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Items: 1 to 50 of 140

1.

Antigen-Specific Immunotherapy with Thyrotropin Receptor Peptides in Graves' Hyperthyroidism: A Phase I Study.

Pearce SHS, Dayan C, Wraith DC, Barrell K, Olive N, Jansson L, Walker-Smith T, Carnegie C, Martin KF, Boelaert K, Gilbert J, Higham CE, Muller I, Murray RD, Perros P, Razvi S, Vaidya B, Wernig F, Kahaly GJ.

Thyroid. 2019 Jul;29(7):1003-1011. doi: 10.1089/thy.2019.0036. Epub 2019 Jun 13.

PMID:
31194638
2.

Immunotherapy With Apitopes Blocks the Immune Response to TSH Receptor in HLA-DR Transgenic Mice.

Jansson L, Vrolix K, Jahraus A, Martin KF, Wraith DC.

Endocrinology. 2018 Sep 1;159(9):3446-3457. doi: 10.1210/en.2018-00306.

PMID:
30099489
3.

Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory.

Burton BR, Tennant RK, Love J, Titball RW, Wraith DC, White HN.

Elife. 2018 May 1;7. pii: e26832. doi: 10.7554/eLife.26832.

4.

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.

Kishore M, Cheung KCP, Fu H, Bonacina F, Wang G, Coe D, Ward EJ, Colamatteo A, Jangani M, Baragetti A, Matarese G, Smith DM, Haas R, Mauro C, Wraith DC, Okkenhaug K, Catapano AL, De Rosa V, Norata GD, Marelli-Berg FM.

Immunity. 2018 Apr 17;48(4):831-832. doi: 10.1016/j.immuni.2018.03.034. No abstract available.

5.

Effects of ATX-MS-1467 immunotherapy over 16 weeks in relapsing multiple sclerosis.

Chataway J, Martin K, Barrell K, Sharrack B, Stolt P, Wraith DC; ATX-MS1467 Study Group.

Neurology. 2018 Mar 13;90(11):e955-e962. doi: 10.1212/WNL.0000000000005118. Epub 2018 Feb 21.

PMID:
29467307
6.

The Future of Immunotherapy: A 20-Year Perspective.

Wraith DC.

Front Immunol. 2017 Nov 28;8:1668. doi: 10.3389/fimmu.2017.01668. eCollection 2017.

7.

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.

Kishore M, Cheung KCP, Fu H, Bonacina F, Wang G, Coe D, Ward EJ, Colamatteo A, Jangani M, Baragetti A, Matarese G, Smith DM, Haas R, Mauro C, Wraith DC, Okkenhaug K, Catapano AL, De Rosa V, Norata GD, Marelli-Berg FM.

Immunity. 2017 Nov 21;47(5):875-889.e10. doi: 10.1016/j.immuni.2017.10.017. Erratum in: Immunity. 2018 Apr 17;48(4):831-832.

8.

IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation.

Mitchell RE, Hassan M, Burton BR, Britton G, Hill EV, Verhagen J, Wraith DC.

Sci Rep. 2017 Sep 12;7(1):11315. doi: 10.1038/s41598-017-11803-y.

9.

A humanized HLA-DR4 mouse model for autoimmune myocarditis.

Şelli ME, Thomas AC, Wraith DC, Newby AC.

J Mol Cell Cardiol. 2017 Jun;107:22-26. doi: 10.1016/j.yjmcc.2017.04.003. Epub 2017 Apr 18.

10.

Protein kinase C theta is required for efficient induction of IL-10-secreting T cells.

Britton GJ, Mitchell RE, Burton BR, Wraith DC.

PLoS One. 2017 Feb 3;12(2):e0171547. doi: 10.1371/journal.pone.0171547. eCollection 2017.

11.

Myeloid-derived suppressor cells mediate tolerance induction in autoimmune disease.

Wegner A, Verhagen J, Wraith DC.

