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Last issue of journal of chemical biology.

Woscholski R, Larijani B.

J Chem Biol. 2017 Oct 7;10(4):157. doi: 10.1007/s12154-017-0176-x. eCollection 2017 Oct. No abstract available.


A tri-functional vanadium(iv) complex to detect cysteine oxidation.

Cilibrizzi A, Fedorova M, Collins J, Leatherbarrow R, Woscholski R, Vilar R.

Dalton Trans. 2017 May 30;46(21):6994-7004. doi: 10.1039/c7dt00076f.


A lipophilic copper(ii) complex as an optical probe for intracellular detection of NO.

Wilson N, Mak LH, Cilibrizzi A, Gee AD, Long NJ, Woscholski R, Vilar R.

Dalton Trans. 2016 Nov 15;45(45):18177-18182.


Vanadyl complexes with dansyl-labelled di-picolinic acid ligands: synthesis, phosphatase inhibition activity and cellular uptake studies.

Collins J, Cilibrizzi A, Fedorova M, Whyte G, Mak LH, Guterman I, Leatherbarrow R, Woscholski R, Vilar R.

Dalton Trans. 2016 Apr 28;45(16):7104-13. doi: 10.1039/c5dt04753f. Epub 2016 Mar 23.


Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins.

Verrastro I, Tveen-Jensen K, Woscholski R, Spickett CM, Pitt AR.

Free Radic Biol Med. 2016 Jan;90:24-34. doi: 10.1016/j.freeradbiomed.2015.11.004. Epub 2015 Nov 10.


OCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates.

Billcliff PG, Noakes CJ, Mehta ZB, Yan G, Mak L, Woscholski R, Lowe M.

Mol Biol Cell. 2016 Jan 1;27(1):90-107. doi: 10.1091/mbc.E15-06-0329. Epub 2015 Oct 28.


Targeting PTEN using small molecule inhibitors.

Mak LH, Woscholski R.

Methods. 2015 May;77-78:63-8. doi: 10.1016/j.ymeth.2015.02.007. Epub 2015 Mar 4. Review.


Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity.

Furse S, Mak L, Tate EW, Templer RH, Ces O, Woscholski R, Gaffney PR.

Org Biomol Chem. 2015 Feb 21;13(7):2001-11. doi: 10.1039/c4ob02258k.


Chemical intervention tools to probe phosphoinositide-dependent signalling.

Woscholski R.

Biochem Soc Trans. 2014 Oct;42(5):1343-8. doi: 10.1042/BST20140186. Review.


Isolation and kinetic characterisation of hydrophobically distinct populations of form I Rubisco.

O'Donnelly K, Zhao G, Patel P, Butt MS, Mak LH, Kretschmer S, Woscholski R, Barter LM.

Plant Methods. 2014 Jun 12;10:17. doi: 10.1186/1746-4811-10-17. eCollection 2014.


A unified nomenclature and amino acid numbering for human PTEN.

Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR.

Sci Signal. 2014 Jul 1;7(332):pe15. doi: 10.1126/scisignal.2005560.


Uncovering allosteric pathways in caspase-1 using Markov transient analysis and multiscale community detection.

Amor B, Yaliraki SN, Woscholski R, Barahona M.

Mol Biosyst. 2014 Aug;10(8):2247-58. doi: 10.1039/c4mb00088a.


Alternative synthetic tools to phospho-specific antibodies for phosphoproteome analysis: progress and prospects.

Murray JI, Spivey AC, Woscholski R.

J Chem Biol. 2013 Jul 9;6(4):175-84. doi: 10.1007/s12154-013-0100-y. eCollection 2013 Jul 9. Review.


Molecular recognition with boronic acids-applications in chemical biology.

Whyte GF, Vilar R, Woscholski R.

J Chem Biol. 2013 Jun 1;6(4):161-74. doi: 10.1007/s12154-013-0099-0. eCollection 2013 Jun 1. Review.


Protocell design through modular compartmentalization.

Miller D, Booth PJ, Seddon JM, Templer RH, Law RV, Woscholski R, Ces O, Barter LM.

J R Soc Interface. 2013 Aug 7;10(87):20130496. doi: 10.1098/rsif.2013.0496. Print 2013 Oct 6.


Acute manipulation of diacylglycerol reveals roles in nuclear envelope assembly & endoplasmic reticulum morphology.

Domart MC, Hobday TM, Peddie CJ, Chung GH, Wang A, Yeh K, Jethwa N, Zhang Q, Wakelam MJ, Woscholski R, Byrne RD, Collinson LM, Poccia DL, Larijani B.

