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Items: 1 to 50 of 108

1.

d-Idose, d-Iduronic Acid, and d-Idonic Acid from d-Glucose via Seven-Carbon Sugars.

Liu Z, Jenkinson SF, Yoshihara A, Wormald MR, Izumori K, Fleet GWJ.

Molecules. 2019 Oct 18;24(20). pii: E3758. doi: 10.3390/molecules24203758.

2.

Isolation from Stevia rebaudiana of DMDP acetic acid, a novel iminosugar amino acid: synthesis and glycosidase inhibition profile of glycine and β-alanine pyrrolidine amino acids.

Martínez RF, Jenkinson SF, Nakagawa S, Kato A, Wormald MR, Fleet GWJ, Hollinshead J, Nash RJ.

Amino Acids. 2019 Jul;51(7):991-998. doi: 10.1007/s00726-019-02730-5. Epub 2019 May 11.

PMID:
31079215
3.

Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity.

Reeves EP, Dunlea DM, McQuillan K, O'Dwyer CA, Carroll TP, Saldova R, Akepati PR, Wormald MR, McElvaney OJ, Shutchaidat V, Henry M, Meleady P, Keenan J, Liberti DC, Kotton DN, Rudd PM, Wilson AA, McElvaney NG.

J Immunol. 2019 Apr 15;202(8):2240-2253. doi: 10.4049/jimmunol.1801045. Epub 2019 Feb 22.

4.

Ataluren, a New Therapeutic for Alpha-1 Antitrypsin-Deficient Individuals with Nonsense Mutations.

Reeves EP, O'Dwyer CA, Dunlea DM, Wormald MR, Hawkins P, Alfares M, Kotton DN, Rowe SM, Wilson AA, McElvaney NG.

Am J Respir Crit Care Med. 2018 Oct 15;198(8):1099-1102. doi: 10.1164/rccm.201802-0338LE. No abstract available.

5.

Erratum: At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody.

Yu C, Gao K, Zhu L, Wang W, Wang L, Zhang F, Liu C, Li M, Wormald MR, Rudd PM, Wang J.

Sci Rep. 2017 Jun 30;7:46385. doi: 10.1038/srep46385.

6.

Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation.

Caldwell JM, Collins MH, Kemme KA, Sherrill JD, Wen T, Rochman M, Stucke EM, Amin L, Tai H, Putnam PE, Jiménez-Dalmaroni MJ, Wormald MR, Porollo A, Abonia JP, Rothenberg ME.

Mucosal Immunol. 2017 Sep;10(5):1190-1201. doi: 10.1038/mi.2016.120. Epub 2017 Jan 4.

7.

Fc gamma receptors: glycobiology and therapeutic prospects.

Hayes JM, Wormald MR, Rudd PM, Davey GP.

J Inflamm Res. 2016 Nov 16;9:209-219. eCollection 2016. Review.

8.

Synthetic Chemical Inducers and Genetic Decoupling Enable Orthogonal Control of the rhaBAD Promoter.

Kelly CL, Liu Z, Yoshihara A, Jenkinson SF, Wormald MR, Otero J, Estévez A, Kato A, Marqvorsen MH, Fleet GW, Estévez RJ, Izumori K, Heap JT.

ACS Synth Biol. 2016 Oct 21;5(10):1136-1145. Epub 2016 Jun 21.

9.

Triacetonide of Glucoheptonic Acid in the Scalable Syntheses of d-Gulose, 6-Deoxy-d-gulose, l-Glucose, 6-Deoxy-l-glucose, and Related Sugars.

Liu Z, Yoshihara A, Jenkinson SF, Wormald MR, Estévez RJ, Fleet GW, Izumori K.

Org Lett. 2016 Aug 19;18(16):4112-5. doi: 10.1021/acs.orglett.6b02041. Epub 2016 Aug 3.

PMID:
27487167
10.

Comprehensive N-Glycan Profiling of Avian Immunoglobulin Y.