Immunology. 2017 May;151(1):26-42. doi: 10.1111/imm.12718. Epub 2017 Mar 2.

12.

PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton.

Britton GJ, Ambler R, Clark DJ, Hill EV, Tunbridge HM, McNally KE, Burton BR, Butterweck P, Sabatos-Peyton C, Hampton-O'Neil LA, Verkade P, Wülfing ChC, Wraith DC.

Elife. 2017 Jan 31;6. pii: e20003. doi: 10.7554/eLife.20003.

13.

Autoimmunity to HSP60 during diet induced obesity in mice.

Şelli ME, Wick G, Wraith DC, Newby AC.

Int J Obes (Lond). 2017 Feb;41(2):348-351. doi: 10.1038/ijo.2016.216. Epub 2016 Nov 30.

14.

Tr1-Like T Cells - An Enigmatic Regulatory T Cell Lineage.

White AM, Wraith DC.

Front Immunol. 2016 Sep 14;7:355. doi: 10.3389/fimmu.2016.00355. eCollection 2016.

15.

CNS infection safety signal of RTS,S/AS01 and possible association with rabies vaccine.

Gessner BD, Wraith DC, Finn A.

Lancet. 2016 Apr 2;387(10026):1376. doi: 10.1016/S0140-6736(16)30081-2. No abstract available.

PMID:
27115819
16.

Preclinical development and first-in-human study of ATX-MS-1467 for immunotherapy of MS.

Streeter HB, Rigden R, Martin KF, Scolding NJ, Wraith DC.

Neurol Neuroimmunol Neuroinflamm. 2015 Mar 12;2(3):e93. doi: 10.1212/NXI.0000000000000093. eCollection 2015 Jun.

17.

Extra-thymically induced T regulatory cell subsets: the optimal target for antigen-specific immunotherapy.

Verhagen J, Wegner A, Wraith DC.

Immunology. 2015 Jun;145(2):171-81. doi: 10.1111/imm.12458. Review.

18.

Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter.

Hill EV, Ng TH, Burton BR, Oakley CM, Malik K, Wraith DC.

Eur J Immunol. 2015 Apr;45(4):1103-15. doi: 10.1002/eji.201444661. Epub 2015 Feb 17.

19.

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice.

Carambia A, Freund B, Schwinge D, Bruns OT, Salmen SC, Ittrich H, Reimer R, Heine M, Huber S, Waurisch C, Eychmüller A, Wraith DC, Korn T, Nielsen P, Weller H, Schramm C, Lüth S, Lohse AW, Heeren J, Herkel J.

J Hepatol. 2015 Jun;62(6):1349-56. doi: 10.1016/j.jhep.2015.01.006. Epub 2015 Jan 21.

20.

Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4(+) T cells tolerized by peptide immunotherapy.

McPherson RC, Konkel JE, Prendergast CT, Thomson JP, Ottaviano R, Leech MD, Kay O, Zandee SE, Sweenie CH, Wraith DC, Meehan RR, Drake AJ, Anderton SM.

Elife. 2014 Dec 29;3. doi: 10.7554/eLife.03416.

21.

Ctla-4 modulates the differentiation of inducible Foxp3+ Treg cells but IL-10 mediates their function in experimental autoimmune encephalomyelitis.

Verhagen J, Gabryšová L, Shepard ER, Wraith DC.

PLoS One. 2014 Sep 19;9(9):e108023. doi: 10.1371/journal.pone.0108023. eCollection 2014.

22.

Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy.

Burton BR, Britton GJ, Fang H, Verhagen J, Smithers B, Sabatos-Peyton CA, Carney LJ, Gough J, Strobel S, Wraith DC.

Nat Commun. 2014 Sep 3;5:4741. doi: 10.1038/ncomms5741.

23.

Blockade of LFA-1 augments in vitro differentiation of antigen-induced Foxp3⁺ Treg cells.

Verhagen J, Wraith DC.

J Immunol Methods. 2014 Dec 1;414:58-64. doi: 10.1016/j.jim.2014.07.012. Epub 2014 Aug 6.

