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Items: 1 to 50 of 107

1.

Dual inhibitors of LSD1 and spermine oxidase.

Holshouser S, Dunworth M, Murray-Stewart T, Peterson YK, Burger P, Kirkpatrick J, Chen HH, Casero RA Jr, Woster PM.

Medchemcomm. 2019 Feb 8;10(5):778-790. doi: 10.1039/c8md00610e. eCollection 2019 May 1.

PMID:
31191868
2.

Citizenship in the World of Medicinal Chemistry: 25 Years as an ACSMEDI Volunteer.

Woster PM.

ACS Med Chem Lett. 2019 Apr 22;10(5):696-698. doi: 10.1021/acsmedchemlett.9b00145. eCollection 2019 May 9.

PMID:
31097983
3.

Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations.

El Bissati K, Redel H, Ting LM, Lykins JD, McPhillie MJ, Upadhya R, Woster PM, Yarlett N, Kim K, Weiss LM.

Front Cell Infect Microbiol. 2019 Feb 14;9:9. doi: 10.3389/fcimb.2019.00009. eCollection 2019.

4.

Polyamine catabolism and oxidative damage.

Murray Stewart T, Dunston TT, Woster PM, Casero RA Jr.

J Biol Chem. 2018 Nov 30;293(48):18736-18745. doi: 10.1074/jbc.TM118.003337. Epub 2018 Oct 17. Review.

PMID:
30333229
5.

Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies.

Murray-Stewart T, Dunworth M, Lui Y, Giardiello FM, Woster PM, Casero RA Jr.

PLoS One. 2018 Aug 23;13(8):e0202677. doi: 10.1371/journal.pone.0202677. eCollection 2018.

6.

Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis.

Kirkpatrick JE, Kirkwood KL, Woster PM.

Epigenetics. 2018;13(5):557-572. doi: 10.1080/15592294.2018.1481703. Epub 2018 Aug 7.

PMID:
29927684
7.

Corrigendum to "Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures" [Bioorg. Med. Chem. 23 (2015) 1601-1612].

Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA Jr, Woster PM.

Bioorg Med Chem. 2018 Jul 23;26(12):3728-3729. doi: 10.1016/j.bmc.2018.05.032. Epub 2018 May 30. No abstract available.

PMID:
29859749
8.

Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis.

Kumarasinghe IR, Woster PM.

Eur J Med Chem. 2018 Mar 25;148:210-220. doi: 10.1016/j.ejmech.2018.01.098. Epub 2018 Feb 7.

9.

Targeting polyamine metabolism for cancer therapy and prevention.

Murray-Stewart TR, Woster PM, Casero RA Jr.

Biochem J. 2016 Oct 1;473(19):2937-53. doi: 10.1042/BCJ20160383. Review.

10.

Antibacterial Diamines Targeting Bacterial Membranes.

Wang B, Pachaiyappan B, Gruber JD, Schmidt MG, Zhang YM, Woster PM.

J Med Chem. 2016 Apr 14;59(7):3140-51. doi: 10.1021/acs.jmedchem.5b01912. Epub 2016 Mar 28.

11.

Epigenetics: Novel Therapeutics Targeting Epigenetics.

Conway SJ, Woster PM, Greenlee WJ, Georg G, Wang S.

J Med Chem. 2016 Feb 25;59(4):1247-8. doi: 10.1021/acs.jmedchem.6b00098. Epub 2016 Jan 29. No abstract available.

PMID:
26824165
12.
13.

Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures.

Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA Jr, Woster PM.

Bioorg Med Chem. 2015 Apr 1;23(7):1601-12. doi: 10.1016/j.bmc.2015.01.049. Epub 2015 Feb 7. Erratum in: Bioorg Med Chem. 2018 Jul 23;26(12):3728-3729.

14.

Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.

Maganti AV, Maier B, Tersey SA, Sampley ML, Mosley AL, Özcan S, Pachaiyappan B, Woster PM, Hunter CS, Stein R, Mirmira RG.

J Biol Chem. 2015 Apr 10;290(15):9812-22. doi: 10.1074/jbc.M114.616219. Epub 2015 Feb 24.

15.

Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites.

Verlinden BK, de Beer M, Pachaiyappan B, Besaans E, Andayi WA, Reader J, Niemand J, van Biljon R, Guy K, Egan T, Woster PM, Birkholtz LM.

Bioorg Med Chem. 2015 Aug 15;23(16):5131-43. doi: 10.1016/j.bmc.2015.01.036. Epub 2015 Jan 28.

16.

3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors.

Kutz CJ, Holshouser SL, Marrow EA, Woster PM.

