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Items: 1 to 50 of 52

1.

A higher throughput and physiologically relevant two-compartmental human ex vivo intestinal tissue system for studying gastrointestinal processes.

Stevens LJ, van Lipzig MMH, Erpelinck SLA, Pronk A, van Gorp J, Wortelboer HM, van de Steeg E.

Eur J Pharm Sci. 2019 Sep 1;137:104989. doi: 10.1016/j.ejps.2019.104989. Epub 2019 Jul 10.

PMID:
31301485
2.

The effect of chitosan on the bioaccessibility and intestinal permeability of acyclovir.

Kubbinga M, Augustijns P, García MA, Heinen C, Wortelboer HM, Verwei M, Langguth P.

Eur J Pharm Biopharm. 2019 Mar;136:147-155. doi: 10.1016/j.ejpb.2019.01.021. Epub 2019 Jan 22.

PMID:
30682491
3.

Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants.

van Groen BD, van de Steeg E, Mooij MG, van Lipzig MMH, de Koning BAE, Verdijk RM, Wortelboer HM, Gaedigk R, Bi C, Leeder JS, van Schaik RHN, van Rosmalen J, Tibboel D, Vaes WH, de Wildt SN.

Eur J Pharm Sci. 2018 Nov 1;124:217-227. doi: 10.1016/j.ejps.2018.08.042. Epub 2018 Aug 30.

4.

Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes.

Wegler C, Gaugaz FZ, Andersson TB, Wiśniewski JR, Busch D, Gröer C, Oswald S, Norén A, Weiss F, Hammer HS, Joos TO, Poetz O, Achour B, Rostami-Hodjegan A, van de Steeg E, Wortelboer HM, Artursson P.

Mol Pharm. 2017 Sep 5;14(9):3142-3151. doi: 10.1021/acs.molpharmaceut.7b00364. Epub 2017 Aug 16.

5.

Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells.

Vaessen SF, van Lipzig MM, Pieters RH, Krul CA, Wortelboer HM, van de Steeg E.

Drug Metab Dispos. 2017 Apr;45(4):353-360. doi: 10.1124/dmd.116.072231. Epub 2017 Feb 2.

PMID:
28153842
6.

Grip on health: A complex systems approach to transform health care.

van Wietmarschen HA, Wortelboer HM, van der Greef J.

J Eval Clin Pract. 2018 Feb;24(1):269-277. doi: 10.1111/jep.12679. Epub 2016 Dec 29.

PMID:
28032412
7.

Nutrient-induced glucagon like peptide-1 release is modulated by serotonin.

Ripken D, van der Wielen N, Wortelboer HM, Meijerink J, Witkamp RF, Hendriks HF.

J Nutr Biochem. 2016 Jun;32:142-50. doi: 10.1016/j.jnutbio.2016.03.006. Epub 2016 Mar 29.

8.

Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life.

Mooij MG, van de Steeg E, van Rosmalen J, Windster JD, de Koning BA, Vaes WH, van Groen BD, Tibboel D, Wortelboer HM, de Wildt SN.

Drug Metab Dispos. 2016 Jul;44(7):1005-13. doi: 10.1124/dmd.115.068577. Epub 2016 Apr 21.

PMID:
27103634
9.

Generation of Bayesian prediction models for OATP-mediated drug-drug interactions based on inhibition screen of OATP1B1, OATP1B1∗15 and OATP1B3.

van de Steeg E, Venhorst J, Jansen HT, Nooijen IH, DeGroot J, Wortelboer HM, Vlaming ML.

Eur J Pharm Sci. 2015 Apr 5;70:29-36. doi: 10.1016/j.ejps.2015.01.004. Epub 2015 Jan 17.

PMID:
25603031
10.

Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.

Bosgra S, van de Steeg E, Vlaming ML, Verhoeckx KC, Huisman MT, Verwei M, Wortelboer HM.

Eur J Pharm Sci. 2014 Dec 18;65:156-66. doi: 10.1016/j.ejps.2014.09.007. Epub 2014 Sep 28.

PMID:
25261337
11.

Steviol glycoside rebaudioside A induces glucagon-like peptide-1 and peptide YY release in a porcine ex vivo intestinal model.

Ripken D, van der Wielen N, Wortelboer HM, Meijerink J, Witkamp RF, Hendriks HF.

J Agric Food Chem. 2014 Aug 20;62(33):8365-70. doi: 10.1021/jf501105w. Epub 2014 Aug 7.

PMID:
25062288
12.

A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices.

Westerhout J, van de Steeg E, Grossouw D, Zeijdner EE, Krul CA, Verwei M, Wortelboer HM.

Eur J Pharm Sci. 2014 Oct 15;63:167-77. doi: 10.1016/j.ejps.2014.07.003. Epub 2014 Jul 18.

PMID:
25046168
13.

