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IFN-γ immune priming of macrophages in vivo induces prolonged STAT1 binding and protection against Cryptococcus neoformans.

Leopold Wager CM, Hole CR, Campuzano A, Castro-Lopez N, Cai H, Caballero Van Dyke MC, Wozniak KL, Wang Y, Wormley FL Jr.

PLoS Pathog. 2018 Oct 10;14(10):e1007358. doi: 10.1371/journal.ppat.1007358. eCollection 2018 Oct.


Screening a Repurposing Library for Inhibitors of Multidrug-Resistant Candida auris Identifies Ebselen as a Repositionable Candidate for Antifungal Drug Development.

Wall G, Chaturvedi AK, Wormley FL Jr, Wiederhold NP, Patterson HP, Patterson TF, Lopez-Ribot JL.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e01084-18. doi: 10.1128/AAC.01084-18. Print 2018 Oct.


Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition.

Esher SK, Ost KS, Kohlbrenner MA, Pianalto KM, Telzrow CL, Campuzano A, Nichols CB, Munro C, Wormley FL Jr, Alspaugh JA.

PLoS Pathog. 2018 Jun 4;14(6):e1007126. doi: 10.1371/journal.ppat.1007126. eCollection 2018 Jun.


Innate Immunity against Cryptococcus, from Recognition to Elimination.

Campuzano A, Wormley FL.

J Fungi (Basel). 2018 Mar 7;4(1). pii: E33. doi: 10.3390/jof4010033. Review.


Induction of Broad-Spectrum Protective Immunity against Disparate Cryptococcus Serotypes.

Van Dyke MCC, Chaturvedi AK, Hardison SE, Leopold Wager CM, Castro-Lopez N, Hole CR, Wozniak KL, Wormley FL Jr.

Front Immunol. 2017 Oct 30;8:1359. doi: 10.3389/fimmu.2017.01359. eCollection 2017.


A Call to Arms: Quest for a Cryptococcal Vaccine.

Caballero Van Dyke MC, Wormley FL Jr.

Trends Microbiol. 2018 May;26(5):436-446. doi: 10.1016/j.tim.2017.10.002. Epub 2017 Nov 2. Review.


Methodology for Anti-Cryptococcal Vaccine Development.

Chaturvedi AK, Wormley FL Jr.

Methods Mol Biol. 2017;1625:129-140. doi: 10.1007/978-1-4939-7104-6_10.


Rim Pathway-Mediated Alterations in the Fungal Cell Wall Influence Immune Recognition and Inflammation.

Ost KS, Esher SK, Leopold Wager CM, Walker L, Wagener J, Munro C, Wormley FL Jr, Alspaugh JA.

MBio. 2017 Jan 31;8(1). pii: e02290-16. doi: 10.1128/mBio.02290-16.


Dectin-3 Is Not Required for Protection against Cryptococcus neoformans Infection.

Campuzano A, Castro-Lopez N, Wozniak KL, Leopold Wager CM, Wormley FL Jr.

PLoS One. 2017 Jan 20;12(1):e0169347. doi: 10.1371/journal.pone.0169347. eCollection 2017.


Antifungal Activity of Plasmacytoid Dendritic Cells against Cryptococcus neoformans In Vitro Requires Expression of Dectin-3 (CLEC4D) and Reactive Oxygen Species.

Hole CR, Leopold Wager CM, Mendiola AS, Wozniak KL, Campuzano A, Lin X, Wormley FL Jr.

Infect Immun. 2016 Aug 19;84(9):2493-504. doi: 10.1128/IAI.00103-16. Print 2016 Sep.


Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi.

Wiederhold NP, Patterson TF, Srinivasan A, Chaturvedi AK, Fothergill AW, Wormley FL, Ramasubramanian AK, Lopez-Ribot JL.

Virulence. 2017 Feb 17;8(2):138-142. doi: 10.1080/21505594.2016.1196301. Epub 2016 Jun 7.


Statins reduce spirochetal burden and modulate immune responses in the C3H/HeN mouse model of Lyme disease.

Van Laar TA, Hole C, Rajasekhar Karna SL, Miller CL, Reddick R, Wormley FL, Seshu J.

Microbes Infect. 2016 Jun;18(6):430-435. doi: 10.1016/j.micinf.2016.03.004. Epub 2016 Mar 16.


Innate host defenses against Cryptococcus neoformans.

Hole C, Wormley FL Jr.

J Microbiol. 2016 Mar;54(3):202-11. doi: 10.1007/s12275-016-5625-7. Epub 2016 Feb 27. Review.


Cryptococcus and Phagocytes: Complex Interactions that Influence Disease Outcome.

Leopold Wager CM, Hole CR, Wozniak KL, Wormley FL Jr.

Front Microbiol. 2016 Feb 9;7:105. doi: 10.3389/fmicb.2016.00105. eCollection 2016. Review.


Development of protective inflammation and cell-mediated immunity against Cryptococcus neoformans after exposure to hyphal mutants.

Zhai B, Wozniak KL, Masso-Silva J, Upadhyay S, Hole C, Rivera A, Wormley FL Jr, Lin X.

