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Inclusion of Older Adults in the Research and Design of Digital Technology.

Mannheim I, Schwartz E, Xi W, Buttigieg SC, McDonnell-Naughton M, Wouters EJM, van Zaalen Y.

Int J Environ Res Public Health. 2019 Oct 2;16(19). pii: E3718. doi: 10.3390/ijerph16193718.


Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation.

Goërtz YMJ, Spruit MA, Van 't Hul AJ, Peters JB, Van Herck M, Nakken N, Djamin RS, Burtin C, Thong MSY, Coors A, Meertens-Kerris Y, Wouters EFM, Prins JB, Franssen FME, Muris JWM, Vanfleteren LEGW, Sprangers MAG, Janssen DJA, Vercoulen JH.

Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619878128. doi: 10.1177/1753466619878128.


Characteristics of Women Who Present for Abortion Beyond the Legal Limit in Flanders, Belgium.

Van de Velde S, Van Eekert N, Van Assche K, Sommerland N, Wouters E.

Perspect Sex Reprod Health. 2019 Sep;51(3):175-183. doi: 10.1363/psrh.12116. Epub 2019 Sep 11.


Effects of a comprehensive, inpatient pulmonary rehabilitation programme in a cachectic patient with very severe COPD and chronic respiratory failure.

Franssen FME, Vanfleteren LEGW, Janssen DJA, Wouters EFM, Spruit MA.

Breathe (Sheff). 2019 Sep;15(3):227-233. doi: 10.1183/20734735.0186-2019.


Cell Type- and Exposure-Specific Modulation of CD63/CD81-Positive and Tissue Factor-Positive Extracellular Vesicle Release in response to Respiratory Toxicants.

Stassen FRM, van Eijck PH, Savelkoul PHM, Wouters EFM, Rohde GGU, Briedé JJ, Reynaert NL, de Kok TM, Benedikter BJ.

Oxid Med Cell Longev. 2019 Aug 14;2019:5204218. doi: 10.1155/2019/5204218. eCollection 2019.


Insights into biased signaling at cannabinoid receptors: synthetic cannabinoid receptor agonists.

Wouters E, Walraed J, Banister SD, Stove CP.

Biochem Pharmacol. 2019 Nov;169:113623. doi: 10.1016/j.bcp.2019.08.025. Epub 2019 Aug 28. Review.


Understanding changes and stability in the long-term use of technologies by seniors who are aging in place: a dynamical framework.

Peek STM, Luijkx KG, Vrijhoef HJM, Nieboer ME, Aarts S, van der Voort CS, Rijnaard MD, Wouters EJM.

BMC Geriatr. 2019 Aug 28;19(1):236. doi: 10.1186/s12877-019-1241-9.


Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function.

Wouters E, de Wit NM, Vanmol J, van der Pol SMA, van Het Hof B, Sommer D, Loix M, Geerts D, Gustafsson JA, Steffensen KR, Vanmierlo T, Bogie JFJ, Hendriks JJA, de Vries HE.

Front Immunol. 2019 Jul 31;10:1811. doi: 10.3389/fimmu.2019.01811. eCollection 2019.


Personalized medicine for patients with COPD: where are we?

Franssen FM, Alter P, Bar N, Benedikter BJ, Iurato S, Maier D, Maxheim M, Roessler FK, Spruit MA, Vogelmeier CF, Wouters EF, Schmeck B.

Int J Chron Obstruct Pulmon Dis. 2019 Jul 9;14:1465-1484. doi: 10.2147/COPD.S175706. eCollection 2019.


Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease.

Piscaer I, van den Ouweland JMW, Vermeersch K, Reynaert NL, Franssen FME, Keene S, Wouters EFM, Janssens W, Vermeer C, Janssen R.

J Clin Med. 2019 Jul 27;8(8). pii: E1116. doi: 10.3390/jcm8081116.