PLoS One. 2012;7(12):e51150. doi: 10.1371/journal.pone.0051150. Epub 2012 Dec 5.


Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases.

Mak LH, Knott J, Scott KA, Scott C, Whyte GF, Ye Y, Mann DJ, Ces O, Stivers J, Woscholski R.

Bioorg Med Chem. 2012 Jul 15;20(14):4371-6. doi: 10.1016/j.bmc.2012.05.040. Epub 2012 May 24.


Engineering de novo membrane-mediated protein-protein communication networks.

Charalambous K, Booth PJ, Woscholski R, Seddon JM, Templer RH, Law RV, Barter LM, Ces O.

J Am Chem Soc. 2012 Apr 4;134(13):5746-9. doi: 10.1021/ja300523q. Epub 2012 Mar 26.


Osmosensitive changes of carbohydrate metabolism in response to cellulose biosynthesis inhibition.

Wormit A, Butt SM, Chairam I, McKenna JF, Nunes-Nesi A, Kjaer L, O'Donnelly K, Fernie AR, Woscholski R, Barter MC, Hamann T.

Plant Physiol. 2012 May;159(1):105-17. doi: 10.1104/pp.112.195198. Epub 2012 Mar 15.


A small molecule mimicking a phosphatidylinositol (4,5)-bisphosphate binding pleckstrin homology domain.

Mak LH, Georgiades SN, Rosivatz E, Whyte GF, Mirabelli M, Vilar R, Woscholski R.

ACS Chem Biol. 2011 Dec 16;6(12):1382-90. doi: 10.1021/cb2003187. Epub 2011 Oct 10.


Characterisation of the PTEN inhibitor VO-OHpic.

Mak LH, Vilar R, Woscholski R.

J Chem Biol. 2010 Oct;3(4):157-63. doi: 10.1007/s12154-010-0041-7. Epub 2010 Jun 4.


Removal or masking of phosphatidylinositol(4,5)bisphosphate from the outer mitochondrial membrane causes mitochondrial fragmentation.

Rosivatz E, Woscholski R.

Cell Signal. 2011 Feb;23(2):478-86. doi: 10.1016/j.cellsig.2010.10.025. Epub 2010 Oct 30.


Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes.

Georgiades SN, Mak LH, Angurell I, Rosivatz E, Firouz Mohd Mustapa M, Polychroni C, Woscholski R, Vilar R.

J Biol Inorg Chem. 2011 Feb;16(2):195-208. doi: 10.1007/s00775-010-0716-0. Epub 2010 Oct 23.


Development of chemical probes: toward the mode of action of a methylene-linked di(aryl acetate) E1.

Smith ME, Gunn RM, Rosivatz E, Mak LH, Woscholski R, Hailes HC.

Bioorg Med Chem. 2010 Jul 15;18(14):4917-27. doi: 10.1016/j.bmc.2010.06.017. Epub 2010 Jun 9.


A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.

Alimonti A, Nardella C, Chen Z, Clohessy JG, Carracedo A, Trotman LC, Cheng K, Varmeh S, Kozma SC, Thomas G, Rosivatz E, Woscholski R, Cognetti F, Scher HI, Pandolfi PP.

J Clin Invest. 2010 Mar;120(3):681-93. doi: 10.1172/JCI40535. Epub 2010 Feb 8.


Not just another journal.

Woscholski R, Larijani B.

J Chem Biol. 2008 Nov;1(1-4):1-2. doi: 10.1007/s12154-008-0001-7. No abstract available.


The novel molecule 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate inhibits phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signalling through JNK activation in cancer cells.

Ho KK, Rosivatz E, Gunn RM, Smith ME, Stavropoulou AV, Rosivatz E, Numbere MG, Wong JB, Lafitte VG, Behrendt JM, Myatt SS, Hailes HC, Woscholski R, Lam EW.

FEBS J. 2009 Aug;276(15):4037-50. doi: 10.1111/j.1742-4658.2009.07112.x. Epub 2009 Jun 22.


Nuclear envelope remnants: fluid membranes enriched in sterols and polyphosphoinositides.

Garnier-Lhomme M, Byrne RD, Hobday TM, Gschmeissner S, Woscholski R, Poccia DL, Dufourc EJ, Larijani B.

PLoS One. 2009;4(1):e4255. doi: 10.1371/journal.pone.0004255. Epub 2009 Jan 23.


Measurement of PTEN activity in vivo by imaging phosphorylated Akt.

Rosivatz E, Woscholski R.