Gilgunn S, Millán Martín S, Wormald MR, Zapatero-Rodríguez J, Conroy PJ, O'Kennedy RJ, Rudd PM, Saldova R.

PLoS One. 2016 Jul 26;11(7):e0159859. doi: 10.1371/journal.pone.0159859. eCollection 2016.

11.

6-Deoxyhexoses from l-Rhamnose in the Search for Inducers of the Rhamnose Operon: Synergy of Chemistry and Biotechnology.

Liu Z, Yoshihara A, Kelly C, Heap JT, Marqvorsen MH, Jenkinson SF, Wormald MR, Otero JM, Estévez A, Kato A, Fleet GW, Estévez RJ, Izumori K.

Chemistry. 2016 Aug 22;22(35):12557-65. doi: 10.1002/chem.201602482. Epub 2016 Jul 21.

12.

At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody.

Yu C, Gao K, Zhu L, Wang W, Wang L, Zhang F, Liu C, Li M, Wormald MR, Rudd PM, Wang J.

Sci Rep. 2016 Jan 29;7:20029. doi: 10.1038/srep20029. Erratum in: Sci Rep. 2017 Jun 30;7:46385.

13.

Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs.

Zhang P, Woen S, Wang T, Liau B, Zhao S, Chen C, Yang Y, Song Z, Wormald MR, Yu C, Rudd PM.

Drug Discov Today. 2016 May;21(5):740-65. doi: 10.1016/j.drudis.2016.01.006. Epub 2016 Jan 25. Review.

14.

The BLT1 Inhibitory Function of α-1 Antitrypsin Augmentation Therapy Disrupts Leukotriene B4 Neutrophil Signaling.

O'Dwyer CA, O'Brien ME, Wormald MR, White MM, Banville N, Hurley K, McCarthy C, McElvaney NG, Reeves EP.

J Immunol. 2015 Oct 15;195(8):3628-41. doi: 10.4049/jimmunol.1500038. Epub 2015 Sep 14.

15.

3-Fluoroazetidinecarboxylic Acids and trans,trans-3,4-Difluoroproline as Peptide Scaffolds: Inhibition of Pancreatic Cancer Cell Growth by a Fluoroazetidine Iminosugar.

Liu Z, Jenkinson SF, Vermaas T, Adachi I, Wormald MR, Hata Y, Kurashima Y, Kaji A, Yu CY, Kato A, Fleet GW.

J Org Chem. 2015 May 1;80(9):4244-58. doi: 10.1021/acs.joc.5b00463. Epub 2015 Apr 17.

PMID:
25859886
16.

L-fucose from vitamin C with only acetonide protection.

Liu Z, Yoshihara A, Wormald MR, Jenkinson SF, Gibson V, Izumori K, Fleet GW.

Org Lett. 2014 Nov 7;16(21):5663-5. doi: 10.1021/ol502733x. Epub 2014 Oct 13.

PMID:
25310515
17.

The role and importance of glycosylation of acute phase proteins with focus on alpha-1 antitrypsin in acute and chronic inflammatory conditions.

McCarthy C, Saldova R, Wormald MR, Rudd PM, McElvaney NG, Reeves EP.

J Proteome Res. 2014 Jul 3;13(7):3131-43. doi: 10.1021/pr500146y. Epub 2014 Jun 12. Review.

PMID:
24892502
18.

Nine of 16 stereoisomeric polyhydroxylated proline amides are potent β-N-acetylhexosaminidase inhibitors.

Ayers BJ, Glawar AF, Martínez RF, Ngo N, Liu Z, Fleet GW, Butters TD, Nash RJ, Yu CY, Wormald MR, Nakagawa S, Adachi I, Kato A, Jenkinson SF.

J Org Chem. 2014 Apr 18;79(8):3398-409. doi: 10.1021/jo500157p. Epub 2014 Apr 7.

PMID:
24641544
19.

Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids.

