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Items: 1 to 50 of 108

1.

The Translational Landscape of the Human Heart.

van Heesch S, Witte F, Schneider-Lunitz V, Schulz JF, Adami E, Faber AB, Kirchner M, Maatz H, Blachut S, Sandmann CL, Kanda M, Worth CL, Schafer S, Calviello L, Merriott R, Patone G, Hummel O, Wyler E, Obermayer B, Mücke MB, Lindberg EL, Trnka F, Memczak S, Schilling M, Felkin LE, Barton PJR, Quaife NM, Vanezis K, Diecke S, Mukai M, Mah N, Oh SJ, Kurtz A, Schramm C, Schwinge D, Sebode M, Harakalova M, Asselbergs FW, Vink A, de Weger RA, Viswanathan S, Widjaja AA, Gärtner-Rommel A, Milting H, Dos Remedios C, Knosalla C, Mertins P, Landthaler M, Vingron M, Linke WA, Seidman JG, Seidman CE, Rajewsky N, Ohler U, Cook SA, Hubner N.

Cell. 2019 May 29. pii: S0092-8674(19)30508-2. doi: 10.1016/j.cell.2019.05.010. [Epub ahead of print]

PMID:
31155234
2.

Novel Therapeutic Targets in Axial Spondyloarthritis.

Worth C, Bowness P, Hussein Al-Mossawi M.

Curr Treatm Opt Rheumatol. 2018;4(2):174-182. doi: 10.1007/s40674-018-0095-1. Epub 2018 Apr 12. Review.

3.

Structural changes of TasA in biofilm formation of Bacillus subtilis.

Diehl A, Roske Y, Ball L, Chowdhury A, Hiller M, Molière N, Kramer R, Stöppler D, Worth CL, Schlegel B, Leidert M, Cremer N, Erdmann N, Lopez D, Stephanowitz H, Krause E, van Rossum BJ, Schmieder P, Heinemann U, Turgay K, Akbey Ü, Oschkinat H.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3237-3242. doi: 10.1073/pnas.1718102115. Epub 2018 Mar 12.

4.

Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level.

Fischer J, Kleinau G, Rutz C, Zwanziger D, Khajavi N, Müller A, Rehders M, Brix K, Worth CL, Führer D, Krude H, Wiesner B, Schülein R, Biebermann H.

Cell Mol Life Sci. 2018 Jun;75(12):2227-2239. doi: 10.1007/s00018-017-2728-1. Epub 2017 Dec 30.

PMID:
29290039
5.

Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells.

Kakar SS, Parte S, Carter K, Joshua IG, Worth C, Rameshwar P, Ratajczak MZ.

Oncotarget. 2017 Aug 10;8(43):74494-74505. doi: 10.18632/oncotarget.20170. eCollection 2017 Sep 26.

6.

GPCR-SSFE 2.0-a fragment-based molecular modeling web tool for Class A G-protein coupled receptors.

Worth CL, Kreuchwig F, Tiemann JKS, Kreuchwig A, Ritschel M, Kleinau G, Hildebrand PW, Krause G.

Nucleic Acids Res. 2017 Jul 3;45(W1):W408-W415. doi: 10.1093/nar/gkx399.

7.

Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work.

Kleinau G, Worth CL, Kreuchwig A, Biebermann H, Marcinkowski P, Scheerer P, Krause G.

Front Endocrinol (Lausanne). 2017 Apr 24;8:86. doi: 10.3389/fendo.2017.00086. eCollection 2017. Review.

8.

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.

Schütte M, Risch T, Abdavi-Azar N, Boehnke K, Schumacher D, Keil M, Yildiriman R, Jandrasits C, Borodina T, Amstislavskiy V, Worth CL, Schweiger C, Liebs S, Lange M, Warnatz HJ, Butcher LM, Barrett JE, Sultan M, Wierling C, Golob-Schwarzl N, Lax S, Uranitsch S, Becker M, Welte Y, Regan JL, Silvestrov M, Kehler I, Fusi A, Kessler T, Herwig R, Landegren U, Wienke D, Nilsson M, Velasco JA, Garin-Chesa P, Reinhard C, Beck S, Schäfer R, Regenbrecht CR, Henderson D, Lange B, Haybaeck J, Keilholz U, Hoffmann J, Lehrach H, Yaspo ML.

Nat Commun. 2017 Feb 10;8:14262. doi: 10.1038/ncomms14262.

9.

DOXIL when combined with Withaferin A (WFA) targets ALDH1 positive cancer stem cells in ovarian cancer.