MBio. 2015 Oct 6;6(5):e01433-15. doi: 10.1128/mBio.01433-15.


STAT1 signaling within macrophages is required for antifungal activity against Cryptococcus neoformans.

Leopold Wager CM, Hole CR, Wozniak KL, Olszewski MA, Mueller M, Wormley FL Jr.

Infect Immun. 2015 Dec;83(12):4513-27. doi: 10.1128/IAI.00935-15. Epub 2015 Sep 8.


Is Development of a Vaccine against Cryptococcus neoformans Feasible?

Leopold Wager CM, Wormley FL Jr.

PLoS Pathog. 2015 Jun 18;11(6):e1004843. doi: 10.1371/journal.ppat.1004843. eCollection 2015 Jun. Review. No abstract available.


Cryptococcal heat shock protein 70 homolog Ssa1 contributes to pulmonary expansion of Cryptococcus neoformans during the afferent phase of the immune response by promoting macrophage M2 polarization.

Eastman AJ, He X, Qiu Y, Davis MJ, Vedula P, Lyons DM, Park YD, Hardison SE, Malachowski AN, Osterholzer JJ, Wormley FL Jr, Williamson PR, Olszewski MA.

J Immunol. 2015 Jun 15;194(12):5999-6010. doi: 10.4049/jimmunol.1402719. Epub 2015 May 13.


Candida albicans VPS4 contributes differentially to epithelial and mucosal pathogenesis.

Rane HS, Hardison S, Botelho C, Bernardo SM, Wormley F Jr, Lee SA.

Virulence. 2014;5(8):810-8. doi: 10.4161/21505594.2014.956648. Epub 2014 Oct 31.


Molecules at the interface of Cryptococcus and the host that determine disease susceptibility.

Wozniak KL, Olszewski MA, Wormley FL Jr.

Fungal Genet Biol. 2015 May;78:87-92. doi: 10.1016/j.fgb.2014.10.013. Epub 2014 Nov 1. Review.


STAT1 signaling is essential for protection against Cryptococcus neoformans infection in mice.

Leopold Wager CM, Hole CR, Wozniak KL, Olszewski MA, Wormley FL Jr.

J Immunol. 2014 Oct 15;193(8):4060-71. doi: 10.4049/jimmunol.1400318. Epub 2014 Sep 8.


Vaccine-mediated immune responses to experimental pulmonary Cryptococcus gattii infection in mice.

Chaturvedi AK, Hameed RS, Wozniak KL, Hole CR, Leopold Wager CM, Weintraub ST, Lopez-Ribot JL, Wormley FL Jr.

PLoS One. 2014 Aug 13;9(8):e104316. doi: 10.1371/journal.pone.0104316. eCollection 2014.


Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis.

Feretzaki M, Hardison SE, Wormley FL Jr, Heitman J.

PLoS One. 2014 Aug 5;9(8):e104432. doi: 10.1371/journal.pone.0104432. eCollection 2014.


Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections.

Leopold Wager CM, Wormley FL Jr.

Mucosal Immunol. 2014 Sep;7(5):1023-35. doi: 10.1038/mi.2014.65. Epub 2014 Jul 30. Review.


Characterization of IL-22 and antimicrobial peptide production in mice protected against pulmonary Cryptococcus neoformans infection.

Wozniak KL, Hole CR, Yano J, Fidel PL Jr, Wormley FL Jr.

Microbiology. 2014 Jul;160(Pt 7):1440-52. doi: 10.1099/mic.0.073445-0. Epub 2014 Apr 23.


Identification and characterization of Cryptococcus neoformans protein fractions that induce protective immune responses.

Chaturvedi AK, Weintraub ST, Lopez-Ribot JL, Wormley FL Jr.

Proteomics. 2013 Dec;13(23-24):3429-41. doi: 10.1002/pmic.201300213.


Cryptococcus antigens and immune responses: implications for a vaccine.

Chaturvedi AK, Wormley FL Jr.

Expert Rev Vaccines. 2013 Nov;12(11):1261-72. doi: 10.1586/14760584.2013.840094. Review.


Depletion of neutrophils in a protective model of pulmonary cryptococcosis results in increased IL-17A production by γδ T cells.

Wozniak KL, Kolls JK, Wormley FL Jr.

BMC Immunol. 2012 Dec 7;13:65. doi: 10.1186/1471-2172-13-65.


Mechanisms of dendritic cell lysosomal killing of Cryptococcus.

Hole CR, Bui H, Wormley FL Jr, Wozniak KL.

Sci Rep. 2012;2:739. doi: 10.1038/srep00739. Epub 2012 Oct 16.


The acute neutrophil response mediated by S100 alarmins during vaginal Candida infections is independent of the Th17-pathway.

Yano J, Kolls JK, Happel KI, Wormley F, Wozniak KL, Fidel PL Jr.

PLoS One. 2012;7(9):e46311. doi: 10.1371/journal.pone.0046311. Epub 2012 Sep 25.


Protective immunity against pulmonary cryptococcosis is associated with STAT1-mediated classical macrophage activation.

