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Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide.

Hunter FW, Devaux JBL, Meng F, Hong CR, Khan A, Tsai P, Ketela TW, Sharma I, Kakadia PM, Marastoni S, Shalev Z, Hickey AJR, Print CG, Bohlander SK, Hart CP, Wouters BG, Wilson WR.

Mol Pharmacol. 2019 Jun;95(6):638-651. doi: 10.1124/mol.118.115196. Epub 2019 Apr 12.


TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry.

Bassan J, Willis LM, Vellanki RN, Nguyen A, Edgar LJ, Wouters BG, Nitz M.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8155-8160. doi: 10.1073/pnas.1821151116. Epub 2019 Apr 10.


Pantoprazole Affecting Docetaxel Resistance Pathways via Autophagy (PANDORA): Phase II Trial of High Dose Pantoprazole (Autophagy Inhibitor) with Docetaxel in Metastatic Castration-Resistant Prostate Cancer (mCRPC).

Hansen AR, Tannock IF, Templeton A, Chen E, Evans A, Knox J, Prawira A, Sridhar SS, Tan S, Vera-Badillo F, Wang L, Wouters BG, Joshua AM.

Oncologist. 2019 Apr 5. pii: theoncologist.2018-0621. doi: 10.1634/theoncologist.2018-0621. [Epub ahead of print]


Experimental and numerical study of band-broadening effects associated with analyte transfer in microfluidic devices for spatial two-dimensional liquid chromatography created by additive manufacturing.

Adamopoulou T, Nawada S, Deridder S, Wouters B, Desmet G, Schoenmakers PJ.

J Chromatogr A. 2019 Aug 2;1598:77-84. doi: 10.1016/j.chroma.2019.03.041. Epub 2019 Mar 22.


Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells.

Lima-Fernandes E, Murison A, da Silva Medina T, Wang Y, Ma A, Leung C, Luciani GM, Haynes J, Pollett A, Zeller C, Duan S, Kreso A, Barsyte-Lovejoy D, Wouters BG, Jin J, Carvalho DD, Lupien M, Arrowsmith CH, O'Brien CA.

Nat Commun. 2019 Mar 29;10(1):1436. doi: 10.1038/s41467-019-09309-4.


On-line microfluidic immobilized-enzyme reactors: A new tool for characterizing synthetic polymers.

Wouters B, Pirok BWJ, Soulis D, Garmendia Perticarini RC, Fokker S, van den Hurk RS, Skolimowski M, Peters RAH, Schoenmakers PJ.

Anal Chim Acta. 2019 Apr 11;1053:62-69. doi: 10.1016/j.aca.2018.12.002. Epub 2018 Dec 12.


Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases.

Connor AA, Denroche RE, Jang GH, Lemire M, Zhang A, Chan-Seng-Yue M, Wilson G, Grant RC, Merico D, Lungu I, Bartlett JMS, Chadwick D, Liang SB, Eagles J, Mbabaali F, Miller JK, Krzyzanowski P, Armstrong H, Luo X, Jorgensen LGT, Romero JM, Bavi P, Fischer SE, Serra S, Hafezi-Bakhtiari S, Caglar D, Roehrl MHA, Cleary S, Hollingsworth MA, Petersen GM, Thayer S, Law CHL, Nanji S, Golan T, Smith AL, Borgida A, Dodd A, Hedley D, Wouters BG, O'Kane GM, Wilson JM, Zogopoulos G, Notta F, Knox JJ, Gallinger S.

Cancer Cell. 2019 Feb 11;35(2):267-282.e7. doi: 10.1016/j.ccell.2018.12.010. Epub 2019 Jan 24.


ONECUT2 is a driver of neuroendocrine prostate cancer.

