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HLA-G protein expression in colorectal cancer evaluated by immunohistochemistry and western blot analysis: Its expression characteristics remain enigmatic.

Swets M, Wouters A, Krijgsman D, van Vlierberghe RLP, Boot A, van Eendenburg JD, van Wezel T, Gelderblom H, van de Velde CJH, van den Elsen PJ, Kuppen PJK.

Clin Immunol. 2018 Jul 10. pii: S1521-6616(17)30774-X. doi: 10.1016/j.clim.2018.07.005. [Epub ahead of print]


A carcinogenic trigger to study the function of tumor suppressor genes in Schmidtea mediterranea.

Van Roten A, Barakat AZA, Wouters A, Tran TA, Mouton S, Noben JP, Gentile L, Smeets K.

Dis Model Mech. 2018 Jul 2. pii: dmm.032573. doi: 10.1242/dmm.032573. [Epub ahead of print]


Prediction of Outcome in Patients With Acute Ischemic Stroke Based on Initial Severity and Improvement in the First 24 h.

Wouters A, Nysten C, Thijs V, Lemmens R.

Front Neurol. 2018 May 7;9:308. doi: 10.3389/fneur.2018.00308. eCollection 2018.


Monitoring EGFR TKI resistance in real time using ddPCR-based liquid biopsy: a case report.

Sorber L, Zwaenepoel K, Wouters A, Janssens A, Hiddinga B, Van Meerbeeck J, Lardon F, Pauwels P, Rolfo C.

J Clin Pathol. 2018 May 31. pii: jclinpath-2018-205210. doi: 10.1136/jclinpath-2018-205210. [Epub ahead of print] No abstract available.


Relating the composition and air/water interfacial properties of wheat, rye, barley, and oat dough liquor.

Janssen F, Wouters AGB, Pauly A, Delcour JA.

Food Chem. 2018 Oct 30;264:126-134. doi: 10.1016/j.foodchem.2018.05.016. Epub 2018 May 3.


MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset.

Thomalla G, Simonsen CZ, Boutitie F, Andersen G, Berthezene Y, Cheng B, Cheripelli B, Cho TH, Fazekas F, Fiehler J, Ford I, Galinovic I, Gellissen S, Golsari A, Gregori J, Günther M, Guibernau J, Häusler KG, Hennerici M, Kemmling A, Marstrand J, Modrau B, Neeb L, Perez de la Ossa N, Puig J, Ringleb P, Roy P, Scheel E, Schonewille W, Serena J, Sunaert S, Villringer K, Wouters A, Thijs V, Ebinger M, Endres M, Fiebach JB, Lemmens R, Muir KW, Nighoghossian N, Pedraza S, Gerloff C; WAKE-UP Investigators.

N Engl J Med. 2018 May 16. doi: 10.1056/NEJMoa1804355. [Epub ahead of print]


Hypoxia-Induced Cisplatin Resistance in Non-Small Cell Lung Cancer Cells Is Mediated by HIF-1α and Mutant p53 and Can Be Overcome by Induction of Oxidative Stress.

Deben C, Deschoolmeester V, De Waele J, Jacobs J, Van den Bossche J, Wouters A, Peeters M, Rolfo C, Smits E, Lardon F, Pauwels P.

Cancers (Basel). 2018 Apr 21;10(4). pii: E126. doi: 10.3390/cancers10040126.


Automated DWI analysis can identify patients within the thrombolysis time window of 4.5 hours.

Wouters A, Cheng B, Christensen S, Dupont P, Robben D, Norrving B, Laage R, Thijs VN, Albers GW, Thomalla G, Lemmens R.

Neurology. 2018 May 1;90(18):e1570-e1577. doi: 10.1212/WNL.0000000000005413. Epub 2018 Apr 4.


Simultaneous targeting of EGFR, HER2, and HER4 by afatinib overcomes intrinsic and acquired cetuximab resistance in head and neck squamous cell carcinoma cell lines.

De Pauw I, Lardon F, Van den Bossche J, Baysal H, Fransen E, Deschoolmeester V, Pauwels P, Peeters M, Vermorken JB, Wouters A.

Mol Oncol. 2018 Jun;12(6):830-854. doi: 10.1002/1878-0261.12197. Epub 2018 May 1.


