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Items: 1 to 50 of 154

1.

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study.

Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J.

Lancet. 2018 May 26;391(10135):2128-2139. doi: 10.1016/S0140-6736(18)30789-X. Epub 2018 May 10.

PMID:
29754777
2.

Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer.

Haynes J, McKee TD, Haller A, Wang Y, Leung C, Gendoo DMA, Lima-Fernandes E, Kreso A, Wolman R, Szentgyorgyi E, Vines DC, Haibe-Kains B, Wouters BG, Metser U, Jaffray DA, Smith M, O'Brien CA.

Clin Cancer Res. 2018 May 1;24(9):2116-2127. doi: 10.1158/1078-0432.CCR-17-1715. Epub 2018 Feb 23.

PMID:
29476017
3.

The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer.

Ding M, Van der Kwast TH, Vellanki RN, Foltz WD, McKee TD, Sonenberg N, Pandolfi PP, Koritzinsky M, Wouters BG.

Mol Cancer Res. 2018 Apr;16(4):682-695. doi: 10.1158/1541-7786.MCR-17-0696. Epub 2018 Feb 16.

PMID:
29453322
4.

The Future of Radiobiology.

Kirsch DG, Diehn M, Kesarwala AH, Maity A, Morgan MA, Schwarz JK, Bristow R, Demaria S, Eke I, Griffin RJ, Haas-Kogan D, Higgins GS, Kimmelman AC, Kimple RJ, Lombaert IM, Ma L, Marples B, Pajonk F, Park CC, Schaue D, Tran PT, Willers H, Wouters BG, Bernhard EJ.

J Natl Cancer Inst. 2018 Apr 1;110(4):329-340. doi: 10.1093/jnci/djx231.

PMID:
29126306
5.

A β-galactosidase probe for the detection of cellular senescence by mass cytometry.

Lumba MA, Willis LM, Santra S, Rana R, Schito L, Rey S, Wouters BG, Nitz M.

Org Biomol Chem. 2017 Aug 2;15(30):6388-6392. doi: 10.1039/c7ob01227f.

PMID:
28726964
6.

Targeting Hypoxia-Inducible Factors for Antiangiogenic Cancer Therapy.

Rey S, Schito L, Wouters BG, Eliasof S, Kerbel RS.

Trends Cancer. 2017 Jul;3(7):529-541. doi: 10.1016/j.trecan.2017.05.002. Epub 2017 Jun 10. Review.

PMID:
28718406
7.

Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors.

Leung E, Cairns RA, Chaudary N, Vellanki RN, Kalliomaki T, Moriyama EH, Mujcic H, Wilson BC, Wouters BG, Hill R, Milosevic M.

BMC Cancer. 2017 Jun 15;17(1):418. doi: 10.1186/s12885-017-3402-6.

8.

Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity.

Tan Q, Joshua AM, Wang M, Bristow RG, Wouters BG, Allen CJ, Tannock IF.

Cancer Chemother Pharmacol. 2017 May;79(5):959-969. doi: 10.1007/s00280-017-3298-5. Epub 2017 Apr 4.

PMID:
28378028
9.

MATE2 Expression Is Associated with Cancer Cell Response to Metformin.

Chowdhury S, Yung E, Pintilie M, Muaddi H, Chaib S, Yeung M, Fusciello M, Sykes J, Pitcher B, Hagenkort A, McKee T, Vellanki R, Chen E, Bristow RG, Wouters BG, Koritzinsky M.

PLoS One. 2016 Dec 13;11(12):e0165214. doi: 10.1371/journal.pone.0165214. eCollection 2016.

10.

Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia.

Adriaens ME, Prickaerts P, Chan-Seng-Yue M, van den Beucken T, Dahlmans VEH, Eijssen LM, Beck T, Wouters BG, Voncken JW, Evelo CTA.

Epigenetics Chromatin. 2016 Nov 1;9:48. doi: 10.1186/s13072-016-0090-4. eCollection 2016.

11.

In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model.

Maeda A, Chen Y, Bu J, Mujcic H, Wouters BG, DaCosta RS.

Int J Radiat Oncol Biol Phys. 2017 Jan 1;97(1):184-194. doi: 10.1016/j.ijrobp.2016.09.005. Epub 2016 Sep 14.

PMID:
27816364
12.

Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3.

Prickaerts P, Adriaens ME, Beucken TVD, Koch E, Dubois L, Dahlmans VEH, Gits C, Evelo CTA, Chan-Seng-Yue M, Wouters BG, Voncken JW.

Epigenetics Chromatin. 2016 Oct 26;9:46. doi: 10.1186/s13072-016-0086-0. eCollection 2016.

13.

Molecular targeting of hypoxia in radiotherapy.

Rey S, Schito L, Koritzinsky M, Wouters BG.

Adv Drug Deliv Rev. 2017 Jan 15;109:45-62. doi: 10.1016/j.addr.2016.10.002. Epub 2016 Oct 19. Review.

PMID:
27771366
14.

Quantifying hypoxia in human cancers using static PET imaging.

Taylor E, Yeung I, Keller H, Wouters BG, Milosevic M, Hedley DW, Jaffray DA.

Phys Med Biol. 2016 Nov 21;61(22):7957-7974. Epub 2016 Oct 25.

PMID:
27779123
15.

Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma.

Connor AA, Denroche RE, Jang GH, Timms L, Kalimuthu SN, Selander I, McPherson T, Wilson GW, Chan-Seng-Yue MA, Borozan I, Ferretti V, Grant RC, Lungu IM, Costello E, Greenhalf W, Palmer D, Ghaneh P, Neoptolemos JP, Buchler M, Petersen G, Thayer S, Hollingsworth MA, Sherker A, Durocher D, Dhani N, Hedley D, Serra S, Pollett A, Roehrl MHA, Bavi P, Bartlett JMS, Cleary S, Wilson JM, Alexandrov LB, Moore M, Wouters BG, McPherson JD, Notta F, Stein LD, Gallinger S.

JAMA Oncol. 2017 Jun 1;3(6):774-783. doi: 10.1001/jamaoncol.2016.3916.

16.

Development of TRACER: tissue roll for analysis of cellular environment and response.

Rodenhizer D, Cojocari D, Wouters BG, McGuigan AP.

Biofabrication. 2016 Oct 18;8(4):045008.

PMID:
27754980
17.

Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution.

Edgar LJ, Vellanki RN, McKee TD, Hedley D, Wouters BG, Nitz M.

Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13159-13163. doi: 10.1002/anie.201607483.

PMID:
27709819
18.

PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.

Banh RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Zhang W, Sinha A, Rose CM, Isasa M, Zhang S, Wu R, Virtanen C, Hitomi T, Habu T, Sidhu SS, Koizumi A, Wilkins SE, Kislinger T, Gygi SP, Schofield CJ, Dennis JW, Wouters BG, Neel BG.

Nat Cell Biol. 2016 Jul;18(7):803-813. doi: 10.1038/ncb3376. Epub 2016 Jun 20.

19.

Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects.

Molavian HR, Goldman A, Phipps CJ, Kohandel M, Wouters BG, Sengupta S, Sivaloganathan S.

Sci Rep. 2016 Jun 9;6:27439. doi: 10.1038/srep27439.

20.

Hypoxia-activated prodrugs: paths forward in the era of personalised medicine.

Hunter FW, Wouters BG, Wilson WR.

Br J Cancer. 2016 May 10;114(10):1071-7. doi: 10.1038/bjc.2016.79. Epub 2016 Apr 12. Review.

21.

Erratum: A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients.

Rodenhizer D, Gaude E, Cojocari D, Mahadevan R, Frezza C, Wouters BG, McGuigan AP.

Nat Mater. 2016 Feb;15(2):244. doi: 10.1038/nmat4515. No abstract available.

PMID:
26796735
22.

A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients.

Rodenhizer D, Gaude E, Cojocari D, Mahadevan R, Frezza C, Wouters BG, McGuigan AP.

Nat Mater. 2016 Feb;15(2):227-34. doi: 10.1038/nmat4482. Epub 2015 Nov 23. Erratum in: Nat Mater. 2016 Feb;15(2):244.

23.

Hypoxia and Predicting Radiation Response.

Hill RP, Bristow RG, Fyles A, Koritzinsky M, Milosevic M, Wouters BG.

Semin Radiat Oncol. 2015 Oct;25(4):260-72. doi: 10.1016/j.semradonc.2015.05.004. Epub 2015 May 15. Review.

