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Items: 1 to 50 of 224

1.

Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy.

Thannickal TC, John J, Shan L, Swaab DF, Wu MF, Ramanathan L, McGregor R, Chew KT, Cornford M, Yamanaka A, Inutsuka A, Fronczek R, Lammers GJ, Worley PF, Siegel JM.

Sci Transl Med. 2018 Jun 27;10(447). pii: eaao4953. doi: 10.1126/scitranslmed.aao4953.

PMID:
29950444
2.

Clinical and Diagnostic Significance of Homer1 in hepatitis B virus-induced Hepatocellular Carcinoma.

Luo P, Feng X, Jing W, Zhu M, Li N, Zhou H, Worley PF, Chai H, Tu J.

J Cancer. 2018 Jan 11;9(4):683-689. doi: 10.7150/jca.22279. eCollection 2018.

3.

FRMPD4 mutations cause X-linked intellectual disability and disrupt dendritic spine morphogenesis.

Piard J, Hu JH, Campeau PM, Rzonca S, Van Esch H, Vincent E, Han M, Rossignol E, Castaneda J, Chelly J, Skinner C, Kalscheuer VM, Wang R, Lemyre E, Kosinska J, Stawinski P, Bal J, Hoffman DA, Schwartz CE, Van Maldergem L, Wang T, Worley PF.

Hum Mol Genet. 2018 Feb 15;27(4):589-600. doi: 10.1093/hmg/ddx426.

PMID:
29267967
4.

Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells.

Peng H, Kasada A, Ueno M, Hoshii T, Tadokoro Y, Nomura N, Ito C, Takase Y, Vu HT, Kobayashi M, Xiao B, Worley PF, Hirao A.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):1129-1135. doi: 10.1016/j.bbrc.2017.11.140. Epub 2017 Nov 22.

PMID:
29175333
5.

Behavioral and Neurochemical Phenotyping of Mice Incapable of Homer1a Induction.

Datko MC, Hu JH, Williams M, Reyes CM, Lominac KD, von Jonquieres G, Klugmann M, Worley PF, Szumlinski KK.

Front Behav Neurosci. 2017 Nov 1;11:208. doi: 10.3389/fnbeh.2017.00208. eCollection 2017.

6.

Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures.

Chang AD, Vaidya PV, Retzbach EP, Chung SJ, Kim U, Baselice K, Maynard K, Stepanian A, Staley M, Xiao L, Blouin A, Han S, Lee J, Worley PF, Tamashiro KL, Hempstead BL, Martinowich K, Ann Wilson M, Baraban JM, Reti IM.

Neuropsychopharmacology. 2018 Apr;43(5):1088-1098. doi: 10.1038/npp.2017.252. Epub 2017 Oct 20.

PMID:
29052614
7.

STIM1 Regulates Somatic Ca2+ Signals and Intrinsic Firing Properties of Cerebellar Purkinje Neurons.

Ryu C, Jang DC, Jung D, Kim YG, Shim HG, Ryu HH, Lee YS, Linden DJ, Worley PF, Kim SJ.

J Neurosci. 2017 Sep 13;37(37):8876-8894. doi: 10.1523/JNEUROSCI.3973-16.2017. Epub 2017 Aug 11.

8.

Exposure to complex environments results in more sparse representations of space in the hippocampus.

Bilkey DK, Cheyne KR, Eckert MJ, Lu X, Chowdhury S, Worley PF, Crandall JE, Abraham WC.

Hippocampus. 2017 Nov;27(11):1178-1191. doi: 10.1002/hipo.22762. Epub 2017 Jul 21.

PMID:
28686801
9.

NPTX2 and cognitive dysfunction in Alzheimer's Disease.

Xiao MF, Xu D, Craig MT, Pelkey KA, Chien CC, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, Brewer J, Edland S, Wegiel J, Tycko B, Savonenko A, Reeves RH, Troncoso JC, McBain CJ, Galasko D, Worley PF.