Kakar SS, Worth CA, Wang Z, Carter K, Ratajczak M, Gunjal P.

J Cancer Stem Cell Res. 2016;4. pii: e1002. Epub 2016 Apr 19.

10.

Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.

Fischer U, Forster M, Rinaldi A, Risch T, Sungalee S, Warnatz HJ, Bornhauser B, Gombert M, Kratsch C, Stütz AM, Sultan M, Tchinda J, Worth CL, Amstislavskiy V, Badarinarayan N, Baruchel A, Bartram T, Basso G, Canpolat C, Cario G, Cavé H, Dakaj D, Delorenzi M, Dobay MP, Eckert C, Ellinghaus E, Eugster S, Frismantas V, Ginzel S, Haas OA, Heidenreich O, Hemmrich-Stanisak G, Hezaveh K, Höll JI, Hornhardt S, Husemann P, Kachroo P, Kratz CP, Te Kronnie G, Marovca B, Niggli F, McHardy AC, Moorman AV, Panzer-Grümayer R, Petersen BS, Raeder B, Ralser M, Rosenstiel P, Schäfer D, Schrappe M, Schreiber S, Schütte M, Stade B, Thiele R, von der Weid N, Vora A, Zaliova M, Zhang L, Zichner T, Zimmermann M, Lehrach H, Borkhardt A, Bourquin JP, Franke A, Korbel JO, Stanulla M, Yaspo ML.

Nat Genet. 2015 Sep;47(9):1020-1029. doi: 10.1038/ng.3362. Epub 2015 Jul 27.

11.

Tobacco cessation treatment education for dental students using standardized patients.

Singleton JA, Carrico RM, Myers JA, Scott DA, Wilson RW, Worth CT.

J Dent Educ. 2014 Jun;78(6):895-905.

12.

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM; International Cancer Genome Consortium PedBrain Tumor Project.

Nat Genet. 2013 Aug;45(8):927-32. doi: 10.1038/ng.2682. Epub 2013 Jun 30.

13.

Residues of a proposed gate region in type I ATP-binding cassette import systems are crucial for function as revealed by mutational analysis.

Weidlich D, Wiesemann N, Heuveling J, Wardelmann K, Landmesser H, Sani KB, Worth CL, Preissner R, Schneider E.

Biochim Biophys Acta. 2013 Sep;1828(9):2164-72. doi: 10.1016/j.bbamem.2013.05.032. Epub 2013 Jun 6. Erratum in: Biochim Biophys Acta. 2014 May;1838(5):1448.

14.

Investigation of a scabies outbreak in a kindergarten in Constance, Germany.

Ariza L, Walter B, Worth C, Brockmann S, Weber ML, Feldmeier H.

Eur J Clin Microbiol Infect Dis. 2013 Mar;32(3):373-80. doi: 10.1007/s10096-012-1752-1. Epub 2012 Sep 28.

PMID:
23052985
15.

Impaired quality of life in adults and children with scabies from an impoverished community in Brazil.

Worth C, Heukelbach J, Fengler G, Walter B, Liesenfeld O, Feldmeier H.

Int J Dermatol. 2012 Mar;51(3):275-82. doi: 10.1111/j.1365-4632.2011.05017.x.

PMID:
22348561
16.

Acute morbidity associated with scabies and other ectoparasitoses rapidly improves after treatment with ivermectin.

Worth C, Heukelbach J, Fengler G, Walter B, Liesenfeld O, Hengge U, Feldmeier H.

Pediatr Dermatol. 2012 Jul-Aug;29(4):430-6. doi: 10.1111/j.1525-1470.2011.01680.x. Epub 2011 Dec 30.

PMID:
22211573
17.

Binding sites in membrane proteins--diversity, druggability and prospects.

Adams R, Worth CL, Guenther S, Dunkel M, Lehmann R, Preissner R.

Eur J Cell Biol. 2012 Apr;91(4):326-39. doi: 10.1016/j.ejcb.2011.06.003. Epub 2011 Aug 27. Review.

PMID:
21872966
18.

Development of immune-specific interaction potentials and their application in the multi-agent-system VaccImm.

Woelke AL, von Eichborn J, Murgueitio MS, Worth CL, Castiglione F, Preissner R.

PLoS One. 2011;6(8):e23257. doi: 10.1371/journal.pone.0023257. Epub 2011 Aug 17.

19.

GPCR-SSFE: a comprehensive database of G-protein-coupled receptor template predictions and homology models.