PMID:
26384274
24.

Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.

Hunter FW, Young RJ, Shalev Z, Vellanki RN, Wang J, Gu Y, Joshi N, Sreebhavan S, Weinreb I, Goldstein DP, Moffat J, Ketela T, Brown KR, Koritzinsky M, Solomon B, Rischin D, Wilson WR, Wouters BG.

Cancer Res. 2015 Oct 1;75(19):4211-23. doi: 10.1158/0008-5472.CAN-15-1107. Epub 2015 Aug 21.

25.

Cell Death Identification in Anticancer Therapy-Letter.

Brown JM, Wouters BG, Kirsch DG.

Cancer Res. 2015 Sep 1;75(17):3681. doi: 10.1158/0008-5472.CAN-15-0908. Epub 2015 Aug 18. No abstract available.

26.

MK3 modulation affects BMI1-dependent and independent cell cycle check-points.

Prickaerts P, Niessen HE, Dahlmans VE, Spaapen F, Salvaing J, Vanhove J, Geijselaers C, Bartels SJ, Partouns I, Neumann D, Speel EJ, Takihara Y, Wouters BG, Voncken JW.

PLoS One. 2015 Apr 8;10(4):e0118840. doi: 10.1371/journal.pone.0118840. eCollection 2015.

27.

CHCHD2 Is Coamplified with EGFR in NSCLC and Regulates Mitochondrial Function and Cell Migration.

Wei Y, Vellanki RN, Coyaud É, Ignatchenko V, Li L, Krieger JR, Taylor P, Tong J, Pham NA, Liu G, Raught B, Wouters BG, Kislinger T, Tsao MS, Moran MF.

Mol Cancer Res. 2015 Jul;13(7):1119-29. doi: 10.1158/1541-7786.MCR-14-0165-T. Epub 2015 Mar 17.

28.

Effect of pantoprazole to enhance activity of docetaxel against human tumour xenografts by inhibiting autophagy.

Tan Q, Joshua AM, Saggar JK, Yu M, Wang M, Kanga N, Zhang JY, Chen X, Wouters BG, Tannock IF.

Br J Cancer. 2015 Mar 3;112(5):832-40. doi: 10.1038/bjc.2015.17. Epub 2015 Feb 3.

29.

Integrating RAS status into prognostic signatures for adenocarcinomas of the lung.

Starmans MH, Pintilie M, Chan-Seng-Yue M, Moon NC, Haider S, Nguyen F, Lau SK, Liu N, Kasprzyk A, Wouters BG, Der SD, Shepherd FA, Jurisica I, Penn LZ, Tsao MS, Lambin P, Boutros PC.

Clin Cancer Res. 2015 Mar 15;21(6):1477-86. doi: 10.1158/1078-0432.CCR-14-1749. Epub 2015 Jan 21.

30.

Radiobiological intercomparison of the 160 MeV and 230 MeV proton therapy beams at the Harvard Cyclotron Laboratory and at Massachusetts General Hospital.

Wouters BG, Skarsgard LD, Gerweck LE, Carabe-Fernandez A, Wong M, Durand RE, Nielson D, Bussiere MR, Wagner M, Biggs P, Paganetti H, Suit HD.

Radiat Res. 2015 Feb;183(2):174-87. doi: 10.1667/RR13795.1. Epub 2015 Jan 14. Erratum in: Radiat Res. 2015 Apr;183(4):e51.

PMID:
25587741
31.

Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.

Belmont PJ, Jiang P, McKee TD, Xie T, Isaacson J, Baryla NE, Roper J, Sinnamon MJ, Lee NV, Kan JL, Guicherit O, Wouters BG, O'Brien CA, Shields D, Olson P, VanArsdale T, Weinrich SL, Rejto P, Christensen JG, Fantin VR, Hung KE, Martin ES.

Sci Signal. 2014 Nov 11;7(351):ra107. doi: 10.1126/scisignal.2005516.

PMID:
25389372
32.

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

van den Beucken T, Koch E, Chu K, Rupaimoole R, Prickaerts P, Adriaens M, Voncken JW, Harris AL, Buffa FM, Haider S, Starmans MHW, Yao CQ, Ivan M, Ivan C, Pecot CV, Boutros PC, Sood AK, Koritzinsky M, Wouters BG.