Clustering of 27,525,663 Death Records from the United States Based on Health Conditions Associated with Death: An Example of big Health Data Exploration.

Janssen DJA, Rechberger S, Wouters EFM, Schols JMGA, Johnson MJ, Currow DC, Curtis JR, Spruit MA.

J Clin Med. 2019 Jun 27;8(7). pii: E922. doi: 10.3390/jcm8070922.


Factors Associated With HIV-Related Stigma Toward Colleagues in the Health Care Workforce in South Africa.

Sommerland N, Wouters E, Masquillier C, Rau A, Engelbrecht M, Kigozi G.

J Assoc Nurses AIDS Care. 2019 Jul-Aug;30(4):451-461. doi: 10.1097/JNC.0000000000000010.


Luminescence- and Fluorescence-Based Complementation Assays to Screen for GPCR Oligomerization: Current State of the Art.

Wouters E, Vasudevan L, Crans RAJ, Saini DK, Stove CP.

Int J Mol Sci. 2019 Jun 17;20(12). pii: E2958. doi: 10.3390/ijms20122958. Review.


Wearable Finger Pulse Oximetry for Continuous Oxygen Saturation Measurements During Daily Home Routines of Patients With Chronic Obstructive Pulmonary Disease (COPD) Over One Week: Observational Study.

Buekers J, Theunis J, De Boever P, Vaes AW, Koopman M, Janssen EV, Wouters EF, Spruit MA, Aerts JM.

JMIR Mhealth Uhealth. 2019 Jun 6;7(6):e12866. doi: 10.2196/12866.


The superexacerbator phenotype in patients with COPD: a descriptive analysis.

Vanfleteren LEGW, Boonen LMC, Spruit MA, Janssen DJA, Wouters EFM, Franssen FME.

ERJ Open Res. 2019 Jun 4;5(2). pii: 00235-2018. doi: 10.1183/23120541.00235-2018. eCollection 2019 Apr.


Vertebral bone attenuation in Hounsfield Units and prevalent vertebral fractures are associated with the short-term risk of vertebral fractures in current and ex-smokers with and without COPD: a 3-year chest CT follow-up study.

van Dort MJ, Driessen JHM, Geusens P, Romme EAPM, Smeenk FWJM, Wouters EFM, van den Bergh JPW.

Osteoporos Int. 2019 Aug;30(8):1561-1571. doi: 10.1007/s00198-019-04977-w. Epub 2019 Jun 3.


Perspectives of Stakeholders on Technology Use in the Care of Community-Living Older Adults with Dementia: A Systematic Literature Review.

van Boekel LC, Wouters EJM, Grimberg BM, van der Meer NJM, Luijkx KG.

Healthcare (Basel). 2019 May 28;7(2). pii: E73. doi: 10.3390/healthcare7020073.


Waiting to inhale: factors associated with healthcare workers' fears of occupationally-acquired tuberculosis (TB).

Engelbrecht M, Rau A, Kigozi G, Janse van Rensburg A, Wouters E, Sommerland N, Masquillier C, Uebel K.

BMC Infect Dis. 2019 May 28;19(1):475. doi: 10.1186/s12879-019-4115-z.


Airflow Obstruction and Cardio-metabolic Comorbidities.

Triest FJJ, Studnicka M, Franssen FME, Vollmer WM, Lamprecht B, Wouters EFM, Burney PGJ, Vanfleteren LEGW.

COPD. 2019 Apr;16(2):109-117. doi: 10.1080/15412555.2019.1614550. Epub 2019 May 27.


It's more than low BMI: prevalence of cachexia and associated mortality in COPD.

McDonald MN, Wouters EFM, Rutten E, Casaburi R, Rennard SI, Lomas DA, Bamman M, Celli B, Agusti A, Tal-Singer R, Hersh CP, Dransfield M, Silverman EK.

Respir Res. 2019 May 22;20(1):100. doi: 10.1186/s12931-019-1073-3.