Guo H, Ci X, Ahmed M, Hua JT, Soares F, Lin D, Puca L, Vosoughi A, Xue H, Li E, Su P, Chen S, Nguyen T, Liang Y, Zhang Y, Xu X, Xu J, Sheahan AV, Ba-Alawi W, Zhang S, Mahamud O, Vellanki RN, Gleave M, Bristow RG, Haibe-Kains B, Poirier JT, Rudin CM, Tsao MS, Wouters BG, Fazli L, Feng FY, Ellis L, van der Kwast T, Berlin A, Koritzinsky M, Boutros PC, Zoubeidi A, Beltran H, Wang Y, He HH.

Nat Commun. 2019 Jan 17;10(1):278. doi: 10.1038/s41467-018-08133-6.


Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.

Jamieson SM, Tsai P, Kondratyev MK, Budhani P, Liu A, Senzer NN, Chiorean EG, Jalal SI, Nemunaitis JJ, Kee D, Shome A, Wong WW, Li D, Poonawala-Lohani N, Kakadia PM, Knowlton NS, Lynch CR, Hong CR, Lee TW, Grénman RA, Caporiccio L, McKee TD, Zaidi M, Butt S, Macann AM, McIvor NP, Chaplin JM, Hicks KO, Bohlander SK, Wouters BG, Hart CP, Print CG, Wilson WR, Curran MA, Hunter FW.

JCI Insight. 2018 Aug 23;3(16). pii: 122204. doi: 10.1172/jci.insight.122204. eCollection 2018 Aug 23.


International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study.

Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J.

Lancet. 2018 May 26;391(10135):2128-2139. doi: 10.1016/S0140-6736(18)30789-X. Epub 2018 May 10.


Personalised pulmonary rehabilitation in COPD.

Wouters EFM, Wouters BBREF, Augustin IML, Houben-Wilke S, Vanfleteren LEGW, Franssen FME.

Eur Respir Rev. 2018 Mar 28;27(147). pii: 170125. doi: 10.1183/16000617.0125-2017. Print 2018 Mar 31. Review.


Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer.

Haynes J, McKee TD, Haller A, Wang Y, Leung C, Gendoo DMA, Lima-Fernandes E, Kreso A, Wolman R, Szentgyorgyi E, Vines DC, Haibe-Kains B, Wouters BG, Metser U, Jaffray DA, Smith M, O'Brien CA.

Clin Cancer Res. 2018 May 1;24(9):2116-2127. doi: 10.1158/1078-0432.CCR-17-1715. Epub 2018 Feb 23.


The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer.

Ding M, Van der Kwast TH, Vellanki RN, Foltz WD, McKee TD, Sonenberg N, Pandolfi PP, Koritzinsky M, Wouters BG.

Mol Cancer Res. 2018 Apr;16(4):682-695. doi: 10.1158/1541-7786.MCR-17-0696. Epub 2018 Feb 16.


Seasonal to decadal variability in ice discharge from the Greenland Ice Sheet.

King MD, Howat IM, Jeong S, Noh MJ, Wouters B, Noël B, van den Broeke MR.

Cryosphere. 2018;12(12):3813-3825. doi: 10.5194/tc-12-3813-2018. Epub 2018 Dec 3.


The Future of Radiobiology.

Kirsch DG, Diehn M, Kesarwala AH, Maity A, Morgan MA, Schwarz JK, Bristow R, Demaria S, Eke I, Griffin RJ, Haas-Kogan D, Higgins GS, Kimmelman AC, Kimple RJ, Lombaert IM, Ma L, Marples B, Pajonk F, Park CC, Schaue D, Tran PT, Willers H, Wouters BG, Bernhard EJ.

J Natl Cancer Inst. 2018 Apr 1;110(4):329-340. doi: 10.1093/jnci/djx231.


The patient with a complex chronic respiratory disease: a specialist of his own life?

Houben-Wilke S, Augustin IM, Wouters BB, Stevens RA, Janssen DJ, Spruit MA, Vanfleteren LE, Franssen FM, Wouters EF.

Expert Rev Respir Med. 2017 Dec;11(12):919-924. doi: 10.1080/17476348.2017.1392242. Epub 2017 Oct 25.


Hitting the target in IDH2 mutant AML.

Wouters BJ.