Elife. 2017 Mar 23;6. pii: e23798. doi: 10.7554/eLife.23798.

10.

Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity.

Ahuja M, Schwartz DM, Tandon M, Son A, Zeng M, Swaim W, Eckhaus M, Hoffman V, Cui Y, Xiao B, Worley PF, Muallem S.

Cell Metab. 2017 Mar 7;25(3):635-646. doi: 10.1016/j.cmet.2017.02.007.

11.

Increased Sparsity of Hippocampal CA1 Neuronal Ensembles in a Mouse Model of Down Syndrome Assayed by Arc Expression.

Smith-Hicks CL, Cai P, Savonenko AV, Reeves RH, Worley PF.

Front Neural Circuits. 2017 Feb 3;11:6. doi: 10.3389/fncir.2017.00006. eCollection 2017.

12.

Dynamic Regulation of Homer Binding to Group I Metabotropic Glutamate Receptors by Preso1 and Converging Kinase Cascades.

Hu JH, Worley PF, Kammermeier PJ.

J Pharmacol Exp Ther. 2017 Apr;361(1):122-129. doi: 10.1124/jpet.116.238394. Epub 2017 Feb 8.

13.

Homer1a drives homeostatic scaling-down of excitatory synapses during sleep.

Diering GH, Nirujogi RS, Roth RH, Worley PF, Pandey A, Huganir RL.

Science. 2017 Feb 3;355(6324):511-515. doi: 10.1126/science.aai8355. Epub 2017 Feb 2.

14.

Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites.

Na Y, Park S, Lee C, Kim DK, Park JM, Sockanathan S, Huganir RL, Worley PF.

Neuron. 2016 Aug 3;91(3):561-73. doi: 10.1016/j.neuron.2016.06.017. Epub 2016 Jul 7.

15.

Pentraxins Coordinate Excitatory Synapse Maturation and Circuit Integration of Parvalbumin Interneurons.

Pelkey KA, Barksdale E, Craig MT, Yuan X, Sukumaran M, Vargish GA, Mitchell RM, Wyeth MS, Petralia RS, Chittajallu R, Karlsson RM, Cameron HA, Murata Y, Colonnese MT, Worley PF, McBain CJ.

Neuron. 2016 May 4;90(3):661. doi: 10.1016/j.neuron.2016.04.024. No abstract available.

16.

Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice.

Guo W, Molinaro G, Collins KA, Hays SA, Paylor R, Worley PF, Szumlinski KK, Huber KM.

J Neurosci. 2016 Feb 17;36(7):2131-47. doi: 10.1523/JNEUROSCI.2921-15.2016.

17.

Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene.

Smothers CT, Szumlinski KK, Worley PF, Woodward JJ.

Synapse. 2016 Jan;70(1):33-9. doi: 10.1002/syn.21869. Epub 2015 Oct 15.

18.

Homer 1a and mGluR5 phosphorylation in reward-sensitive metaplasticity: A hypothesis of neuronal selection and bidirectional synaptic plasticity.

Marton TM, Hussain Shuler MG, Worley PF.

Brain Res. 2015 Dec 2;1628(Pt A):17-28. doi: 10.1016/j.brainres.2015.06.037. Epub 2015 Jul 14. Review.

PMID:
26187757
19.

Cerebellar associative sensory learning defects in five mouse autism models.

Kloth AD, Badura A, Li A, Cherskov A, Connolly SG, Giovannucci A, Bangash MA, Grasselli G, Peñagarikano O, Piochon C, Tsai PT, Geschwind DH, Hansel C, Sahin M, Takumi T, Worley PF, Wang SS.

Elife. 2015 Jul 9;4:e06085. doi: 10.7554/eLife.06085.

20.

Structural basis of arc binding to synaptic proteins: implications for cognitive disease.

Zhang W, Wu J, Ward MD, Yang S, Chuang YA, Xiao M, Li R, Leahy DJ, Worley PF.