Blood Eosinophil Counts, Withdrawal of Inhaled Corticosteroids and Risk of COPD Exacerbations and Mortality in the Clinical Practice Research Datalink (CPRD).

Oshagbemi OA, Franssen FME, van Kraaij S, Braeken DCW, Wouters EFM, Maitland-van der Zee AH, Driessen JHM, de Vries F.

COPD. 2019 Apr;16(2):152-159. doi: 10.1080/15412555.2019.1608172. Epub 2019 May 23.


Functional evaluation of carboxy metabolites of synthetic cannabinoid receptor agonists featuring scaffolds based on L-valine or L-tert-leucine.

Wouters E, Mogler L, Cannaert A, Auwärter V, Stove C.

Drug Test Anal. 2019 Aug;11(8):1183-1191. doi: 10.1002/dta.2607. Epub 2019 Jun 18.


Disease-Specific Comorbidity Clusters in COPD and Accelerated Aging.

Triest FJJ, Franssen FME, Reynaert N, Gaffron S, Spruit MA, Janssen DJA, Rutten EPA, Wouters EFM, Vanfleteren LEGW.

J Clin Med. 2019 Apr 14;8(4). pii: E511. doi: 10.3390/jcm8040511.


The Medusa faces of dyspnoea in COPD.

Wouters EFM.

Eur Respir J. 2019 Apr 18;53(4). pii: 1900487. doi: 10.1183/13993003.00487-2019. Print 2019 Apr. No abstract available.


Distinct Dopamine D₂ Receptor Antagonists Differentially Impact D₂ Receptor Oligomerization.

Wouters E, Marín AR, Dalton JAR, Giraldo J, Stove C.

Int J Mol Sci. 2019 Apr 4;20(7). pii: E1686. doi: 10.3390/ijms20071686.


Revealing Methodological Challenges in Chronic Obstructive Pulmonary Disease Studies Assessing Comorbidities: A Narrative Review.

Houben-Wilke S, Triest FJJ, Franssen FME, Janssen DJA, Wouters EFM, Vanfleteren LEGW.

Chronic Obstr Pulm Dis. 2019 Apr 9;6(2):166-177. doi: 10.15326/jcopdf.6.2.2018.0145. Epub 2019 Apr 9. Review.


Exhaled Volatile Organic Compounds Are Able to Discriminate between Neutrophilic and Eosinophilic Asthma.

Schleich FN, Zanella D, Stefanuto PH, Bessonov K, Smolinska A, Dallinga JW, Henket M, Paulus V, Guissard F, Graff S, Moermans C, Wouters EFM, Van Steen K, van Schooten FJ, Focant JF, Louis R.

Am J Respir Crit Care Med. 2019 Aug 15;200(4):444-453. doi: 10.1164/rccm.201811-2210OC.


Effects of Pulmonary Rehabilitation on Gait Characteristics in Patients with COPD.

Liu WY, Meijer K, Delbressine JM, Willems PJ, Wouters EF, Spruit MA.

J Clin Med. 2019 Apr 5;8(4). pii: E459. doi: 10.3390/jcm8040459.


Clinical outcome and cost-effectiveness of a 1-year nutritional intervention programme in COPD patients with low muscle mass: The randomized controlled NUTRAIN trial.

van Beers M, Rutten-van Mölken MPMH, van de Bool C, Boland M, Kremers SPJ, Franssen FME, van Helvoort A, Gosker HR, Wouters EF, Schols AMWJ.

Clin Nutr. 2019 Mar 18. pii: S0261-5614(19)30114-1. doi: 10.1016/j.clnu.2019.03.001. [Epub ahead of print]


Risk stratification for short-term mortality at hospital admission for acute exacerbations of COPD.

Sprooten RTM, Rohde GGU, Lawyer G, Leijte WT, Wouters EFM, Franssen FME.

Respirology. 2019 Aug;24(8):765-776. doi: 10.1111/resp.13538. Epub 2019 Mar 21.


