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Electroceutical Treatment of Pseudomonas aeruginosa Biofilms.

Dusane DH, Lochab V, Jones T, Peters CW, Sindeldecker D, Das A, Roy S, Sen CK, Subramaniam VV, Wozniak DJ, Prakash S, Stoodley P.

Sci Rep. 2019 Feb 14;9(1):2008. doi: 10.1038/s41598-018-37891-y.


Staphylococcus aureus Biofilm Infection Compromises Wound Healing by Causing Deficiencies in Granulation Tissue Collagen.

Roy S, Santra S, Das A, Dixith S, Sinha M, Ghatak S, Ghosh N, Banerjee P, Khanna S, Mathew-Steiner S, Ghatak PD, Blackstone BN, Powell HM, Bergdall VK, Wozniak DJ, Sen CK.

Ann Surg. 2019 Jan 3. doi: 10.1097/SLA.0000000000003053. [Epub ahead of print]


Genomic and Phenotypic Diversity among Ten Laboratory Isolates of Pseudomonas aeruginosa PAO1.

Chandler CE, Horspool AM, Hill PJ, Wozniak DJ, Schertzer JW, Rasko DA, Ernst RK.

J Bacteriol. 2019 Feb 11;201(5). pii: e00595-18. doi: 10.1128/JB.00595-18. Print 2019 Mar 1.


CdrA Interactions within the Pseudomonas aeruginosa Biofilm Matrix Safeguard It from Proteolysis and Promote Cellular Packing.

Reichhardt C, Wong C, Passos da Silva D, Wozniak DJ, Parsek MR.

MBio. 2018 Sep 25;9(5). pii: e01376-18. doi: 10.1128/mBio.01376-18.


Viscoelastic properties of Pseudomonas aeruginosa variant biofilms.

Gloag ES, German GK, Stoodley P, Wozniak DJ.

Sci Rep. 2018 Jun 26;8(1):9691. doi: 10.1038/s41598-018-28009-5.


Staphylococcus aureus biofilms release leukocidins to elicit extracellular trap formation and evade neutrophil-mediated killing.

Bhattacharya M, Berends ETM, Chan R, Schwab E, Roy S, Sen CK, Torres VJ, Wozniak DJ.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7416-7421. doi: 10.1073/pnas.1721949115. Epub 2018 Jun 25.


Publisher Correction: Anti-Psl Targeting of Pseudomonas aeruginosa Biofilms for Neutrophil-Mediated Disruption.

Ray VA, Hill PJ, Stover CK, Roy S, Sen CK, Yu L, Wozniak DJ, DiGiandomenico A.

Sci Rep. 2018 Jun 20;8(1):9637. doi: 10.1038/s41598-018-26660-6.


Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety.

Li L, Okumu A, Dellos-Nolan S, Li Z, Karmahapatra S, English A, Yalowich JC, Wozniak DJ, Mitton-Fry MJ.

Bioorg Med Chem Lett. 2018 Aug 1;28(14):2477-2480. doi: 10.1016/j.bmcl.2018.06.003. Epub 2018 Jun 1.


Use of a leukocyte-targeted peptide probe as a potential tracer for imaging the tuberculosis granuloma.

Locke LW, Kothandaraman S, Tweedle M, Chaney S, Wozniak DJ, Schlesinger LS.

Tuberculosis (Edinb). 2018 Jan;108:201-210. doi: 10.1016/ Epub 2018 Jan 8.


Mixed Communities of Mucoid and Nonmucoid Pseudomonas aeruginosa Exhibit Enhanced Resistance to Host Antimicrobials.

Malhotra S, Limoli DH, English AE, Parsek MR, Wozniak DJ.

MBio. 2018 Mar 27;9(2). pii: e00275-18. doi: 10.1128/mBio.00275-18.


Pseudomonas aeruginosa rugose small-colony variants evade host clearance, are hyper-inflammatory, and persist in multiple host environments.

Pestrak MJ, Chaney SB, Eggleston HC, Dellos-Nolan S, Dixit S, Mathew-Steiner SS, Roy S, Parsek MR, Sen CK, Wozniak DJ.

PLoS Pathog. 2018 Feb 2;14(2):e1006842. doi: 10.1371/journal.ppat.1006842. eCollection 2018 Feb.


An IgaA/UmoB Family Protein from Serratia marcescens Regulates Motility, Capsular Polysaccharide Biosynthesis, and Secondary Metabolite Production.

Stella NA, Brothers KM, Callaghan JD, Passerini AM, Sigindere C, Hill PJ, Liu X, Wozniak DJ, Shanks RMQ.