Interaction of digitalis-like compounds with liver uptake transporters NTCP, OATP1B1, and OATP1B3.

Gozalpour E, Greupink R, Wortelboer HM, Bilos A, Schreurs M, Russel FG, Koenderink JB.

Mol Pharm. 2014 Jun 2;11(6):1844-55. doi: 10.1021/mp400699p. Epub 2014 May 6.

PMID:
24754247
14.

Protein transport across the small intestine in food allergy.

Reitsma M, Westerhout J, Wichers HJ, Wortelboer HM, Verhoeckx KC.

Mol Nutr Food Res. 2014 Jan;58(1):194-205. doi: 10.1002/mnfr.201300204. Epub 2013 Dec 3. Review.

PMID:
24395537
15.

Combined analysis of pharmacokinetic and efficacy data of preclinical studies with statins markedly improves translation of drug efficacy to human trials.

van de Steeg E, Kleemann R, Jansen HT, van Duyvenvoorde W, Offerman EH, Wortelboer HM, Degroot J.

J Pharmacol Exp Ther. 2013 Dec;347(3):635-44. doi: 10.1124/jpet.113.208595. Epub 2013 Sep 18.

PMID:
24049060
16.

Interaction of immunosuppressive drugs with human organic anion transporter (OAT) 1 and OAT3, and multidrug resistance-associated protein (MRP) 2 and MRP4.

El-Sheikh AA, Greupink R, Wortelboer HM, van den Heuvel JJ, Schreurs M, Koenderink JB, Masereeuw R, Russel FG.

Transl Res. 2013 Dec;162(6):398-409. doi: 10.1016/j.trsl.2013.08.003. Epub 2013 Sep 12.

PMID:
24036158
17.

Ex vivo systems to study host-microbiota interactions in the gastrointestinal tract.

Roeselers G, Ponomarenko M, Lukovac S, Wortelboer HM.

Best Pract Res Clin Gastroenterol. 2013 Feb;27(1):101-13. doi: 10.1016/j.bpg.2013.03.018. Review.

PMID:
23768556
18.

Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions.

Ellens H, Deng S, Coleman J, Bentz J, Taub ME, Ragueneau-Majlessi I, Chung SP, Herédi-Szabó K, Neuhoff S, Palm J, Balimane P, Zhang L, Jamei M, Hanna I, O'Connor M, Bednarczyk D, Forsgard M, Chu X, Funk C, Guo A, Hillgren KM, Li L, Pak AY, Perloff ES, Rajaraman G, Salphati L, Taur JS, Weitz D, Wortelboer HM, Xia CQ, Xiao G, Yamagata T, Lee CA.

Drug Metab Dispos. 2013 Jul;41(7):1367-74. doi: 10.1124/dmd.112.050542. Epub 2013 Apr 25.

19.

Variability in P-glycoprotein inhibitory potency (IC₅₀) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria.

Bentz J, O'Connor MP, Bednarczyk D, Coleman J, Lee C, Palm J, Pak YA, Perloff ES, Reyner E, Balimane P, Brännström M, Chu X, Funk C, Guo A, Hanna I, Herédi-Szabó K, Hillgren K, Li L, Hollnack-Pusch E, Jamei M, Lin X, Mason AK, Neuhoff S, Patel A, Podila L, Plise E, Rajaraman G, Salphati L, Sands E, Taub ME, Taur JS, Weitz D, Wortelboer HM, Xia CQ, Xiao G, Yabut J, Yamagata T, Zhang L, Ellens H.

Drug Metab Dispos. 2013 Jul;41(7):1347-66. doi: 10.1124/dmd.112.050500. Epub 2013 Apr 25.

20.

Measurement of palmitoylethanolamide and other N-acylethanolamines during physiological and pathological conditions.

Balvers MG, Verhoeckx KC, Meijerink J, Wortelboer HM, Witkamp RF.

CNS Neurol Disord Drug Targets. 2013 Feb 1;12(1):23-33. Review.

PMID:
23394528
21.

Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of OATP1B1.

van de Steeg E, Greupink R, Schreurs M, Nooijen IH, Verhoeckx KC, Hanemaaijer R, Ripken D, Monshouwer M, Vlaming ML, DeGroot J, Verwei M, Russel FG, Huisman MT, Wortelboer HM.

Drug Metab Dispos. 2013 Mar;41(3):592-601. doi: 10.1124/dmd.112.049023. Epub 2012 Dec 17.

PMID:
23248200
22.

Liquid chromatography-tandem mass spectrometry analysis of free and esterified fatty acid N-acyl ethanolamines in plasma and blood cells.

Balvers MG, Wortelboer HM, Witkamp RF, Verhoeckx KC.

Anal Biochem. 2013 Mar 15;434(2):275-83. doi: 10.1016/j.ab.2012.11.008. Epub 2012 Nov 29.