Jiménez-Dalmaroni MJ, Radcliffe CM, Harvey DJ, Wormald MR, Verdino P, Ainge GD, Larsen DS, Painter GF, Ulevitch R, Beutler B, Rudd PM, Dwek RA, Wilson IA.

Innate Immun. 2015 Feb;21(2):175-93. doi: 10.1177/1753425914524077. Epub 2014 Mar 3.

20.

The presence of outer arm fucose residues on the N-glycans of tissue inhibitor of metalloproteinases-1 reduces its activity.

Kim HIe, Saldova R, Park JH, Lee YH, Harvey DJ, Wormald MR, Wynne K, Elia G, Kim HJ, Rudd PM, Lee ST.

J Proteome Res. 2013 Aug 2;12(8):3547-60. doi: 10.1021/pr400276r. Epub 2013 Jul 1.

PMID:
23815085
21.

N-linked glycan structures of the human Fcγ receptors produced in NS0 cells.

Cosgrave EF, Struwe WB, Hayes JM, Harvey DJ, Wormald MR, Rudd PM.

J Proteome Res. 2013 Aug 2;12(8):3721-37. doi: 10.1021/pr400344h. Epub 2013 Jul 11.

PMID:
23777450
22.

Synthesis from D-altrose of (5R,6R,7R,8S)-5,7-dihydroxy-8-hydroxymethylconidine and 2,4-dideoxy-2,4-imino-D-glucitol, azetidine analogues of swainsonine and 1,4-dideoxy-1,4-imino-D-mannitol.

Araújo N, Jenkinson SF, Martínez RF, Glawar AF, Wormald MR, Butters TD, Nakagawa S, Adachi I, Kato A, Yoshihara A, Akimitsu K, Izumori K, Fleet GW.

Org Lett. 2012 Aug 17;14(16):4174-7. Epub 2012 Jul 27.

PMID:
22839435
23.

Modeling of the N-glycosylated transferrin receptor suggests how transferrin binding can occur within the surface coat of Trypanosoma brucei.

Mehlert A, Wormald MR, Ferguson MA.

PLoS Pathog. 2012;8(4):e1002618. doi: 10.1371/journal.ppat.1002618. Epub 2012 Apr 5.

24.

Eight stereoisomers of homonojirimycin from D-mannose.

Lenagh-Snow GM, Jenkinson SF, Newberry SJ, Kato A, Nakagawa S, Adachi I, Wormald MR, Yoshihara A, Morimoto K, Akimitsu K, Izumori K, Fleet GW.

Org Lett. 2012 Apr 20;14(8):2050-3. doi: 10.1021/ol3005744. Epub 2012 Apr 3.

PMID:
22472134
25.

Differential N-glycosylation of a monoclonal antibody expressed in tobacco leaves with and without endoplasmic reticulum retention signal apparently induces similar in vivo stability in mice.

Triguero A, Cabrera G, Rodríguez M, Soto J, Zamora Y, Pérez M, Wormald MR, Cremata JA.

Plant Biotechnol J. 2011 Dec;9(9):1120-30. doi: 10.1111/j.1467-7652.2011.00638.x. Epub 2011 Aug 7.

26.

High throughput isolation and glycosylation analysis of IgG-variability and heritability of the IgG glycome in three isolated human populations.

Pucić M, Knezević A, Vidic J, Adamczyk B, Novokmet M, Polasek O, Gornik O, Supraha-Goreta S, Wormald MR, Redzić I, Campbell H, Wright A, Hastie ND, Wilson JF, Rudan I, Wuhrer M, Rudd PM, Josić D, Lauc G.

Mol Cell Proteomics. 2011 Oct;10(10):M111.010090. doi: 10.1074/mcp.M111.010090. Epub 2011 Jun 8.

27.

Tuning the cavity of cyclodextrins: altered sugar adaptors in protein pores.

Li WW, Claridge TD, Li Q, Wormald MR, Davis BG, Bayley H.