Methods Mol Biol. 2009;462:213-22. doi: 10.1007/978-1-60327-115-8_14.


Spatial localization of PtdInsP2 in phase-separated giant unilamellar vesicles with a fluorescent PLC-delta 1 PH domain.

Mulet X, Rosivatz E, Ho KK, Gauthé BL, Ces O, Templer RH, Woscholski R.

Methods Mol Biol. 2009;462:135-44. doi: 10.1007/978-1-60327-115-8_8.


Evidence that phosphatidylinositol promotes curved membrane interfaces.

Mulet X, Templer RH, Woscholski R, Ces O.

Langmuir. 2008 Aug 19;24(16):8443-7. doi: 10.1021/la801114n. Epub 2008 Jul 23.


Specific N-terminal protein labelling: use of FMDV 3C pro protease and native chemical ligation.

Busch GK, Tate EW, Gaffney PR, Rosivatz E, Woscholski R, Leatherbarrow RJ.

Chem Commun (Camb). 2008 Aug 7;(29):3369-71. doi: 10.1039/b806727a. Epub 2008 Jun 25.


Identification of cyclin A2 as the downstream effector of the nuclear phosphatidylinositol 4,5-bisphosphate signaling network.

Ho KK, Anderson AA, Rosivatz E, Lam EW, Woscholski R, Mann DJ.

J Biol Chem. 2008 Feb 29;283(9):5477-85. Epub 2007 Dec 12.


A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN).

Rosivatz E, Matthews JG, McDonald NQ, Mulet X, Ho KK, Lossi N, Schmid AC, Mirabelli M, Pomeranz KM, Erneux C, Lam EW, Vilar R, Woscholski R.

ACS Chem Biol. 2006 Dec 15;1(12):780-90.


Does history repeat itself? The emergence of a new discipline.

Barter LM, Klug DR, Woscholski R.

ACS Chem Biol. 2006 Dec 15;1(12):737-40. No abstract available. Erratum in: ACS Chem Biol. 2007 Apr 20;2(4):271.


Compartmental signal modulation: Endosomal phosphatidylinositol 3-phosphate controls endosome morphology and selective cargo sorting.

Fili N, Calleja V, Woscholski R, Parker PJ, Larijani B.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15473-8. Epub 2006 Oct 9.


Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCalpha.

Byrne RD, Rosivatz E, Parsons M, Larijani B, Parker PJ, Ng T, Woscholski R.

Cell Signal. 2007 Feb;19(2):321-9. Epub 2006 Aug 30.


Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation.

Schmid AC, Wise HM, Mitchell CA, Nussbaum R, Woscholski R.

FEBS Lett. 2004 Oct 8;576(1-2):9-13.


Bisperoxovanadium compounds are potent PTEN inhibitors.

Schmid AC, Byrne RD, Vilar R, Woscholski R.

FEBS Lett. 2004 May 21;566(1-3):35-8.


Phosphatases as small-molecule targets: inhibiting the endogenous inhibitors of kinases.

Schmid AC, Woscholski R.

Biochem Soc Trans. 2004 Apr;32(Pt 2):348-9. Review.


Differential hydrophobicity drives self-assembly in Huntington's disease.

Burke MG, Woscholski R, Yaliraki SN.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13928-33. Epub 2003 Nov 14.


Monitoring conformational changes of proteins in cells by fluorescence lifetime imaging microscopy.

Calleja V, Ameer-Beg SM, Vojnovic B, Woscholski R, Downward J, Larijani B.

Biochem J. 2003 May 15;372(Pt 1):33-40. Erratum in: Biochem J. 2003 Aug 1;373(Pt 3):999.


Characterization and purification of phosphatidylinositol trisphosphate 5-phosphatase from rat brain tissues.

Woscholski R.

Methods Enzymol. 2002;345:335-45. No abstract available.


Synthesis and function of 3-phosphorylated inositol lipids.

Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD.

Annu Rev Biochem. 2001;70:535-602. Review.


SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases.

Hughes WE, Woscholski R, Cooke FT, Patrick RS, Dove SK, McDonald NQ, Parker PJ.

J Biol Chem. 2000 Jan 14;275(2):801-8.


Identification and characterisation of a novel splice variant of synaptojanin1.

Woscholski R, Finan PM, Radley E, Parker PJ.

FEBS Lett. 1998 Jul 31;432(1-2):5-8.


Inositol lipid 5-phosphatases--traffic signals and signal traffic.

Woscholski R, Parker PJ.

Trends Biochem Sci. 1997 Nov;22(11):427-31. Review.


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