Appl Environ Microbiol. 2018 Mar 1;84(6). pii: e02575-17. doi: 10.1128/AEM.02575-17. Print 2018 Mar 15.


Anti-Psl Targeting of Pseudomonas aeruginosa Biofilms for Neutrophil-Mediated Disruption.

Ray VA, Hill PJ, Stover CK, Roy S, Sen CK, Yu L, Wozniak DJ, DiGiandomenico A.

Sci Rep. 2017 Nov 22;7(1):16065. doi: 10.1038/s41598-017-16215-6. Erratum in: Sci Rep. 2018 Jun 20;8(1):9637.


PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer.

Wozniak DJ, Kajdacsy-Balla A, Macias V, Ball-Kell S, Zenner ML, Bie W, Tyner AL.

Nat Commun. 2017 Nov 15;8(1):1508. doi: 10.1038/s41467-017-01574-5.


Electric Field Based Dressing Disrupts Mixed-Species Bacterial Biofilm Infection and Restores Functional Wound Healing.

Barki KG, Das A, Dixith S, Ghatak PD, Mathew-Steiner S, Schwab E, Khanna S, Wozniak DJ, Roy S, Sen CK.

Ann Surg. 2019 Apr;269(4):756-766. doi: 10.1097/SLA.0000000000002504.


Congo Red Stain Identifies Matrix Overproduction and Is an Indirect Measurement for c-di-GMP in Many Species of Bacteria.

Jones CJ, Wozniak DJ.

Methods Mol Biol. 2017;1657:147-156. doi: 10.1007/978-1-4939-7240-1_12.


Modifications of Pseudomonas aeruginosa cell envelope in the cystic fibrosis airway alters interactions with immune cells.

Hill PJ, Scordo JM, Arcos J, Kirkby SE, Wewers MD, Wozniak DJ, Torrelles JB.

Sci Rep. 2017 Jul 6;7(1):4761. doi: 10.1038/s41598-017-05253-9.


Psl Produced by Mucoid Pseudomonas aeruginosa Contributes to the Establishment of Biofilms and Immune Evasion.

Jones CJ, Wozniak DJ.

MBio. 2017 Jun 20;8(3). pii: e00864-17. doi: 10.1128/mBio.00864-17.


Histopathological comparisons of Staphylococcus aureus and Pseudomonas aeruginosa experimental infected porcine burn wounds.

Chaney SB, Ganesh K, Mathew-Steiner S, Stromberg P, Roy S, Sen CK, Wozniak DJ.

Wound Repair Regen. 2017 May;25(3):541-549. doi: 10.1111/wrr.12527. Epub 2017 May 18.


Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms.

Baker P, Hill PJ, Snarr BD, Alnabelseya N, Pestrak MJ, Lee MJ, Jennings LK, Tam J, Melnyk RA, Parsek MR, Sheppard DC, Wozniak DJ, Howell PL.

Sci Adv. 2016 May 20;2(5):e1501632. doi: 10.1126/sciadv.1501632. eCollection 2016 May.


Staphylococcus aureus Protein A Mediates Interspecies Interactions at the Cell Surface of Pseudomonas aeruginosa.

Armbruster CR, Wolter DJ, Mishra M, Hayden HS, Radey MC, Merrihew G, MacCoss MJ, Burns J, Wozniak DJ, Parsek MR, Hoffman LR.

MBio. 2016 May 24;7(3). pii: e00538-16. doi: 10.1128/mBio.00538-16.


Pseudomonas aeruginosa AmrZ Binds to Four Sites in the algD Promoter, Inducing DNA-AmrZ Complex Formation and Transcriptional Activation.

Xu B, Soukup RJ, Jones CJ, Fishel R, Wozniak DJ.

J Bacteriol. 2016 Sep 9;198(19):2673-81. doi: 10.1128/JB.00259-16. Print 2016 Oct 1.


What's on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and as a Target for Therapeutic Intervention.

Gunn JS, Bakaletz LO, Wozniak DJ.

J Biol Chem. 2016 Jun 10;291(24):12538-46. doi: 10.1074/jbc.R115.707547. Epub 2016 Apr 21. Review.


Prevention and treatment of Staphylococcus aureus biofilms.

Bhattacharya M, Wozniak DJ, Stoodley P, Hall-Stoodley L.

Expert Rev Anti Infect Ther. 2015;13(12):1499-516. doi: 10.1586/14787210.2015.1100533. Epub 2015 Nov 13. Review.


The Pseudomonas aeruginosa AmrZ C-terminal domain mediates tetramerization and is required for its activator and repressor functions.

Xu B, Ju Y, Soukup RJ, Ramsey DM, Fishel R, Wysocki VH, Wozniak DJ.