Popping smart pills in medical school: Are competition and stress associated with the misuse of prescription stimulants among students?

De Bruyn S, Wouters E, Ponnet K, Van Hal G.

Subst Use Misuse. 2019;54(7):1191-1202. doi: 10.1080/10826084.2019.1572190. Epub 2019 Mar 20.


Pulmonary rehabilitation, physical activity, respiratory failure and palliative respiratory care.

Spruit MA, Rochester CL, Pitta F, Kenn K, Schols AMWJ, Hart N, Wouters EFM, Nava S, Dreher M, Janssen DJA, Johnson MJ, Curtis RJ, Sastry M, Franssen FME.

Thorax. 2019 Jul;74(7):693-699. doi: 10.1136/thoraxjnl-2018-212044. Epub 2019 Mar 14.


Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles.

Benedikter BJ, Bouwman FG, Heinzmann ACA, Vajen T, Mariman EC, Wouters EFM, Savelkoul PHM, Koenen RR, Rohde GGU, van Oerle R, Spronk HM, Stassen FRM.

J Extracell Vesicles. 2019 Mar 5;8(1):1585163. doi: 10.1080/20013078.2019.1585163. eCollection 2019.


Organizational aspects of pulmonary rehabilitation in chronic respiratory diseases.

Spruit MA, Wouters EFM.

Respirology. 2019 Sep;24(9):838-843. doi: 10.1111/resp.13512. Epub 2019 Feb 27. Review.


Sociodemographic Factors Influencing the Use of eHealth in People with Chronic Diseases.

Reiners F, Sturm J, Bouw LJW, Wouters EJM.

Int J Environ Res Public Health. 2019 Feb 21;16(4). pii: E645. doi: 10.3390/ijerph16040645. Review.


Artificial intelligence outperforms pulmonologists in the interpretation of pulmonary function tests.

Topalovic M, Das N, Burgel PR, Daenen M, Derom E, Haenebalcke C, Janssen R, Kerstjens HAM, Liistro G, Louis R, Ninane V, Pison C, Schlesser M, Vercauter P, Vogelmeier CF, Wouters E, Wynants J, Janssens W; Pulmonary Function Study Investigators; Pulmonary Function Study Investigators:.

Eur Respir J. 2019 Apr 11;53(4). pii: 1801660. doi: 10.1183/13993003.01660-2018. Print 2019 Apr.


Out of the silos: identifying cross-cutting features of health-related stigma to advance measurement and intervention.

van Brakel WH, Cataldo J, Grover S, Kohrt BA, Nyblade L, Stockton M, Wouters E, Yang LH.

BMC Med. 2019 Feb 15;17(1):13. doi: 10.1186/s12916-018-1245-x.


Stigma in health facilities: why it matters and how we can change it.

Nyblade L, Stockton MA, Giger K, Bond V, Ekstrand ML, Lean RM, Mitchell EMH, Nelson RE, Sapag JC, Siraprapasiri T, Turan J, Wouters E.

BMC Med. 2019 Feb 15;17(1):25. doi: 10.1186/s12916-019-1256-2.


Emphysema: looking beyond alpha-1 antitrypsin deficiency.

Janssen R, Piscaer I, Franssen FME, Wouters EFM.

Expert Rev Respir Med. 2019 Apr;13(4):381-397. doi: 10.1080/17476348.2019.1580575. Epub 2019 Feb 22.


Thoracic Kyphosis on Chest CT Scans Is Associated With Incident Vertebral Fractures in Smokers.

van Dort MJ, Driessen JH, Romme EA, Geusens P, Willems PC, Smeenk FW, Wouters EF, van den Bergh JP.

J Bone Miner Res. 2019 May;34(5):859-866. doi: 10.1002/jbmr.3672. Epub 2019 Feb 27.


Understanding User Practices When Drawing up Requirements-The Case of Designing Assistive Devices for Mobility.