Neuron. 2015 Apr 22;86(2):490-500. doi: 10.1016/j.neuron.2015.03.030. Epub 2015 Apr 9.

21.

Protein Kinase C Epsilon Activity in the Nucleus Accumbens and Central Nucleus of the Amygdala Mediates Binge Alcohol Consumption.

Cozzoli DK, Courson J, Rostock C, Campbell RR, Wroten MG, McGregor H, Caruana AL, Miller BW, Hu JH, Wu Zhang P, Xiao B, Worley PF, Crabbe JC, Finn DA, Szumlinski KK.

Biol Psychiatry. 2016 Mar 15;79(6):443-51. doi: 10.1016/j.biopsych.2015.01.019. Epub 2015 Mar 5.

22.

Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons.

Pelkey KA, Barksdale E, Craig MT, Yuan X, Sukumaran M, Vargish GA, Mitchell RM, Wyeth MS, Petralia RS, Chittajallu R, Karlsson RM, Cameron HA, Murata Y, Colonnese MT, Worley PF, McBain CJ.

Neuron. 2015 Mar 18;85(6):1257-72. doi: 10.1016/j.neuron.2015.02.020. Epub 2015 Mar 5.

23.

Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade.

Tyagi R, Shahani N, Gorgen L, Ferretti M, Pryor W, Chen PY, Swarnkar S, Worley PF, Karbstein K, Snyder SH, Subramaniam S.

Cell Rep. 2015 Feb 4. pii: S2211-1247(15)00027-3. doi: 10.1016/j.celrep.2015.01.014. [Epub ahead of print]

24.

Gene expression analyses identify Narp contribution in the development of L-DOPA-induced dyskinesia.

Charbonnier-Beaupel F, Malerbi M, Alcacer C, Tahiri K, Carpentier W, Wang C, During M, Xu D, Worley PF, Girault JA, Hervé D, Corvol JC.

J Neurosci. 2015 Jan 7;35(1):96-111. doi: 10.1523/JNEUROSCI.5231-13.2015.

25.

Rheb1 mediates DISC1-dependent regulation of new neuron development in the adult hippocampus.

Kang E, Kim JY, Liu CY, Xiao B, Chen PY, Christian KM, Worley PF, Song H, Ming GL.

Neurogenesis (Austin). 2015 Nov 10;2(1):e1081715. doi: 10.1080/23262133.2015.1081715. eCollection 2015.

26.

The canonical Notch pathway effector RBP-J regulates neuronal plasticity and expression of GABA transporters in hippocampal networks.

Liu S, Wang Y, Worley PF, Mattson MP, Gaiano N.

Hippocampus. 2015 May;25(5):670-8. doi: 10.1002/hipo.22402. Epub 2015 Mar 27.

27.

Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain.

Zou Y, Jiang W, Wang J, Li Z, Zhang J, Bu J, Zou J, Zhou L, Yu S, Cui Y, Yang W, Luo L, Lu QR, Liu Y, Chen M, Worley PF, Xiao B.

J Neurosci. 2014 Nov 19;34(47):15764-78. doi: 10.1523/JNEUROSCI.2267-14.2014.

28.

Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival.

Huang C, Chen M, Pang D, Bi D, Zou Y, Xia X, Yang W, Luo L, Deng R, Tan H, Zhou L, Yu S, Guo L, Du X, Cui Y, Hu J, Mao Q, Worley PF, Xiao B.

Dev Cell. 2014 Aug 25;30(4):479-87. doi: 10.1016/j.devcel.2014.06.011.

29.

Selective expression of Narp in primary nociceptive neurons: role in microglia/macrophage activation following nerve injury.

Miskimon M, Han S, Lee JJ, Ringkamp M, Wilson MA, Petralia RS, Dong X, Worley PF, Baraban JM, Reti IM.