J Am Chem Soc. 2011 Feb 16;133(6):1987-2001. doi: 10.1021/ja1100867. Epub 2011 Jan 18.

PMID:
21244029
28.

4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group.

da Cruz FP, Newberry S, Jenkinson SF, Wormald MR, Butters TD, Alonzi DS, Nakagawa S, Becq F, Norez C, Nash RJ, Kato A, Fleet GW.

Tetrahedron Lett. 2011 Jan 12;52(2):219-223.

29.

A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.

Doores KJ, Fulton Z, Hong V, Patel MK, Scanlan CN, Wormald MR, Finn MG, Burton DR, Wilson IA, Davis BG.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17107-12. doi: 10.1073/pnas.1002717107. Epub 2010 Sep 17.

30.

Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans.

Dunlop DC, Bonomelli C, Mansab F, Vasiljevic S, Doores KJ, Wormald MR, Palma AS, Feizi T, Harvey DJ, Dwek RA, Crispin M, Scanlan CN.

Glycobiology. 2010 Jul;20(7):812-23. doi: 10.1093/glycob/cwq020. Epub 2010 Feb 24.

31.

Synthesis and solution-phase conformation of the RG-I fragment of the plant polysaccharide pectin reveals a modification-modulated assembly mechanism.

Scanlan EM, Mackeen MM, Wormald MR, Davis BG.

J Am Chem Soc. 2010 Jun 2;132(21):7238-9. doi: 10.1021/ja9090963.

PMID:
20099847
32.

The conformational properties of the Glc3Man unit suggest conformational biasing within the chaperone-assisted glycoprotein folding pathway.

Mackeen MM, Almond A, Deschamps M, Cumpstey I, Fairbanks AJ, Tsang C, Rudd PM, Butters TD, Dwek RA, Wormald MR.

J Mol Biol. 2009 Mar 27;387(2):335-47. doi: 10.1016/j.jmb.2009.01.043. Epub 2009 Jan 29.

PMID:
19356590
33.

Design, synthesis, and biological evaluation of enantiomeric beta-N-acetylhexosaminidase inhibitors LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff disease.

Rountree JS, Butters TD, Wormald MR, Boomkamp SD, Dwek RA, Asano N, Ikeda K, Evinson EL, Nash RJ, Fleet GW.

ChemMedChem. 2009 Mar;4(3):378-92. doi: 10.1002/cmdc.200800350.

PMID:
19145603
34.

Glycosylation changes on serum glycoproteins in ovarian cancer may contribute to disease pathogenesis.

Saldova R, Wormald MR, Dwek RA, Rudd PM.

Dis Markers. 2008;25(4-5):219-32. Review.

35.

Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.

Scanlan CN, Ritchie GE, Baruah K, Crispin M, Harvey DJ, Singer BB, Lucka L, Wormald MR, Wentworth P Jr, Zitzmann N, Rudd PM, Burton DR, Dwek RA.

J Mol Biol. 2007 Sep 7;372(1):16-22. Epub 2007 Jun 16.

PMID:
17631311
36.

Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin.

Ziółkowska NE, Shenoy SR, O'Keefe BR, McMahon JB, Palmer KE, Dwek RA, Wormald MR, Wlodawer A.

Proteins. 2007 May 15;67(3):661-70.

PMID:
17340634
37.

Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor.

Radcliffe CM, Arnold JN, Suter DM, Wormald MR, Harvey DJ, Royle L, Mimura Y, Kimura Y, Sim RB, Inogès S, Rodriguez-Calvillo M, Zabalegui N, de Cerio AL, Potter KN, Mockridge CI, Dwek RA, Bendandi M, Rudd PM, Stevenson FK.

J Biol Chem. 2007 Mar 9;282(10):7405-15. Epub 2006 Dec 29.

38.

Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3.

Fry SA, Van den Steen PE, Royle L, Wormald MR, Leathem AJ, Opdenakker G, McDonnell JM, Dwek RA, Rudd PM.