24.

TGF-β-dependent induction of CD4⁺CD25⁺Foxp3⁺ Tregs by liver sinusoidal endothelial cells.

Carambia A, Freund B, Schwinge D, Heine M, Laschtowitz A, Huber S, Wraith DC, Korn T, Schramm C, Lohse AW, Heeren J, Herkel J.

J Hepatol. 2014 Sep;61(3):594-9. doi: 10.1016/j.jhep.2014.04.027. Epub 2014 May 2.

PMID:
24798620
25.

New inhibitory signaling by CTLA-4.

Wülfing C, Tunbridge HM, Wraith DC.

Nat Immunol. 2014 May;15(5):408-9. doi: 10.1038/ni.2870. No abstract available.

PMID:
24747703
26.

Regulation of adaptive immunity; the role of interleukin-10.

Ng TH, Britton GJ, Hill EV, Verhagen J, Burton BR, Wraith DC.

Front Immunol. 2013 May 31;4:129. doi: 10.3389/fimmu.2013.00129. eCollection 2013.

27.

Modification of the FoxP3 transcription factor principally affects inducible T regulatory cells in a model of experimental autoimmune encephalomyelitis.

Verhagen J, Burton BR, Britton GJ, Shepard ER, Anderton SM, Wraith DC.

PLoS One. 2013 Apr 8;8(4):e61334. doi: 10.1371/journal.pone.0061334. Print 2013.

28.

CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire.

Verhagen J, Genolet R, Britton GJ, Stevenson BJ, Sabatos-Peyton CA, Dyson J, Luescher IF, Wraith DC.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):E221-30. doi: 10.1073/pnas.1208573110. Epub 2012 Dec 24.

29.

The adaptive immune system in diseases of the central nervous system.

Wraith DC, Nicholson LB.

J Clin Invest. 2012 Apr;122(4):1172-9. doi: 10.1172/JCI58648. Epub 2012 Apr 2. Review.

30.

CD4+ T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice.

Steinitz KN, van Helden PM, Binder B, Wraith DC, Unterthurner S, Hermann C, Schuster M, Ahmad RU, Weiller M, Lubich C, de la Rosa M, Schwarz HP, Reipert BM.

Blood. 2012 Apr 26;119(17):4073-82. doi: 10.1182/blood-2011-08-374645. Epub 2012 Mar 6.

31.

Comment on "Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells".

Verhagen J, Wraith DC.

J Immunol. 2010 Dec 15;185(12):7129; author reply 7130. doi: 10.4049/jimmunol.1090105. No abstract available.

32.

Human mesenchymal stem cells infiltrate the spinal cord, reduce demyelination, and localize to white matter lesions in experimental autoimmune encephalomyelitis.

Gordon D, Pavlovska G, Uney JB, Wraith DC, Scolding NJ.

J Neuropathol Exp Neurol. 2010 Nov;69(11):1087-95. doi: 10.1097/NEN.0b013e3181f97392.

PMID:
20940628
33.

Antigen-specific immunotherapy of autoimmune and allergic diseases.

Sabatos-Peyton CA, Verhagen J, Wraith DC.

Curr Opin Immunol. 2010 Oct;22(5):609-15. doi: 10.1016/j.coi.2010.08.006. Epub 2010 Sep 17. Review.

34.

Fusion between human mesenchymal stem cells and rodent cerebellar Purkinje cells.

Kemp K, Gordon D, Wraith DC, Mallam E, Hartfield E, Uney J, Wilkins A, Scolding N.

Neuropathol Appl Neurobiol. 2011 Feb;37(2):166-78. doi: 10.1111/j.1365-2990.2010.01122.x.

35.

Antigenic strength controls the generation of antigen-specific IL-10-secreting T regulatory cells.

Gabrysová L, Wraith DC.

Eur J Immunol. 2010 May;40(5):1386-95. doi: 10.1002/eji.200940151.