Environ Microbiol Rep. 2016 Feb;8(1):85-90. doi: 10.1111/1758-2229.12354. Epub 2015 Dec 21.


A novel technique using potassium permanganate and reflectance confocal microscopy to image biofilm extracellular polymeric matrix reveals non-eDNA networks in Pseudomonas aeruginosa biofilms.

Swearingen MC, Mehta A, Mehta A, Nistico L, Hill PJ, Falzarano AR, Wozniak DJ, Hall-Stoodley L, Stoodley P.

Pathog Dis. 2016 Feb;74(1):ftv104. doi: 10.1093/femspd/ftv104. Epub 2015 Nov 3.


Characterization of the Pseudomonas aeruginosa Glycoside Hydrolase PslG Reveals That Its Levels Are Critical for Psl Polysaccharide Biosynthesis and Biofilm Formation.

Baker P, Whitfield GB, Hill PJ, Little DJ, Pestrak MJ, Robinson H, Wozniak DJ, Howell PL.

J Biol Chem. 2015 Nov 20;290(47):28374-87. doi: 10.1074/jbc.M115.674929. Epub 2015 Sep 30.


Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix.

Jennings LK, Storek KM, Ledvina HE, Coulon C, Marmont LS, Sadovskaya I, Secor PR, Tseng BS, Scian M, Filloux A, Wozniak DJ, Howell PL, Parsek MR.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11353-8. doi: 10.1073/pnas.1503058112. Epub 2015 Aug 26.


Development of a Novel Method for Analyzing Pseudomonas aeruginosa Twitching Motility and Its Application to Define the AmrZ Regulon.

Xu B, Wozniak DJ.

PLoS One. 2015 Aug 26;10(8):e0136426. doi: 10.1371/journal.pone.0136426. eCollection 2015.


Bacterial Extracellular Polysaccharides in Biofilm Formation and Function.

Limoli DH, Jones CJ, Wozniak DJ.

Microbiol Spectr. 2015 Jun;3(3). doi: 10.1128/microbiolspec.MB-0011-2014. Review.


Identification of OprF as a complement component C3 binding acceptor molecule on the surface of Pseudomonas aeruginosa.

Mishra M, Ressler A, Schlesinger LS, Wozniak DJ.

Infect Immun. 2015 Aug;83(8):3006-14. doi: 10.1128/IAI.00081-15. Epub 2015 May 11.


Complete Genome Sequence of Pseudomonas aeruginosa Mucoid Strain FRD1, Isolated from a Cystic Fibrosis Patient.

Silo-Suh LA, Suh SJ, Ohman DE, Wozniak DJ, Pridgeon JW.

Genome Announc. 2015 Mar 19;3(2). pii: e00153-15. doi: 10.1128/genomeA.00153-15.


The exopolysaccharide Psl-eDNA interaction enables the formation of a biofilm skeleton in Pseudomonas aeruginosa.

Wang S, Liu X, Liu H, Zhang L, Guo Y, Yu S, Wozniak DJ, Ma LZ.

Environ Microbiol Rep. 2015 Apr;7(2):330-40. doi: 10.1111/1758-2229.12252. Epub 2015 Jan 23.


Mutagenesis by host antimicrobial peptides: insights into microbial evolution during chronic infections.

Limoli DH, Wozniak DJ.

Microb Cell. 2014 Jun 29;1(7):247-249. doi: 10.15698/mic2014.07.157.


Surface-associated microbes continue to surprise us in their sophisticated strategies for assembling biofilm communities.

Wozniak DJ, Parsek MR.

F1000Prime Rep. 2014 May 6;6:26. doi: 10.12703/P6-26. eCollection 2014. Review.


Mixed-species biofilm compromises wound healing by disrupting epidermal barrier function.

Roy S, Elgharably H, Sinha M, Ganesh K, Chaney S, Mann E, Miller C, Khanna S, Bergdall VK, Powell HM, Cook CH, Gordillo GM, Wozniak DJ, Sen CK.

J Pathol. 2014 Aug;233(4):331-343. doi: 10.1002/path.4360. Epub 2014 May 27.


Cationic antimicrobial peptides promote microbial mutagenesis and pathoadaptation in chronic infections.

Limoli DH, Rockel AB, Host KM, Jha A, Kopp BT, Hollis T, Wozniak DJ.

PLoS Pathog. 2014 Apr 24;10(4):e1004083. doi: 10.1371/journal.ppat.1004083. eCollection 2014 Apr.


ChIP-Seq and RNA-Seq reveal an AmrZ-mediated mechanism for cyclic di-GMP synthesis and biofilm development by Pseudomonas aeruginosa.