Nat Commun. 2014 Oct 29;5:5203. doi: 10.1038/ncomms6203.

33.

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression.

Rupaimoole R, Wu SY, Pradeep S, Ivan C, Pecot CV, Gharpure KM, Nagaraja AS, Armaiz-Pena GN, McGuire M, Zand B, Dalton HJ, Filant J, Miller JB, Lu C, Sadaoui NC, Mangala LS, Taylor M, van den Beucken T, Koch E, Rodriguez-Aguayo C, Huang L, Bar-Eli M, Wouters BG, Radovich M, Ivan M, Calin GA, Zhang W, Lopez-Berestein G, Sood AK.

Nat Commun. 2014 Oct 29;5:5202. doi: 10.1038/ncomms6202.

34.

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.

Pettersen EO, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, Ree AH, Flatmark K, Lyng H, Calzada MJ, Peso LD, Landazuri MO, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton DC, Haider S, Buffa FM, Harris AL, Scozzafava A, Supuran CT, Moser I, Jobst G, Busk M, Toustrup K, Overgaard J, Alsner J, Pouyssegur J, Chiche J, Mazure N, Marchiq I, Parks S, Ahmed A, Ashcroft M, Pastorekova S, Cao Y, Rouschop KM, Wouters BG, Koritzinsky M, Mujcic H, Cojocari D.

J Enzyme Inhib Med Chem. 2015;30(5):689-721. doi: 10.3109/14756366.2014.966704. Epub 2014 Oct 27. Review.

PMID:
25347767
35.

Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands.

Weinreb I, Piscuoglio S, Martelotto LG, Waggott D, Ng CK, Perez-Ordonez B, Harding NJ, Alfaro J, Chu KC, Viale A, Fusco N, da Cruz Paula A, Marchio C, Sakr RA, Lim R, Thompson LD, Chiosea SI, Seethala RR, Skalova A, Stelow EB, Fonseca I, Assaad A, How C, Wang J, de Borja R, Chan-Seng-Yue M, Howlett CJ, Nichols AC, Wen YH, Katabi N, Buchner N, Mullen L, Kislinger T, Wouters BG, Liu FF, Norton L, McPherson JD, Rubin BP, Clarke BA, Weigelt B, Boutros PC, Reis-Filho JS.

Nat Genet. 2014 Nov;46(11):1166-9. doi: 10.1038/ng.3096. Epub 2014 Sep 21.

36.

Identification of hypoxic cells using an organotellurium tag compatible with mass cytometry.

Edgar LJ, Vellanki RN, Halupa A, Hedley D, Wouters BG, Nitz M.

Angew Chem Int Ed Engl. 2014 Oct 20;53(43):11473-7. doi: 10.1002/anie.201405233. Epub 2014 Sep 4.

PMID:
25195589
37.

Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells.

Chan N, Ali M, McCallum GP, Kumareswaran R, Koritzinsky M, Wouters BG, Wells PG, Gallinger S, Bristow RG.

Mol Cancer Res. 2014 Oct;12(10):1407-15. doi: 10.1158/1541-7786.MCR-14-0246. Epub 2014 Jul 16.

38.

Hypoxia signaling and the metastatic phenotype.

Mujcic H, Hill RP, Koritzinsky M, Wouters BG.

Curr Mol Med. 2014;14(5):565-79. Review.

PMID:
24894165
39.

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.

van Galen P, Kreso A, Mbong N, Kent DG, Fitzmaurice T, Chambers JE, Xie S, Laurenti E, Hermans K, Eppert K, Marciniak SJ, Goodall JC, Green AR, Wouters BG, Wienholds E, Dick JE.

Nature. 2014 Jun 12;510(7504):268-72. doi: 10.1038/nature13228. Epub 2014 Apr 28.

PMID:
24776803
40.

Post-transcriptional regulation of MRE11 expression in muscle-invasive bladder tumours.

Martin RM, Kerr M, Teo MT, Jevons SJ, Koritzinsky M, Wouters BG, Bhattarai S, Kiltie AE.

Oncotarget. 2014 Feb 28;5(4):993-1003.

41.

RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.

Ramaekers CH, van den Beucken T, Bristow RG, Chiu RK, Durocher D, Wouters BG.

