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Items: 1 to 50 of 132

1.

Lactoferrin-induced myeloid-derived suppressor cell therapy attenuates pathologic inflammatory conditions in newborn mice.

Liu Y, Perego M, Xiao Q, He Y, Fu S, He J, Liu W, Li X, Tang Y, Li X, Yuan W, Zhou W, Wu F, Jia C, Cui Q, Worthen GS, Jensen EA, Gabrilovich DI, Zhou J.

J Clin Invest. 2019 Oct 1;129(10):4261-4275. doi: 10.1172/JCI128164.

2.

Using selective lung injury to improve murine models of spatially heterogeneous lung diseases.

Paris AJ, Guo L, Dai N, Katzen JB, Patel PN, Worthen GS, Brenner JS.

PLoS One. 2019 Apr 3;14(4):e0202456. doi: 10.1371/journal.pone.0202456. eCollection 2019.

3.

Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice.

Lubkin A, Lee WL, Alonzo F 3rd, Wang C, Aligo J, Keller M, Girgis NM, Reyes-Robles T, Chan R, O'Malley A, Buckley P, Vozhilla N, Vasquez MT, Su J, Sugiyama M, Yeung ST, Coffre M, Bajwa S, Chen E, Martin P, Kim SY, Loomis C, Worthen GS, Shopsin B, Khanna KM, Weinstock D, Lynch AS, Koralov SB, Loke P, Cadwell K, Torres VJ.

Cell Host Microbe. 2019 Mar 13;25(3):463-470.e9. doi: 10.1016/j.chom.2019.01.015. Epub 2019 Feb 21.

PMID:
30799265
4.

Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury.

Hotz MJ, Qing D, Shashaty MGS, Zhang P, Faust H, Sondheimer N, Rivella S, Worthen GS, Mangalmurti NS.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):470-480. doi: 10.1164/rccm.201706-1161OC.

5.

The clinical and immunological performance of 28 days survival model of cecal ligation and puncture in humanized mice.

Laudanski K, Lapko N, Zawadka M, Zhou BX, Danet-Desnoyers G, Worthen GS.

PLoS One. 2017 Jul 17;12(7):e0180377. doi: 10.1371/journal.pone.0180377. eCollection 2017.

6.
7.

The Duffy antigen receptor for chemokines regulates asthma pathophysiology.

Chapman DG, Mougey EB, Van der Velden JL, Lahue KG, Aliyeva M, Daphtary N, George KL, Hoffman SM, Schneider RW, Tracy RP, Worthen GS, Poynter ME, Peters SP, Lima JJ, Janssen-Heininger YMW, Irvin CG.

Clin Exp Allergy. 2017 Sep;47(9):1214-1222. doi: 10.1111/cea.12949. Epub 2017 Jun 9.

8.

Critical role of CXCL4 in the lung pathogenesis of influenza (H1N1) respiratory infection.

Guo L, Feng K, Wang YC, Mei JJ, Ning RT, Zheng HW, Wang JJ, Worthen GS, Wang X, Song J, Li QH, Liu LD.

Mucosal Immunol. 2017 Nov;10(6):1529-1541. doi: 10.1038/mi.2017.1. Epub 2017 Jan 25.

PMID:
28120850
9.

Platelet-Specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury.

Bdeir K, Gollomp K, Stasiak M, Mei J, Papiewska-Pajak I, Zhao G, Worthen GS, Cines DB, Poncz M, Kowalska MA.

Am J Respir Cell Mol Biol. 2017 Feb;56(2):261-270. doi: 10.1165/rcmb.2015-0245OC.

10.

Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury.

Paris AJ, Liu Y, Mei J, Dai N, Guo L, Spruce LA, Hudock KM, Brenner JS, Zacharias WJ, Mei HD, Slamowitz AR, Bhamidipati K, Beers MF, Seeholzer SH, Morrisey EE, Worthen GS.

Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1062-L1075. doi: 10.1152/ajplung.00327.2016. Epub 2016 Sep 30.

11.

A core viral protein binds host nucleosomes to sequester immune danger signals.

Avgousti DC, Herrmann C, Kulej K, Pancholi NJ, Sekulic N, Petrescu J, Molden RC, Blumenthal D, Paris AJ, Reyes ED, Ostapchuk P, Hearing P, Seeholzer SH, Worthen GS, Black BE, Garcia BA, Weitzman MD.

Nature. 2016 Jul 7;535(7610):173-7. Epub 2016 Jun 29.

12.

CD11b+Ly6G+ cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis.

Liu Y, O'Leary CE, Wang LS, Bhatti TR, Dai N, Kapoor V, Liu P, Mei J, Guo L, Oliver PM, Albelda SM, Worthen GS.

Oncoimmunology. 2015 Jul 28;5(1):e1061175. eCollection 2016.

13.

Ketamine affects in vitro differentiation of monocyte into immature dendritic cells.

Laudanski K, Qing M, Oszkiel H, Zawadka M, Lapko N, Nowak Z, Worthen GS.

Anesthesiology. 2015 Sep;123(3):628-41. doi: 10.1097/ALN.0000000000000783.

PMID:
26197043
14.

Red blood cells induce necroptosis of lung endothelial cells and increase susceptibility to lung inflammation.

Qing DY, Conegliano D, Shashaty MG, Seo J, Reilly JP, Worthen GS, Huh D, Meyer NJ, Mangalmurti NS.

Am J Respir Crit Care Med. 2014 Dec 1;190(11):1243-54. doi: 10.1164/rccm.201406-1095OC.

15.

An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.

Gibbs J, Ince L, Matthews L, Mei J, Bell T, Yang N, Saer B, Begley N, Poolman T, Pariollaud M, Farrow S, DeMayo F, Hussell T, Worthen GS, Ray D, Loudon A.

Nat Med. 2014 Aug;20(8):919-26. doi: 10.1038/nm.3599. Epub 2014 Jul 27.

16.

CXCL5 is required for angiogenesis, but not structural adaptation after small bowel resection.

Rowland KJ, Diaz-Miron J, Guo J, Erwin CR, Mei J, Worthen GS, Warner BW.

J Pediatr Surg. 2014 Jun;49(6):976-80; discussion 980. doi: 10.1016/j.jpedsurg.2014.01.034. Epub 2014 Feb 3.

17.

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice.

Deshmukh HS, Liu Y, Menkiti OR, Mei J, Dai N, O'Leary CE, Oliver PM, Kolls JK, Weiser JN, Worthen GS.

Nat Med. 2014 May;20(5):524-30. doi: 10.1038/nm.3542. Epub 2014 Apr 20.

18.

Neutralizing Th2 inflammation in neonatal islets prevents β-cell failure in adult IUGR rats.

Jaeckle Santos LJ, Li C, Doulias PT, Ischiropoulos H, Worthen GS, Simmons RA.

Diabetes. 2014 May;63(5):1672-84. doi: 10.2337/db13-1226. Epub 2014 Jan 9.

19.

Delayed resolution of lung inflammation in Il-1rn-/- mice reflects elevated IL-17A/granulocyte colony-stimulating factor expression.

Hudock KM, Liu Y, Mei J, Marino RC, Hale JE, Dai N, Worthen GS.

Am J Respir Cell Mol Biol. 2012 Oct;47(4):436-44. doi: 10.1165/rcmb.2012-0104OC. Epub 2012 May 16.

20.

The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines.

Ramon HE, Beal AM, Liu Y, Worthen GS, Oliver PM.

J Immunol. 2012 Apr 15;188(8):4023-31. doi: 10.4049/jimmunol.1102779. Epub 2012 Mar 7.

21.

Role of CXCL5 in leukocyte recruitment to the lungs during secondhand smoke exposure.

Balamayooran G, Batra S, Cai S, Mei J, Worthen GS, Penn AL, Jeyaseelan S.

