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Items: 1 to 50 of 582

1.

Long-term treatment with olanzapine increases the number of Sox2 and doublecortin expressing cells in the adult subventricular zone.

Lasut B, Palasz A, Filipczyk L, Arias-Carrion O, Rojczyk E, Savchyna M, Bogus K, Worthington JJ, Krzystanek M, Wiaderkiewicz R.

CNS Neurol Disord Drug Targets. 2018 Jun 26. doi: 10.2174/1871527317666180627113544. [Epub ahead of print]

PMID:
29952270
2.

Prospective association between major depressive disorder and leukocyte telomere length over two years.

Vance MC, Bui E, Hoeppner SS, Kovachy B, Prescott J, Mischoulon D, Walton ZE, Dong M, Nadal MF, Worthington JJ, Hoge EA, Cassano P, Orr EH, Fava M, de Vivo I, Wong KK, Simon NM.

Psychoneuroendocrinology. 2018 Apr;90:157-164. doi: 10.1016/j.psyneuen.2018.02.015. Epub 2018 Feb 21.

PMID:
29499556
3.

Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala.

Pałasz A, Pałka M, Filipczyk Ł, Menezes IC, Rojczyk E, Worthington JJ, Piwowarczyk-Nowak A, Krzystanek M, Wiaderkiewicz R.

J Neural Transm (Vienna). 2018 Jul;125(7):1099-1105. doi: 10.1007/s00702-018-1868-2. Epub 2018 Feb 27.

4.

Outcomes of Elderly Patients Undergoing Elective Abdominal Surgery.

Zoog ESL, Worthington JA, Singh A, Stanley JD.

Am Surg. 2017 Dec 1;83(12):1460-1462. No abstract available.

PMID:
29336773
5.

Medication disposal practices: Increasing patient and clinician education on safe methods.

Kinrys G, Gold AK, Worthington JJ, Nierenberg AA.

J Int Med Res. 2018 Mar;46(3):927-939. doi: 10.1177/0300060517738681. Epub 2018 Jan 11.

6.

Genotypic variability-based genome-wide association study identifies non-additive loci HLA-C and IL12B for psoriasis.

Wei WH, Massey J, Worthington J, Barton A, Warren RB.

J Hum Genet. 2018 Mar;63(3):289-296. doi: 10.1038/s10038-017-0350-6. Epub 2017 Dec 19.

PMID:
29259305
7.

The potential role of the novel hypothalamic neuropeptides nesfatin-1, phoenixin, spexin and kisspeptin in the pathogenesis of anxiety and anorexia nervosa.

Pałasz A, Janas-Kozik M, Borrow A, Arias-Carrión O, Worthington JJ.

Neurochem Int. 2018 Feb;113:120-136. doi: 10.1016/j.neuint.2017.12.006. Epub 2017 Dec 15. Review.

PMID:
29253527
8.

Tenecteplase versus alteplase before endovascular thrombectomy (EXTEND-IA TNK): A multicenter, randomized, controlled study.

Campbell BC, Mitchell PJ, Churilov L, Yassi N, Kleinig TJ, Yan B, Dowling RJ, Bush SJ, Dewey HM, Thijs V, Simpson M, Brooks M, Asadi H, Wu TY, Shah DG, Wijeratne T, Ang T, Miteff F, Levi C, Krause M, Harrington TJ, Faulder KC, Steinfort BS, Bailey P, Rice H, de Villiers L, Scroop R, Collecutt W, Wong AA, Coulthard A, Barber PA, McGuinness B, Field D, Ma H, Chong W, Chandra RV, Bladin CF, Brown H, Redmond K, Leggett D, Cloud G, Madan A, Mahant N, O'Brien B, Worthington J, Parker G, Desmond PM, Parsons MW, Donnan GA, Davis SM; EXTEND-IA TNK Investigators.

Int J Stroke. 2018 Apr;13(3):328-334. doi: 10.1177/1747493017733935. Epub 2017 Sep 27.

PMID:
28952914
9.

The unidirectional hypoxia-activated prodrug OCT1002 inhibits growth and vascular development in castrate-resistant prostate tumors.