Blood. 2017 Aug 10;130(6):693-694. doi: 10.1182/blood-2017-06-790394. No abstract available.


Nanoparticle Analysis by Online Comprehensive Two-Dimensional Liquid Chromatography combining Hydrodynamic Chromatography and Size-Exclusion Chromatography with Intermediate Sample Transformation.

Pirok BWJ, Abdulhussain N, Aalbers T, Wouters B, Peters RAH, Schoenmakers PJ.

Anal Chem. 2017 Sep 5;89(17):9167-9174. doi: 10.1021/acs.analchem.7b01906. Epub 2017 Aug 8.


A β-galactosidase probe for the detection of cellular senescence by mass cytometry.

Lumba MA, Willis LM, Santra S, Rana R, Schito L, Rey S, Wouters BG, Nitz M.

Org Biomol Chem. 2017 Aug 2;15(30):6388-6392. doi: 10.1039/c7ob01227f.


Targeting Hypoxia-Inducible Factors for Antiangiogenic Cancer Therapy.

Rey S, Schito L, Wouters BG, Eliasof S, Kerbel RS.

Trends Cancer. 2017 Jul;3(7):529-541. doi: 10.1016/j.trecan.2017.05.002. Epub 2017 Jun 10. Review.


Prototyping of thermoplastic microfluidic chips and their application in high-performance liquid chromatography separations of small molecules.

Wouters S, De Vos J, Dores-Sousa JL, Wouters B, Desmet G, Eeltink S.

J Chromatogr A. 2017 Nov 10;1523:224-233. doi: 10.1016/j.chroma.2017.05.063. Epub 2017 Jun 1.


Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors.

Leung E, Cairns RA, Chaudary N, Vellanki RN, Kalliomaki T, Moriyama EH, Mujcic H, Wilson BC, Wouters BG, Hill R, Milosevic M.

BMC Cancer. 2017 Jun 15;17(1):418. doi: 10.1186/s12885-017-3402-6.


Minimal Residual Disease Monitoring of Acute Myeloid Leukemia by Massively Multiplex Digital PCR in Patients with NPM1 Mutations.

Mencia-Trinchant N, Hu Y, Alas MA, Ali F, Wouters BJ, Lee S, Ritchie EK, Desai P, Guzman ML, Roboz GJ, Hassane DC.

J Mol Diagn. 2017 Jul;19(4):537-548. doi: 10.1016/j.jmoldx.2017.03.005. Epub 2017 May 16.


Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers.

Glass JL, Hassane D, Wouters BJ, Kunimoto H, Avellino R, Garrett-Bakelman FE, Guryanova OA, Bowman R, Redlich S, Intlekofer AM, Meydan C, Qin T, Fall M, Alonso A, Guzman ML, Valk PJM, Thompson CB, Levine R, Elemento O, Delwel R, Melnick A, Figueroa ME.

Cancer Discov. 2017 Aug;7(8):868-883. doi: 10.1158/2159-8290.CD-16-1032. Epub 2017 Apr 13.


Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity.

Tan Q, Joshua AM, Wang M, Bristow RG, Wouters BG, Allen CJ, Tannock IF.

Cancer Chemother Pharmacol. 2017 May;79(5):959-969. doi: 10.1007/s00280-017-3298-5. Epub 2017 Apr 4.


A tipping point in refreezing accelerates mass loss of Greenland's glaciers and ice caps.

Noël B, van de Berg WJ, Lhermitte S, Wouters B, Machguth H, Howat I, Citterio M, Moholdt G, Lenaerts JT, van den Broeke MR.

Nat Commun. 2017 Mar 31;8:14730. doi: 10.1038/ncomms14730.


Personalized medicine and chronic obstructive pulmonary disease.

Wouters EF, Wouters BB, Augustin IM, Franssen FM.

Curr Opin Pulm Med. 2017 May;23(3):241-246. doi: 10.1097/MCP.0000000000000377. Review.


A cyclic-olefin-copolymer microfluidic immobilized-enzyme reactor for rapid digestion of proteins from dried blood spots.