Am J Respir Cell Mol Biol. 2012 Jul;47(1):104-11. doi: 10.1165/rcmb.2011-0260OC. Epub 2012 Feb 23.

22.

Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils.

Fridlender ZG, Sun J, Mishalian I, Singhal S, Cheng G, Kapoor V, Horng W, Fridlender G, Bayuh R, Worthen GS, Albelda SM.

PLoS One. 2012;7(2):e31524. doi: 10.1371/journal.pone.0031524. Epub 2012 Feb 14.

23.

Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice.

Mei J, Liu Y, Dai N, Hoffmann C, Hudock KM, Zhang P, Guttentag SH, Kolls JK, Oliver PM, Bushman FD, Worthen GS.

J Clin Invest. 2012 Mar;122(3):974-86. doi: 10.1172/JCI60588. Epub 2012 Feb 13.

24.

IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants.

Floros J, Londono D, Gordon D, Silveyra P, Diangelo SL, Viscardi RM, Worthen GS, Shenberger J, Wang G, Lin Z, Thomas NJ.

Pediatr Res. 2012 Jan;71(1):107-14. doi: 10.1038/pr.2011.14.

25.

IL-17A and TNF-α exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro.

Liu Y, Mei J, Gonzales L, Yang G, Dai N, Wang P, Zhang P, Favara M, Malcolm KC, Guttentag S, Worthen GS.

J Immunol. 2011 Mar 1;186(5):3197-205. doi: 10.4049/jimmunol.1002016. Epub 2011 Jan 31.

26.

Infusion of mature megakaryocytes into mice yields functional platelets.

Fuentes R, Wang Y, Hirsch J, Wang C, Rauova L, Worthen GS, Kowalska MA, Poncz M.

J Clin Invest. 2010 Nov;120(11):3917-22. doi: 10.1172/JCI43326. Epub 2010 Oct 25.

27.

CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection.

Mei J, Liu Y, Dai N, Favara M, Greene T, Jeyaseelan S, Poncz M, Lee JS, Worthen GS.

Immunity. 2010 Jul 23;33(1):106-17. doi: 10.1016/j.immuni.2010.07.009.

28.

Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN.

Fridlender ZG, Sun J, Kim S, Kapoor V, Cheng G, Ling L, Worthen GS, Albelda SM.

Cancer Cell. 2009 Sep 8;16(3):183-94. doi: 10.1016/j.ccr.2009.06.017.

29.

A novel method for long term bone marrow culture and genetic modification of murine neutrophils via retroviral transduction.

Zemans RL, Briones N, Young SK, Malcolm KC, Refaeli Y, Downey GP, Worthen GS.

J Immunol Methods. 2009 Jan 30;340(2):102-15. doi: 10.1016/j.jim.2008.10.004. Epub 2008 Nov 14.

30.

Myeloid differentiation protein-2-dependent and -independent neutrophil accumulation during Escherichia coli pneumonia.

Cai S, Zemans RL, Young SK, Worthen GS, Jeyaseelan S.

Am J Respir Cell Mol Biol. 2009 Jun;40(6):701-9. doi: 10.1165/rcmb.2008-0152OC. Epub 2008 Nov 6.

31.

Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense.

Smoak K, Madenspacher J, Jeyaseelan S, Williams B, Dixon D, Poch KR, Nick JA, Worthen GS, Fessler MB.

J Immunol. 2008 Mar 1;180(5):3305-12.

32.

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia.

Jeyaseelan S, Young SK, Fessler MB, Liu Y, Malcolm KC, Yamamoto M, Akira S, Worthen GS.

J Immunol. 2007 Mar 1;178(5):3153-60.

33.

Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation.

Oliver PM, Cao X, Worthen GS, Shi P, Briones N, MacLeod M, White J, Kirby P, Kappler J, Marrack P, Yang B.

Immunity. 2006 Dec;25(6):929-40. Epub 2006 Nov 30.

