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Items: 35


Combining Vascular Normalization with an Oncolytic Virus Enhances Immunotherapy in Advanced Stage Ovarian Cancer.

Matuszewska K, Santry LA, Van Vloten JP, Au Yeung A, Major P, Lawler J, Wootton SK, Bridle BW, Petrik J.

Clin Cancer Res. 2018 Sep 11. pii: clincanres.0220.2018. doi: 10.1158/1078-0432.CCR-18-0220. [Epub ahead of print]


Use of Precision-Cut Lung Slices as an Ex Vivo Tool for Evaluating Viruses and Viral Vectors for Gene and Oncolytic Therapy.

Rosales Gerpe MC, van Vloten JP, Santry LA, de Jong J, Mould RC, Pelin A, Bell JC, Bridle BW, Wootton SK.

Mol Ther Methods Clin Dev. 2018 Aug 4;10:245-256. doi: 10.1016/j.omtm.2018.07.010. eCollection 2018 Sep 21.


A Novel Triple-Mutant AAV6 Capsid Induces Rapid and Potent Transgene Expression in the Muscle and Respiratory Tract of Mice.

van Lieshout LP, Domm JM, Rindler TN, Frost KL, Sorensen DL, Medina SJ, Booth SA, Bridges JP, Wootton SK.

Mol Ther Methods Clin Dev. 2018 Apr 14;9:323-329. doi: 10.1016/j.omtm.2018.04.005. eCollection 2018 Jun 15.


In ovo administration of Toll-like receptor ligands encapsulated in PLGA nanoparticles impede tumor development in chickens infected with Marek's disease virus.

Bavananthasivam J, Alkie TN, Astill J, Abdul-Careem MF, Wootton SK, Behboudi S, Yitbarek A, Sharif S.

Vaccine. 2018 Jun 27;36(28):4070-4076. doi: 10.1016/j.vaccine.2018.05.091. Epub 2018 May 30.


Production and Purification of High-Titer Newcastle Disease Virus for Use in Preclinical Mouse Models of Cancer.

Santry LA, McAusland TM, Susta L, Wood GA, Major PP, Petrik JJ, Bridle BW, Wootton SK.

Mol Ther Methods Clin Dev. 2017 Oct 16;9:181-191. doi: 10.1016/j.omtm.2017.10.004. eCollection 2018 Jun 15.


Intramuscular Adeno-Associated Virus-Mediated Expression of Monoclonal Antibodies Provides 100% Protection Against Ebola Virus Infection in Mice.

van Lieshout LP, Soule G, Sorensen D, Frost KL, He S, Tierney K, Safronetz D, Booth SA, Kobinger GP, Qiu X, Wootton SK.

J Infect Dis. 2018 Mar 5;217(6):916-925. doi: 10.1093/infdis/jix644.


Critical Interactions between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies.

van Vloten JP, Workenhe ST, Wootton SK, Mossman KL, Bridle BW.

J Immunol. 2018 Jan 15;200(2):450-458. doi: 10.4049/jimmunol.1701021. Review.


Enhancing Immune Responses to Cancer Vaccines Using Multi-Site Injections.

Mould RC, AuYeung AWK, van Vloten JP, Susta L, Mutsaers AJ, Petrik JJ, Wood GA, Wootton SK, Karimi K, Bridle BW.

Sci Rep. 2017 Aug 16;7(1):8322. doi: 10.1038/s41598-017-08665-9.


AAV vector distribution in the mouse respiratory tract following four different methods of administration.

Santry LA, Ingrao JC, Yu DL, de Jong JG, van Lieshout LP, Wood GA, Wootton SK.

BMC Biotechnol. 2017 May 15;17(1):43. doi: 10.1186/s12896-017-0365-2.


Construction of a molecular clone of ovine enzootic nasal tumor virus.

Walsh SR, Gerpe MC, Wootton SK.

Virol J. 2016 Dec 30;13(1):209. doi: 10.1186/s12985-016-0660-x.


Truncation of the enzootic nasal tumor virus envelope protein cytoplasmic tail increases Env-mediated fusion and infectivity.

Walsh SR, de Jong JG, van Vloten JP, Gerpe MC, Santry LA, Wootton SK.

J Gen Virol. 2017 Jan;98(1):108-120. doi: 10.1099/jgv.0.000654. Epub 2017 Feb 6.


Akt isoform specific effects in ovarian cancer progression.

Linnerth-Petrik NM, Santry LA, Moorehead R, Jücker M, Wootton SK, Petrik J.

Oncotarget. 2016 Nov 15;7(46):74820-74833. doi: 10.18632/oncotarget.11204.


Seroconversion of sheep experimentally infected with enzootic nasal tumor virus.

Walsh SR, Stinson KJ, Wootton SK.

BMC Res Notes. 2016 Jan 7;9:15. doi: 10.1186/s13104-015-1824-2.


Effects of interferon-γ knockdown on vaccine-induced immunity against Marek's disease in chickens.

Haq K, Wootton SK, Barjesteh N, Golovan S, Bendall A, Sharif S.