Jones CJ, Newsom D, Kelly B, Irie Y, Jennings LK, Xu B, Limoli DH, Harrison JJ, Parsek MR, White P, Wozniak DJ.

PLoS Pathog. 2014 Mar 6;10(3):e1003984. doi: 10.1371/journal.ppat.1003984. eCollection 2014 Mar.


First evidence of sternal wound biofilm following cardiac surgery.

Elgharably H, Mann E, Awad H, Ganesh K, Ghatak PD, Gordillo G, Sai-Sudhakar CB, Roy S, Wozniak DJ, Sen CK.

PLoS One. 2013 Aug 1;8(8):e70360. doi: 10.1371/journal.pone.0070360. Print 2013.


A spider web strategy of type IV pili-mediated migration to build a fibre-like Psl polysaccharide matrix in Pseudomonas aeruginosa biofilms.

Wang S, Parsek MR, Wozniak DJ, Ma LZ.

Environ Microbiol. 2013 Aug;15(8):2238-53. doi: 10.1111/1462-2920.12095. Epub 2013 Feb 20.


AmrZ modulates Pseudomonas aeruginosa biofilm architecture by directly repressing transcription of the psl operon.

Jones CJ, Ryder CR, Mann EE, Wozniak DJ.

J Bacteriol. 2013 Apr;195(8):1637-44. doi: 10.1128/JB.02190-12. Epub 2013 Jan 25.


Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa.

Irie Y, Borlee BR, O'Connor JR, Hill PJ, Harwood CS, Wozniak DJ, Parsek MR.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20632-6. doi: 10.1073/pnas.1217993109. Epub 2012 Nov 21.


The mcsB gene of the clpC operon is required for stress tolerance and virulence in Staphylococcus aureus.

Wozniak DJ, Tiwari KB, Soufan R, Jayaswal RK.

Microbiology. 2012 Oct;158(Pt 10):2568-76. Epub 2012 Aug 17.


Crystallization of Pseudomonas aeruginosa AmrZ protein: development of a comprehensive method for obtaining and optimization of protein-DNA crystals.

Pryor EE Jr, Wozniak DJ, Hollis T.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Aug 1;68(Pt 8):985-93. doi: 10.1107/S1744309112025316. Epub 2012 Jul 31.


Synthesis of multiple Pseudomonas aeruginosa biofilm matrix exopolysaccharides is post-transcriptionally regulated.

Ma L, Wang J, Wang S, Anderson EM, Lam JS, Parsek MR, Wozniak DJ.

Environ Microbiol. 2012 Aug;14(8):1995-2005. doi: 10.1111/j.1462-2920.2012.02753.x. Epub 2012 Apr 19.


The transcription factor AmrZ utilizes multiple DNA binding modes to recognize activator and repressor sequences of Pseudomonas aeruginosa virulence genes.

Pryor EE Jr, Waligora EA, Xu B, Dellos-Nolan S, Wozniak DJ, Hollis T.

PLoS Pathog. 2012;8(4):e1002648. doi: 10.1371/journal.ppat.1002648. Epub 2012 Apr 12.


The roles of biofilm matrix polysaccharide Psl in mucoid Pseudomonas aeruginosa biofilms.

Ma L, Wang S, Wang D, Parsek MR, Wozniak DJ.

FEMS Immunol Med Microbiol. 2012 Jul;65(2):377-80. doi: 10.1111/j.1574-695X.2012.00934.x. Epub 2012 Mar 12.


Pseudomonas biofilm matrix composition and niche biology.

Mann EE, Wozniak DJ.

FEMS Microbiol Rev. 2012 Jul;36(4):893-916. doi: 10.1111/j.1574-6976.2011.00322.x. Epub 2012 Jan 23. Review.


The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix.

Colvin KM, Irie Y, Tart CS, Urbano R, Whitney JC, Ryder C, Howell PL, Wozniak DJ, Parsek MR.

Environ Microbiol. 2012 Aug;14(8):1913-28. doi: 10.1111/j.1462-2920.2011.02657.x. Epub 2011 Dec 19.


Comprehensive analysis of microRNA genomic loci identifies pervasive repetitive-element origins.

Borchert GM, Holton NW, Williams JD, Hernan WL, Bishop IP, Dembosky JA, Elste JE, Gregoire NS, Kim JA, Koehler WW, Lengerich JC, Medema AA, Nguyen MA, Ower GD, Rarick MA, Strong BN, Tardi NJ, Tasker NM, Wozniak DJ, Gatto C, Larson ED.

Mob Genet Elements. 2011 May;1(1):8-17.

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