PMID:
23201387
23.

Fish oil and inflammatory status alter the n-3 to n-6 balance of the endocannabinoid and oxylipin metabolomes in mouse plasma and tissues.

Balvers MG, Verhoeckx KC, Bijlsma S, Rubingh CM, Meijerink J, Wortelboer HM, Witkamp RF.

Metabolomics. 2012 Dec;8(6):1130-1147. Epub 2012 Apr 11.

24.

Effects of long- and short-chain fatty acids on the release of gastrointestinal hormones using an ex vivo porcine intestinal tissue model.

Voortman T, Hendriks HF, Witkamp RF, Wortelboer HM.

J Agric Food Chem. 2012 Sep 12;60(36):9035-42. doi: 10.1021/jf2045697. Epub 2012 Aug 30.

PMID:
22757966
25.

Time-dependent effect of in vivo inflammation on eicosanoid and endocannabinoid levels in plasma, liver, ileum and adipose tissue in C57BL/6 mice fed a fish-oil diet.

Balvers MG, Verhoeckx KC, Meijerink J, Bijlsma S, Rubingh CM, Wortelboer HM, Witkamp RF.

Int Immunopharmacol. 2012 Jun;13(2):204-14. doi: 10.1016/j.intimp.2012.03.022. Epub 2012 Apr 9.

PMID:
22498761
26.

Increasing oxime efficacy by blood-brain barrier modulation.

Joosen MJ, van der Schans MJ, van Dijk CG, Kuijpers WC, Wortelboer HM, van Helden HP.

Toxicol Lett. 2011 Sep 25;206(1):67-71. doi: 10.1016/j.toxlet.2011.05.231. Epub 2011 May 11.

PMID:
21600273
27.

Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties.

Balvers MG, Verhoeckx KC, Plastina P, Wortelboer HM, Meijerink J, Witkamp RF.

Biochim Biophys Acta. 2010 Oct;1801(10):1107-14. doi: 10.1016/j.bbalip.2010.06.006. Epub 2010 Jun 27.

PMID:
20601112
28.

Effect of body fat distribution on the transcription response to dietary fat interventions.

Radonjic M, van Erk MJ, Pasman WJ, Wortelboer HM, Hendriks HF, van Ommen B.

Genes Nutr. 2009 Jun;4(2):143-9. doi: 10.1007/s12263-009-0122-9. Epub 2009 Apr 30.

29.

Short-term fatty acid intervention elicits differential gene expression responses in adipose tissue from lean and overweight men.

van Erk MJ, Pasman WJ, Wortelboer HM, van Ommen B, Hendriks HF.

Genes Nutr. 2008 Dec;3(3-4):127-37. doi: 10.1007/s12263-008-0096-z. Epub 2008 Nov 26.

30.

Glutathione-dependent interaction of heavy metal compounds with multidrug resistance proteins MRP1 and MRP2.

Wortelboer HM, Balvers MG, Usta M, van Bladeren PJ, Cnubben NH.

Environ Toxicol Pharmacol. 2008 Jul;26(1):102-8. doi: 10.1016/j.etap.2008.02.006. Epub 2008 Feb 23.

PMID:
21783896
31.

Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in Caco-2 cells.

Usta M, Wortelboer HM, Vervoort J, Boersma MG, Rietjens IM, van Bladeren PJ, Cnubben NH.

Chem Res Toxicol. 2007 Dec;20(12):1895-902. Epub 2007 Nov 1.

PMID:
17975885
32.

The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential.

van Zanden JJ, van der Woude H, Vaessen J, Usta M, Wortelboer HM, Cnubben NH, Rietjens IM.

Biochem Pharmacol. 2007 Jul 15;74(2):345-51. Epub 2007 Apr 6.

PMID:
17509533
33.

A sandwich-cultured rat hepatocyte system with increased metabolic competence evaluated by gene expression profiling.

Kienhuis AS, Wortelboer HM, Maas WJ, van Herwijnen M, Kleinjans JC, van Delft JH, Stierum RH.

Toxicol In Vitro. 2007 Aug;21(5):892-901. Epub 2007 Jan 20.

PMID:
17336492
34.

Comparison of coumarin-induced toxicity between sandwich-cultured primary rat hepatocytes and rats in vivo: a toxicogenomics approach.

Kienhuis AS, Wortelboer HM, Hoflack JC, Moonen EJ, Kleinjans JC, van Ommen B, van Delft JH, Stierum RH.

Drug Metab Dispos. 2006 Dec;34(12):2083-90. Epub 2006 Sep 8.

PMID:
16963487
35.

Metabolism of ATP-binding cassette drug transporter inhibitors: complicating factor for multidrug resistance.

Cnubben NH, Wortelboer HM, van Zanden JJ, Rietjens IM, van Bladeren PJ.