Worth CL, Kreuchwig A, Kleinau G, Krause G.

BMC Bioinformatics. 2011 May 23;12:185. doi: 10.1186/1471-2105-12-185.

20.

SDM--a server for predicting effects of mutations on protein stability and malfunction.

Worth CL, Preissner R, Blundell TL.

Nucleic Acids Res. 2011 Jul;39(Web Server issue):W215-22. doi: 10.1093/nar/gkr363. Epub 2011 May 18.

21.

From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs).

Kleinau G, Hoyer I, Kreuchwig A, Haas AK, Rutz C, Furkert J, Worth CL, Krause G, Schülein R.

J Biol Chem. 2011 Jul 22;286(29):25859-71. doi: 10.1074/jbc.M110.196980. Epub 2011 May 17.

22.

Comparison of dermoscopy, skin scraping, and the adhesive tape test for the diagnosis of scabies in a resource-poor setting.

Walter B, Heukelbach J, Fengler G, Worth C, Hengge U, Feldmeier H.

Arch Dermatol. 2011 Apr;147(4):468-73. doi: 10.1001/archdermatol.2011.51.

PMID:
21482897
23.

Evidence-based tobacco cessation treatment by dental hygienists.

Studts JL, Burris JL, Kearns DK, Worth CT, Sorrell CL.

J Dent Hyg. 2011 Winter;85(1):13-21. Epub 2011 Jan 1.

PMID:
21396259
24.

Meet me halfway: when genomics meets structural bioinformatics.

Gong S, Worth CL, Cheng TM, Blundell TL.

J Cardiovasc Transl Res. 2011 Jun;4(3):281-303. doi: 10.1007/s12265-011-9259-1. Epub 2011 Feb 25.

PMID:
21350909
25.

Research resource: Update and extension of a glycoprotein hormone receptors web application.

Kreuchwig A, Kleinau G, Kreuchwig F, Worth CL, Krause G.

Mol Endocrinol. 2011 Apr;25(4):707-12. doi: 10.1210/me.2010-0510. Epub 2011 Feb 3.

26.

FragmentStore--a comprehensive database of fragments linking metabolites, toxic molecules and drugs.

Ahmed J, Worth CL, Thaben P, Matzig C, Blasse C, Dunkel M, Preissner R.

Nucleic Acids Res. 2011 Jan;39(Database issue):D1049-54. doi: 10.1093/nar/gkq969. Epub 2010 Oct 21.

27.

SuperSweet--a resource on natural and artificial sweetening agents.

Ahmed J, Preissner S, Dunkel M, Worth CL, Eckert A, Preissner R.

Nucleic Acids Res. 2011 Jan;39(Database issue):D377-82. doi: 10.1093/nar/gkq917. Epub 2010 Oct 14.

28.
29.
30.

2010 FIFA world cup South Africa: travel health issues and new options for protection against meningococcal disease.

Zuckerman JN, Bröker M, Worth C.

Travel Med Infect Dis. 2010 Mar;8(2):68-73. doi: 10.1016/j.tmaid.2010.04.004. Review.

PMID:
20478511
31.

Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor.

Kleinau G, Jaeschke H, Worth CL, Mueller S, Gonzalez J, Paschke R, Krause G.

PLoS One. 2010 Mar 18;5(3):e9745. doi: 10.1371/journal.pone.0009745.

32.

Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor.

Kleinau G, Haas AK, Neumann S, Worth CL, Hoyer I, Furkert J, Rutz C, Gershengorn MC, Schülein R, Krause G.

FASEB J. 2010 Jul;24(7):2347-54. doi: 10.1096/fj.09-149146. Epub 2010 Feb 23.

33.

Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models.

Worth CL, Kleinau G, Krause G.

PLoS One. 2009 Sep 16;4(9):e7011. doi: 10.1371/journal.pone.0007011.

34.

Structural and functional constraints in the evolution of protein families.

Worth CL, Gong S, Blundell TL.

Nat Rev Mol Cell Biol. 2009 Oct;10(10):709-20. doi: 10.1038/nrm2762. Epub 2009 Sep 16. Review.

PMID:
19756040
35.

"Providers practice prevention": promoting dental hygienists' use of evidence-based treatment of tobacco use and dependence.

Studts JL, Burris JL, Kearns DK, Worth CT, Sorrell CL.

J Dent Educ. 2009 Sep;73(9):1069-82.

36.

Structural and functional restraints in the evolution of protein families and superfamilies.