Nesbitt H, Worthington J, Errington RJ, Patterson LH, Smith PJ, McKeown SR, McKenna DJ.

Prostate. 2017 Nov;77(15):1539-1547. doi: 10.1002/pros.23434. Epub 2017 Sep 24.

PMID:
28944496
10.

Decreasing Risk of Fatal Subarachnoid Hemorrhage and Other Epidemiological Trends in the Era of Coiling Implementation in Australia.

Worthington JM, Goumas C, Jalaludin B, Gattellari M.

Front Neurol. 2017 Aug 31;8:424. doi: 10.3389/fneur.2017.00424. eCollection 2017.

11.

Supplemental Nutrition Assistance Program Participation and Emergency Food Pantry Use.

Mabli J, Worthington J.

J Nutr Educ Behav. 2017 Sep;49(8):647-656.e1. doi: 10.1016/j.jneb.2016.12.001.

PMID:
28889853
12.

Physician performance feedback in a Canadian academic center.

Garvin D, Worthington J, McGuire S, Burgetz S, Forster AJ, Patey A, Gerin-Lajoie C, Turnbull J, Roth V.

Leadersh Health Serv (Bradf Engl). 2017 Oct 2;30(4):457-474. doi: 10.1108/LHS-08-2016-0037. Epub 2017 Sep 11.

PMID:
28889779
13.

Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity.

Worthington JJ, Reimann F, Gribble FM.

Mucosal Immunol. 2018 Jan;11(1):3-20. doi: 10.1038/mi.2017.73. Epub 2017 Aug 30. Review.

PMID:
28853441
14.

Genotypic variability based association identifies novel non-additive loci DHCR7 and IRF4 in sero-negative rheumatoid arthritis.

Wei WH, Viatte S, Merriman TR, Barton A, Worthington J.

Sci Rep. 2017 Jul 13;7(1):5261. doi: 10.1038/s41598-017-05447-1.

15.

An MIF Promoter Polymorphism Is Associated with Susceptibility to Pulmonary Arterial Hypertension in Diffuse Cutaneous Systemic Sclerosis.

Bossini-Castillo L, Campillo-Davó D, López-Isac E, Carmona FD, Simeon CP, Carreira P, Callejas-Rubio JL, Castellví I, Fernández-Nebro A, Rodríguez-Rodríguez L, Rubio-Rivas M, García-Hernández FJ, Madroñero AB, Beretta L, Santaniello A, Lunardi C, Airó P, Hoffmann-Vold AM, Kreuter A, Riemekasten G, Witte T, Hunzelmann N, Vonk MC, Voskuyl AE, de Vries-Bouwstra J, Shiels P, Herrick A, Worthington J, Radstake TRDJ, Martin J; Spanish Scleroderma Group.

J Rheumatol. 2017 Oct;44(10):1453-1457. doi: 10.3899/jrheum.161369. Epub 2017 Jul 1.

PMID:
28668810
16.

Evaluating physician awareness of common health care costs in the emergency department.

Gandhi R, Stiell I, Forster A, Worthington J, Ziss M, Kitts JB, Malik R.

CJEM. 2017 Jun 29:1-11. doi: 10.1017/cem.2017.43. [Epub ahead of print]

PMID:
28659219
17.

Differentiating Incident from Recurrent Stroke Using Administrative Data: The Impact of Varying Lengths of Look-Back Periods on the Risk of Misclassification.

Worthington JM, Gattellari M, Goumas C, Jalaludin B.

Neuroepidemiology. 2017;48(3-4):111-118. doi: 10.1159/000478016. Epub 2017 Jun 22.

18.

The genetics revolution in rheumatology: large scale genomic arrays and genetic mapping.

Eyre S, Orozco G, Worthington J.

Nat Rev Rheumatol. 2017 Jul;13(7):421-432. doi: 10.1038/nrrheum.2017.80. Epub 2017 Jun 1. Review.

PMID:
28569263
20.

Enabling front line-driven perioperative quality improvement through organizational infrastructure built around the Comprehensive Unit Based Safety Program.