Preclinical Strategies to Identify Off-Target Toxicity of High-Affinity TCRs.

Bijen HM, van der Steen DM, Hagedoorn RS, Wouters AK, Wooldridge L, Falkenburg JHF, Heemskerk MHM.

Mol Ther. 2018 May 2;26(5):1206-1214. doi: 10.1016/j.ymthe.2018.02.017. Epub 2018 Feb 23.


Reversibility of peripheral blood leukocyte phenotypic and functional changes after exposure to and withdrawal from tofacitinib, a Janus kinase inhibitor, in healthy volunteers.

Weinhold KJ, Bukowski JF, Brennan TV, Noveck RJ, Staats JS, Lin L, Stempora L, Hammond C, Wouters A, Mojcik CF, Cheng J, Collinge M, Jesson MI, Hazra A, Biswas P, Lan S, Clark JD, Hodge JA.

Clin Immunol. 2018 Jun;191:10-20. doi: 10.1016/j.clim.2018.03.002. Epub 2018 Mar 5.


Poly(I:C) primes primary human glioblastoma cells for an immune response invigorated by PD-L1 blockade.

De Waele J, Marcq E, Van Audenaerde JR, Van Loenhout J, Deben C, Zwaenepoel K, Van de Kelft E, Van der Planken D, Menovsky T, Van den Bergh JM, Willemen Y, Pauwels P, Berneman ZN, Lardon F, Peeters M, Wouters A, Smits EL.

Oncoimmunology. 2017 Dec 12;7(3):e1407899. doi: 10.1080/2162402X.2017.1407899. eCollection 2018.


Effects of medical school selection on student motivation: a PhD thesis report.

Wouters A.

Perspect Med Educ. 2018 Feb;7(1):54-57. doi: 10.1007/s40037-017-0398-1.


Motivation and academic performance of medical students from ethnic minorities and majority: a comparative study.

Isik U, Wouters A, Ter Wee MM, Croiset G, Kusurkar RA.

BMC Med Educ. 2017 Nov 28;17(1):233. doi: 10.1186/s12909-017-1079-9.


Planarians Customize Their Stem Cell Responses Following Genotoxic Stress as a Function of Exposure Time and Regenerative State.

Stevens AS, Wouters A, Ploem JP, Pirotte N, Van Roten A, Willems M, Hellings N, Franken C, Koppen G, Artois T, Plusquin M, Smeets K.

Toxicol Sci. 2018 Mar 1;162(1):251-263. doi: 10.1093/toxsci/kfx247.


A Comparison of Relative Time to Peak and Tmax for Mismatch-Based Patient Selection.

Wouters A, Christensen S, Straka M, Mlynash M, Liggins J, Bammer R, Thijs V, Lemmens R, Albers GW, Lansberg MG.

Front Neurol. 2017 Oct 13;8:539. doi: 10.3389/fneur.2017.00539. eCollection 2017.


Dual Targeting of Epidermal Growth Factor Receptor and HER3 by MEHD7945A as Monotherapy or in Combination with Cisplatin Partially Overcomes Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma Cell Lines.

De Pauw I, Wouters A, Van den Bossche J, Deschoolmeester V, Baysal H, Pauwels P, Peeters M, Vermorken JB, Lardon F.

Cancer Biother Radiopharm. 2017 Sep;32(7):229-238.


The Safety and Immunogenicity of Live Zoster Vaccination in Patients With Rheumatoid Arthritis Before Starting Tofacitinib: A Randomized Phase II Trial.

Winthrop KL, Wouters AG, Choy EH, Soma K, Hodge JA, Nduaka CI, Biswas P, Needle E, Passador S, Mojcik CF, Rigby WF.

Arthritis Rheumatol. 2017 Oct;69(10):1969-1977. doi: 10.1002/art.40187. Epub 2017 Sep 6.


MDM2 SNP309 and SNP285 Act as Negative Prognostic Markers for Non-small Cell Lung Cancer Adenocarcinoma Patients.

Deben C, Op de Beeck K, Van den Bossche J, Jacobs J, Lardon F, Wouters A, Peeters M, Van Camp G, Rolfo C, Deschoolmeester V, Pauwels P.