Expert Opin Drug Metab Toxicol. 2005 Aug;1(2):219-32. Review.

PMID:
16922638
36.

Reversal of in vitro cellular MRP1 and MRP2 mediated vincristine resistance by the flavonoid myricetin.

van Zanden JJ, de Mul A, Wortelboer HM, Usta M, van Bladeren PJ, Rietjens IM, Cnubben NH.

Biochem Pharmacol. 2005 Jun 1;69(11):1657-65. Epub 2005 Apr 13.

PMID:
15896345
37.

Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of alpha,beta-unsaturated carbonyl compounds.

Wortelboer HM, Usta M, van Zanden JJ, van Bladeren PJ, Rietjens IM, Cnubben NH.

Biochem Pharmacol. 2005 Jun 15;69(12):1879-90.

PMID:
15885658
38.

Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2.

van Zanden JJ, Wortelboer HM, Bijlsma S, Punt A, Usta M, Bladeren PJ, Rietjens IM, Cnubben NH.

Biochem Pharmacol. 2005 Feb 15;69(4):699-708. Epub 2004 Dec 23.

PMID:
15670588
39.

Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells.

van Zanden JJ, Geraets L, Wortelboer HM, van Bladeren PJ, Rietjens IM, Cnubben NH.

Biochem Pharmacol. 2004 Apr 15;67(8):1607-17.

PMID:
15041478
40.

Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin.

Wortelboer HM, Usta M, van der Velde AE, Boersma MG, Spenkelink B, van Zanden JJ, Rietjens IM, van Bladeren PJ, Cnubben NH.

Chem Res Toxicol. 2003 Dec;16(12):1642-51.

PMID:
14680379
41.
42.

Differences in the effects of model inducers of cytochrome P450 on the biotransformation of scoparone in rat and hamster liver.

Mennes WC, Luijckx NB, Wortelboer HM, Noordhoek J, Blaauboer BJ.

Arch Toxicol. 1993;67(2):92-7.

PMID:
8481107
43.

Effects of indole-3-carbinol on biotransformation enzymes in the rat: in vivo changes in liver and small intestinal mucosa in comparison with primary hepatocyte cultures.

Wortelboer HM, van der Linden EC, de Kruif CA, Noordhoek J, Blaauboer BJ, van Bladeren PJ, Falke HE.

Food Chem Toxicol. 1992 Jul;30(7):589-99.

PMID:
1521833
44.

Acid reaction products of indole-3-carbinol and their effects on cytochrome P450 and phase II enzymes in rat and monkey hepatocytes.

Wortelboer HM, de Kruif CA, van Iersel AA, Falke HE, Noordhoek J, Blaauboer BJ.

Biochem Pharmacol. 1992 Apr 1;43(7):1439-47.

PMID:
1567468
45.

Effects of cooked brussels sprouts on cytochrome P-450 profile and phase II enzymes in liver and small intestinal mucosa of the rat.

Wortelboer HM, de Kruif CA, van Iersel AA, Noordhoek J, Blaauboer BJ, van Bladeren PJ, Falke HE.

Food Chem Toxicol. 1992 Jan;30(1):17-27.

PMID:
1544602
46.

Interlaboratory comparison of microsomal ethoxyresorufin and pentoxyresorufin O-dealkylation determinations: standardization of assay conditions.

Rutten AA, Falke HE, Catsburg JF, Wortelboer HM, Blaauboer BJ, Doorn L, van Leeuwen FX, Theelen R, Rietjens IM.

Arch Toxicol. 1992;66(4):237-44.

PMID:
1514921
47.

Comparison of cytochrome P450 isoenzyme profiles in rat liver and hepatocyte cultures. The effects of model inducers on apoproteins and biotransformation activities.

Wortelboer HM, de Kruif CA, van Iersel AA, Falke HE, Noordhoek J, Blaauboer BJ.

Biochem Pharmacol. 1991 Jul 5;42(2):381-90.

PMID:
1859452
48.

Structure elucidation of acid reaction products of indole-3-carbinol: detection in vivo and enzyme induction in vitro.

De Kruif CA, Marsman JW, Venekamp JC, Falke HE, Noordhoek J, Blaauboer BJ, Wortelboer HM.

Chem Biol Interact. 1991;80(3):303-15.

PMID:
1954658
49.

The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers.

Wortelboer HM, de Kruif CA, van Iersel AA, Falke HE, Noordhoek J, Blaauboer BJ.

Biochem Pharmacol. 1990 Dec 1;40(11):2525-34.

PMID:
2268371
50.

Effect of normobaric hyperoxia on antioxidant defenses of HeLa and CHO cells.

Gille JJ, Wortelboer HM, Joenje H.

Free Radic Biol Med. 1988;4(2):85-91.

PMID:
3345921

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