Wouters B, Dapic I, Valkenburg TS, Wouters S, Niezen L, Eeltink S, Corthals GL, Schoenmakers PJ.

J Chromatogr A. 2017 Mar 31;1491:36-42. doi: 10.1016/j.chroma.2017.01.078. Epub 2017 Jan 28.


MATE2 Expression Is Associated with Cancer Cell Response to Metformin.

Chowdhury S, Yung E, Pintilie M, Muaddi H, Chaib S, Yeung M, Fusciello M, Sykes J, Pitcher B, Hagenkort A, McKee T, Vellanki R, Chen E, Bristow RG, Wouters BG, Koritzinsky M.

PLoS One. 2016 Dec 13;11(12):e0165214. doi: 10.1371/journal.pone.0165214. eCollection 2016.


Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia.

Adriaens ME, Prickaerts P, Chan-Seng-Yue M, van den Beucken T, Dahlmans VEH, Eijssen LM, Beck T, Wouters BG, Voncken JW, Evelo CTA.

Epigenetics Chromatin. 2016 Nov 1;9:48. doi: 10.1186/s13072-016-0090-4. eCollection 2016.


In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model.

Maeda A, Chen Y, Bu J, Mujcic H, Wouters BG, DaCosta RS.

Int J Radiat Oncol Biol Phys. 2017 Jan 1;97(1):184-194. doi: 10.1016/j.ijrobp.2016.09.005. Epub 2016 Sep 14.


Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3.

Prickaerts P, Adriaens ME, Beucken TVD, Koch E, Dubois L, Dahlmans VEH, Gits C, Evelo CTA, Chan-Seng-Yue M, Wouters BG, Voncken JW.

Epigenetics Chromatin. 2016 Oct 26;9:46. doi: 10.1186/s13072-016-0086-0. eCollection 2016.


Molecular targeting of hypoxia in radiotherapy.

Rey S, Schito L, Koritzinsky M, Wouters BG.

Adv Drug Deliv Rev. 2017 Jan 15;109:45-62. doi: 10.1016/j.addr.2016.10.002. Epub 2016 Oct 19. Review.


Quantifying hypoxia in human cancers using static PET imaging.

Taylor E, Yeung I, Keller H, Wouters BG, Milosevic M, Hedley DW, Jaffray DA.

Phys Med Biol. 2016 Nov 21;61(22):7957-7974. Epub 2016 Oct 25.


Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma.

Connor AA, Denroche RE, Jang GH, Timms L, Kalimuthu SN, Selander I, McPherson T, Wilson GW, Chan-Seng-Yue MA, Borozan I, Ferretti V, Grant RC, Lungu IM, Costello E, Greenhalf W, Palmer D, Ghaneh P, Neoptolemos JP, Buchler M, Petersen G, Thayer S, Hollingsworth MA, Sherker A, Durocher D, Dhani N, Hedley D, Serra S, Pollett A, Roehrl MHA, Bavi P, Bartlett JMS, Cleary S, Wilson JM, Alexandrov LB, Moore M, Wouters BG, McPherson JD, Notta F, Stein LD, Gallinger S.

JAMA Oncol. 2017 Jun 1;3(6):774-783. doi: 10.1001/jamaoncol.2016.3916.


Development of TRACER: tissue roll for analysis of cellular environment and response.

Rodenhizer D, Cojocari D, Wouters BG, McGuigan AP.

Biofabrication. 2016 Oct 18;8(4):045008.


Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution.

Edgar LJ, Vellanki RN, McKee TD, Hedley D, Wouters BG, Nitz M.

Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13159-13163. doi: 10.1002/anie.201607483.


Geodetic measurements reveal similarities between post-Last Glacial Maximum and present-day mass loss from the Greenland ice sheet.

Khan SA, Sasgen I, Bevis M, van Dam T, Bamber JL, Wahr J, Willis M, Kjær KH, Wouters B, Helm V, Csatho B, Fleming K, Bjørk AA, Aschwanden A, Knudsen P, Munneke PK.