34.
35.

Dual role for RhoA in suppression and induction of cytokines in the human neutrophil.

Fessler MB, Arndt PG, Just I, Nick JA, Malcolm KC, Worthen GS.

Blood. 2007 Feb 1;109(3):1248-56. Epub 2006 Oct 3.

36.
37.

Human lung project: evaluating variance of gene expression in the human lung.

Gruber MP, Coldren CD, Woolum MD, Cosgrove GP, Zeng C, Barón AE, Moore MD, Cool CD, Worthen GS, Brown KK, Geraci MW.

Am J Respir Cell Mol Biol. 2006 Jul;35(1):65-71. Epub 2006 Feb 23.

38.
39.
40.

Enhanced Pseudomonas aeruginosa biofilm development mediated by human neutrophils.

Walker TS, Tomlin KL, Worthen GS, Poch KR, Lieber JG, Saavedra MT, Fessler MB, Malcolm KC, Vasil ML, Nick JA.

Infect Immun. 2005 Jun;73(6):3693-701.

41.

Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium.

Jeyaseelan S, Manzer R, Young SK, Yamamoto M, Akira S, Mason RJ, Worthen GS.

Am J Respir Cell Mol Biol. 2005 Jun;32(6):531-9. Epub 2005 Mar 18.

42.

Inhibition of c-Jun N-terminal kinase limits lipopolysaccharide-induced pulmonary neutrophil influx.

Arndt PG, Young SK, Lieber JG, Fessler MB, Nick JA, Worthen GS.

Am J Respir Crit Care Med. 2005 May 1;171(9):978-86. Epub 2005 Feb 25.

PMID:
15735060
43.

Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury.

Jeyaseelan S, Chu HW, Young SK, Freeman MW, Worthen GS.

Infect Immun. 2005 Mar;73(3):1754-63.

44.

A role for hydroxy-methylglutaryl coenzyme a reductase in pulmonary inflammation and host defense.

Fessler MB, Young SK, Jeyaseelan S, Lieber JG, Arndt PG, Nick JA, Worthen GS.

Am J Respir Crit Care Med. 2005 Mar 15;171(6):606-15. Epub 2004 Dec 10.

PMID:
15591471
45.

Transcriptional profiling of lipopolysaccharide-induced acute lung injury.

Jeyaseelan S, Chu HW, Young SK, Worthen GS.

Infect Immun. 2004 Dec;72(12):7247-56.

46.

Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil.

Fessler MB, Arndt PG, Frasch SC, Lieber JG, Johnson CA, Murphy RC, Nick JA, Bratton DL, Malcolm KC, Worthen GS.

J Biol Chem. 2004 Sep 17;279(38):39989-98. Epub 2004 Jul 15.

47.

Extracellular superoxide dismutase attenuates lipopolysaccharide-induced neutrophilic inflammation.

Bowler RP, Nicks M, Tran K, Tanner G, Chang LY, Young SK, Worthen GS.

Am J Respir Cell Mol Biol. 2004 Oct;31(4):432-9. Epub 2004 Jul 15.

PMID:
15256385
48.

Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis.

Cosgrove GP, Brown KK, Schiemann WP, Serls AE, Parr JE, Geraci MW, Schwarz MI, Cool CD, Worthen GS.

Am J Respir Crit Care Med. 2004 Aug 1;170(3):242-51. Epub 2004 Apr 29.

PMID:
15117744
49.

Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis.

Suratt BT, Petty JM, Young SK, Malcolm KC, Lieber JG, Nick JA, Gonzalo JA, Henson PM, Worthen GS.

Blood. 2004 Jul 15;104(2):565-71. Epub 2004 Mar 30.

PMID:
15054039
50.

Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways.

Arndt PG, Suzuki N, Avdi NJ, Malcolm KC, Worthen GS.

J Biol Chem. 2004 Mar 19;279(12):10883-91. Epub 2003 Dec 29.

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