Medchemcomm. 2014 Dec;5(12):1863-1870.

17.

Epigenetics: novel therapeutics targeting epigenetics.

Conway SJ, Woster PM, Shen JK, Georg G, Wang S.

J Med Chem. 2015 Jan 22;58(2):523-4. doi: 10.1021/jm501941q. Epub 2014 Dec 22. No abstract available.

PMID:
25532017
18.

Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase.

Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM Jr, Fox JG, Woster PM, Casero RA Jr, Correa P, Wilson KT.

Oncogene. 2015 Jun;34(26):3429-40. doi: 10.1038/onc.2014.273. Epub 2014 Sep 1.

19.

Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1.

Kumarasinghe IR, Woster PM.

ACS Med Chem Lett. 2013 Nov 8;5(1):29-33. doi: 10.1021/ml4002997. eCollection 2014 Jan 9.

20.

Design of small molecule epigenetic modulators.

Pachaiyappan B, Woster PM.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):21-32. doi: 10.1016/j.bmcl.2013.11.001. Epub 2013 Nov 13. Review.

21.
22.

Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease.

Dewdney TG, Wang Y, Liu Z, Sharma SK, Reiter SJ, Brunzelle JS, Kovari IA, Woster PM, Kovari LC.

Bioorg Med Chem. 2013 Dec 1;21(23):7430-4. doi: 10.1016/j.bmc.2013.09.045. Epub 2013 Sep 27.

PMID:
24128815
23.

Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism.

Murray-Stewart T, Hanigan CL, Woster PM, Marton LJ, Casero RA Jr.

Mol Cancer Ther. 2013 Oct;12(10):2088-99. doi: 10.1158/1535-7163.MCT-13-0418. Epub 2013 Aug 13.

24.

Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites.

Hayes CS, DeFeo-Mattox K, Woster PM, Gilmour SK.

Amino Acids. 2014 Mar;46(3):543-52. doi: 10.1007/s00726-013-1559-0. Epub 2013 Jul 25.

25.

The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.

Murray-Stewart T, Woster PM, Casero RA Jr.

Amino Acids. 2014 Mar;46(3):585-94. doi: 10.1007/s00726-013-1485-1. Epub 2013 Mar 19.

26.

Polyamines and cancer: implications for chemotherapy and chemoprevention.

Nowotarski SL, Woster PM, Casero RA Jr.

Expert Rev Mol Med. 2013 Feb 22;15:e3. doi: 10.1017/erm.2013.3. Review.

27.

Polyamine-based small molecule epigenetic modulators.

Sharma SK, Hazeldine S, Crowley ML, Hanson A, Beattie R, Varghese S, Senanayake TM, Hirata A, Hirata F, Huang Y, Wu Y, Steinbergs N, Murray-Stewart T, Bytheway I, Casero RA Jr, Woster PM.

Medchemcomm. 2012;3(1):14-21. Epub 2011 Nov 26.

28.
29.

Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1.

Hazeldine S, Pachaiyappan B, Steinbergs N, Nowotarski S, Hanson AS, Casero RA Jr, Woster PM.

J Med Chem. 2012 Sep 13;55(17):7378-91. doi: 10.1021/jm3002845. Epub 2012 Sep 4.

30.

Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds.

Yedidi RS, Liu Z, Wang Y, Brunzelle JS, Kovari IA, Woster PM, Kovari LC, Gupta D.

Biochem Biophys Res Commun. 2012 May 11;421(3):413-7. doi: 10.1016/j.bbrc.2012.03.096. Epub 2012 Mar 24.

31.

Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota.

Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ.

J Biol Chem. 2011 Dec 16;286(50):43301-12. doi: 10.1074/jbc.M111.307835. Epub 2011 Oct 24.

32.

Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities.

Verlinden BK, Niemand J, Snyman J, Sharma SK, Beattie RJ, Woster PM, Birkholtz LM.

J Med Chem. 2011 Oct 13;54(19):6624-33. doi: 10.1021/jm200463z. Epub 2011 Sep 14.

33.

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis.

Goodwin AC, Destefano Shields CE, Wu S, Huso DL, Wu X, Murray-Stewart TR, Hacker-Prietz A, Rabizadeh S, Woster PM, Sears CL, Casero RA Jr.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15354-9. doi: 10.1073/pnas.1010203108. Epub 2011 Aug 29.

34.

Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells.

Fraser AV, Goodwin AC, Hacker-Prietz A, Sugar E, Woster PM, Casero RA Jr.

Amino Acids. 2012 Feb;42(2-3):529-38. doi: 10.1007/s00726-011-1030-z. Epub 2011 Aug 4.

35.

Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells.