J Neuroimmunol. 2014 Sep 15;274(1-2):86-95. doi: 10.1016/j.jneuroim.2014.06.016. Epub 2014 Jun 28.

30.

Loss of predominant Shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission.

Kouser M, Speed HE, Dewey CM, Reimers JM, Widman AJ, Gupta N, Liu S, Jaramillo TC, Bangash M, Xiao B, Worley PF, Powell CM.

J Neurosci. 2013 Nov 20;33(47):18448-68. doi: 10.1523/JNEUROSCI.3017-13.2013.

31.

Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model.

Das I, Park JM, Shin JH, Jeon SK, Lorenzi H, Linden DJ, Worley PF, Reeves RH.

Sci Transl Med. 2013 Sep 4;5(201):201ra120. doi: 10.1126/scitranslmed.3005983.

32.

Binge alcohol drinking by mice requires intact group 1 metabotropic glutamate receptor signaling within the central nucleus of the amygdala.

Cozzoli DK, Courson J, Wroten MG, Greentree DI, Lum EN, Campbell RR, Thompson AB, Maliniak D, Worley PF, Jonquieres G, Klugmann M, Finn DA, Szumlinski KK.

Neuropsychopharmacology. 2014 Jan;39(2):435-44. doi: 10.1038/npp.2013.214. Epub 2013 Aug 21.

33.

A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization.

Park JM, Hu JH, Milshteyn A, Zhang PW, Moore CG, Park S, Datko MC, Domingo RD, Reyes CM, Wang XJ, Etzkorn FA, Xiao B, Szumlinski KK, Kern D, Linden DJ, Worley PF.

Cell. 2013 Aug 1;154(3):637-50. doi: 10.1016/j.cell.2013.07.001.

34.

Homers at the Interface between Reward and Pain.

Obara I, Goulding SP, Gould AT, Lominac KD, Hu JH, Zhang PW, von Jonquieres G, Dehoff M, Xiao B, Seeburg PH, Worley PF, Klugmann M, Szumlinski KK.

Front Psychiatry. 2013 Jun 7;4:39. doi: 10.3389/fpsyt.2013.00039. eCollection 2013.

35.

Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic long-term potentiation.

Raynaud F, Janossy A, Dahl J, Bertaso F, Perroy J, Varrault A, Vidal M, Worley PF, Boeckers TM, Bockaert J, Marin P, Fagni L, Homburger V.

J Neurosci. 2013 Jun 5;33(23):9699-715. doi: 10.1523/JNEUROSCI.2725-12.2013.

36.

Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain.

Obara I, Goulding SP, Hu JH, Klugmann M, Worley PF, Szumlinski KK.

Pain. 2013 Oct;154(10):1932-45. doi: 10.1016/j.pain.2013.03.035. Epub 2013 Apr 2.

PMID:
23685007
37.

Medial premotor cortex shows a reduction in inhibitory markers and mediates recovery in a mouse model of focal stroke.

Zeiler SR, Gibson EM, Hoesch RE, Li MY, Worley PF, O'Brien RJ, Krakauer JW.

Stroke. 2013 Feb;44(2):483-9. doi: 10.1161/STROKEAHA.112.676940. Epub 2013 Jan 15. Erratum in: Stroke. 2013 Mar;44(3):e22.

38.

Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ.

Okuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF, Bito H.

Cell. 2012 May 11;149(4):886-98. doi: 10.1016/j.cell.2012.02.062.

39.

Preso1 dynamically regulates group I metabotropic glutamate receptors.

Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF.

Nat Neurosci. 2012 Jun;15(6):836-44. doi: 10.1038/nn.3103.

40.

Epigenetic modulation of Homer1a transcription regulation in amygdala and hippocampus with pavlovian fear conditioning.

Mahan AL, Mou L, Shah N, Hu JH, Worley PF, Ressler KJ.

J Neurosci. 2012 Mar 28;32(13):4651-9. doi: 10.1523/JNEUROSCI.3308-11.2012.

41.

