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Items: 1 to 50 of 92


The quantification and regulation of microtubule dynamics in the mitotic spindle.

Vicente JJ, Wordeman L.

Curr Opin Cell Biol. 2019 May 17;60:36-43. doi: 10.1016/ [Epub ahead of print] Review.


GPR124 regulates microtubule assembly, mitotic progression, and glioblastoma cell proliferation.

Cherry AE, Vicente JJ, Xu C, Morrison RS, Ong SE, Wordeman L, Stella N.

Glia. 2019 Aug;67(8):1558-1570. doi: 10.1002/glia.23628. Epub 2019 May 6.


De novo design of self-assembling helical protein filaments.

Shen H, Fallas JA, Lynch E, Sheffler W, Parry B, Jannetty N, Decarreau J, Wagenbach M, Vicente JJ, Chen J, Wang L, Dowling Q, Oberdorfer G, Stewart L, Wordeman L, De Yoreo J, Jacobs-Wagner C, Kollman J, Baker D.

Science. 2018 Nov 9;362(6415):705-709. doi: 10.1126/science.aau3775.


Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells.

Diaz P, Horne E, Xu C, Hamel E, Wagenbach M, Petrov RR, Uhlenbruck B, Haas B, Hothi P, Wordeman L, Gussio R, Stella N.

Eur J Med Chem. 2018 Nov 5;159:74-89. doi: 10.1016/j.ejmech.2018.09.026. Epub 2018 Sep 11.


β-tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cells.

Parker AL, Teo WS, Pandzic E, Vicente JJ, McCarroll JA, Wordeman L, Kavallaris M.

Life Sci Alliance. 2018;1(2). pii: e201800059. doi: 10.26508/lsa.201800059. Epub 2018 Apr 19.


Corrigendum: The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation.

Decarreau J, Wagenbach M, Lynch E, Halpern AR, Vaughan JC, Kollman J, Wordeman L.

Nat Cell Biol. 2017 May 31;19(6):740. doi: 10.1038/ncb3546. No abstract available.


Arf GAPs and molecular motors.

Luo R, Reed CE, Sload JA, Wordeman L, Randazzo PA, Chen PW.

Small GTPases. 2019 May;10(3):196-209. doi: 10.1080/21541248.2017.1308850. Epub 2017 Apr 21.


The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation.

Decarreau J, Wagenbach M, Lynch E, Halpern AR, Vaughan JC, Kollman J, Wordeman L.

Nat Cell Biol. 2017 Apr;19(4):384-390. doi: 10.1038/ncb3486. Epub 2017 Mar 6. Erratum in: Nat Cell Biol. 2017 May 31;19(6):740.


Direct functional interaction of the kinesin-13 family member kinesin-like protein 2A (Kif2A) and Arf GAP with GTP-binding protein-like, ankyrin repeats and PH domains 1 (AGAP1).

Luo R, Chen PW, Wagenbach M, Jian X, Jenkins L, Wordeman L, Randazzo PA.

J Biol Chem. 2016 Dec 2;291(49):25761. No abstract available.


Direct Functional Interaction of the Kinesin-13 Family Member Kinesin-like Protein 2A (Kif2A) and Arf GAP with GTP-binding Protein-like, Ankyrin Repeats and PH Domains1 (AGAP1).

Luo R, Chen PW, Wagenbach M, Jian X, Jenkins L, Wordeman L, Randazzo PA.

J Biol Chem. 2016 Oct 7;291(41):21350-21362. doi: 10.1074/jbc.M116.732479. Epub 2016 Aug 16. Erratum in: J Biol Chem. 2016 Dec 2;291(49):25761.


ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme.

Cherry AE, Haas BR, Naydenov AV, Fung S, Xu C, Swinney K, Wagenbach M, Freeling J, Canton DA, Coy J, Horne EA, Rickman B, Vicente JJ, Scott JD, Ho RJ, Liggitt D, Wordeman L, Stella N.

Mol Cancer Ther. 2016 Sep;15(9):2018-29. doi: 10.1158/1535-7163.MCT-15-0800. Epub 2016 Jun 20.


Molecular insight into the regulation and function of MCAK.

Ritter A, Kreis NN, Louwen F, Wordeman L, Yuan J.

Crit Rev Biochem Mol Biol. 2015 Jul-Aug;51(4):228-45. doi: 10.1080/10409238.2016.1178705. Epub 2016 May 5. Review.


Divergent microtubule assembly rates after short- versus long-term loss of end-modulating kinesins.

Wordeman L, Decarreau J, Vicente JJ, Wagenbach M.

Mol Biol Cell. 2016 Apr 15;27(8):1300-9. doi: 10.1091/mbc.E15-11-0803. Epub 2016 Feb 24.


Oxidative stress decreases microtubule growth and stability in ventricular myocytes.

Drum BM, Yuan C, Li L, Liu Q, Wordeman L, Santana LF.

J Mol Cell Cardiol. 2016 Apr;93:32-43. doi: 10.1016/j.yjmcc.2016.02.012. Epub 2016 Feb 19.


Revisiting Actin's role in early centrosome separation.

Wordeman L, Decarreau J.