Moloo H, Brooke R, Sundaresan S, Skinner B, Berg A, Doering P, Worthington J, Forster A, Schramm D.

Can J Surg. 2016 Dec;59(6):422-424.

21.

Effects of ErbB2 Overexpression on the Proteome and ErbB Ligand-specific Phosphosignaling in Mammary Luminal Epithelial Cells.

Worthington J, Spain G, Timms JF.

Mol Cell Proteomics. 2017 Apr;16(4):608-621. doi: 10.1074/mcp.M116.061267. Epub 2017 Feb 7.

22.

Identifying Causal Genes at the Multiple Sclerosis Associated Region 6q23 Using Capture Hi-C.

Martin P, McGovern A, Massey J, Schoenfelder S, Duffus K, Yarwood A, Barton A, Worthington J, Fraser P, Eyre S, Orozco G.

PLoS One. 2016 Nov 18;11(11):e0166923. doi: 10.1371/journal.pone.0166923. eCollection 2016.

23.

Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.

McGovern A, Schoenfelder S, Martin P, Massey J, Duffus K, Plant D, Yarwood A, Pratt AG, Anderson AE, Isaacs JD, Diboll J, Thalayasingam N, Ospelt C, Barton A, Worthington J, Fraser P, Eyre S, Orozco G.

Genome Biol. 2016 Nov 1;17(1):212.

24.

Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8.

Fenton TM, Kelly A, Shuttleworth EE, Smedley C, Atakilit A, Powrie F, Campbell S, Nishimura SL, Sheppard D, Levison S, Worthington JJ, Lehtinen MJ, Travis MA.

Mucosal Immunol. 2017 May;10(3):624-634. doi: 10.1038/mi.2016.94. Epub 2016 Oct 26.

25.

Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response.

Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O, Rodriguez Cutillas P, Cuello F, Shattock MJ, Marber MS, Conte MR, Greenstein A, Greensmith DJ, Venetucci L, Timms JF, Eaton P.

Nat Commun. 2016 Oct 26;7:13187. doi: 10.1038/ncomms13187.

26.
27.

Escitalopram affects spexin expression in the rat hypothalamus, hippocampus and striatum.

Pałasz A, Suszka-Świtek A, Filipczyk Ł, Bogus K, Rojczyk E, Worthington J, Krzystanek M, Wiaderkiewicz R.

Pharmacol Rep. 2016 Dec;68(6):1326-1331. doi: 10.1016/j.pharep.2016.09.002. Epub 2016 Sep 3.

PMID:
27710862
28.

Targeting Hypoxic Prostate Tumors Using the Novel Hypoxia-Activated Prodrug OCT1002 Inhibits Expression of Genes Associated with Malignant Progression.

Nesbitt H, Byrne NM, Williams SN, Ming L, Worthington J, Errington RJ, Patterson LH, Smith PJ, McKeown SR, McKenna DJ.

Clin Cancer Res. 2017 Apr 1;23(7):1797-1808. doi: 10.1158/1078-0432.CCR-16-1361. Epub 2016 Oct 3.

29.

A synonymous variant in TREX1 is associated with systemic sclerosis and severe digital ischaemia.

Hughes M, Little J, Herrick AL, Pushpakom S, Byers H, Worthington J, Newman WG.

Scand J Rheumatol. 2017 Jan;46(1):77-78. doi: 10.1080/03009742.2016.1195872. Epub 2016 Aug 30. No abstract available.

PMID:
27574969
30.

Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon.

Krzystanek M, Bogus K, Pałasz A, Wiaderkiewicz A, Filipczyk Ł, Rojczyk E, Worthington J, Wiaderkiewicz R.

Pharmacol Rep. 2016 Oct;68(5):990-5. doi: 10.1016/j.pharep.2016.05.009. Epub 2016 Jul 6.

PMID:
27391358
31.

Implementation of a structured hospital-wide morbidity and mortality rounds model.

Kwok ESH, Calder LA, Barlow-Krelina E, Mackie C, Seely AJE, Cwinn AA, Worthington JR, Frank JR.