Biochemistry. 2006 Dec 26;45(51):15249-58. Epub 2006 Dec 6.

PMID:
17176047
39.

Structural comparison of differently glycosylated forms of acid-beta-glucosidase, the defective enzyme in Gaucher disease.

Brumshtein B, Wormald MR, Silman I, Futerman AH, Sussman JL.

Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1458-65. Epub 2006 Nov 23.

PMID:
17139081
40.

The impact of glycosylation on the biological function and structure of human immunoglobulins.

Arnold JN, Wormald MR, Sim RB, Rudd PM, Dwek RA.

Annu Rev Immunol. 2007;25:21-50. Review.

PMID:
17029568
41.

Structural aspects of glycomes with a focus on N-glycosylation and glycoprotein folding.

Petrescu AJ, Wormald MR, Dwek RA.

Curr Opin Struct Biol. 2006 Oct;16(5):600-7. Epub 2006 Aug 30. Review.

PMID:
16938454
42.

Sialylation of urinary prothrombin fragment 1 is implicated as a contributory factor in the risk of calcium oxalate kidney stone formation.

Webber D, Radcliffe CM, Royle L, Tobiasen G, Merry AH, Rodgers AL, Sturrock ED, Wormald MR, Harvey DJ, Dwek RA, Rudd PM.

FEBS J. 2006 Jul;273(13):3024-37.

43.

Chromophore structure in the photocycle of the cyanobacterial phytochrome Cph1.

van Thor JJ, Mackeen M, Kuprov I, Dwek RA, Wormald MR.

Biophys J. 2006 Sep 1;91(5):1811-22. Epub 2006 Jun 2.

44.
45.

Variable region heavy chain glycosylation determines the anticoagulant activity of a factor VIII antibody.

Jacquemin M, Radcliffe CM, Lavend'homme R, Wormald MR, Vanderelst L, Wallays G, Dewaele J, Collen D, Vermylen J, Dwek RA, Saint-Remy JM, Rudd PM, Dewerchin M.

J Thromb Haemost. 2006 May;4(5):1047-55.

46.

The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors.

Van den Steen PE, Van Aelst I, Hvidberg V, Piccard H, Fiten P, Jacobsen C, Moestrup SK, Fry S, Royle L, Wormald MR, Wallis R, Rudd PM, Dwek RA, Opdenakker G.

J Biol Chem. 2006 Jul 7;281(27):18626-37. Epub 2006 May 3.

47.

Remnant epitopes, autoimmunity and glycosylation.

Opdenakker G, Dillen C, Fiten P, Martens E, Van Aelst I, Van den Steen PE, Nelissen I, Starckx S, Descamps FJ, Hu J, Piccard H, Van Damme J, Wormald MR, Rudd PM, Dwek RA.

Biochim Biophys Acta. 2006 Apr;1760(4):610-5. Epub 2006 Jan 6. Review.

PMID:
16439062
48.

Differential glycosylation of gelatinase B from neutrophils and breast cancer cells.

Fry SA, Van den Steen PE, Royle L, Wormald MR, Leathem AJ, Opdenakker G, Rudd PM, Dwek RA.

Adv Exp Med Biol. 2005;564:103-12. No abstract available.

PMID:
16400814
49.

Glycosylation influences the lectin activities of the macrophage mannose receptor.

Su Y, Bakker T, Harris J, Tsang C, Brown GD, Wormald MR, Gordon S, Dwek RA, Rudd PM, Martinez-Pomares L.

J Biol Chem. 2005 Sep 23;280(38):32811-20. Epub 2005 Jun 27.

50.

Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin.

Arnold JN, Wormald MR, Suter DM, Radcliffe CM, Harvey DJ, Dwek RA, Rudd PM, Sim RB.

J Biol Chem. 2005 Aug 12;280(32):29080-7. Epub 2005 Jun 14.

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