Ethanol up-regulates nucleus accumbens neuronal activity dependent pentraxin (Narp): implications for alcohol-induced behavioral plasticity.

Ary AW, Cozzoli DK, Finn DA, Crabbe JC, Dehoff MH, Worley PF, Szumlinski KK.

Alcohol. 2012 Jun;46(4):377-87. doi: 10.1016/j.alcohol.2011.10.003. Epub 2012 Mar 22.

42.

Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures.

Cozzoli DK, Courson J, Caruana AL, Miller BW, Greentree DI, Thompson AB, Wroten MG, Zhang PW, Xiao B, Hu JH, Klugmann M, Metten P, Worley PF, Crabbe JC, Szumlinski KK.

Alcohol Clin Exp Res. 2012 Sep;36(9):1623-33. doi: 10.1111/j.1530-0277.2012.01776.x. Epub 2012 Mar 20.

43.

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome.

Ronesi JA, Collins KA, Hays SA, Tsai NP, Guo W, Birnbaum SG, Hu JH, Worley PF, Gibson JR, Huber KM.

Nat Neurosci. 2012 Jan 22;15(3):431-40, S1. doi: 10.1038/nn.3033.

44.

Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons.

Mazei-Robison MS, Koo JW, Friedman AK, Lansink CS, Robison AJ, Vinish M, Krishnan V, Kim S, Siuta MA, Galli A, Niswender KD, Appasani R, Horvath MC, Neve RL, Worley PF, Snyder SH, Hurd YL, Cheer JF, Han MH, Russo SJ, Nestler EJ.

Neuron. 2011 Dec 22;72(6):977-90. doi: 10.1016/j.neuron.2011.10.012.

45.

Neuronal activity regulates glutamate transporter dynamics in developing astrocytes.

Benediktsson AM, Marrs GS, Tu JC, Worley PF, Rothstein JD, Bergles DE, Dailey ME.

Glia. 2012 Feb;60(2):175-88. doi: 10.1002/glia.21249. Epub 2011 Nov 2.

46.

Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation.

Wu J, Petralia RS, Kurushima H, Patel H, Jung MY, Volk L, Chowdhury S, Shepherd JD, Dehoff M, Li Y, Kuhl D, Huganir RL, Price DL, Scannevin R, Troncoso JC, Wong PC, Worley PF.

Cell. 2011 Oct 28;147(3):615-28. doi: 10.1016/j.cell.2011.09.036.

47.

Alzheimer's therapeutics: translation of preclinical science to clinical drug development.

Savonenko AV, Melnikova T, Hiatt A, Li T, Worley PF, Troncoso JC, Wong PC, Price DL.

Neuropsychopharmacology. 2012 Jan;37(1):261-77. doi: 10.1038/npp.2011.211. Epub 2011 Sep 21. Review.

48.

Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism.

Bangash MA, Park JM, Melnikova T, Wang D, Jeon SK, Lee D, Syeda S, Kim J, Kouser M, Schwartz J, Cui Y, Zhao X, Speed HE, Kee SE, Tu JC, Hu JH, Petralia RS, Linden DJ, Powell CM, Savonenko A, Xiao B, Worley PF.

Cell. 2011 May 27;145(5):758-72. doi: 10.1016/j.cell.2011.03.052. Epub 2011 May 12. Retraction in: Cell. 2013 Jan 17;152(1-2):367.

49.

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, Xiao B, Worley PF, Powell JD.

Nat Immunol. 2011 Apr;12(4):295-303. doi: 10.1038/ni.2005. Epub 2011 Feb 27.

50.

Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks.

Alberi L, Liu S, Wang Y, Badie R, Smith-Hicks C, Wu J, Pierfelice TJ, Abazyan B, Mattson MP, Kuhl D, Pletnikov M, Worley PF, Gaiano N.

Neuron. 2011 Feb 10;69(3):437-44. doi: 10.1016/j.neuron.2011.01.004.

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