36.

Isolation and characterization of human interleukin-10-secreting T cells from peripheral blood.

Mazza G, Sabatos-Peyton CA, Protheroe RE, Herman A, Campbell JD, Wraith DC.

Hum Immunol. 2010 Mar;71(3):225-34. doi: 10.1016/j.humimm.2009.12.003. Epub 2010 Jan 7.

37.

A hazardous vapour trail from abattoir to neuropathy clinic.

Willison HJ, Wraith DC.

Lancet Neurol. 2010 Jan;9(1):22-4. doi: 10.1016/S1474-4422(09)70323-0. Epub 2009 Nov 27. No abstract available.

PMID:
19945915
38.

A role for galanin in human and experimental inflammatory demyelination.

Wraith DC, Pope R, Butzkueven H, Holder H, Vanderplank P, Lowrey P, Day MJ, Gundlach AL, Kilpatrick TJ, Scolding N, Wynick D.

Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15466-71. doi: 10.1073/pnas.0903360106. Epub 2009 Aug 26.

39.

Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells.

Gabrysová L, Nicolson KS, Streeter HB, Verhagen J, Sabatos-Peyton CA, Morgan DJ, Wraith DC.

J Exp Med. 2009 Aug 3;206(8):1755-67. doi: 10.1084/jem.20082118. Epub 2009 Jul 27.

40.

Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.

Verhagen J, Gabrysová L, Minaee S, Sabatos CA, Anderson G, Sharpe AH, Wraith DC.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3306-11. doi: 10.1073/pnas.0803186106. Epub 2009 Feb 13.

41.

Therapeutic peptide vaccines for treatment of autoimmune diseases.

Wraith DC.

Immunol Lett. 2009 Feb 21;122(2):134-6. doi: 10.1016/j.imlet.2008.11.013. Epub 2008 Dec 25. Review.

42.

Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs.

Lüth S, Huber S, Schramm C, Buch T, Zander S, Stadelmann C, Brück W, Wraith DC, Herkel J, Lohse AW.

J Clin Invest. 2008 Oct;118(10):3403-10. doi: 10.1172/JCI32132.

43.

Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease.

Zhu B, Symonds AL, Martin JE, Kioussis D, Wraith DC, Li S, Wang P.

J Exp Med. 2008 Sep 29;205(10):2295-307. doi: 10.1084/jem.20080187. Epub 2008 Sep 8.

44.

Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis.

O'Connor RA, Prendergast CT, Sabatos CA, Lau CW, Leech MD, Wraith DC, Anderton SM.

J Immunol. 2008 Sep 15;181(6):3750-4.

45.

Preparing for first-in-man studies: the challenges for translational immunology post-TGN1412.

Dayan CM, Wraith DC.

Clin Exp Immunol. 2008 Feb;151(2):231-4. doi: 10.1111/j.1365-2249.2007.03559.x. Review.

46.

The role of CTLA-4 in immune regulation.

Verhagen J, Sabatos CA, Wraith DC.

Immunol Lett. 2008 Jan 15;115(1):73-4. Epub 2007 Nov 8. No abstract available.

47.

CD86 has sustained costimulatory effects on CD8 T cells.

Thomas IJ, Petrich de Marquesini LG, Ravanan R, Smith RM, Guerder S, Flavell RA, Wraith DC, Wen L, Wong FS.

J Immunol. 2007 Nov 1;179(9):5936-46.

48.

Anti-cytokine vaccines and the immunotherapy of autoimmune diseases.

Wraith DC.

Eur J Immunol. 2006 Nov;36(11):2844-8. Review.

49.

Avidity and the art of self non-self discrimination.

Wraith DC.

Immunity. 2006 Aug;25(2):191-3. No abstract available.

50.

Natural and induced regulatory T cells: targets for immunotherapy of autoimmune disease and allergy.

Nicolson KS, Wraith DC.

Inflamm Allergy Drug Targets. 2006 Sep;5(3):141-8. Review.

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