Holtkamp FC, Wouters EJM, Verkerk MJ.

Int J Environ Res Public Health. 2019 Jan 24;16(3). pii: E318. doi: 10.3390/ijerph16030318.


Cluster-randomised trial of a nurse-led advance care planning session in patients with COPD and their loved ones.

Houben CHM, Spruit MA, Luyten H, Pennings HJ, van den Boogaart VEM, Creemers JPHM, Wesseling G, Wouters EFM, Janssen DJA.

Thorax. 2019 Apr;74(4):328-336. doi: 10.1136/thoraxjnl-2018-211943. Epub 2019 Jan 19.


The validation of Short Interspersed Nuclear Elements (SINEs) as a RT-qPCR normalization strategy in a rodent model for temporal lobe epilepsy.

Crans RAJ, Janssens J, Daelemans S, Wouters E, Raedt R, Van Dam D, De Deyn PP, Van Craenenbroeck K, Stove CP.

PLoS One. 2019 Jan 10;14(1):e0210567. doi: 10.1371/journal.pone.0210567. eCollection 2019.


Comprehensive Lung Function Assessment Does not Allow to Infer Response to Pulmonary Rehabilitation in Patients with COPD.

Augustin IML, Wouters EFM, Houben-Wilke S, Gaffron S, Janssen DJA, Franssen FME, Spruit MA.

J Clin Med. 2018 Dec 27;8(1). pii: E27. doi: 10.3390/jcm8010027.


Spirometric changes during exacerbations of COPD: a post hoc analysis of the WISDOM trial.

Watz H, Tetzlaff K, Magnussen H, Mueller A, Rodriguez-Roisin R, Wouters EFM, Vogelmeier C, Calverley PMA.

Respir Res. 2018 Dec 13;19(1):251. doi: 10.1186/s12931-018-0944-3.


Impact of pulmonary rehabilitation on activities of daily living in patients with chronic obstructive pulmonary disease.

Vaes AW, Delbressine JML, Mesquita R, Goertz YMJ, Janssen DJA, Nakken N, Franssen FME, Vanfleteren LEGW, Wouters EFM, Spruit MA.

J Appl Physiol (1985). 2019 Mar 1;126(3):607-615. doi: 10.1152/japplphysiol.00790.2018. Epub 2018 Nov 29.


Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease.

Van Herck M, Spruit MA, Burtin C, Djamin R, Antons J, Goërtz YMJ, Ebadi Z, Janssen DJA, Vercoulen JH, Peters JB, Thong MSY, Otker J, Coors A, Sprangers MAG, Muris JWM, Wouters EFM, van 't Hul AJ.

J Clin Med. 2018 Nov 23;7(12). pii: E471. doi: 10.3390/jcm7120471.


Contribution of individual COPD assessment test (CAT) items to CAT total score and effects of pulmonary rehabilitation on CAT scores.

Houben-Wilke S, Janssen DJA, Franssen FME, Vanfleteren LEGW, Wouters EFM, Spruit MA.

Health Qual Life Outcomes. 2018 Oct 30;16(1):205. doi: 10.1186/s12955-018-1034-4.


Validation and responsiveness of the Late-Life Function and Disability Instrument Computerized Adaptive Test in community-dwelling stroke survivors.

Wondergem R, Pisters MF, Wouters EM, de Bie RA, Visser-Meily JM, Veenhof C.

Eur J Phys Rehabil Med. 2019 Aug;55(4):424-432. doi: 10.23736/S1973-9087.18.05359-5. Epub 2018 Oct 29.


Trends in moderate and severe exacerbations among COPD patients in the UK from 2005 to 2013.

Oshagbemi OA, Keene SJ, Driessen JHM, Jordan R, Wouters EFM, de Boer A, de Vries F, Franssen FME.

Respir Med. 2018 Nov;144:1-6. doi: 10.1016/j.rmed.2018.09.010. Epub 2018 Sep 17.


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