Sci Adv. 2016 Sep 21;2(9):e1600931. eCollection 2016 Sep.


DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma.

Mansouri S, Singh S, Alamsahebpour A, Burrell K, Li M, Karabork M, Ekinci C, Koch E, Solaroglu I, Chang JT, Wouters B, Aldape K, Zadeh G.

Oncotarget. 2016 Aug 30;7(35):56431-56446. doi: 10.18632/oncotarget.10570.


PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.

Banh RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Zhang W, Sinha A, Rose CM, Isasa M, Zhang S, Wu R, Virtanen C, Hitomi T, Habu T, Sidhu SS, Koizumi A, Wilkins SE, Kislinger T, Gygi SP, Schofield CJ, Dennis JW, Wouters BG, Neel BG.

Nat Cell Biol. 2016 Jul;18(7):803-813. doi: 10.1038/ncb3376. Epub 2016 Jun 20.


Separation of Time Scales in a Quantum Newton's Cradle.

van den Berg R, Wouters B, Eliëns S, De Nardis J, Konik RM, Caux JS.

Phys Rev Lett. 2016 Jun 3;116(22):225302. doi: 10.1103/PhysRevLett.116.225302. Epub 2016 Jun 1.


Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects.

Molavian HR, Goldman A, Phipps CJ, Kohandel M, Wouters BG, Sengupta S, Sivaloganathan S.

Sci Rep. 2016 Jun 9;6:27439. doi: 10.1038/srep27439.


Spatial and temporal Antarctic Ice Sheet mass trends, glacio-isostatic adjustment, and surface processes from a joint inversion of satellite altimeter, gravity, and GPS data.

Martín-Español A, Zammit-Mangion A, Clarke PJ, Flament T, Helm V, King MA, Luthcke SB, Petrie E, Rémy F, Schön N, Wouters B, Bamber JL.

J Geophys Res Earth Surf. 2016 Feb;121(2):182-200. Epub 2016 Feb 3.


Hypoxia-activated prodrugs: paths forward in the era of personalised medicine.

Hunter FW, Wouters BG, Wilson WR.

Br J Cancer. 2016 May 10;114(10):1071-7. doi: 10.1038/bjc.2016.79. Epub 2016 Apr 12. Review.


epiGBS: reference-free reduced representation bisulfite sequencing.

van Gurp TP, Wagemaker NC, Wouters B, Vergeer P, Ouborg JN, Verhoeven KJ.

Nat Methods. 2016 Apr;13(4):322-4. doi: 10.1038/nmeth.3763. Epub 2016 Feb 8.


Erratum: A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients.

Rodenhizer D, Gaude E, Cojocari D, Mahadevan R, Frezza C, Wouters BG, McGuigan AP.

Nat Mater. 2016 Feb;15(2):244. doi: 10.1038/nmat4515. No abstract available.


Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia.

Wouters BJ, Delwel R.

Blood. 2016 Jan 7;127(1):42-52. doi: 10.1182/blood-2015-07-604512. Epub 2015 Dec 10. Review.


A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients.

Rodenhizer D, Gaude E, Cojocari D, Mahadevan R, Frezza C, Wouters BG, McGuigan AP.

Nat Mater. 2016 Feb;15(2):227-34. doi: 10.1038/nmat4482. Epub 2015 Nov 23. Erratum in: Nat Mater. 2016 Feb;15(2):244.


Complete Generalized Gibbs Ensembles in an Interacting Theory.

Ilievski E, De Nardis J, Wouters B, Caux JS, Essler FH, Prosen T.

Phys Rev Lett. 2015 Oct 9;115(15):157201. doi: 10.1103/PhysRevLett.115.157201. Epub 2015 Oct 7.


Towards ultra-high peak capacities and peak-production rates using spatial three-dimensional liquid chromatography.

Wouters B, Davydova E, Wouters S, Vivo-Truyols G, Schoenmakers PJ, Eeltink S.

Lab Chip. 2015 Dec 7;15(23):4415-22. doi: 10.1039/c5lc01169h.


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