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Items: 13


Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure.

Pfluger PT, Kirchner H, Günnel S, Schrott B, Perez-Tilve D, Fu S, Benoit SC, Horvath T, Joost HG, Wortley KE, Sleeman MW, Tschöp MH.

Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G610-8. Epub 2007 Nov 29.


Peptide YY regulates bone turnover in rodents.

Wortley KE, Garcia K, Okamoto H, Thabet K, Anderson KD, Shen V, Herman JP, Valenzuela D, Yancopoulos GD, Tschöp MH, Murphy A, Sleeman MW.

Gastroenterology. 2007 Nov;133(5):1534-43. Epub 2007 Aug 15.


Growth hormone secretagogue (ghrelin-) receptors--a complex drug target for the regulation of body weight.

Nogueiras R, Perez-Tilve D, Wortley KE, Tschöp M.

CNS Neurol Disord Drug Targets. 2006 Jun;5(3):335-43. Review.


Agouti-related protein-deficient mice display an age-related lean phenotype.

Wortley KE, Anderson KD, Yasenchak J, Murphy A, Valenzuela D, Diano S, Yancopoulos GD, Wiegand SJ, Sleeman MW.

Cell Metab. 2005 Dec;2(6):421-7.


Absence of ghrelin protects against early-onset obesity.

Wortley KE, del Rincon JP, Murray JD, Garcia K, Iida K, Thorner MO, Sleeman MW.

J Clin Invest. 2005 Dec;115(12):3573-8.


Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5.

Macdonald LE, Wortley KE, Gowen LC, Anderson KD, Murray JD, Poueymirou WT, Simmons MV, Barber D, Valenzuela DM, Economides AN, Wiegand SJ, Yancopoulos GD, Sleeman MW, Murphy AJ.

Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2496-501. Epub 2005 Feb 7.


Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.

Sleeman MW, Wortley KE, Lai KM, Gowen LC, Kintner J, Kline WO, Garcia K, Stitt TN, Yancopoulos GD, Wiegand SJ, Glass DJ.

Nat Med. 2005 Feb;11(2):199-205. Epub 2005 Jan 16. Erratum in: Nat Med. 2005 Mar;11(3):353.


Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference.

Wortley KE, Anderson KD, Garcia K, Murray JD, Malinova L, Liu R, Moncrieffe M, Thabet K, Cox HJ, Yancopoulos GD, Wiegand SJ, Sleeman MW.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):8227-32. Epub 2004 May 17.


Hypothalamic control of energy balance: different peptides, different functions.

Leibowitz SF, Wortley KE.

Peptides. 2004 Mar;25(3):473-504. Review.


Cocaine- and amphetamine-regulated transcript in the arcuate nucleus stimulates lipid metabolism to control body fat accrual on a high-fat diet.

Wortley KE, Chang GQ, Davydova Z, Fried SK, Leibowitz SF.

Regul Pept. 2004 Feb 15;117(2):89-99.


Peptides that regulate food intake: orexin gene expression is increased during states of hypertriglyceridemia.

Wortley KE, Chang GQ, Davydova Z, Leibowitz SF.

Am J Physiol Regul Integr Comp Physiol. 2003 Jun;284(6):R1454-65. Epub 2003 Jan 30.

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