J Cancer. 2017 Jul 15;8(12):2154-2162. doi: 10.7150/jca.19254. eCollection 2017.


[Management of chronic osteomyelitis by long-term antibiotic suppression].

Kabore C, Wouters A, Frippiat F, Gillet P.

Rev Med Liege. 2017 Jul;72(7-8):363-368. French.


Towards Prognostic Profiling of Non-Small Cell Lung Cancer: New Perspectives on the Relevance of Polo-Like Kinase 1 Expression, the TP53 Mutation Status and Hypoxia.

Van den Bossche J, Deben C, Op de Beeck K, Deschoolmeester V, Hermans C, De Pauw I, Jacobs J, Van Schil P, Vermorken JB, Pauwels P, Peeters M, Lardon F, Wouters A.

J Cancer. 2017 May 12;8(8):1441-1452. doi: 10.7150/jca.18455. eCollection 2017.


Students' approaches to medical school choice: relationship with students' characteristics and motivation.

Wouters A, Croiset G, Schripsema NR, Cohen-Schotanus J, Spaai GWG, Hulsman RL, Kusurkar RA.

Int J Med Educ. 2017 Jun 12;8:217-226. doi: 10.5116/ijme.5921.5090.


Motivation of Dutch high school students from various backgrounds for applying to study medicine: a qualitative study.

Wouters A, Croiset G, Isik U, Kusurkar RA.

BMJ Open. 2017 Jun 2;7(5):e014779. doi: 10.1136/bmjopen-2016-014779.


Brain lesions associated with acute toxic hepatopathy in cattle.

Wouters ATB, Wouters F, Boabaid FM, Watanabe TTN, Fredo G, Varaschin MS, Driemeier D.

J Vet Diagn Invest. 2017 May;29(3):287-292. doi: 10.1177/1040638717699242. Epub 2017 Mar 31.


Deep sequencing of the TP53 gene reveals a potential risk allele for non-small cell lung cancer and supports the negative prognostic value of TP53 variants.

Deben C, Van den Bossche J, Van Der Steen N, Lardon F, Wouters A, de Beeck KO, Hermans C, Jacobs J, Peeters M, Van Camp G, Rolfo C, Deschoolmeester V, Pauwels P.

Tumour Biol. 2017 Feb;39(2):1010428317694327. doi: 10.1177/1010428317694327.


Participation and selection effects of a voluntary selection process.

Schripsema NR, van Trigt AM, Lucieer SM, Wouters A, Croiset G, Themmen APN, Borleffs JCC, Cohen-Schotanus J.

Adv Health Sci Educ Theory Pract. 2017 May;22(2):463-476. doi: 10.1007/s10459-017-9762-5. Epub 2017 Feb 10.


Exploring the Relationship between Structural and Air-Water Interfacial Properties of Wheat (Triticum aestivum L.) Gluten Hydrolysates in a Food System Relevant pH Range.

Wouters AG, Fierens E, Rombouts I, Brijs K, Joye IJ, Delcour JA.

J Agric Food Chem. 2017 Feb 15;65(6):1263-1271. doi: 10.1021/acs.jafc.6b05062. Epub 2017 Feb 6.


Long-Term Depletion of Conventional Dendritic Cells Cannot Be Maintained in an Atherosclerotic Zbtb46-DTR Mouse Model.

Rombouts M, Cools N, Grootaert MO, de Bakker F, Van Brussel I, Wouters A, De Meyer GR, De Winter BY, Schrijvers DM.

PLoS One. 2017 Jan 6;12(1):e0169608. doi: 10.1371/journal.pone.0169608. eCollection 2017.


A multi-site study on medical school selection, performance, motivation and engagement.

Wouters A, Croiset G, Schripsema NR, Cohen-Schotanus J, Spaai GWG, Hulsman RL, Kusurkar RA.

Adv Health Sci Educ Theory Pract. 2017 May;22(2):447-462. doi: 10.1007/s10459-016-9745-y. Epub 2017 Jan 4.


Foam fractionation as a tool to study the air-water interface structure-function relationship of wheat gluten hydrolysates.

Wouters AGB, Rombouts I, Schoebrechts N, Fierens E, Brijs K, Blecker C, Delcour JA.

