CL, Coban Akdemir Z, Wang L, Jayakumaran G, Trcka D, Weiss A, Hernandez JJ, Pan Q, Han H, Xu X, Xia Z, Salinger AP, Wilson M, Vizeacoumar F, Datti A, Li W, Cooney AJ, Barton MC, Blencowe BJ, Wrana JL, Dent SY.

Genes Dev. 2015 Apr 15;29(8):803-16. doi: 10.1101/gad.255109.114. Epub 2015 Apr 15. Erratum in: Genes Dev. 2015 Jun 15;29(12):1341.

39.

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

So J, Pasculescu A, Dai AY, Williton K, James A, Nguyen V, Creixell P, Schoof EM, Sinclair J, Barrios-Rodiles M, Gu J, Krizus A, Williams R, Olhovsky M, Dennis JW, Wrana JL, Linding R, Jorgensen C, Pawson T, Colwill K.

Sci Signal. 2015 Apr 7;8(371):rs3. doi: 10.1126/scisignal.2005700.

PMID:
25852190
40.

Distinct polarity cues direct Taz/Yap and TGFβ receptor localization to differentially control TGFβ-induced Smad signaling.

Narimatsu M, Samavarchi-Tehrani P, Varelas X, Wrana JL.

Dev Cell. 2015 Mar 9;32(5):652-6. doi: 10.1016/j.devcel.2015.02.019.

41.

A highly conserved program of neuronal microexons is misregulated in autistic brains.

Irimia M, Weatheritt RJ, Ellis JD, Parikshak NN, Gonatopoulos-Pournatzis T, Babor M, Quesnel-Vallières M, Tapial J, Raj B, O'Hanlon D, Barrios-Rodiles M, Sternberg MJ, Cordes SP, Roth FP, Wrana JL, Geschwind DH, Blencowe BJ.

Cell. 2014 Dec 18;159(7):1511-23. doi: 10.1016/j.cell.2014.11.035.

42.

Next-generation RNA sequencing of archival formalin-fixed paraffin-embedded urothelial bladder cancer.

Liu Y, Noon AP, Aguiar Cabeza E, Shen J, Kuk C, Ilczynski C, Ni R, Sukhu B, Chan K, Barbosa-Morais NL, Hermanns T, Blencowe BJ, Azad A, van der Kwast TH, Catto JW, Zlotta AR, Wrana JL.

Eur Urol. 2014 Dec;66(6):982-6. doi: 10.1016/j.eururo.2014.07.045. Epub 2014 Sep 6.

PMID:
25199720
43.

A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening.

Jeon J, Nim S, Teyra J, Datti A, Wrana JL, Sidhu SS, Moffat J, Kim PM.

Genome Med. 2014 Jul 30;6(7):57. doi: 10.1186/s13073-014-0057-7. eCollection 2014.

44.

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state.

Shimoda M, Principe S, Jackson HW, Luga V, Fang H, Molyneux SD, Shao YW, Aiken A, Waterhouse PD, Karamboulas C, Hess FM, Ohtsuka T, Okada Y, Ailles L, Ludwig A, Wrana JL, Kislinger T, Khokha R.

Nat Cell Biol. 2014 Sep;16(9):889-901. doi: 10.1038/ncb3021. Epub 2014 Aug 24.

PMID:
25150980
45.

The emerging role of exosomes in Wnt secretion and transport.

Zhang L, Wrana JL.

Curr Opin Genet Dev. 2014 Aug;27:14-9. doi: 10.1016/j.gde.2014.03.006. Epub 2014 May 8. Review.

PMID:
24791688
46.

CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human β₂-adrenergic receptor.

Kittanakom S, Barrios-Rodiles M, Petschnigg J, Arnoldo A, Wong V, Kotlyar M, Heisler LE, Jurisica I, Wrana JL, Nislow C, Stagljar I.

Biochem Biophys Res Commun. 2014 Mar 21;445(4):746-56. doi: 10.1016/j.bbrc.2014.02.033. Epub 2014 Feb 19.

PMID:
24561123
47.

Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells.

Beyer TA, Weiss A, Khomchuk Y, Huang K, Ogunjimi AA, Varelas X, Wrana JL.

Cell Rep. 2013 Dec 26;5(6):1611-24. doi: 10.1016/j.celrep.2013.11.021. Epub 2013 Dec 12.

48.

Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.

Xu G, Barrios-Rodiles M, Jerkic M, Turinsky AL, Nadon R, Vera S, Voulgaraki D, Wrana JL, Toporsian M, Letarte M.

Mol Cell Proteomics. 2014 Feb;13(2):489-502. doi: 10.1074/mcp.M113.033464. Epub 2013 Dec 7.

49.

Tumor-stroma interaction: Revealing fibroblast-secreted exosomes as potent regulators of Wnt-planar cell polarity signaling in cancer metastasis.

Luga V, Wrana JL.

Cancer Res. 2013 Dec 1;73(23):6843-7. doi: 10.1158/0008-5472.CAN-13-1791. Epub 2013 Nov 21. Review.

50.

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

Couzens AL, Knight JD, Kean MJ, Teo G, Weiss A, Dunham WH, Lin ZY, Bagshaw RD, Sicheri F, Pawson T, Wrana JL, Choi H, Gingras AC.

Sci Signal. 2013 Nov 19;6(302):rs15. doi: 10.1126/scisignal.2004712.

PMID:
24255178

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