BMJ Qual Saf. 2017 Jun;26(6):439-448. doi: 10.1136/bmjqs-2016-005459. Epub 2016 Jun 29.

PMID:
27358230
32.

Inflammatory cytokines in major depressive disorder: A case-control study.

Cassano P, Bui E, Rogers AH, Walton ZE, Ross R, Zeng M, Nadal-Vicens M, Mischoulon D, Baker AW, Keshaviah A, Worthington J, Hoge EA, Alpert J, Fava M, Wong KK, Simon NM.

Aust N Z J Psychiatry. 2017 Jan;51(1):23-31. doi: 10.1177/0004867416652736. Epub 2016 Sep 29.

33.

Women physicians as healthcare leaders: a qualitative study.

Roth VR, Theriault A, Clement C, Worthington J.

J Health Organ Manag. 2016 Jun 20;30(4):648-65. doi: 10.1108/JHOM-09-2014-0164.

PMID:
27296884
34.

Genetic susceptibility to rheumatoid arthritis and its implications for novel drug discovery.

Yarwood A, Eyre S, Worthington J.

Expert Opin Drug Discov. 2016 Aug;11(8):805-13. doi: 10.1080/17460441.2016.1195366. Epub 2016 Jun 7. Review.

PMID:
27267163
35.

A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus.

Márquez A, Vidal-Bralo L, Rodríguez-Rodríguez L, González-Gay MA, Balsa A, González-Álvaro I, Carreira P, Ortego-Centeno N, Ayala-Gutiérrez MM, García-Hernández FJ, González-Escribano MF, Sabio JM, Tolosa C, Suárez A, González A, Padyukov L, Worthington J, Vyse T, Alarcón-Riquelme ME, Martín J.

Ann Rheum Dis. 2017 Jan;76(1):286-294. doi: 10.1136/annrheumdis-2016-209436. Epub 2016 May 18.

PMID:
27193031
36.

A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.

Han B, Pouget JG, Slowikowski K, Stahl E, Lee CH, Diogo D, Hu X, Park YR, Kim E, Gregersen PK, Dahlqvist SR, Worthington J, Martin J, Eyre S, Klareskog L, Huizinga T, Chen WM, Onengut-Gumuscu S, Rich SS; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Wray NR, Raychaudhuri S.

Nat Genet. 2016 Jul;48(7):803-10. doi: 10.1038/ng.3572. Epub 2016 May 16.

37.

Tuft Cells: A New Flavor in Innate Epithelial Immunity.

Grencis RK, Worthington JJ.

Trends Parasitol. 2016 Aug;32(8):583-585. doi: 10.1016/j.pt.2016.04.016. Epub 2016 May 5.

PMID:
27161767
38.

Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies.

López-Isac E, Martín JE, Assassi S, Simeón CP, Carreira P, Ortego-Centeno N, Freire M, Beltrán E, Narváez J, Alegre-Sancho JJ; Spanish Scleroderma Group, Fernández-Gutiérrez B, Balsa A, Ortiz AM, González-Gay MA, Beretta L, Santaniello A, Bellocchi C, Lunardi C, Moroncini G, Gabrielli A, Witte T, Hunzelmann N, Distler JH, Riekemasten G, van der Helm-van Mil AH, de Vries-Bouwstra J, Magro-Checa C, Voskuyl AE, Vonk MC, Molberg Ø, Merriman T, Hesselstrand R, Nordin A, Padyukov L, Herrick A, Eyre S, Koeleman BP, Denton CP, Fonseca C, Radstake TR, Worthington J, Mayes MD, Martín J.

Arthritis Rheumatol. 2016 Sep;68(9):2338-44. doi: 10.1002/art.39730.

39.

Major histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis.

Wei WH, Bowes J, Plant D, Viatte S, Yarwood A, Massey J, Worthington J, Eyre S.

Sci Rep. 2016 Apr 25;6:25014. doi: 10.1038/srep25014.

40.

The Physician Quality Improvement Initiative: Engaging Physicians in Quality Improvement, Patient Safety, Accountability and their Provision of High-Quality Patient Care.