Cell Cycle. 2016;15(2):162-3. doi: 10.1080/15384101.2015.1130090. No abstract available.


A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells.

Hehnly H, Canton D, Bucko P, Langeberg LK, Ogier L, Gelman I, Santana LF, Wordeman L, Scott JD.

Elife. 2015 Sep 25;4:e09384. doi: 10.7554/eLife.09384.


HX-MS2 for high performance conformational analysis of complex protein states.

Burns KM, Sarpe V, Wagenbach M, Wordeman L, Schriemer DC.

Protein Sci. 2015 Aug;24(8):1313-24. doi: 10.1002/pro.2707. Epub 2015 May 29. Erratum in: Protein Sci. 2016 Jan;25(1):302-3.


Mitosis, microtubule dynamics and the evolution of kinesins.

Vicente JJ, Wordeman L.

Exp Cell Res. 2015 May 15;334(1):61-9. doi: 10.1016/j.yexcr.2015.02.010. Epub 2015 Feb 20. Review. No abstract available.


Mass spec studio for integrative structural biology.

Rey M, Sarpe V, Burns KM, Buse J, Baker CA, van Dijk M, Wordeman L, Bonvin AM, Schriemer DC.

Structure. 2014 Oct 7;22(10):1538-48. doi: 10.1016/j.str.2014.08.013. Epub 2014 Sep 18.


Nucleotide exchange in dimeric MCAK induces longitudinal and lateral stress at microtubule ends to support depolymerization.

Burns KM, Wagenbach M, Wordeman L, Schriemer DC.

Structure. 2014 Aug 5;22(8):1173-1183. doi: 10.1016/j.str.2014.06.010. Epub 2014 Jul 24.


Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells.

Ertych N, Stolz A, Stenzinger A, Weichert W, Kaulfuß S, Burfeind P, Aigner A, Wordeman L, Bastians H.

Nat Cell Biol. 2014 Aug;16(8):779-91. doi: 10.1038/ncb2994. Epub 2014 Jun 29.


Rapid measurement of mitotic spindle orientation in cultured mammalian cells.

Decarreau J, Driver J, Asbury C, Wordeman L.

Methods Mol Biol. 2014;1136:31-40. doi: 10.1007/978-1-4939-0329-0_2.


Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.

Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW.

Chromosome Res. 2013 Apr;21(2):101-6. doi: 10.1007/s10577-013-9347-y. Epub 2013 Apr 12.


Roles for focal adhesion kinase (FAK) in blastomere abscission and vesicle trafficking during cleavage in the sea urchin embryo.

Schumpert B, García MG, Wessel GM, Wordeman L, Hille MB.

Mech Dev. 2013 Apr-May;130(4-5):290-303. doi: 10.1016/j.mod.2012.12.003. Epub 2013 Jan 8.


Gravin is a transitory effector of polo-like kinase 1 during cell division.

Canton DA, Keene CD, Swinney K, Langeberg LK, Nguyen V, Pelletier L, Pawson T, Wordeman L, Stella N, Scott JD.

Mol Cell. 2012 Nov 30;48(4):547-59. doi: 10.1016/j.molcel.2012.09.002. Epub 2012 Oct 11.


FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility.

Siesser PF, Motolese M, Walker MP, Goldfarb D, Gewain K, Yan F, Kulikauskas RM, Chien AJ, Wordeman L, Major MB.

Sci Signal. 2012 Sep 4;5(240):ra64. doi: 10.1126/scisignal.2002871.


Kif18A and chromokinesins confine centromere movements via microtubule growth suppression and spatial control of kinetochore tension.

Stumpff J, Wagenbach M, Franck A, Asbury CL, Wordeman L.

Dev Cell. 2012 May 15;22(5):1017-29. doi: 10.1016/j.devcel.2012.02.013.


MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment.

Domnitz SB, Wagenbach M, Decarreau J, Wordeman L.

J Cell Biol. 2012 Apr 16;197(2):231-7. doi: 10.1083/jcb.201108147. Epub 2012 Apr 9.


Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.

Sanhaji M, Friel CT, Wordeman L, Louwen F, Yuan J.

Oncotarget. 2011 Dec;2(12):935-47. Review.


AKAP220 protein organizes signaling elements that impact cell migration.

Logue JS, Whiting JL, Tunquist B, Sacks DB, Langeberg LK, Wordeman L, Scott JD.

J Biol Chem. 2011 Nov 11;286(45):39269-81. doi: 10.1074/jbc.M111.277756. Epub 2011 Sep 2.


A tethering mechanism controls the processivity and kinetochore-microtubule plus-end enrichment of the kinesin-8 Kif18A.

Stumpff J, Du Y, English CA, Maliga Z, Wagenbach M, Asbury CL, Wordeman L, Ohi R.

Mol Cell. 2011 Sep 2;43(5):764-75. doi: 10.1016/j.molcel.2011.07.022.


Mip1 associates with both the Mps1 kinase and actin, and is required for cell cortex stability and anaphase spindle positioning.

Mattison CP, Stumpff J, Wordeman L, Winey M.

Cell Cycle. 2011 Mar 1;10(5):783-93. Epub 2011 Mar 1.