Colloids Surf B Biointerfaces. 2017 Mar 1;151:295-303. doi: 10.1016/j.colsurfb.2016.12.031. Epub 2016 Dec 22.


Better to be alone than in bad company: The antagonistic effect of cisplatin and crizotinib combination therapy in non-small cell lung cancer.

Van Der Steen N, Deben C, Deschoolmeester V, Wouters A, Lardon F, Rolfo C, Germonpré P, Giovannetti E, Peters GJ, Pauwels P.

World J Clin Oncol. 2016 Dec 10;7(6):425-432. doi: 10.5306/wjco.v7.i6.425.


Prediction of Stroke Onset Is Improved by Relative Fluid-Attenuated Inversion Recovery and Perfusion Imaging Compared to the Visual Diffusion-Weighted Imaging/Fluid-Attenuated Inversion Recovery Mismatch.

Wouters A, Dupont P, Norrving B, Laage R, Thomalla G, Albers GW, Thijs V, Lemmens R.

Stroke. 2016 Oct;47(10):2559-64. doi: 10.1161/STROKEAHA.116.013903. Epub 2016 Sep 6.


Preclinical and clinical studies on afatinib in monotherapy and in combination regimens: Potential impact in colorectal cancer.

De Pauw I, Wouters A, Van den Bossche J, Peeters M, Pauwels P, Deschoolmeester V, Vermorken JB, Lardon F.

Pharmacol Ther. 2016 Oct;166:71-83. doi: 10.1016/j.pharmthera.2016.06.014. Epub 2016 Jun 29. Review.


Primary skeletal muscle myoblasts from chronic heart failure patients exhibit loss of anti-inflammatory and proliferative activity.

Sente T, Van Berendoncks AM, Jonckheere AI, Rodenburg RJ, Lauwers P, Van Hoof V, Wouters A, Lardon F, Hoymans VY, Vrints CJ.

BMC Cardiovasc Disord. 2016 May 26;16:107. doi: 10.1186/s12872-016-0278-3.


Spotlight on Volasertib: Preclinical and Clinical Evaluation of a Promising Plk1 Inhibitor.

Van den Bossche J, Lardon F, Deschoolmeester V, De Pauw I, Vermorken JB, Specenier P, Pauwels P, Peeters M, Wouters A.

Med Res Rev. 2016 Jul;36(4):749-86. doi: 10.1002/med.21392. Epub 2016 May 3. Review.


Efficacy Screening of Gloriosa Superba Extracts in a Murine Pancreatic Cancer Model Using (18)F-FDG PET/CT for Monitoring Treatment Response.

Capistrano R, Vangestel C, Wouters A, Dockx Y, Pauwels P, Stroobants S, Apers S, Lardon F, Pieters L, Staelens S.

Cancer Biother Radiopharm. 2016 Apr;31(3):99-109. doi: 10.1089/cbr.2015.1954.


APR-246 (PRIMA-1(MET)) strongly synergizes with AZD2281 (olaparib) induced PARP inhibition to induce apoptosis in non-small cell lung cancer cell lines.

Deben C, Lardon F, Wouters A, Op de Beeck K, Van den Bossche J, Jacobs J, Van Der Steen N, Peeters M, Rolfo C, Deschoolmeester V, Pauwels P.

Cancer Lett. 2016 Jun 1;375(2):313-322. doi: 10.1016/j.canlet.2016.03.017. Epub 2016 Mar 11.


Association Between Time From Stroke Onset and Fluid-Attenuated Inversion Recovery Lesion Intensity Is Modified by Status of Collateral Circulation.

Wouters A, Dupont P, Christensen S, Norrving B, Laage R, Thomalla G, Albers G, Thijs V, Lemmens R.

Stroke. 2016 Apr;47(4):1018-22. doi: 10.1161/STROKEAHA.115.012010. Epub 2016 Feb 25.


Reducing Compounds Equivocally Influence Oxidation during Digestion of a High-Fat Beef Product, which Promotes Cytotoxicity in Colorectal Carcinoma Cell Lines.

Van Hecke T, Wouters A, Rombouts C, Izzati T, Berardo A, Vossen E, Claeys E, Van Camp J, Raes K, Vanhaecke L, Peeters M, De Vos WH, De Smet S.