Can J Vet Res. 2015 Jan;79(1):1-7.


The sheep tetherin paralog oBST2B blocks envelope glycoprotein incorporation into nascent retroviral virions.

Murphy L, Varela M, Desloire S, Ftaich N, Murgia C, Golder M, Neil S, Spencer TE, Wootton SK, Lavillette D, Terzian C, Palmarini M, Arnaud F.

J Virol. 2015 Jan;89(1):535-44. doi: 10.1128/JVI.02751-14. Epub 2014 Oct 22.


Immunogenetics of small ruminant lentiviral infections.

Stonos N, Wootton SK, Karrow N.

Viruses. 2014 Aug 22;6(8):3311-33. doi: 10.3390/v6083311. Review.


Development of an ante-mortem diagnostic test for enzootic nasal tumor virus and detection of neutralizing antibodies in host serum.

Walsh SR, Stinson KJ, Menzies PI, Wootton SK.

J Gen Virol. 2014 Aug;95(Pt 8):1843-54. doi: 10.1099/vir.0.064956-0. Epub 2014 May 16.


Opposing functions of Akt isoforms in lung tumor initiation and progression.

Linnerth-Petrik NM, Santry LA, Petrik JJ, Wootton SK.

PLoS One. 2014 Apr 10;9(4):e94595. doi: 10.1371/journal.pone.0094595. eCollection 2014.


Jaagsiekte sheep retrovirus detected in human lung cancer tissue arrays.

Linnerth-Petrik NM, Walsh SR, Bogner PN, Morrison C, Wootton SK.

BMC Res Notes. 2014 Mar 19;7:160. doi: 10.1186/1756-0500-7-160.


Experimental transmission of enzootic nasal adenocarcinoma in sheep.

Walsh SR, Linnerth-Petrik NM, Yu DL, Foster RA, Menzies PI, Diaz-Méndez A, Chalmers HJ, Wootton SK.

Vet Res. 2013 Jul 30;44:66. doi: 10.1186/1297-9716-44-66.


Genetic characterization of small ruminant lentiviruses circulating in naturally infected sheep and goats in Ontario, Canada.

Santry LA, de Jong J, Gold AC, Walsh SR, Menzies PI, Wootton SK.

Virus Res. 2013 Jul;175(1):30-44. doi: 10.1016/j.virusres.2013.03.019. Epub 2013 Apr 10.


Small interfering RNA-mediated knockdown of chicken interferon-γ expression.

Haq K, Wootton SK, Barjesteh N, St Paul M, Golovan S, Bendall AJ, Sharif S.

J Interferon Cytokine Res. 2013 Jun;33(6):319-27. doi: 10.1089/jir.2012.0141. Epub 2013 Mar 4.


Adeno-associated virus vector mediated expression of an oncogenic retroviral envelope protein induces lung adenocarcinomas in immunocompetent mice.

Linnerth-Petrik NM, Santry LA, Yu DL, Wootton SK.

PLoS One. 2012;7(12):e51400. doi: 10.1371/journal.pone.0051400. Epub 2012 Dec 10.


Lung cancer in mice induced by the jaagsiekte sheep retrovirus envelope protein is not maintained by rare cancer stem cells, but tumorigenicity does correlate with Wnt pathway activation.

Vaughan AE, Halbert CL, Wootton SK, Miller AD.

Mol Cancer Res. 2012 Jan;10(1):86-95. doi: 10.1158/1541-7786.MCR-11-0285. Epub 2011 Nov 7.


Jaagsiekte sheep retrovirus and enzootic nasal tumor virus promoters drive gene expression in all airway epithelial cells of mice but only induce tumors in the alveolar region of the lungs.

Yu DL, Linnerth-Petrik NM, Halbert CL, Walsh SR, Miller AD, Wootton SK.

J Virol. 2011 Aug;85(15):7535-45. doi: 10.1128/JVI.00400-11. Epub 2011 May 18.


Paranasal sinus masses of Rocky Mountain bighorn sheep (Ovis canadensis canadensis).

Fox KA, Wootton SK, Quackenbush SL, Wolfe LL, Levan IK, Miller MW, Spraker TR.

Vet Pathol. 2011 May;48(3):706-12. doi: 10.1177/0300985810383873. Epub 2010 Oct 6.


Full-length genome sequence analysis of enzootic nasal tumor virus reveals an unusually high degree of genetic stability.

Walsh SR, Linnerth-Petrik NM, Laporte AN, Menzies PI, Foster RA, Wootton SK.

Virus Res. 2010 Jul;151(1):74-87. doi: 10.1016/j.virusres.2010.04.002. Epub 2010 Apr 14.


Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV.

Wootton SK, Metzger MJ, Hudkins KL, Alpers CE, York D, DeMartini JC, Miller AD.

Retrovirology. 2006 Dec 19;3:94.


Sheep retrovirus structural protein induces lung tumours.

Wootton SK, Halbert CL, Miller AD.

Nature. 2005 Apr 14;434(7035):904-7.


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