In vitro reconstitution of the functional interplay between MCAK and EB3 at microtubule plus ends.

Montenegro Gouveia S, Leslie K, Kapitein LC, Buey RM, Grigoriev I, Wagenbach M, Smal I, Meijering E, Hoogenraad CC, Wordeman L, Steinmetz MO, Akhmanova A.

Curr Biol. 2010 Oct 12;20(19):1717-22. doi: 10.1016/j.cub.2010.08.020. Epub 2010 Sep 16.


Long astral microtubules uncouple mitotic spindles from the cytokinetic furrow.

Rankin KE, Wordeman L.

J Cell Biol. 2010 Jul 12;190(1):35-43. doi: 10.1083/jcb.201004017. Epub 2010 Jul 5.


Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B.

Tien JF, Umbreit NT, Gestaut DR, Franck AD, Cooper J, Wordeman L, Gonen T, Asbury CL, Davis TN.

J Cell Biol. 2010 May 17;189(4):713-23. doi: 10.1083/jcb.200910142.


Reconstitution and functional analysis of kinetochore subcomplexes.

Gestaut DR, Cooper J, Asbury CL, Davis TN, Wordeman L.

Methods Cell Biol. 2010;95:641-56. doi: 10.1016/S0091-679X(10)95032-2. Review.


MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes.

Vogt E, Sanhaji M, Klein W, Seidel T, Wordeman L, Eichenlaub-Ritter U.

Mol Hum Reprod. 2010 Sep;16(9):665-84. doi: 10.1093/molehr/gaq025. Epub 2010 Apr 20.


How kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays.

Wordeman L.

Semin Cell Dev Biol. 2010 May;21(3):260-8. doi: 10.1016/j.semcdb.2010.01.018. Epub 2010 Jan 28. Review.


Catalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK.

Cooper JR, Wagenbach M, Asbury CL, Wordeman L.

Nat Struct Mol Biol. 2010 Jan;17(1):77-82. doi: 10.1038/nsmb.1728. Epub 2009 Dec 6.


Microtubule length control, a team sport?

Wordeman L, Stumpff J.

Dev Cell. 2009 Oct;17(4):437-8. doi: 10.1016/j.devcel.2009.10.002.


Motor-dependent microtubule disassembly driven by tubulin tyrosination.

Peris L, Wagenbach M, Lafanechère L, Brocard J, Moore AT, Kozielski F, Job D, Wordeman L, Andrieux A.

J Cell Biol. 2009 Jun 29;185(7):1159-66. doi: 10.1083/jcb.200902142.


TIP150 interacts with and targets MCAK at the microtubule plus ends.

Jiang K, Wang J, Liu J, Ward T, Wordeman L, Davidson A, Wang F, Yao X.

EMBO Rep. 2009 Aug;10(8):857-65. doi: 10.1038/embor.2009.94. Epub 2009 Jun 19.


A new model for binding of kinesin 13 to curved microtubule protofilaments.

Mulder AM, Glavis-Bloom A, Moores CA, Wagenbach M, Carragher B, Wordeman L, Milligan RA.

J Cell Biol. 2009 Apr 6;185(1):51-7. doi: 10.1083/jcb.200812052. Epub 2009 Mar 30.


The Ndc80 kinetochore complex forms load-bearing attachments to dynamic microtubule tips via biased diffusion.

Powers AF, Franck AD, Gestaut DR, Cooper J, Gracyzk B, Wei RR, Wordeman L, Davis TN, Asbury CL.

Cell. 2009 Mar 6;136(5):865-75. doi: 10.1016/j.cell.2008.12.045.


The diffusive interaction of microtubule binding proteins.

Cooper JR, Wordeman L.

Curr Opin Cell Biol. 2009 Feb;21(1):68-73. doi: 10.1016/ Epub 2009 Jan 29. Review.


A kinesin-13 mutant catalytically depolymerizes microtubules in ADP.

Wagenbach M, Domnitz S, Wordeman L, Cooper J.

J Cell Biol. 2008 Nov 17;183(4):617-23. doi: 10.1083/jcb.200805145. Epub 2008 Nov 10.


Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation.

Gestaut DR, Graczyk B, Cooper J, Widlund PO, Zelter A, Wordeman L, Asbury CL, Davis TN.

Nat Cell Biol. 2008 Apr;10(4):407-14. doi: 10.1038/ncb1702. Epub 2008 Mar 23.


The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment.

Stumpff J, von Dassow G, Wagenbach M, Asbury C, Wordeman L.

Dev Cell. 2008 Feb;14(2):252-62. doi: 10.1016/j.devcel.2007.11.014.


MCAK facilitates chromosome movement by promoting kinetochore microtubule turnover.

Wordeman L, Wagenbach M, von Dassow G.

J Cell Biol. 2007 Dec 3;179(5):869-79. Epub 2007 Nov 26.


In vitro and in vivo analysis of microtubule-destabilizing kinesins.

Stumpff J, Cooper J, Domnitz S, Moore AT, Rankin KE, Wagenbach M, Wordeman L.

Methods Mol Biol. 2007;392:37-49.

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