J Agric Food Chem. 2016 Feb 24;64(7):1600-9. doi: 10.1021/acs.jafc.5b05915. Epub 2016 Feb 12.


Motivation of medical students: selection by motivation or motivation by selection.

Wouters A, Croiset G, Galindo-Garre F, Kusurkar RA.

BMC Med Educ. 2016 Jan 29;16:37. doi: 10.1186/s12909-016-0560-1.


Myocarditis caused by Feline Immunodeficiency Virus in Five Cats with Hypertrophic Cardiomyopathy.

Rolim VM, Casagrande RA, Wouters AT, Driemeier D, Pavarini SP.

J Comp Pathol. 2016 Jan;154(1):3-8. doi: 10.1016/j.jcpa.2015.10.180. Epub 2016 Jan 12.


Magnetic resonance imaging-based endovascular versus medical stroke treatment for symptom onset up to 12 h.

Wouters A, Lemmens R, Christensen S, Wilms G, Dupont P, Mlynash M, Schneider A, Laage R, Cereda CW, Lansberg MG, Albers GW, Thijs V; AXIS 2 and DEFUSE 2 study investigators.

Int J Stroke. 2016 Jan;11(1):127-33. doi: 10.1177/1747493015607503.


Baseline [(18)F]FMISO μPET as a Predictive Biomarker for Response to HIF-1α Inhibition Combined with 5-FU Chemotherapy in a Human Colorectal Cancer Xenograft Model.

De Bruycker S, Vangestel C, Van den Wyngaert T, Wyffels L, Wouters A, Pauwels P, Staelens S, Stroobants S.

Mol Imaging Biol. 2016 Aug;18(4):606-16. doi: 10.1007/s11307-015-0926-5.



Sente T, Van Berendoncks AM, Wouters A, Lardon F, Hoymans VY, Vrints CJ.

Commun Agric Appl Biol Sci. 2015;80(1):145-9. No abstract available.


In vitro and in vivo investigations on the antitumour activity of Chelidonium majus.

Capistrano I R, Wouters A, Lardon F, Gravekamp C, Apers S, Pieters L.

Phytomedicine. 2015 Dec 15;22(14):1279-87. doi: 10.1016/j.phymed.2015.10.013. Epub 2015 Nov 10.


Establishment and characterization of cetuximab resistant head and neck squamous cell carcinoma cell lines: focus on the contribution of the AP-1 transcription factor.

Boeckx C, Blockx L, de Beeck KO, Limame R, Camp GV, Peeters M, Vermorken JB, Specenier P, Wouters A, Baay M, Lardon F.

Am J Cancer Res. 2015 May 15;5(6):1921-38. eCollection 2015.


The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer.

Deben C, Wouters A, Op de Beeck K, van Den Bossche J, Jacobs J, Zwaenepoel K, Peeters M, Van Meerbeeck J, Lardon F, Rolfo C, Deschoolmeester V, Pauwels P.

Oncotarget. 2015 Sep 8;6(26):22666-79.


Fatal systemic toxoplasmosis in Valley quail (Callipepla californica).

Casagrande RA, Pena HF, Cabral AD, Rolim VM, de Oliveira LG, Boabaid FM, Wouters AT, Wouters F, Cruz CE, Driemeier D.

Int J Parasitol Parasites Wildl. 2015 May 7;4(2):264-7. doi: 10.1016/j.ijppaw.2015.04.003. eCollection 2015 Aug.


Association between the perfusion/diffusion and diffusion/FLAIR mismatch: data from the AXIS2 trial.

Wouters A, Dupont P, Ringelstein EB, Norrving B, Chamorro A, Grond M, Laage R, Schneider A, Wilms G, Thomalla G, Lemmens R, Thijs VN.

J Cereb Blood Flow Metab. 2015 Oct;35(10):1681-6. doi: 10.1038/jcbfm.2015.108. Epub 2015 Jun 3.


The hypoxic tumor microenvironment and drug resistance against EGFR inhibitors: preclinical study in cetuximab-sensitive head and neck squamous cell carcinoma cell lines.

Boeckx C, Van den Bossche J, De Pauw I, Peeters M, Lardon F, Baay M, Wouters A.

BMC Res Notes. 2015 Jun 2;8:203. doi: 10.1186/s13104-015-1197-6.

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