Hardison SE, Herrera G, Young ML, Hole CR, Wozniak KL, Wormley FL Jr.

J Immunol. 2012 Oct 15;189(8):4060-8. doi: 10.4049/jimmunol.1103455. Epub 2012 Sep 14.


Vaccine and immunotherapeutic approaches for the prevention of cryptococcosis: lessons learned from animal models.

Hole CR, Wormley FL Jr.

Front Microbiol. 2012 Aug 28;3:291. doi: 10.3389/fmicb.2012.00291. eCollection 2012.


Immunology of fungal infections: lessons learned from animal models.

Steele C, Wormley FL Jr.

Curr Opin Microbiol. 2012 Aug;15(4):413-9. doi: 10.1016/j.mib.2012.05.017. Epub 2012 Jul 2. Review.


Fatal disseminated Cryptococcus gattii infection in New Mexico.

Walraven CJ, Gerstein W, Hardison SE, Wormley F, Lockhart SR, Harris JR, Fothergill A, Wickes B, Gober-Wilcox J, Massie L, Ku TS, Firacative C, Meyer W, Lee SA.

PLoS One. 2011;6(12):e28625. doi: 10.1371/journal.pone.0028625. Epub 2011 Dec 14.


Induction of protective immunity against cryptococcosis.

Wozniak KL, Hardison S, Olszewski M, Wormley FL Jr.

Mycopathologia. 2012 Jun;173(5-6):387-94. doi: 10.1007/s11046-011-9505-8. Epub 2011 Dec 6. Review.


Validation of the tetracycline regulatable gene expression system for the study of the pathogenesis of infectious disease.

Chaturvedi AK, Lazzell AL, Saville SP, Wormley FL Jr, Monteagudo C, Lopez-Ribot JL.

PLoS One. 2011;6(5):e20449. doi: 10.1371/journal.pone.0020449. Epub 2011 May 25.


Protective immunity against experimental pulmonary cryptococcosis in T cell-depleted mice.

Wozniak KL, Young ML, Wormley FL Jr.

Clin Vaccine Immunol. 2011 May;18(5):717-23. doi: 10.1128/CVI.00036-11. Epub 2011 Mar 30.


Role of IL-17A on resolution of pulmonary C. neoformans infection.

Wozniak KL, Hardison SE, Kolls JK, Wormley FL.

PLoS One. 2011 Feb 17;6(2):e17204. doi: 10.1371/journal.pone.0017204.


Interleukin-17 is not required for classical macrophage activation in a pulmonary mouse model of Cryptococcus neoformans infection.

Hardison SE, Wozniak KL, Kolls JK, Wormley FL Jr.

Infect Immun. 2010 Dec;78(12):5341-51. doi: 10.1128/IAI.00845-10. Epub 2010 Oct 4.


Pulmonary infection with an interferon-gamma-producing Cryptococcus neoformans strain results in classical macrophage activation and protection.

Hardison SE, Ravi S, Wozniak KL, Young ML, Olszewski MA, Wormley FL Jr.

Am J Pathol. 2010 Feb;176(2):774-85. doi: 10.2353/ajpath.2010.090634. Epub 2010 Jan 7.


Insights into the mechanisms of protective immunity against Cryptococcus neoformans infection using a mouse model of pulmonary cryptococcosis.

Wozniak KL, Ravi S, Macias S, Young ML, Olszewski MA, Steele C, Wormley FL.

PLoS One. 2009 Sep 3;4(9):e6854. doi: 10.1371/journal.pone.0006854.


A proteomic-based approach for the identification of immunodominant Cryptococcus neoformans proteins.

Young M, Macias S, Thomas D, Wormley FL Jr.

Proteomics. 2009 May;9(9):2578-88. doi: 10.1002/pmic.200800713.


Biofilm formation by Cryptococcus neoformans under distinct environmental conditions.

Ravi S, Pierce C, Witt C, Wormley FL Jr.

Mycopathologia. 2009 Jun;167(6):307-14. doi: 10.1007/s11046-008-9180-6. Epub 2009 Jan 8.


A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing.

Pierce CG, Uppuluri P, Tristan AR, Wormley FL Jr, Mowat E, Ramage G, Lopez-Ribot JL.

Nat Protoc. 2008;3(9):1494-500. doi: 10.1038/nport.2008.141.


Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain.

Wormley FL Jr, Perfect JR, Steele C, Cox GM.

Infect Immun. 2007 Mar;75(3):1453-62. Epub 2007 Jan 8.


Identification and characterization of an SKN7 homologue in Cryptococcus neoformans.

Wormley FL Jr, Heinrich G, Miller JL, Perfect JR, Cox GM.

Infect Immun. 2005 Aug;73(8):5022-30.


Immunology of infection caused by Cryptococcus neoformans.

Wormley FL Jr, Perfect JR.

Methods Mol Med. 2005;118:193-8.


The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.

Onyewu C, Wormley FL Jr, Perfect JR, Heitman J.

Infect Immun. 2004 Dec;72(12):7330-3.


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