PLoS One. 2014 Feb 28;9(2):e89997. doi: 10.1371/journal.pone.0089997. eCollection 2014.

42.

Two phases of disulfide bond formation have differing requirements for oxygen.

Koritzinsky M, Levitin F, van den Beucken T, Rumantir RA, Harding NJ, Chu KC, Boutros PC, Braakman I, Wouters BG.

J Cell Biol. 2013 Nov 25;203(4):615-27. doi: 10.1083/jcb.201307185. Epub 2013 Nov 18.

43.

Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response.

Zannella VE, Dal Pra A, Muaddi H, McKee TD, Stapleton S, Sykes J, Glicksman R, Chaib S, Zamiara P, Milosevic M, Wouters BG, Bristow RG, Koritzinsky M.

Clin Cancer Res. 2013 Dec 15;19(24):6741-50. doi: 10.1158/1078-0432.CCR-13-1787. Epub 2013 Oct 18.

44.

Towards the introduction of the 'Immunoscore' in the classification of malignant tumours.

Galon J, Mlecnik B, Bindea G, Angell HK, Berger A, Lagorce C, Lugli A, Zlobec I, Hartmann A, Bifulco C, Nagtegaal ID, Palmqvist R, Masucci GV, Botti G, Tatangelo F, Delrio P, Maio M, Laghi L, Grizzi F, Asslaber M, D'Arrigo C, Vidal-Vanaclocha F, Zavadova E, Chouchane L, Ohashi PS, Hafezi-Bakhtiari S, Wouters BG, Roehrl M, Nguyen L, Kawakami Y, Hazama S, Okuno K, Ogino S, Gibbs P, Waring P, Sato N, Torigoe T, Itoh K, Patel PS, Shukla SN, Wang Y, Kopetz S, Sinicrope FA, Scripcariu V, Ascierto PA, Marincola FM, Fox BA, Pagès F.

J Pathol. 2014 Jan;232(2):199-209. doi: 10.1002/path.4287. Review.

45.

Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3.

Mujcic H, Nagelkerke A, Rouschop KM, Chung S, Chaudary N, Span PN, Clarke B, Milosevic M, Sykes J, Hill RP, Koritzinsky M, Wouters BG.

Clin Cancer Res. 2013 Nov 15;19(22):6126-37. doi: 10.1158/1078-0432.CCR-13-0526. Epub 2013 Sep 17.

46.

The roles of reactive oxygen species and autophagy in mediating the tolerance of tumor cells to cycling hypoxia.

Koritzinsky M, Wouters BG.

Semin Radiat Oncol. 2013 Oct;23(4):252-61. doi: 10.1016/j.semradonc.2013.05.006. Review.

PMID:
24012339
47.

High tumor interstitial fluid pressure identifies cervical cancer patients with improved survival from radiotherapy plus cisplatin versus radiotherapy alone.

Milosevic MF, Pintilie M, Hedley DW, Bristow RG, Wouters BG, Oza AM, Laframboise S, Hill RP, Fyles AW.

Int J Cancer. 2014 Oct 1;135(7):1692-9. doi: 10.1002/ijc.28403. Epub 2014 Apr 25.

48.

Hypoxia and metastasis in an orthotopic cervix cancer xenograft model.

Chaudary N, Mujcic H, Wouters BG, Hill RP.

Radiother Oncol. 2013 Sep;108(3):506-10. doi: 10.1016/j.radonc.2013.06.019. Epub 2013 Jul 12.

PMID:
23856487
49.

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia.

Schaaf MB, Cojocari D, Keulers TG, Jutten B, Starmans MH, de Jong MC, Begg AC, Savelkouls KG, Bussink J, Vooijs M, Wouters BG, Rouschop KM.

Radiother Oncol. 2013 Sep;108(3):529-34. doi: 10.1016/j.radonc.2013.06.015. Epub 2013 Jul 9.

PMID:
23849170
50.

New small molecule inhibitors of UPR activation demonstrate that PERK, but not IRE1α signaling is essential for promoting adaptation and survival to hypoxia.

Cojocari D, Vellanki RN, Sit B, Uehling D, Koritzinsky M, Wouters BG.

Radiother Oncol. 2013 Sep;108(3):541-7. doi: 10.1016/j.radonc.2013.06.005. Epub 2013 Jul 3.

PMID:
23830192

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