Zhu Q, Huang Y, Marton LJ, Woster PM, Davidson NE, Casero RA Jr.

Amino Acids. 2012 Feb;42(2-3):887-98. doi: 10.1007/s00726-011-1004-1. Epub 2011 Jul 30.

36.

Use of polyamine derivatives as selective histone deacetylase inhibitors.

Woster PM.

Methods Mol Biol. 2011;720:475-91. doi: 10.1007/978-1-61779-034-8_31.

37.

Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm.

Cervelli M, Bellavia G, Fratini E, Amendola R, Polticelli F, Barba M, Federico R, Signore F, Gucciardo G, Grillo R, Woster PM, Casero RA Jr, Mariottini P.

BMC Cancer. 2010 Oct 14;10:555. doi: 10.1186/1471-2407-10-555.

38.

(Bis)urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators.

Sharma SK, Wu Y, Steinbergs N, Crowley ML, Hanson AS, Casero RA, Woster PM.

J Med Chem. 2010 Jul 22;53(14):5197-212. doi: 10.1021/jm100217a.

39.

Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents.

Gupta D, Yedidi RS, Varghese S, Kovari LC, Woster PM.

J Med Chem. 2010 May 27;53(10):4234-47. doi: 10.1021/jm100233b.

PMID:
20438064
40.

Suppression of exogenous gene expression by spermidine/spermine N1-acetyltransferase 1 (SSAT1) cotransfection.

Lee SB, Park JH, Woster PM, Casero RA Jr, Park MH.

J Biol Chem. 2010 May 14;285(20):15548-56. doi: 10.1074/jbc.M109.092007. Epub 2010 Mar 8.

41.

A novel histone deacetylase inhibitor prevents IL-1beta induced metabolic dysfunction in pancreatic beta-cells.

Susick L, Senanayake T, Veluthakal R, Woster PM, Kowluru A.

J Cell Mol Med. 2009 Aug;13(8B):1877-85. doi: 10.1111/j.1582-4934.2009.00672.x.

42.

Polyamine analogues targeting epigenetic gene regulation.

Huang Y, Marton LJ, Woster PM, Casero RA.

Essays Biochem. 2009 Nov 4;46:95-110. doi: 10.1042/bse0460007. Review.

43.

Design of polyamine-based therapeutic agents: new targets and new directions.

Senanayake MD, Amunugama H, Boncher TD, Casero RA, Woster PM.

Essays Biochem. 2009 Nov 4;46:77-94. doi: 10.1042/bse0460006. Review.

44.

Foreword: American Chemical Society Division of Medicinal Chemistry. Celebrating 100 years of excellence.

Woster PM.

J Med Chem. 2009 Dec 10;52(23):7333-8. doi: 10.1021/jm901089d. No abstract available.

PMID:
19954244
45.

Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes.

Huang Y, Stewart TM, Wu Y, Baylin SB, Marton LJ, Perkins B, Jones RJ, Woster PM, Casero RA Jr.

Clin Cancer Res. 2009 Dec 1;15(23):7217-28. doi: 10.1158/1078-0432.CCR-09-1293. Epub 2009 Nov 24.

46.

A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model.

Basu HS, Thompson TA, Church DR, Clower CC, Mehraein-Ghomi F, Amlong CA, Martin CT, Woster PM, Lindstrom MJ, Wilding G.

Cancer Res. 2009 Oct 1;69(19):7689-95. doi: 10.1158/0008-5472.CAN-08-2472. Epub 2009 Sep 22.

47.

The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines.

Pledgie-Tracy A, Billam M, Hacker A, Sobolewski MD, Woster PM, Zhang Z, Casero RA, Davidson NE.

Cancer Chemother Pharmacol. 2010 May;65(6):1067-81. doi: 10.1007/s00280-009-1112-8. Epub 2009 Aug 30.

48.

Recent advances in the development of polyamine analogues as antitumor agents.

Casero RA Jr, Woster PM.

J Med Chem. 2009 Aug 13;52(15):4551-73. doi: 10.1021/jm900187v. Review. No abstract available.

49.

Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi.

Bacchi CJ, Yarlett N, Faciane E, Bi X, Rattendi D, Weiss LM, Woster PM.

Antimicrob Agents Chemother. 2009 Jun;53(6):2599-604. doi: 10.1128/AAC.00267-08. Epub 2009 Feb 17.

50.

Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes.

Wei G, DeFeo K, Hayes CS, Woster PM, Mandik-Nayak L, Gilmour SK.

Cancer Res. 2008 Apr 1;68(7):2214-22. doi: 10.1158/0008-5472.CAN-07-5030.

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