Wentlandt K, Degendorfer N, Clarke C, Panet H, Worthington J, McLean RF, Chan CK.

Healthc Q. 2016;18(4):36-41.

PMID:
27009706
41.

Androgen deprivation in LNCaP prostate tumour xenografts induces vascular changes and hypoxic stress, resulting in promotion of epithelial-to-mesenchymal transition.

Byrne NM, Nesbitt H, Ming L, McKeown SR, Worthington J, McKenna DJ.

Br J Cancer. 2016 Mar 15;114(6):659-68. doi: 10.1038/bjc.2016.29. Epub 2016 Mar 8.

42.

CAEP 2015 Academic Symposium: Leadership within the emergency medicine academic community and beyond.

Sinclair D, Worthington JR, Joubert G, Holroyd BR, Stempien J, Letovsky E, Rutledge T, LeBlanc C, Pitters C, McCallum A, Carr B, Gerace R, Stiell IG, Artz JD, Christenson J.

CJEM. 2016 May;18 Suppl 1:S1-9. doi: 10.1017/cem.2016.9. Epub 2016 Mar 7.

PMID:
26947971
43.

Replication of Associations of Genetic Loci Outside the HLA Region With Susceptibility to Anti-Cyclic Citrullinated Peptide-Negative Rheumatoid Arthritis.

Viatte S, Massey J, Bowes J, Duffus K; arcOGEN Consortium, Eyre S, Barton A, Worthington J.

Arthritis Rheumatol. 2016 Jul;68(7):1603-13. doi: 10.1002/art.39619.

44.

Immunochip Analyses of Epistasis in Rheumatoid Arthritis Confirm Multiple Interactions within MHC and Suggest Novel Non-MHC Epistatic Signals.

Wei WH, Loh CY, Worthington J, Eyre S.

J Rheumatol. 2016 May;43(5):839-45. doi: 10.3899/jrheum.150836. Epub 2016 Feb 15.

PMID:
26879349
45.

Quality gaps identified through mortality review.

Kobewka DM, van Walraven C, Turnbull J, Worthington J, Calder L, Forster A.

BMJ Qual Saf. 2017 Feb;26(2):141-149. doi: 10.1136/bmjqs-2015-004735. Epub 2016 Feb 8.

46.

Association of Toll-like receptor 4 (TLR4) with chronic plaque type psoriasis and psoriatic arthritis.

Smith RL, Hébert HL, Massey J, Bowes J, Marzo-Ortega H, Ho P, McHugh NJ, Worthington J, Barton A, Griffiths CE, Warren RB.

Arch Dermatol Res. 2016 Apr;308(3):201-5. doi: 10.1007/s00403-016-1620-4. Epub 2016 Feb 1.

47.

Differential Methylation as a Biomarker of Response to Etanercept in Patients With Rheumatoid Arthritis.

Plant D, Webster A, Nair N, Oliver J, Smith SL, Eyre S, Hyrich KL, Wilson AG, Morgan AW, Isaacs JD, Worthington J, Barton A.

Arthritis Rheumatol. 2016 Jun;68(6):1353-60. doi: 10.1002/art.39590. Epub 2016 Apr 21.

48.

Cryopreservation of cells does not substantially alter the DNA methylome of CD3+CD4+ T cells.

Webster AP, Smith SL, Worthington J, Barton A, Plant D.

Scand J Rheumatol. 2016 Jul;45(4):329-30. doi: 10.3109/03009742.2015.1115896. Epub 2015 Dec 21. No abstract available.

PMID:
26690697
49.

Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci.

Martin P, McGovern A, Orozco G, Duffus K, Yarwood A, Schoenfelder S, Cooper NJ, Barton A, Wallace C, Fraser P, Worthington J, Eyre S.

Nat Commun. 2015 Nov 30;6:10069. doi: 10.1038/ncomms10069.

50.

The intestinal immunoendocrine axis: novel cross-talk between enteroendocrine cells and the immune system during infection and inflammatory disease.

Worthington JJ.

Biochem Soc Trans. 2015 Aug;43(4):727-33. doi: 10.1042/BST20150090. Epub 2015 Aug 3. Review.

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