Gong S, Worth CL, Bickerton GR, Lee S, Tanramluk D, Blundell TL.

Biochem Soc Trans. 2009 Aug;37(Pt 4):727-33. doi: 10.1042/BST0370727. Review.

PMID:
19614584
37.

Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis.

Forman JR, Worth CL, Bickerton GR, Eisen TG, Blundell TL.

Proteins. 2009 Oct;77(1):84-96. doi: 10.1002/prot.22419.

PMID:
19408298
38.

Non-reducible hip dislocation in the ED.

Worth C, Harris A.

Emerg Med J. 2009 Jan;26(1):42. doi: 10.1136/emj.2008.058370. No abstract available.

PMID:
19104097
39.

Molecular and structural effects of inverse agonistic mutations on signaling of the thyrotropin receptor--a basally active GPCR.

Kleinau G, Jaeschke H, Mueller S, Worth CL, Paschke R, Krause G.

Cell Mol Life Sci. 2008 Nov;65(22):3664-76. doi: 10.1007/s00018-008-8450-2.

PMID:
18850313
40.

Satisfaction of hydrogen-bonding potential influences the conservation of polar sidechains.

Worth CL, Blundell TL.

Proteins. 2009 May 1;75(2):413-29. doi: 10.1002/prot.22248.

PMID:
18837037
41.

Transcriptomic screening of microvascular endothelial cells implicates novel molecular regulators of vascular dysfunction after spinal cord injury.

Benton RL, Maddie MA, Worth CA, Mahoney ET, Hagg T, Whittemore SR.

J Cereb Blood Flow Metab. 2008 Nov;28(11):1771-85. doi: 10.1038/jcbfm.2008.76. Epub 2008 Jul 9.

42.

Detection of Campylobacter jejuni from the skin of broiler chickens, ducks, squab, quail, and guinea fowl carcasses.

McCrea BA, Tonooka KH, Van Worth C, Atwill ER, Schrader JS.

Foodborne Pathog Dis. 2008 Feb;5(1):53-7. doi: 10.1089/fpd.2007.0039.

PMID:
18260815
43.

A structural bioinformatics approach to the analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) and their relation to disease.

Worth CL, Bickerton GR, Schreyer A, Forman JR, Cheng TM, Lee S, Gong S, Burke DF, Blundell TL.

J Bioinform Comput Biol. 2007 Dec;5(6):1297-318.

PMID:
18172930
44.

Tobacco cessation treatment knowledge, attitudes and practices of Kentucky physicians.

Studts JL, Matera EL, Worth CT, Ghate SR, Miller BF 4th, Thomas SD, Sorrell CL.

J Ky Med Assoc. 2007 Oct;105(10):497-507.

PMID:
18038512
45.

AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity.

Ferguson BJ, Alexander C, Rossi SW, Liiv I, Rebane A, Worth CL, Wong J, Laan M, Peterson P, Jenkinson EJ, Anderson G, Scott HS, Cooke A, Rich T.

J Biol Chem. 2008 Jan 18;283(3):1723-31. Epub 2007 Nov 1.

46.

Tobacco cessation counseling training with standardized patients.

Walsh SE, Singleton JA, Worth CT, Krugler J, Moore R, Wesley GC, Mitchell CK.

J Dent Educ. 2007 Sep;71(9):1171-8.

47.

Genome bioinformatic analysis of nonsynonymous SNPs.

Burke DF, Worth CL, Priego EM, Cheng T, Smink LJ, Todd JA, Blundell TL.

BMC Bioinformatics. 2007 Aug 20;8:301.

48.

An antifungal and plant growth promoting metabolite from a sterile dark ectotrophic fungus.

Kim HJ, Vinale F, Ghisalberti EL, Worth CM, Sivasithamparam K, Skelton BW, White AH.

Phytochemistry. 2006 Oct;67(20):2277-80. Epub 2006 Aug 30.

PMID:
16942784
49.

Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery.

Blundell TL, Sibanda BL, Montalvão RW, Brewerton S, Chelliah V, Worth CL, Harmer NJ, Davies O, Burke D.

Philos Trans R Soc Lond B Biol Sci. 2006 Mar 29;361(1467):413-23. Review.

50.

Fluorescence-activated cell sorting of EGFP-labeled neural crest cells from murine embryonic craniofacial tissue.

Singh S, Bhattacherjee V, Mukhopadhyay P, Worth CA, Wellhausen SR, Warner CP, Greene RM, Pisano MM.

J Biomed Biotechnol. 2005;2005(3):232-7.

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